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The map label for this gene is relA [H]

Identifier: 23099479

GI number: 23099479

Start: 2049547

End: 2051751

Strand: Reverse

Name: relA [H]

Synonym: OB2024

Alternate gene names: 23099479

Gene position: 2051751-2049547 (Counterclockwise)

Preceding gene: 23099480

Following gene: 23099478

Centisome position: 56.51

GC content: 34.83

Gene sequence:

>2205_bases
ATGGCAAAAGATGAAAATGTGACGATAAGGGATATAGTGGAACAAGTAAAAACTTATTTATCTGAAGATGATGTCGCATT
AATTGAACAAGCATATGAGTTTGCTTCCGATGCGCATAAAGATCAATTTCGGAAATCTGGAGAACCATATATTATCCATC
CTGTTCAAGTTGCAGGTATATTAGCTGACTTACAAATGGATTCAGAAACGATTTCTGCCGGGTTTTTACATGATGTGGTA
GAGGATACCGATGTAACAGTAGAACAATTAGAAGAAGCATTTAATCATGAAATTGCGATGTTGGTAGATGGTGTGACCAA
GTTAGGAAAAATTCGATACGAAACAAAAGAAGCACAGCAAGCAGAAAATCATCGAAAAATGTTTGTAGCAATGGCAAAAG
ACATACGTGTTATTATGATTAAGCTTGCAGATCGATTGCATAATATGCGTACATTAAAACATCTTGCTCCAGAAAAACAG
CGCAGAATTTCTAATGAAACATTAGAAATCTTTGCTCCGTTGGCACATCGATTAGGTATTTCTACTATTAAATGGGAGTT
AGAAGATACTGCTTTGCGCTATTTAAACCCACAGCAGTATTACCGGATCGTTCAGTTAATGAAGCAAAAGCGTGAAGAAA
GAGAATCTTATATTCAAGAAGTCATAGATGAGTTGGCCCTTGAATTAGACACGGTTAATATTGAAGCAGAAATGTCCGGC
CGACCGAAACATTTATATAGTATCTATCAAAAAATGGTAAAACAGAAAAAGCAATTTAATGAAATTTATGATTTACTTGC
TGTACGAATTCTTGTTGAAAATATTAAAGATTGTTATGCCGTACTTGGTATTATTCACACAAATTGGAAACCAATGCCAG
GACGATTCAAAGACTATATCGCAATGCCCAAACAAAATTTGTATCAATCACTTCATACAACGGTCATTGGTCCAAAAGGG
GATCCGTTAGAAGTACAGATACGTACAAAAGAAATGCATGATATTGCTGAATACGGTATTGCTGCACATTGGGCATATAA
AGAAGGTAAGACTTCTCGAGAAAAAAGTAGTTTCGAGGAAAAGCTATCTTGGTTCCGAGAAATTTTAGAATGGCAAAGTG
AAACTCATGATGCAGAAGAATTTATTGAGTCCTTGAAGATTGATTTATTTTCAGATATGGTATATGTTTTTACACCAAAA
GGGGAAGTGATTGAACTTCCTTCTGGTTCAATTCCTTTAGATTTTGCATTTAAAATCCATACGGAAATAGGTAATAAGAC
GATTGGTTCAAAAATTAACGGTAAAATGGAGCCATTAGATTACGAATTACAAAATGGCGATATCGTGGAAGTAATGACAT
CTAAACATTCTTATGGACCTTCTCAAGATTGGTTAAAGATGGTACAAACTTCACAAGCGAAGAGTAAAATTAAACAGTTC
TTTAAAAAGCAACAGCGAGATGAAAATGTTGTTAAAGGAAAAGAAGCTGTCGAAAAAGAAATACGTGAAAATGATATTGA
TCCTAAAGAAGTTTTAACCCAAGATAACTTAAATAGGGTTTTTGACAAATTTAACTTTCAAAACGAAGAAGATATGTATG
CTGCAGTTGGTTATCAAGGAATTACTGCTTCATTAATTGCAACGAGATTGACAGAAAAAATAAGACAATCTCGCGAGAAA
GAACAAGATTTGCAAGCAACTATTGAAGAAGTTAAGACGGAATCGGACCAGCATATAAAAAGAATGTACAAAAAGGACTC
TGGTGTACGAGTAGCTGGTGTAGATAACTTGCTAGTTCGAATCGCTAAATGTTGTAATCCAGTTCCAGGGGATGAAATTT
TAGGCTATATTACAAAAGGCAGAGGTGTATCGGTACACCGAGCAGATTGTCCAAATGTTCAAACGGAGGAAGCGAAACAA
CGATATATAGATGTAATGTGGGAAAGTGAATACGCTGAGCAGAAGCAATATCATGTTGATTTACAAATAACTGGTTACGA
TCGACGAGGACTCGTAAATGAAGTGCTACAAGCAGTTAATGAAATGAAAACGAATATTACCCATGTAAATGGCAGGTCAG
ATCGAAATAAGATGGCGATTATTCAATTAACTATATTAATTCATAATACTAGTCATTTGCGAAAAATTGTTGATCGAATT
AAACAAATTAGTGATGTTTATACTGTAACTAGGACAGTGCAATAA

