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The map label for this gene is ezrA

Identifier: 23099655

GI number: 23099655

Start: 2233751

End: 2235445

Strand: Reverse

Name: ezrA

Synonym: OB2200

Alternate gene names: 23099655

Gene position: 2235445-2233751 (Counterclockwise)

Preceding gene: 23099656

Following gene: 23099654

Centisome position: 61.57

GC content: 33.16

Gene sequence:

>1695_bases
ATGGTTTTCGTCATCAGCGTCATTTTAGCAATTATTGTAATATTAACCATTGGACTTATTCTAAGAAAACGAATTTATGA
CAAAGTAGACCATCAAGAAAAGTGGAAAATGGATATTATGGCAAGGGATGTAGCACAACAAATAAGTAAGATTAAAAGCC
TTAATTTGTCCGGAGAAACACAAGAAAAATTTGAACTTTGGAAAGGTCGCTGGGAGCATATCATTACAAAGGAACTTCCA
GACATTGAAGATCATTTATTTGATGCAGAAGATGCAGCGGATAAATTTAGAATGAAAAGAGCGAACAATATCTTAACTGA
AGGAGACCAGAAACTTCAAAATATTGAAGTTAAAATAGAAGAAATACTTGAGGAATTAGATGAATTGTTAAGCTCTGAAA
AAACGAGCAGAGAAGAGGTTGCTCAAATTGTTCCTACAATTAAACTTCTTCGTAAAACACTTTCGCAATCGAGATATCAA
TATGGGAAAGCAGAGAAATTTTTTGATAAAAAGTTGGATGAGTTTGATACTCAACTGGCTACATATGAAGATAATGTTGA
ATCAGGAGATTACTTAGAAGCTAATAGACTAATACAGGTCTTAAAAGAAGAAATTGCTGAGTTTGAAATCAAGATGGAGC
AATTCCCAGAAATCTTAAGAAGGTGTAAGCAGGATTTACCATCTCAGTTAGAACAAGTTTTAGCAGGTCTCCAAGAGATG
AAAAATGACGGCTATCGCGTAAAGCATTTTGGATTTGATAAAGAAATTATTACATACCAAGATCAGCTCAAGAATTTACA
ACAGCAAATAGAACAAGGTGATATTACCGATGTTTCAACTAAATTGGACGAGATAGAAGAACGTATTACCGAAATGTATG
AATCTCTTGAAGGAGAAGCTATTGCTAAAAATTATTTAGAGCAGCGTATACCAGAGTATGAGAAATCAATTAGCGAAATT
GCCGCTACTTATGATGATACAAAATTGGAAGTTGAGGAATTACAGAAAGCTTATTTTGTAGAAAATAATGATATGGAACG
ATTTTTTACCATCGGAAAAACCATTTCTACTTTAAGAGAACAATTAAAAGAACTTCACAAAGAAATGGATGACGATCAAA
AATCACATTCCGATTTACAAAATATAGTTGAAGATGGATTTGATAAAATTGAACAGCTTGAAGAACAGCATGAAGAATTT
AAAAAATCTATTGAAAACCTTAGAAAAGATGAAATGGAAGCAAGAGAAAAGCTTATAGAGATGCGAAGACAACTTTATGA
GTTGAATAGAAAGATAAAAAAGAGTAATATACCAGGTGTACCAGGATTTATTTGGACAAGATTTGAAACGGCTTCTGCAA
AGAATAGTCAAGTAGTAGATGTCTTAGAAGATTATCCATTAGATATTGCGAAAGTGCAACATGCATTATCGGAAGCAAAA
CAAGCGGTTGATCAAACACATGAGCAAATTGATATTATGCTTGATCAAGCATACCTAACGGAACAAGTGATTCAATATGC
GAACCGTTATCGTAGCCAACAACCAGATTTAAATGGAAAATTAAAAGAGGCTGAGCGATTATTCCGGAATTATGAATATG
AATTATCTTTAGAGCATGCTGCAAAAGCAATTGAAGAAATTGAGCCTGGAGCATTAAAGCGAATTGAAGAGAATCAACTA
ACTTTGAATAGATAG

Upstream 100 bases:

>100_bases
TATCATTAAGTAAATATAGTTACGTATACTTAAATTTTAATATATATGATTAAAAATAGATTGTAATTGATTTGTAGGTA
TTCTGGTTGGGAGGCATATT

Downstream 100 bases:

>100_bases
ATTTTATAAAGGCTGTCATTAAGAGACGATATGTTTCTTGAGTCAGCCTTACATTTTTGTAAAAGTAGGTGAGATAGTAT
GATTTATTTAGATAATAGTG

Product: septation ring formation regulator EzrA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 564; Mature: 564

Protein sequence:

>564_residues
MVFVISVILAIIVILTIGLILRKRIYDKVDHQEKWKMDIMARDVAQQISKIKSLNLSGETQEKFELWKGRWEHIITKELP
DIEDHLFDAEDAADKFRMKRANNILTEGDQKLQNIEVKIEEILEELDELLSSEKTSREEVAQIVPTIKLLRKTLSQSRYQ
YGKAEKFFDKKLDEFDTQLATYEDNVESGDYLEANRLIQVLKEEIAEFEIKMEQFPEILRRCKQDLPSQLEQVLAGLQEM
KNDGYRVKHFGFDKEIITYQDQLKNLQQQIEQGDITDVSTKLDEIEERITEMYESLEGEAIAKNYLEQRIPEYEKSISEI
AATYDDTKLEVEELQKAYFVENNDMERFFTIGKTISTLREQLKELHKEMDDDQKSHSDLQNIVEDGFDKIEQLEEQHEEF
KKSIENLRKDEMEAREKLIEMRRQLYELNRKIKKSNIPGVPGFIWTRFETASAKNSQVVDVLEDYPLDIAKVQHALSEAK
QAVDQTHEQIDIMLDQAYLTEQVIQYANRYRSQQPDLNGKLKEAERLFRNYEYELSLEHAAKAIEEIEPGALKRIEENQL
TLNR

Sequences:

>Translated_564_residues
MVFVISVILAIIVILTIGLILRKRIYDKVDHQEKWKMDIMARDVAQQISKIKSLNLSGETQEKFELWKGRWEHIITKELP
DIEDHLFDAEDAADKFRMKRANNILTEGDQKLQNIEVKIEEILEELDELLSSEKTSREEVAQIVPTIKLLRKTLSQSRYQ
YGKAEKFFDKKLDEFDTQLATYEDNVESGDYLEANRLIQVLKEEIAEFEIKMEQFPEILRRCKQDLPSQLEQVLAGLQEM
KNDGYRVKHFGFDKEIITYQDQLKNLQQQIEQGDITDVSTKLDEIEERITEMYESLEGEAIAKNYLEQRIPEYEKSISEI
AATYDDTKLEVEELQKAYFVENNDMERFFTIGKTISTLREQLKELHKEMDDDQKSHSDLQNIVEDGFDKIEQLEEQHEEF
KKSIENLRKDEMEAREKLIEMRRQLYELNRKIKKSNIPGVPGFIWTRFETASAKNSQVVDVLEDYPLDIAKVQHALSEAK
QAVDQTHEQIDIMLDQAYLTEQVIQYANRYRSQQPDLNGKLKEAERLFRNYEYELSLEHAAKAIEEIEPGALKRIEENQL
TLNR
>Mature_564_residues
MVFVISVILAIIVILTIGLILRKRIYDKVDHQEKWKMDIMARDVAQQISKIKSLNLSGETQEKFELWKGRWEHIITKELP
DIEDHLFDAEDAADKFRMKRANNILTEGDQKLQNIEVKIEEILEELDELLSSEKTSREEVAQIVPTIKLLRKTLSQSRYQ
YGKAEKFFDKKLDEFDTQLATYEDNVESGDYLEANRLIQVLKEEIAEFEIKMEQFPEILRRCKQDLPSQLEQVLAGLQEM
KNDGYRVKHFGFDKEIITYQDQLKNLQQQIEQGDITDVSTKLDEIEERITEMYESLEGEAIAKNYLEQRIPEYEKSISEI
AATYDDTKLEVEELQKAYFVENNDMERFFTIGKTISTLREQLKELHKEMDDDQKSHSDLQNIVEDGFDKIEQLEEQHEEF
KKSIENLRKDEMEAREKLIEMRRQLYELNRKIKKSNIPGVPGFIWTRFETASAKNSQVVDVLEDYPLDIAKVQHALSEAK
QAVDQTHEQIDIMLDQAYLTEQVIQYANRYRSQQPDLNGKLKEAERLFRNYEYELSLEHAAKAIEEIEPGALKRIEENQL
TLNR

