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The map label for this gene is pdhA [H]

Identifier: 23098867

GI number: 23098867

Start: 1455222

End: 1456304

Strand: Direct

Name: pdhA [H]

Synonym: OB1412

Alternate gene names: 23098867

Gene position: 1455222-1456304 (Clockwise)

Preceding gene: 23098866

Following gene: 23098868

Centisome position: 40.08

GC content: 37.58

Gene sequence:

>1083_bases
TTGAAACAAGTACTTGAAAATATTGAGAGTCAGTTCGAAATGTTCCAAATTCTAGATGAAAATGGAAAAATAGTTAACAA
AGATGATATGCCCGATCTATCTGATGATGAGCTAAAGGAGATTATGAGACGTATGGTATACACACGTATACTTGATCAAC
GTTCTACTGCTTTAAACCGTCAAGGTAGATTAGGTTTCTATGCACCAACAGCTGGACAAGAAGCTTCTCAACTTGGAAGT
CAGTTCGCACTAGAAAAAGAAGACTTCATTTTACCGGGATATCGTGATGTTCCACAATTAATTTGGCAAGGTCTTCCACT
ATATCAAGCATTCTTATTCTCTAAAGGACATTTTCACGGTAACCAATATCCTGACGAATTAAGAGCTCTTAGCCCACAAA
TTATTATTGGTGCACAGTATGTACAAACTGCTGGAGTAGCACTTGGAATTAAAAAACGTGGTAATAAAAATGTAGCTATT
ACTTACACTGGTGATGGTGGTACTTCCCAAGGTGATTTTTATGAAGGTATAAACTTTGCTGGTGCCTATAAAGCTCCTGC
AATTTTCGTAGTTCAAAACAATCGTTTTGCTATTTCTGTACCTGTTGAAAAACAAACAAACGCCAAAACATTAGCTCAAA
AAGCAGTTGCTGCTGGAATAGAAGGTATTCAGGTTGATGGTATGGATGTTTTAGCGGTATATGCTGCGACTAAATTTGCT
CGTGAACGTGCCGTTAATGGTGAGGGACCAACGTTAATCGAAACATTAACTTACCGTTTCGGTCCACATACTTTATCAGG
AGACGATCCTACTCGTTACCGTACAGAAGATATGGACAACGAATGGGAGAAAAAAGATCCAATCGTTCGTTTCCGTACGT
ATCTTGAAAGCAAAAAGCTTTGGTCAGAAGAAGACGAAAACAATGCTATTGAGCAAGCAAAAGAAGATATTAAAAAGGCA
ATCAAGCAAGCAGAAGAGCAGCCTAAACAAAAAGTAACTGATTTAATTGCGAATATGTACGAAGAGCTACCAACTCATCT
ACAGGAGCAAAATGAAATTTATAAAGAAAAGGAGTCGAAGTAA

Upstream 100 bases:

>100_bases
TATGGAAAGGGTAAACCAATAATATGTAATTTTTTGTGATCTTGGGTAGGCTAGGAAAGAAAATAATAAAGCATATATGG
AAAGGAAGAGGTGAACCATT

Downstream 100 bases:

>100_bases
ATCATGGCACAAATGACAATGATTCAAGCTATCACTGATGCAATGCGCGTAGAATTGAAAAATGATGAAAACGTGCTTGT
TTTTGGTGAAGATGTTGGAC

Product: pyruvate dehydrogenase E1 alpha subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 360; Mature: 360

Protein sequence:

>360_residues
MKQVLENIESQFEMFQILDENGKIVNKDDMPDLSDDELKEIMRRMVYTRILDQRSTALNRQGRLGFYAPTAGQEASQLGS
QFALEKEDFILPGYRDVPQLIWQGLPLYQAFLFSKGHFHGNQYPDELRALSPQIIIGAQYVQTAGVALGIKKRGNKNVAI
TYTGDGGTSQGDFYEGINFAGAYKAPAIFVVQNNRFAISVPVEKQTNAKTLAQKAVAAGIEGIQVDGMDVLAVYAATKFA
RERAVNGEGPTLIETLTYRFGPHTLSGDDPTRYRTEDMDNEWEKKDPIVRFRTYLESKKLWSEEDENNAIEQAKEDIKKA
IKQAEEQPKQKVTDLIANMYEELPTHLQEQNEIYKEKESK

