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The map label for this gene is sirC [H]

Identifier: 23099112

GI number: 23099112

Start: 1700594

End: 1701223

Strand: Direct

Name: sirC [H]

Synonym: OB1657

Alternate gene names: 23099112

Gene position: 1700594-1701223 (Clockwise)

Preceding gene: 23099111

Following gene: 23099113

Centisome position: 46.84

GC content: 37.94

Gene sequence:

>630_bases
ATGGCTTTCACTCCACTGATGATTGATTTAAGTGACAGGCATGTCGTAATAGTCGGCGGAGGAAAAGTAGCTCTTCGCAG
AGCAAAAACACTTTTGGAAAACAATGCTGTTGTAACGGTGATAAGTCCGAAAGCAGTGGAAGCTATTGTATACCTATGGC
AAGAAGGACAATTACTTTGGAAAGAGAAAGTTATTGAAGCCACGGATCTTAAAGATGCTTTTCTTATTATTGTCGCTACG
AATAATCCTATCGTTAATCAACATGTAATCAACTGGGCACCAAAAGAGTCACTGATCAATGCTGCAGCAGAAGTGGAAAA
AGGAAATGTTGCTTTTCCAACTTATTTTAGAAGAGGACATCTCTCTGTTAGTGTATCGACGAATGGAGCAAGCCCGCAAT
TCGCGGTCAAAATGAAAGAAGAGCTTGAACGTTTATATCCTGAAGACTACGGAGATTATATCCATTTTTTATCTGAATGC
CGACAGCTTATTAAGAAATCTCTATTAGATAAATTTCAGCAGAAGTTGCTATTGAAAGAGCTTTTGTCGGAGGAATATTT
AGACAAAGATAGGCAGAGAAGGTTTATTGAATGGTTCAAGAAAAATGATAGAAAGAGTGAATCAGATTGA

Upstream 100 bases:

>100_bases
TCGTCAATTGTCTGATCATCCAATTATGGTCGAAGCATTGAAAGAACGAGTTTTAGAAGCAATTCATTCAAATACAAACT
TATAGAGGGGAGGTTAGATA

Downstream 100 bases:

>100_bases
TGGAGAAGGAAGCTAAAAGAATTGGCATCGCAGCGAGCCGAAGATCAGATGAAATCGCAGCGCTTGTTAAAAAGATTGGT
GGAACTCCTATAGTATTTTC

Product: precorrin-2 dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 209; Mature: 208

Protein sequence:

>209_residues
MAFTPLMIDLSDRHVVIVGGGKVALRRAKTLLENNAVVTVISPKAVEAIVYLWQEGQLLWKEKVIEATDLKDAFLIIVAT
NNPIVNQHVINWAPKESLINAAAEVEKGNVAFPTYFRRGHLSVSVSTNGASPQFAVKMKEELERLYPEDYGDYIHFLSEC
RQLIKKSLLDKFQQKLLLKELLSEEYLDKDRQRRFIEWFKKNDRKSESD

Sequences:

>Translated_209_residues
MAFTPLMIDLSDRHVVIVGGGKVALRRAKTLLENNAVVTVISPKAVEAIVYLWQEGQLLWKEKVIEATDLKDAFLIIVAT
NNPIVNQHVINWAPKESLINAAAEVEKGNVAFPTYFRRGHLSVSVSTNGASPQFAVKMKEELERLYPEDYGDYIHFLSEC
RQLIKKSLLDKFQQKLLLKELLSEEYLDKDRQRRFIEWFKKNDRKSESD
>Mature_208_residues
AFTPLMIDLSDRHVVIVGGGKVALRRAKTLLENNAVVTVISPKAVEAIVYLWQEGQLLWKEKVIEATDLKDAFLIIVATN
NPIVNQHVINWAPKESLINAAAEVEKGNVAFPTYFRRGHLSVSVSTNGASPQFAVKMKEELERLYPEDYGDYIHFLSECR
QLIKKSLLDKFQQKLLLKELLSEEYLDKDRQRRFIEWFKKNDRKSESD

Specific function: Catalyzes the dehydrogenation of precorrin-2 to form sirohydrochlorin used as precursor in both siroheme biosynthesis and in the anaerobic branch of adenosylcobalamin biosynthesis [H]

COG id: COG1648

COG function: function code H; Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789768, Length=198, Percent_Identity=27.7777777777778, Blast_Score=78, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR006367 [H]

Pfam domain/function: NA

EC number: =1.3.1.76 [H]

Molecular weight: Translated: 24019; Mature: 23888

Theoretical pI: Translated: 8.42; Mature: 8.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFTPLMIDLSDRHVVIVGGGKVALRRAKTLLENNAVVTVISPKAVEAIVYLWQEGQLLW
CCCCCEEEEECCCEEEEECCCHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHCCCCHH
KEKVIEATDLKDAFLIIVATNNPIVNQHVINWAPKESLINAAAEVEKGNVAFPTYFRRGH
HHHHHHHCCCCCEEEEEEECCCCCCCHHHCCCCCHHHHHHHHHHHCCCCEECCHHEECCE
LSVSVSTNGASPQFAVKMKEELERLYPEDYGDYIHFLSECRQLIKKSLLDKFQQKLLLKE
EEEEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLSEEYLDKDRQRRFIEWFKKNDRKSESD
HHHHHHHCHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
AFTPLMIDLSDRHVVIVGGGKVALRRAKTLLENNAVVTVISPKAVEAIVYLWQEGQLLW
CCCCEEEEECCCEEEEECCCHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHCCCCHH
KEKVIEATDLKDAFLIIVATNNPIVNQHVINWAPKESLINAAAEVEKGNVAFPTYFRRGH
HHHHHHHCCCCCEEEEEEECCCCCCCHHHCCCCCHHHHHHHHHHHCCCCEECCHHEECCE
LSVSVSTNGASPQFAVKMKEELERLYPEDYGDYIHFLSECRQLIKKSLLDKFQQKLLLKE
EEEEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLSEEYLDKDRQRRFIEWFKKNDRKSESD
HHHHHHHCHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA