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The map label for this gene is dtd

Identifier: 23099478

GI number: 23099478

Start: 2048799

End: 2049245

Strand: Reverse

Name: dtd

Synonym: OB2023

Alternate gene names: 23099478

Gene position: 2049245-2048799 (Counterclockwise)

Preceding gene: 23099479

Following gene: 23099476

Centisome position: 56.44

GC content: 32.66

Gene sequence:

>447_bases
ATGAAGGTAGTAATACAAAGATCAAAAGAAGCAAGTGTAACAGTAGATGATCAAATTATTGGCAATATATCCAGTGGGTT
TGTTGTGTTGTTAGGTATCACACATGAAGATACATATGAAGATATACAATACTTGGTATCAAAGATTCCTAATCTGCGTG
TATTTGAAGATGAAAATGGGAAAATGAATTTATCCTTAAAAGATGTAGGAGGAAGTATTCTTTCTGTTTCTCAATTCACA
TTATATGGAGATACTCGAAAAGGAAGAAGACCGAACTTTATGCAAGCAGCAAAACCATCAGTAGCAGAAGATTTATATAA
TAAGTTCAATACCTCTTTAATAGACGAAGGGATACATGTTGAAACTGGGGAATTTGGTGCTATGATGGATGTGAAATTAA
CAAATGATGGACCTGTAACTCTAATCATTGATAGTAAAGATAGATAA

Upstream 100 bases:

>100_bases
AATCTGTTCAGTTCAAAGTCCTTTAGGTCATGATATATTTAATGGGTGAATCAAATCTCCAAATGATGTAGTTTCATTTT
AAGGTTAGGAGTTAATTAGT

Downstream 100 bases:

>100_bases
AAGATCGCCAGCTATAGGAACGCTGGCGATTTTTTATTGGTTAAAATGTGTGGATAATCCTTCGAGTATTCCACTTACTA
ACTGTTTTTGATAACCAGTA

Product: D-tyrosyl-tRNA(Tyr) deacylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 148; Mature: 148

Protein sequence:

>148_residues
MKVVIQRSKEASVTVDDQIIGNISSGFVVLLGITHEDTYEDIQYLVSKIPNLRVFEDENGKMNLSLKDVGGSILSVSQFT
LYGDTRKGRRPNFMQAAKPSVAEDLYNKFNTSLIDEGIHVETGEFGAMMDVKLTNDGPVTLIIDSKDR

Sequences:

>Translated_148_residues
MKVVIQRSKEASVTVDDQIIGNISSGFVVLLGITHEDTYEDIQYLVSKIPNLRVFEDENGKMNLSLKDVGGSILSVSQFT
LYGDTRKGRRPNFMQAAKPSVAEDLYNKFNTSLIDEGIHVETGEFGAMMDVKLTNDGPVTLIIDSKDR
>Mature_148_residues
MKVVIQRSKEASVTVDDQIIGNISSGFVVLLGITHEDTYEDIQYLVSKIPNLRVFEDENGKMNLSLKDVGGSILSVSQFT
LYGDTRKGRRPNFMQAAKPSVAEDLYNKFNTSLIDEGIHVETGEFGAMMDVKLTNDGPVTLIIDSKDR

Specific function: Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine

COG id: COG1490

COG function: function code J; D-Tyr-tRNAtyr deacylase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DTD family

Homologues:

Organism=Homo sapiens, GI30795227, Length=148, Percent_Identity=45.945945945946, Blast_Score=110, Evalue=5e-25,
Organism=Escherichia coli, GI1790320, Length=143, Percent_Identity=43.3566433566434, Blast_Score=128, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI115533292, Length=151, Percent_Identity=43.046357615894, Blast_Score=119, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6319982, Length=150, Percent_Identity=44.6666666666667, Blast_Score=128, Evalue=4e-31,
Organism=Drosophila melanogaster, GI281361569, Length=150, Percent_Identity=44, Blast_Score=124, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DTD_OCEIH (Q8EPR6)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_692944.1
- ProteinModelPortal:   Q8EPR6
- SMR:   Q8EPR6
- GeneID:   1018512
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB2023
- NMPDR:   fig|221109.1.peg.2021
- HOGENOM:   HBG286048
- OMA:   MKAVIQR
- ProtClustDB:   PRK05273
- BioCyc:   OIHE221109:OB2023-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00518
- InterPro:   IPR003732
- Gene3D:   G3DSA:3.50.80.10
- PANTHER:   PTHR10472
- TIGRFAMs:   TIGR00256

Pfam domain/function: PF02580 Tyr_Deacylase; SSF69500 DTyrtRNA_deacyls

EC number: NA

Molecular weight: Translated: 16402; Mature: 16402

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: NA

Important sites: ACT_SITE 80-80

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVVIQRSKEASVTVDDQIIGNISSGFVVLLGITHEDTYEDIQYLVSKIPNLRVFEDENG
CEEEEECCCCCEEEECHHEECCCCCCEEEEEEECCCCCHHHHHHHHHHCCCEEEEECCCC
KMNLSLKDVGGSILSVSQFTLYGDTRKGRRPNFMQAAKPSVAEDLYNKFNTSLIDEGIHV
EEEEEECCCCCCEEEEEEEEEEECCCCCCCCCCHHHCCCHHHHHHHHHHCHHHHCCCCEE
ETGEFGAMMDVKLTNDGPVTLIIDSKDR
ECCCCCEEEEEEECCCCCEEEEEECCCC
>Mature Secondary Structure
MKVVIQRSKEASVTVDDQIIGNISSGFVVLLGITHEDTYEDIQYLVSKIPNLRVFEDENG
CEEEEECCCCCEEEECHHEECCCCCCEEEEEEECCCCCHHHHHHHHHHCCCEEEEECCCC
KMNLSLKDVGGSILSVSQFTLYGDTRKGRRPNFMQAAKPSVAEDLYNKFNTSLIDEGIHV
EEEEEECCCCCCEEEEEEEEEEECCCCCCCCCCHHHCCCHHHHHHHHHHCHHHHCCCCEE
ETGEFGAMMDVKLTNDGPVTLIIDSKDR
ECCCCCEEEEEEECCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376