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The map label for this gene is iscS2 [H]

Identifier: 23099654

GI number: 23099654

Start: 2232533

End: 2233672

Strand: Reverse

Name: iscS2 [H]

Synonym: OB2199

Alternate gene names: 23099654

Gene position: 2233672-2232533 (Counterclockwise)

Preceding gene: 23099655

Following gene: 23099653

Centisome position: 61.52

GC content: 35.79

Gene sequence:

>1140_bases
ATGATTTATTTAGATAATAGTGCAACAACTCAGCCAAAAGAAGAGGTTATTCAAAGCTTTCAACTAGCTTCTTCTCAATT
CTTTGCAAATCCCTCTTCTATTCATCCGCTTGGTGGAAGAGTAGAAAAACTATTACGTACTGCTAAGCAACAAGCAGCAG
AAACGTTGGGAGTTAGAAGTGAAGAAATTATCTTTACATCCGGTGGTACAGAAGGAAATAATACCGCTATTAAAGGAATA
GCTTTAGAGCATGGGCAGAGAGGCAAGCATATAATTACCACCGAAGCGGAACACCCATCTATTTATGATACGTGTACAAG
TTTAGAGAACTTAGGCTATCGAATTACTTTCTTACCAGTAGACGAGAATGGATTGGTTTCAGTGAAGCAAGTAGAAGAAG
CAATAGAGCCTGATACCATCTTAATAACAATGATGTATGTTAATAATGAAATTGGAGCCATTCAGCCAATTGAAGCGATT
GGAACTATGTTGAAAAAACATCCAAAAGTATTTTTCCATGTAGATGCAGTTCAAGCATTAGGAAAAGTACCATTGAAATT
AACTGGAAGTGGTATTGATTTATGTACCTTTTCTGGTCATAAAATCCATGGATTAAAAGGAACAGGAATGCTTTTTGTGG
AAAAAACAACGACACTATTTCCGTTGATGCATGGAGGTAATCAAGAATATGGCGTGCGTTCGGGGACAGAAAATGTCGCT
GGTGCAGTATCATTTGTAAAAGCACTTCGTCTAGTCATGGAACAATATAAACAAAATATACAACATCTAACCCACTTAAA
TGAAGTATTAAGAAAAGGGTTATCTGAATTGAAGGATATCGTTATCCATTCTTCCTCAAATGGAGCACCACATATTATTA
ATTTTTCCGTACTCGGTGTAAAGCCAGAAGTAATGATTCATACTTTAAGTGAAAAGGAAATATATATTTCGACTAAATCT
GCTTGCTCTTCGAAAGAATTAGATGAAAGCAGAATTCTTATTGCTTGTGGAAAATCGCGAGAAGAAGCAATATCTGGCCT
ACGTGTTAGTTTTTCTTATGATAATACGGTGGCAGAAGTAGAACTGTTTTTAAAAGAACTGCATAATGCAATTAAACAAT
ATAAAGAAGCATTGGGGTAG

Upstream 100 bases:

>100_bases
TCAACTAACTTTGAATAGATAGATTTTATAAAGGCTGTCATTAAGAGACGATATGTTTCTTGAGTCAGCCTTACATTTTT
GTAAAAGTAGGTGAGATAGT

Downstream 100 bases:

>100_bases
ATAGTAATGAATTACGATCATATATTAATACGCTATGGAGAAATGGCGTTAAAAGGAAAGAACATAAAACAATTTATCAT
AAAATTACAGGAAAATATTC

Product: L-cysteine sulfurtransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MIYLDNSATTQPKEEVIQSFQLASSQFFANPSSIHPLGGRVEKLLRTAKQQAAETLGVRSEEIIFTSGGTEGNNTAIKGI
ALEHGQRGKHIITTEAEHPSIYDTCTSLENLGYRITFLPVDENGLVSVKQVEEAIEPDTILITMMYVNNEIGAIQPIEAI
GTMLKKHPKVFFHVDAVQALGKVPLKLTGSGIDLCTFSGHKIHGLKGTGMLFVEKTTTLFPLMHGGNQEYGVRSGTENVA
GAVSFVKALRLVMEQYKQNIQHLTHLNEVLRKGLSELKDIVIHSSSNGAPHIINFSVLGVKPEVMIHTLSEKEIYISTKS
ACSSKELDESRILIACGKSREEAISGLRVSFSYDNTVAEVELFLKELHNAIKQYKEALG

Sequences:

>Translated_379_residues
MIYLDNSATTQPKEEVIQSFQLASSQFFANPSSIHPLGGRVEKLLRTAKQQAAETLGVRSEEIIFTSGGTEGNNTAIKGI
ALEHGQRGKHIITTEAEHPSIYDTCTSLENLGYRITFLPVDENGLVSVKQVEEAIEPDTILITMMYVNNEIGAIQPIEAI
GTMLKKHPKVFFHVDAVQALGKVPLKLTGSGIDLCTFSGHKIHGLKGTGMLFVEKTTTLFPLMHGGNQEYGVRSGTENVA
GAVSFVKALRLVMEQYKQNIQHLTHLNEVLRKGLSELKDIVIHSSSNGAPHIINFSVLGVKPEVMIHTLSEKEIYISTKS
ACSSKELDESRILIACGKSREEAISGLRVSFSYDNTVAEVELFLKELHNAIKQYKEALG
>Mature_379_residues
MIYLDNSATTQPKEEVIQSFQLASSQFFANPSSIHPLGGRVEKLLRTAKQQAAETLGVRSEEIIFTSGGTEGNNTAIKGI
ALEHGQRGKHIITTEAEHPSIYDTCTSLENLGYRITFLPVDENGLVSVKQVEEAIEPDTILITMMYVNNEIGAIQPIEAI
GTMLKKHPKVFFHVDAVQALGKVPLKLTGSGIDLCTFSGHKIHGLKGTGMLFVEKTTTLFPLMHGGNQEYGVRSGTENVA
GAVSFVKALRLVMEQYKQNIQHLTHLNEVLRKGLSELKDIVIHSSSNGAPHIINFSVLGVKPEVMIHTLSEKEIYISTKS
ACSSKELDESRILIACGKSREEAISGLRVSFSYDNTVAEVELFLKELHNAIKQYKEALG

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=380, Percent_Identity=36.8421052631579, Blast_Score=243, Evalue=2e-64,
Organism=Homo sapiens, GI156713448, Length=413, Percent_Identity=30.5084745762712, Blast_Score=173, Evalue=2e-43,
Organism=Escherichia coli, GI48994898, Length=383, Percent_Identity=37.8590078328982, Blast_Score=252, Evalue=3e-68,
Organism=Escherichia coli, GI1787970, Length=294, Percent_Identity=25.1700680272109, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1789175, Length=402, Percent_Identity=23.134328358209, Blast_Score=85, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI25143064, Length=366, Percent_Identity=37.1584699453552, Blast_Score=226, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI17533177, Length=331, Percent_Identity=31.7220543806647, Blast_Score=145, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6319831, Length=383, Percent_Identity=36.2924281984334, Blast_Score=238, Evalue=1e-63,
Organism=Drosophila melanogaster, GI20129463, Length=380, Percent_Identity=37.3684210526316, Blast_Score=248, Evalue=4e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 41557; Mature: 41557

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIYLDNSATTQPKEEVIQSFQLASSQFFANPSSIHPLGGRVEKLLRTAKQQAAETLGVRS
CEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
EEIIFTSGGTEGNNTAIKGIALEHGQRGKHIITTEAEHPSIYDTCTSLENLGYRITFLPV
CEEEEECCCCCCCCCEEEEEEECCCCCCCEEEEECCCCCCHHHHHHHHHHCCEEEEEEEE
DENGLVSVKQVEEAIEPDTILITMMYVNNEIGAIQPIEAIGTMLKKHPKVFFHVDAVQAL
CCCCCEEHHHHHHHCCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHCCCEEEEEHHHHHH
GKVPLKLTGSGIDLCTFSGHKIHGLKGTGMLFVEKTTTLFPLMHGGNQEYGVRSGTENVA
CCCCEEEECCCEEEEEECCCEEECCCCCCEEEEECCCEEEEEEECCCCCCCCCCCCHHHH
GAVSFVKALRLVMEQYKQNIQHLTHLNEVLRKGLSELKDIVIHSSSNGAPHIINFSVLGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCEEEEEEEECC
KPEVMIHTLSEKEIYISTKSACSSKELDESRILIACGKSREEAISGLRVSFSYDNTVAEV
CCEEEEEEECCCEEEEEECCCCCCCCCCCCEEEEEECCCHHHHHCCEEEEEECCCHHHHH
ELFLKELHNAIKQYKEALG
HHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIYLDNSATTQPKEEVIQSFQLASSQFFANPSSIHPLGGRVEKLLRTAKQQAAETLGVRS
CEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
EEIIFTSGGTEGNNTAIKGIALEHGQRGKHIITTEAEHPSIYDTCTSLENLGYRITFLPV
CEEEEECCCCCCCCCEEEEEEECCCCCCCEEEEECCCCCCHHHHHHHHHHCCEEEEEEEE
DENGLVSVKQVEEAIEPDTILITMMYVNNEIGAIQPIEAIGTMLKKHPKVFFHVDAVQAL
CCCCCEEHHHHHHHCCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHCCCEEEEEHHHHHH
GKVPLKLTGSGIDLCTFSGHKIHGLKGTGMLFVEKTTTLFPLMHGGNQEYGVRSGTENVA
CCCCEEEECCCEEEEEECCCEEECCCCCCEEEEECCCEEEEEEECCCCCCCCCCCCHHHH
GAVSFVKALRLVMEQYKQNIQHLTHLNEVLRKGLSELKDIVIHSSSNGAPHIINFSVLGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCEEEEEEEECC
KPEVMIHTLSEKEIYISTKSACSSKELDESRILIACGKSREEAISGLRVSFSYDNTVAEV
CCEEEEEEECCCEEEEEECCCCCCCCCCCCEEEEEECCCHHHHHCCEEEEEECCCHHHHH
ELFLKELHNAIKQYKEALG
HHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]