Upstream 100 bases:

>100_bases
TGTCGAAATCCAAGTTCAAGTAAGTGCAATCTGTCTTGATTACATATGAAATGATTTTCGTTTTACAATATAAGAATATA
CAGCAAGTAAAGGTGATTAC

Downstream 100 bases:

>100_bases
TTTTCTCAAGCGATTAAGACAAAAAAATCTAAGGCATAAGATAGATGCGAGTAGTTAGCTTTTTAAAATTTGCTTCAGAA
ATATACTGTTTTTATCCTAT

Product: GTP pyrophosphokinase

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 734; Mature: 733

Protein sequence:

>734_residues
MAKDENVTIRDIVEQVKTYLSEDDVALIEQAYEFASDAHKDQFRKSGEPYIIHPVQVAGILADLQMDSETISAGFLHDVV
EDTDVTVEQLEEAFNHEIAMLVDGVTKLGKIRYETKEAQQAENHRKMFVAMAKDIRVIMIKLADRLHNMRTLKHLAPEKQ
RRISNETLEIFAPLAHRLGISTIKWELEDTALRYLNPQQYYRIVQLMKQKREERESYIQEVIDELALELDTVNIEAEMSG
RPKHLYSIYQKMVKQKKQFNEIYDLLAVRILVENIKDCYAVLGIIHTNWKPMPGRFKDYIAMPKQNLYQSLHTTVIGPKG
DPLEVQIRTKEMHDIAEYGIAAHWAYKEGKTSREKSSFEEKLSWFREILEWQSETHDAEEFIESLKIDLFSDMVYVFTPK
GEVIELPSGSIPLDFAFKIHTEIGNKTIGSKINGKMEPLDYELQNGDIVEVMTSKHSYGPSQDWLKMVQTSQAKSKIKQF
FKKQQRDENVVKGKEAVEKEIRENDIDPKEVLTQDNLNRVFDKFNFQNEEDMYAAVGYQGITASLIATRLTEKIRQSREK
EQDLQATIEEVKTESDQHIKRMYKKDSGVRVAGVDNLLVRIAKCCNPVPGDEILGYITKGRGVSVHRADCPNVQTEEAKQ
RYIDVMWESEYAEQKQYHVDLQITGYDRRGLVNEVLQAVNEMKTNITHVNGRSDRNKMAIIQLTILIHNTSHLRKIVDRI
KQISDVYTVTRTVQ

Sequences:

