Click here to switch to the map view.

The map label for this gene is ctaB

Identifier: 23098891

GI number: 23098891

Start: 1476420

End: 1477364

Strand: Direct

Name: ctaB

Synonym: OB1436

Alternate gene names: 23098891

Gene position: 1476420-1477364 (Clockwise)

Preceding gene: 23098889

Following gene: 23098892

Centisome position: 40.67

GC content: 34.18

Gene sequence:

>945_bases
ATGAATAAAGTAGAAATGACCTATTCCGAGTTAATAGGCAATACCTCTATCTCTAATAAACAAAAGGTTGTAATGTTTAC
TTCTGAGATAAAGGCATTAATAAAAATTGGGATTGTAAACTCAAACCTAATTACAACGATAGCAGGTTTTTTATTGGCTA
TATCGTTTACGAGTTCCTCCTTTATGAGTAATTGGGGCACATTTCTCCTTACAATTATAGGTACTGCATTAGTAATTGCA
GGAGGTTGTATCGTTAATAATTGGTACGATGTTGATATTGATCCGAAAATGTCGAGAACAAAAAATAGACCAACAGTAAC
AGGGTTCTTTTCTCTCAAATCAGTTCTTACGTTTGGTTTATTAACAACAGCAGTTGGATTACTATTGTTAATGTTTACAT
CATGGTATGCGACGTTATTTGCTTTTATTGGATGGTTTGGCTATGTCGTATTATATACAATATGGTCGAAAAGACGATAT
ACGTTAAATACCGTTATAGGGAGCCTTTCAGGTGCAATGCCCCCATTAATTGGTTGGGCTGCAATTAGTCCTTCATTCCA
TATAGTGCCGTTTGTTATGTTCTTAATTATGTTCATTTGGCAAACGCCACACTTCTTAGCGCTAGCAATGAAGAAACGAG
ATGAATATGAAGCGGCTGGAATACCAATGCTACCAGTAGTAAGAGGAATGGCAGTTACAAAAAGACAAATTATTGTCTAT
ATAGCATGTTTGCTTCCATTACCATTCTTTTTATTACCAACAATGGGAATTACATTTGCGGTAATTGCAACTCTCTTAAA
TTTGGGATGGTTGGCAATAGCCTTTACTGGACTATTCGTTGATGAAGATAAGAAATGGGCAAACACAATATTTATCTTCT
CACTGAATTATTTAATTATATTATTTCCGTTAATGATTATCGTTAAGTTACCTATATTTAGCTAA

Upstream 100 bases:

>100_bases
TGATACCAATGAAATTGTAAGCAGAATAGGATAGAATAAAAATATATTCTTATTCTGGTTATTATTATGTCTTCTTACTG
AAGTGTGAAGGGGGGATACA

Downstream 100 bases:

>100_bases
TGTTATGTTATTCCTTAAAAATAAACATATAAAAGGAAACAACAAGAAGAAAGAGAGGTATTCTTACATGAAAGGTTGGA
TGGGAAAATCGAAAGTTTTC

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MNKVEMTYSELIGNTSISNKQKVVMFTSEIKALIKIGIVNSNLITTIAGFLLAISFTSSSFMSNWGTFLLTIIGTALVIA
GGCIVNNWYDVDIDPKMSRTKNRPTVTGFFSLKSVLTFGLLTTAVGLLLLMFTSWYATLFAFIGWFGYVVLYTIWSKRRY
TLNTVIGSLSGAMPPLIGWAAISPSFHIVPFVMFLIMFIWQTPHFLALAMKKRDEYEAAGIPMLPVVRGMAVTKRQIIVY
IACLLPLPFFLLPTMGITFAVIATLLNLGWLAIAFTGLFVDEDKKWANTIFIFSLNYLIILFPLMIIVKLPIFS

Sequences:

