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The map label for this gene is hemD [H]

Identifier: 23099113

GI number: 23099113

Start: 1701220

End: 1702026

Strand: Direct

Name: hemD [H]

Synonym: OB1658

Alternate gene names: 23099113

Gene position: 1701220-1702026 (Clockwise)

Preceding gene: 23099112

Following gene: 23099114

Centisome position: 46.86

GC content: 38.04

Gene sequence:

>807_bases
TTGATGGAGAAGGAAGCTAAAAGAATTGGCATCGCAGCGAGCCGAAGATCAGATGAAATCGCAGCGCTTGTTAAAAAGAT
TGGTGGAACTCCTATAGTATTTTCCATTCAAGGAGAACAGATTTTAAATAATGAAACGAGTGAACATGATGTCTTTGAAC
TGATTGACAACGCTTTTGACTTTGTTGTGTTGACTACCGGTATAGGAGCTTCAACATTGGAAGAAGCTTCATTGCGTGTC
AGTCGTTTCCCTGAATTTATCTCGAAGCTCAGTAGTATTCCGTTGGCTATACGTGGTAGTAAAACGGAGAAATGGCTGAA
GCGTCATTCCCTGGATGCGAAGGTTGTTTCAACAGATGGAACGATGCAAAATCTACTATATTCCTTGCAATCAGTAATAG
GAGGGAATTCCAAGACAGTTTTTTTGCAGACATATAATGAGGACGATATTGTATTAAAAGAAAAACTTGAAAATCTAGGC
TGTAATGTATATATGTCAAAGCCATATCGTTACAGAAATCCAGATAAAGAAACGATAGCTAAATTGGAGTCAAATATAGT
CGAGCAAAATCTCGAAGCCGTAATTTTCACGAGTAAAACCCAGGTCAAAAACTTATTTCAAATGGCGTCTGATACAGCGT
TATTGACAGAAGCCTTTAATAAACATGTAACGGCTGTAGCAGTTGGAAAAGTAACCGCCAATCAGCTGAATCAATATGGT
GTTAGCCGAGTGGTTCAACCTGCAAATCAAAAGATGGGTGCTATGGTAATCGAACTTAGGGATTATCTTTTAAAAAATAC
TAATTAA

Upstream 100 bases:

>100_bases
TGCTATTGAAAGAGCTTTTGTCGGAGGAATATTTAGACAAAGATAGGCAGAGAAGGTTTATTGAATGGTTCAAGAAAAAT
GATAGAAAGAGTGAATCAGA

Downstream 100 bases:

>100_bases
TAAAATGATGGAGGTTTTGCATTTGAGTTCTGTAGAAATGAAAGAACAGGAGAATATTCTGCCTCATGGTGGTGAGCTCA
TCGATAGGGAATTAACAGGA

Product: uroporphyrinogen-III synthase

Products: uroporphyrinogen III; H2O

Alternate protein names: NA

Number of amino acids: Translated: 268; Mature: 268

Protein sequence:

>268_residues
MMEKEAKRIGIAASRRSDEIAALVKKIGGTPIVFSIQGEQILNNETSEHDVFELIDNAFDFVVLTTGIGASTLEEASLRV
SRFPEFISKLSSIPLAIRGSKTEKWLKRHSLDAKVVSTDGTMQNLLYSLQSVIGGNSKTVFLQTYNEDDIVLKEKLENLG
CNVYMSKPYRYRNPDKETIAKLESNIVEQNLEAVIFTSKTQVKNLFQMASDTALLTEAFNKHVTAVAVGKVTANQLNQYG
VSRVVQPANQKMGAMVIELRDYLLKNTN

Sequences:

>Translated_268_residues
MMEKEAKRIGIAASRRSDEIAALVKKIGGTPIVFSIQGEQILNNETSEHDVFELIDNAFDFVVLTTGIGASTLEEASLRV
SRFPEFISKLSSIPLAIRGSKTEKWLKRHSLDAKVVSTDGTMQNLLYSLQSVIGGNSKTVFLQTYNEDDIVLKEKLENLG
CNVYMSKPYRYRNPDKETIAKLESNIVEQNLEAVIFTSKTQVKNLFQMASDTALLTEAFNKHVTAVAVGKVTANQLNQYG
VSRVVQPANQKMGAMVIELRDYLLKNTN
>Mature_268_residues
MMEKEAKRIGIAASRRSDEIAALVKKIGGTPIVFSIQGEQILNNETSEHDVFELIDNAFDFVVLTTGIGASTLEEASLRV
SRFPEFISKLSSIPLAIRGSKTEKWLKRHSLDAKVVSTDGTMQNLLYSLQSVIGGNSKTVFLQTYNEDDIVLKEKLENLG
CNVYMSKPYRYRNPDKETIAKLESNIVEQNLEAVIFTSKTQVKNLFQMASDTALLTEAFNKHVTAVAVGKVTANQLNQYG
VSRVVQPANQKMGAMVIELRDYLLKNTN

Specific function: Unknown

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003754 [H]

Pfam domain/function: PF02602 HEM4 [H]

EC number: 4.2.1.75

Molecular weight: Translated: 29812; Mature: 29812

Theoretical pI: Translated: 8.39; Mature: 8.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMEKEAKRIGIAASRRSDEIAALVKKIGGTPIVFSIQGEQILNNETSEHDVFELIDNAFD
CCCHHHHHHCCHHCCCHHHHHHHHHHHCCCCEEEEECCCHHHCCCCCHHHHHHHHHCCCC
FVVLTTGIGASTLEEASLRVSRFPEFISKLSSIPLAIRGSKTEKWLKRHSLDAKVVSTDG
EEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHCCCCEEEECCC
TMQNLLYSLQSVIGGNSKTVFLQTYNEDDIVLKEKLENLGCNVYMSKPYRYRNPDKETIA
HHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHCCCEEEECCCCCCCCCCHHHHH
KLESNIVEQNLEAVIFTSKTQVKNLFQMASDTALLTEAFNKHVTAVAVGKVTANQLNQYG
HHHHHHHHCCCCEEEEECHHHHHHHHHHHCCHHHHHHHHHCCEEEEEECHHHHHHHHHHH
VSRVVQPANQKMGAMVIELRDYLLKNTN
HHHHHCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MMEKEAKRIGIAASRRSDEIAALVKKIGGTPIVFSIQGEQILNNETSEHDVFELIDNAFD
CCCHHHHHHCCHHCCCHHHHHHHHHHHCCCCEEEEECCCHHHCCCCCHHHHHHHHHCCCC
FVVLTTGIGASTLEEASLRVSRFPEFISKLSSIPLAIRGSKTEKWLKRHSLDAKVVSTDG
EEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHCCCCEEEECCC
TMQNLLYSLQSVIGGNSKTVFLQTYNEDDIVLKEKLENLGCNVYMSKPYRYRNPDKETIA
HHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHCCCEEEECCCCCCCCCCHHHHH
KLESNIVEQNLEAVIFTSKTQVKNLFQMASDTALLTEAFNKHVTAVAVGKVTANQLNQYG
HHHHHHHHCCCCEEEEECHHHHHHHHHHHCCHHHHHHHHHCCEEEEEECHHHHHHHHHHH
VSRVVQPANQKMGAMVIELRDYLLKNTN
HHHHHCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: hydroxymethylbilane

Specific reaction: hydroxymethylbilane = uroporphyrinogen III + H2O

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9579062; 9384377 [H]