>Translated_734_residues
MAKDENVTIRDIVEQVKTYLSEDDVALIEQAYEFASDAHKDQFRKSGEPYIIHPVQVAGILADLQMDSETISAGFLHDVV
EDTDVTVEQLEEAFNHEIAMLVDGVTKLGKIRYETKEAQQAENHRKMFVAMAKDIRVIMIKLADRLHNMRTLKHLAPEKQ
RRISNETLEIFAPLAHRLGISTIKWELEDTALRYLNPQQYYRIVQLMKQKREERESYIQEVIDELALELDTVNIEAEMSG
RPKHLYSIYQKMVKQKKQFNEIYDLLAVRILVENIKDCYAVLGIIHTNWKPMPGRFKDYIAMPKQNLYQSLHTTVIGPKG
DPLEVQIRTKEMHDIAEYGIAAHWAYKEGKTSREKSSFEEKLSWFREILEWQSETHDAEEFIESLKIDLFSDMVYVFTPK
GEVIELPSGSIPLDFAFKIHTEIGNKTIGSKINGKMEPLDYELQNGDIVEVMTSKHSYGPSQDWLKMVQTSQAKSKIKQF
FKKQQRDENVVKGKEAVEKEIRENDIDPKEVLTQDNLNRVFDKFNFQNEEDMYAAVGYQGITASLIATRLTEKIRQSREK
EQDLQATIEEVKTESDQHIKRMYKKDSGVRVAGVDNLLVRIAKCCNPVPGDEILGYITKGRGVSVHRADCPNVQTEEAKQ
RYIDVMWESEYAEQKQYHVDLQITGYDRRGLVNEVLQAVNEMKTNITHVNGRSDRNKMAIIQLTILIHNTSHLRKIVDRI
KQISDVYTVTRTVQ
>Mature_733_residues
AKDENVTIRDIVEQVKTYLSEDDVALIEQAYEFASDAHKDQFRKSGEPYIIHPVQVAGILADLQMDSETISAGFLHDVVE
DTDVTVEQLEEAFNHEIAMLVDGVTKLGKIRYETKEAQQAENHRKMFVAMAKDIRVIMIKLADRLHNMRTLKHLAPEKQR
RISNETLEIFAPLAHRLGISTIKWELEDTALRYLNPQQYYRIVQLMKQKREERESYIQEVIDELALELDTVNIEAEMSGR
PKHLYSIYQKMVKQKKQFNEIYDLLAVRILVENIKDCYAVLGIIHTNWKPMPGRFKDYIAMPKQNLYQSLHTTVIGPKGD
PLEVQIRTKEMHDIAEYGIAAHWAYKEGKTSREKSSFEEKLSWFREILEWQSETHDAEEFIESLKIDLFSDMVYVFTPKG
EVIELPSGSIPLDFAFKIHTEIGNKTIGSKINGKMEPLDYELQNGDIVEVMTSKHSYGPSQDWLKMVQTSQAKSKIKQFF
KKQQRDENVVKGKEAVEKEIRENDIDPKEVLTQDNLNRVFDKFNFQNEEDMYAAVGYQGITASLIATRLTEKIRQSREKE
QDLQATIEEVKTESDQHIKRMYKKDSGVRVAGVDNLLVRIAKCCNPVPGDEILGYITKGRGVSVHRADCPNVQTEEAKQR
YIDVMWESEYAEQKQYHVDLQITGYDRRGLVNEVLQAVNEMKTNITHVNGRSDRNKMAIIQLTILIHNTSHLRKIVDRIK
QISDVYTVTRTVQ

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Homo sapiens, GI38348360, Length=145, Percent_Identity=34.4827586206897, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI1790082, Length=724, Percent_Identity=40.7458563535912, Blast_Score=570, Evalue=1e-164,
Organism=Escherichia coli, GI1789147, Length=693, Percent_Identity=39.2496392496393, Blast_Score=540, Evalue=1e-154,
Organism=Caenorhabditis elegans, GI25143118, Length=137, Percent_Identity=35.7664233576642, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24650996, Length=132, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 84965; Mature: 84834