Specific function: Negative regulator of ftsZ ring formation; modulates the frequency and position of ftsZ ring formation. Inhibits ftsZ ring formation at polar sites. Interacts either with ftsZ or with one of its binding partners to promote depolymerization

COG id: COG4477

COG function: function code D; Negative regulator of septation ring formation

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein. Note=Colocalized with ftsZ to the nascent septal site

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ezrA family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): EZRA_OCEIH (Q8EPB2)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_693121.1
- ProteinModelPortal:   Q8EPB2
- GeneID:   1015520
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB2200
- NMPDR:   fig|221109.1.peg.2198
- OMA:   MDIQELH
- ProtClustDB:   PRK04778
- BioCyc:   OIHE221109:OB2200-MONOMER
- HAMAP:   MF_00728
- InterPro:   IPR010379

Pfam domain/function: PF06160 EzrA

EC number: NA

Molecular weight: Translated: 66434; Mature: 66434

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xfa3c778)-;

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVFVISVILAIIVILTIGLILRKRIYDKVDHQEKWKMDIMARDVAQQISKIKSLNLSGET
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
QEKFELWKGRWEHIITKELPDIEDHLFDAEDAADKFRMKRANNILTEGDQKLQNIEVKIE
HHHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
EILEELDELLSSEKTSREEVAQIVPTIKLLRKTLSQSRYQYGKAEKFFDKKLDEFDTQLA
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
TYEDNVESGDYLEANRLIQVLKEEIAEFEIKMEQFPEILRRCKQDLPSQLEQVLAGLQEM
HHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KNDGYRVKHFGFDKEIITYQDQLKNLQQQIEQGDITDVSTKLDEIEERITEMYESLEGEA
HCCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHH
IAKNYLEQRIPEYEKSISEIAATYDDTKLEVEELQKAYFVENNDMERFFTIGKTISTLRE
HHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
QLKELHKEMDDDQKSHSDLQNIVEDGFDKIEQLEEQHEEFKKSIENLRKDEMEAREKLIE
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MRRQLYELNRKIKKSNIPGVPGFIWTRFETASAKNSQVVDVLEDYPLDIAKVQHALSEAK
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHH
QAVDQTHEQIDIMLDQAYLTEQVIQYANRYRSQQPDLNGKLKEAERLFRNYEYELSLEHA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCEEEHHHH
AKAIEEIEPGALKRIEENQLTLNR
HHHHHHCCCHHHHHHHHCCCCCCH
>Mature Secondary Structure
MVFVISVILAIIVILTIGLILRKRIYDKVDHQEKWKMDIMARDVAQQISKIKSLNLSGET
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
QEKFELWKGRWEHIITKELPDIEDHLFDAEDAADKFRMKRANNILTEGDQKLQNIEVKIE
HHHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
EILEELDELLSSEKTSREEVAQIVPTIKLLRKTLSQSRYQYGKAEKFFDKKLDEFDTQLA
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
TYEDNVESGDYLEANRLIQVLKEEIAEFEIKMEQFPEILRRCKQDLPSQLEQVLAGLQEM
HHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KNDGYRVKHFGFDKEIITYQDQLKNLQQQIEQGDITDVSTKLDEIEERITEMYESLEGEA
HCCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHH
IAKNYLEQRIPEYEKSISEIAATYDDTKLEVEELQKAYFVENNDMERFFTIGKTISTLRE
HHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
QLKELHKEMDDDQKSHSDLQNIVEDGFDKIEQLEEQHEEFKKSIENLRKDEMEAREKLIE
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MRRQLYELNRKIKKSNIPGVPGFIWTRFETASAKNSQVVDVLEDYPLDIAKVQHALSEAK
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHH
QAVDQTHEQIDIMLDQAYLTEQVIQYANRYRSQQPDLNGKLKEAERLFRNYEYELSLEHA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCEEEHHHH
AKAIEEIEPGALKRIEENQLTLNR
HHHHHHCCCHHHHHHHHCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12235376