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The map label for this gene is ywcA [H]

Identifier: 23099897

GI number: 23099897

Start: 2497918

End: 2499447

Strand: Reverse

Name: ywcA [H]

Synonym: OB2442

Alternate gene names: 23099897

Gene position: 2499447-2497918 (Counterclockwise)

Preceding gene: 23099898

Following gene: 23099896

Centisome position: 68.85

GC content: 37.65

Gene sequence:

>1530_bases
ATGAATTTAATAGTTGTCATTTTATTTCTAGCAATCGTATCACTTACTTTGGTGATTACATACTTTGCAGCAAAGCGGAC
TCAATCAACTGGAGATTTTTACACAGCTGGCGGTGGTTTAACTGGTTGGCAAAATGGACTAGCTATTGCTGGAGATTATT
TATCCGCTGCATCTTTCTTAGGTATTGCAGGTGCAATCGCTTTATATGGATTTGATGGTTTTTTCTATAGTATTGGTTTT
TTAATTGCTTATTTAGTAGTAATGTTTTTAGTCGCAGAGCCTTTACGTAATTTAGGTAAGTACACATTGGCAGATATGAT
TAATTCAAGATTTGATGCTAAAAAAGTAAGGGCTGTTGCAGCAATTAGTACGATTACCATTGTTATCTTCTATATGATTG
CCCAGTTAGTAGGAGCAGGAGCACTTATTCAATTATTATTTGGTATTGATTACTGGATGGCGGTTTTACTCGTTGGAGTC
ATGATGACTATATATGTATTGTTTGGTGGTATGACTGCAACCAGTTGGGTTCAAATTATAAAAGCTGTACTTTTAATGTT
AGGAACTGTAATTATTGCATTCTTGGTGTTAATGAAATTTAACTTTAATATTTTTCAGATGTTCTCAGAGGTGAAGACCG
TAACTAGTCACGGTGATGCCTATCTTCAACCAGGGTTAAAATATACTGTTCCATTAGATACGATATCATTGATGCTGGCT
TTGGTTTTAGGGACGGCAGGTTTACCTCATATTTTAATGAGATTTTTTACGGTGAAAGACGCAAGAACAGCACGTTCATC
AGTAGTAACAGCCACATGGGTGGTTGGGATATTTTATATTCTTACGATATTTTTAGGGTTTGGTGCAGCAGCATTTGTTG
GAGAAAGCAATATACTTGAAGCGAATCCTGCTGGAAATATGGCAGCACCACTGCTTGCAGAAGCATTAGGTGGAGATTTA
TTAATGTCATTTGTTGCAGCAGTTGCGTTTGCTACTATATTAGCAGTTGTAGCAGGCCTCGTTCTCTCTGGTGCTTCCGC
ATTTGCCCATGATATCTACGGTCAAATAATTAAAAAAGGAAAGGCTTCAGATAGGGAGCAAATGTTAGCGGCAAAATGGG
CATCTTTAGGTGTATCTGTATTTTCGATATTACTTTCACTATTTGCACAATCACTTAACGTGGCATTTCTCGTATCTTTA
GCCTTCTGTGTGGCAGCCAGTGCAAACTTACCAGTAATACTATACACCATATATTGGAAACGTTTTAATACATCGGGAGC
AATTACTGCGATGTTATCAGGGTTATTAACTGCAATAATTTTAGTTTCTATGAGCCCGAATGTATTCGCTTTAGACGGAA
GTGCAATTTTTGTTGGTGATCCTTTATTTCCATTAACAAATCCAGCATTAATATCAGTTCCTGTCGGGTTCTTAGGTGGC
TTCCTGGGTACGATTCTTTCAAAAGAATTGGATCCTGGTAGATATGCAGAAGTTAAGGTTAGGGCGAACACAGGATATCG
CGGGAACTAG

Upstream 100 bases:

>100_bases
ACATGGGTGCTTTGTATCGTTTATGTGAAACGATCTGCAAAATTTGATAAACAGGCTGATGAGATCATCGAAGAAGAAAT
AGAAGGGGAGAGGTAATTTA

Downstream 100 bases:

>100_bases
TTAGAAATTAAAACTATTTTTACTGTTAATAGATATAGTATTTTCTAAACCAATTTACTCTATGATATAAACGATCAGGA
GTAGATTGGTTTTTTTATGA

Product: Na(+)-dependent symporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 509; Mature: 509

Protein sequence:

>509_residues
MNLIVVILFLAIVSLTLVITYFAAKRTQSTGDFYTAGGGLTGWQNGLAIAGDYLSAASFLGIAGAIALYGFDGFFYSIGF
LIAYLVVMFLVAEPLRNLGKYTLADMINSRFDAKKVRAVAAISTITIVIFYMIAQLVGAGALIQLLFGIDYWMAVLLVGV
MMTIYVLFGGMTATSWVQIIKAVLLMLGTVIIAFLVLMKFNFNIFQMFSEVKTVTSHGDAYLQPGLKYTVPLDTISLMLA
LVLGTAGLPHILMRFFTVKDARTARSSVVTATWVVGIFYILTIFLGFGAAAFVGESNILEANPAGNMAAPLLAEALGGDL
LMSFVAAVAFATILAVVAGLVLSGASAFAHDIYGQIIKKGKASDREQMLAAKWASLGVSVFSILLSLFAQSLNVAFLVSL
AFCVAASANLPVILYTIYWKRFNTSGAITAMLSGLLTAIILVSMSPNVFALDGSAIFVGDPLFPLTNPALISVPVGFLGG
FLGTILSKELDPGRYAEVKVRANTGYRGN

Sequences:

>Translated_509_residues
MNLIVVILFLAIVSLTLVITYFAAKRTQSTGDFYTAGGGLTGWQNGLAIAGDYLSAASFLGIAGAIALYGFDGFFYSIGF
LIAYLVVMFLVAEPLRNLGKYTLADMINSRFDAKKVRAVAAISTITIVIFYMIAQLVGAGALIQLLFGIDYWMAVLLVGV
MMTIYVLFGGMTATSWVQIIKAVLLMLGTVIIAFLVLMKFNFNIFQMFSEVKTVTSHGDAYLQPGLKYTVPLDTISLMLA
LVLGTAGLPHILMRFFTVKDARTARSSVVTATWVVGIFYILTIFLGFGAAAFVGESNILEANPAGNMAAPLLAEALGGDL
LMSFVAAVAFATILAVVAGLVLSGASAFAHDIYGQIIKKGKASDREQMLAAKWASLGVSVFSILLSLFAQSLNVAFLVSL
AFCVAASANLPVILYTIYWKRFNTSGAITAMLSGLLTAIILVSMSPNVFALDGSAIFVGDPLFPLTNPALISVPVGFLGG
FLGTILSKELDPGRYAEVKVRANTGYRGN
>Mature_509_residues
MNLIVVILFLAIVSLTLVITYFAAKRTQSTGDFYTAGGGLTGWQNGLAIAGDYLSAASFLGIAGAIALYGFDGFFYSIGF
LIAYLVVMFLVAEPLRNLGKYTLADMINSRFDAKKVRAVAAISTITIVIFYMIAQLVGAGALIQLLFGIDYWMAVLLVGV
MMTIYVLFGGMTATSWVQIIKAVLLMLGTVIIAFLVLMKFNFNIFQMFSEVKTVTSHGDAYLQPGLKYTVPLDTISLMLA
LVLGTAGLPHILMRFFTVKDARTARSSVVTATWVVGIFYILTIFLGFGAAAFVGESNILEANPAGNMAAPLLAEALGGDL
LMSFVAAVAFATILAVVAGLVLSGASAFAHDIYGQIIKKGKASDREQMLAAKWASLGVSVFSILLSLFAQSLNVAFLVSL
AFCVAASANLPVILYTIYWKRFNTSGAITAMLSGLLTAIILVSMSPNVFALDGSAIFVGDPLFPLTNPALISVPVGFLGG
FLGTILSKELDPGRYAEVKVRANTGYRGN

Specific function: Unknown

COG id: COG4147

COG function: function code R; Predicted symporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=437, Percent_Identity=24.2562929061785, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI4507031, Length=470, Percent_Identity=21.063829787234, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI14140236, Length=479, Percent_Identity=20.6680584551148, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1790503, Length=515, Percent_Identity=47.7669902912621, Blast_Score=446, Evalue=1e-126,
Organism=Escherichia coli, GI1787251, Length=437, Percent_Identity=26.0869565217391, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI87082237, Length=447, Percent_Identity=22.8187919463087, Blast_Score=81, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 54146; Mature: 54146

Theoretical pI: Translated: 9.35; Mature: 9.35

Prosite motif: PS00456 NA_SOLUT_SYMP_1 ; PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHCCCCCCCEEEEEEEECCCCCCC
>Mature Secondary Structure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HHHHHHHCCCCCCCEEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7934828; 9384377 [H]