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKDENVTIRDIVEQVKTYLSEDDVALIEQAYEFASDAHKDQFRKSGEPYIIHPVQVAGI
CCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHH
LADLQMDSETISAGFLHDVVEDTDVTVEQLEEAFNHEIAMLVDGVTKLGKIRYETKEAQQ
HHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
AENHRKMFVAMAKDIRVIMIKLADRLHNMRTLKHLAPEKQRRISNETLEIFAPLAHRLGI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCHHHHHHHHHHHHHCCC
STIKWELEDTALRYLNPQQYYRIVQLMKQKREERESYIQEVIDELALELDTVNIEAEMSG
HHEEEEHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCC
RPKHLYSIYQKMVKQKKQFNEIYDLLAVRILVENIKDCYAVLGIIHTNWKPMPGRFKDYI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
AMPKQNLYQSLHTTVIGPKGDPLEVQIRTKEMHDIAEYGIAAHWAYKEGKTSREKSSFEE
HCCHHHHHHHHHHHEECCCCCCEEEEEEHHHHHHHHHHCHHHEEECCCCCCCHHHHHHHH
KLSWFREILEWQSETHDAEEFIESLKIDLFSDMVYVFTPKGEVIELPSGSIPLDFAFKIH
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCEEEEECCCCCEEECCCCCCCEEEEEEEE
TEIGNKTIGSKINGKMEPLDYELQNGDIVEVMTSKHSYGPSQDWLKMVQTSQAKSKIKQF
HHHCCCCCCCCCCCCCCCCCEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHH
FKKQQRDENVVKGKEAVEKEIRENDIDPKEVLTQDNLNRVFDKFNFQNEEDMYAAVGYQG
HHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCC
ITASLIATRLTEKIRQSREKEQDLQATIEEVKTESDQHIKRMYKKDSGVRVAGVDNLLVR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCEEECHHHHHHH
IAKCCNPVPGDEILGYITKGRGVSVHRADCPNVQTEEAKQRYIDVMWESEYAEQKQYHVD
HHHHCCCCCCHHHHHHHCCCCCCEEECCCCCCCCHHHHHHHHHHHHCCHHHHCCCCEEEE
LQITGYDRRGLVNEVLQAVNEMKTNITHVNGRSDRNKMAIIQLTILIHNTSHLRKIVDRI
EEEECCCCCCHHHHHHHHHHHHHHCCEECCCCCCCCCEEEEEEEEEEECHHHHHHHHHHH
KQISDVYTVTRTVQ
HHHHHHHHHHHCCC
>Mature Secondary Structure 
AKDENVTIRDIVEQVKTYLSEDDVALIEQAYEFASDAHKDQFRKSGEPYIIHPVQVAGI
CCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHH
LADLQMDSETISAGFLHDVVEDTDVTVEQLEEAFNHEIAMLVDGVTKLGKIRYETKEAQQ
HHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
AENHRKMFVAMAKDIRVIMIKLADRLHNMRTLKHLAPEKQRRISNETLEIFAPLAHRLGI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCHHHHHHHHHHHHHCCC
STIKWELEDTALRYLNPQQYYRIVQLMKQKREERESYIQEVIDELALELDTVNIEAEMSG
HHEEEEHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCC
RPKHLYSIYQKMVKQKKQFNEIYDLLAVRILVENIKDCYAVLGIIHTNWKPMPGRFKDYI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
AMPKQNLYQSLHTTVIGPKGDPLEVQIRTKEMHDIAEYGIAAHWAYKEGKTSREKSSFEE
HCCHHHHHHHHHHHEECCCCCCEEEEEEHHHHHHHHHHCHHHEEECCCCCCCHHHHHHHH
KLSWFREILEWQSETHDAEEFIESLKIDLFSDMVYVFTPKGEVIELPSGSIPLDFAFKIH
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCEEEEECCCCCEEECCCCCCCEEEEEEEE
TEIGNKTIGSKINGKMEPLDYELQNGDIVEVMTSKHSYGPSQDWLKMVQTSQAKSKIKQF
HHHCCCCCCCCCCCCCCCCCEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHH
FKKQQRDENVVKGKEAVEKEIRENDIDPKEVLTQDNLNRVFDKFNFQNEEDMYAAVGYQG
HHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCC
ITASLIATRLTEKIRQSREKEQDLQATIEEVKTESDQHIKRMYKKDSGVRVAGVDNLLVR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCEEECHHHHHHH
IAKCCNPVPGDEILGYITKGRGVSVHRADCPNVQTEEAKQRYIDVMWESEYAEQKQYHVD
HHHHCCCCCCHHHHHHHCCCCCCEEECCCCCCCCHHHHHHHHHHHHCCHHHHCCCCEEEE
LQITGYDRRGLVNEVLQAVNEMKTNITHVNGRSDRNKMAIIQLTILIHNTSHLRKIVDRI
EEEECCCCCCHHHHHHHHHHHHHHCCEECCCCCCCCCEEEEEEEEEEECHHHHHHHHHHH
KQISDVYTVTRTVQ
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9383190; 9384377 [H]