>Translated_314_residues
MNKVEMTYSELIGNTSISNKQKVVMFTSEIKALIKIGIVNSNLITTIAGFLLAISFTSSSFMSNWGTFLLTIIGTALVIA
GGCIVNNWYDVDIDPKMSRTKNRPTVTGFFSLKSVLTFGLLTTAVGLLLLMFTSWYATLFAFIGWFGYVVLYTIWSKRRY
TLNTVIGSLSGAMPPLIGWAAISPSFHIVPFVMFLIMFIWQTPHFLALAMKKRDEYEAAGIPMLPVVRGMAVTKRQIIVY
IACLLPLPFFLLPTMGITFAVIATLLNLGWLAIAFTGLFVDEDKKWANTIFIFSLNYLIILFPLMIIVKLPIFS
>Mature_314_residues
MNKVEMTYSELIGNTSISNKQKVVMFTSEIKALIKIGIVNSNLITTIAGFLLAISFTSSSFMSNWGTFLLTIIGTALVIA
GGCIVNNWYDVDIDPKMSRTKNRPTVTGFFSLKSVLTFGLLTTAVGLLLLMFTSWYATLFAFIGWFGYVVLYTIWSKRRY
TLNTVIGSLSGAMPPLIGWAAISPSFHIVPFVMFLIMFIWQTPHFLALAMKKRDEYEAAGIPMLPVVRGMAVTKRQIIVY
IACLLPLPFFLLPTMGITFAVIATLLNLGWLAIAFTGLFVDEDKKWANTIFIFSLNYLIILFPLMIIVKLPIFS

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily

Homologues:

Organism=Homo sapiens, GI17921982, Length=288, Percent_Identity=31.9444444444444, Blast_Score=98, Evalue=8e-21,
Organism=Escherichia coli, GI1786631, Length=274, Percent_Identity=37.956204379562, Blast_Score=171, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI71998235, Length=235, Percent_Identity=28.5106382978723, Blast_Score=74, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6325085, Length=200, Percent_Identity=29, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI19921064, Length=288, Percent_Identity=30.5555555555556, Blast_Score=107, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COXX_OCEIH (Q8CXI8)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_692357.1
- GeneID:   1017671
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB1436
- NMPDR:   fig|221109.1.peg.1438
- HOGENOM:   HBG656003
- OMA:   VGYCAVT
- ProtClustDB:   PRK04375
- BioCyc:   OIHE221109:OB1436-MONOMER
- HAMAP:   MF_00154
- InterPro:   IPR006369
- InterPro:   IPR000537
- PANTHER:   PTHR11048:SF3
- TIGRFAMs:   TIGR01473

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.-

Molecular weight: Translated: 35060; Mature: 35060

Theoretical pI: Translated: 10.11; Mature: 10.11

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xeaaeea8)-; HASH(0xd613418)-; HASH(0xe13ddd0)-; HASH(0xe1c6a70)-; HASH(0xd613244)-; HASH(0xdd952d0)-; HASH(0xd189e50)-; HASH(0xe23aa1c)-;

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKVEMTYSELIGNTSISNKQKVVMFTSEIKALIKIGIVNSNLITTIAGFLLAISFTSSS
CCCHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
FMSNWGTFLLTIIGTALVIAGGCIVNNWYDVDIDPKMSRTKNRPTVTGFFSLKSVLTFGL
HHHHHHHHHHHHHHHHHHHHCCEEECCEEECCCCCCHHHCCCCCCEEHHHHHHHHHHHHH
LTTAVGLLLLMFTSWYATLFAFIGWFGYVVLYTIWSKRRYTLNTVIGSLSGAMPPLIGWA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHH
AISPSFHIVPFVMFLIMFIWQTPHFLALAMKKRDEYEAAGIPMLPVVRGMAVTKRQIIVY
HCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHH
IACLLPLPFFLLPTMGITFAVIATLLNLGWLAIAFTGLFVDEDKKWANTIFIFSLNYLII
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHEEEEHHHHHHHH
LFPLMIIVKLPIFS
HHHHHHHHHCCCCH
>Mature Secondary Structure
MNKVEMTYSELIGNTSISNKQKVVMFTSEIKALIKIGIVNSNLITTIAGFLLAISFTSSS
CCCHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
FMSNWGTFLLTIIGTALVIAGGCIVNNWYDVDIDPKMSRTKNRPTVTGFFSLKSVLTFGL
HHHHHHHHHHHHHHHHHHHHCCEEECCEEECCCCCCHHHCCCCCCEEHHHHHHHHHHHHH
LTTAVGLLLLMFTSWYATLFAFIGWFGYVVLYTIWSKRRYTLNTVIGSLSGAMPPLIGWA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHH
AISPSFHIVPFVMFLIMFIWQTPHFLALAMKKRDEYEAAGIPMLPVVRGMAVTKRQIIVY
HCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHH
IACLLPLPFFLLPTMGITFAVIATLLNLGWLAIAFTGLFVDEDKKWANTIFIFSLNYLII
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHEEEEHHHHHHHH
LFPLMIIVKLPIFS
HHHHHHHHHCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12235376