Sequences:

>Translated_360_residues
MKQVLENIESQFEMFQILDENGKIVNKDDMPDLSDDELKEIMRRMVYTRILDQRSTALNRQGRLGFYAPTAGQEASQLGS
QFALEKEDFILPGYRDVPQLIWQGLPLYQAFLFSKGHFHGNQYPDELRALSPQIIIGAQYVQTAGVALGIKKRGNKNVAI
TYTGDGGTSQGDFYEGINFAGAYKAPAIFVVQNNRFAISVPVEKQTNAKTLAQKAVAAGIEGIQVDGMDVLAVYAATKFA
RERAVNGEGPTLIETLTYRFGPHTLSGDDPTRYRTEDMDNEWEKKDPIVRFRTYLESKKLWSEEDENNAIEQAKEDIKKA
IKQAEEQPKQKVTDLIANMYEELPTHLQEQNEIYKEKESK
>Mature_360_residues
MKQVLENIESQFEMFQILDENGKIVNKDDMPDLSDDELKEIMRRMVYTRILDQRSTALNRQGRLGFYAPTAGQEASQLGS
QFALEKEDFILPGYRDVPQLIWQGLPLYQAFLFSKGHFHGNQYPDELRALSPQIIIGAQYVQTAGVALGIKKRGNKNVAI
TYTGDGGTSQGDFYEGINFAGAYKAPAIFVVQNNRFAISVPVEKQTNAKTLAQKAVAAGIEGIQVDGMDVLAVYAATKFA
RERAVNGEGPTLIETLTYRFGPHTLSGDDPTRYRTEDMDNEWEKKDPIVRFRTYLESKKLWSEEDENNAIEQAKEDIKKA
IKQAEEQPKQKVTDLIANMYEELPTHLQEQNEIYKEKESK

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI11386135, Length=356, Percent_Identity=34.8314606741573, Blast_Score=211, Evalue=6e-55,
Organism=Homo sapiens, GI258645172, Length=356, Percent_Identity=34.8314606741573, Blast_Score=207, Evalue=9e-54,
Organism=Homo sapiens, GI291084742, Length=323, Percent_Identity=28.1733746130031, Blast_Score=131, Evalue=9e-31,
Organism=Homo sapiens, GI4505685, Length=323, Percent_Identity=28.1733746130031, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI4885543, Length=321, Percent_Identity=27.7258566978193, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI291084744, Length=292, Percent_Identity=28.4246575342466, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI291084757, Length=306, Percent_Identity=27.1241830065359, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI86563355, Length=350, Percent_Identity=33.7142857142857, Blast_Score=197, Evalue=5e-51,
Organism=Caenorhabditis elegans, GI86563357, Length=350, Percent_Identity=33.7142857142857, Blast_Score=197, Evalue=5e-51,
Organism=Caenorhabditis elegans, GI32564172, Length=336, Percent_Identity=30.0595238095238, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17536047, Length=336, Percent_Identity=30.0595238095238, Blast_Score=138, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6321026, Length=359, Percent_Identity=27.2980501392758, Blast_Score=128, Evalue=1e-30,
Organism=Drosophila melanogaster, GI21355903, Length=349, Percent_Identity=32.6647564469914, Blast_Score=183, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24639740, Length=288, Percent_Identity=31.9444444444444, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24639744, Length=288, Percent_Identity=31.9444444444444, Blast_Score=122, Evalue=6e-28,
Organism=Drosophila melanogaster, GI28571106, Length=288, Percent_Identity=31.9444444444444, Blast_Score=122, Evalue=6e-28,
Organism=Drosophila melanogaster, GI24639746, Length=288, Percent_Identity=31.9444444444444, Blast_Score=121, Evalue=6e-28,
Organism=Drosophila melanogaster, GI24639748, Length=347, Percent_Identity=27.3775216138329, Blast_Score=119, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017596 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 40762; Mature: 40762

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQVLENIESQFEMFQILDENGKIVNKDDMPDLSDDELKEIMRRMVYTRILDQRSTALNR
CHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
QGRLGFYAPTAGQEASQLGSQFALEKEDFILPGYRDVPQLIWQGLPLYQAFLFSKGHFHG
CCCCEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHCCCCCC
NQYPDELRALSPQIIIGAQYVQTAGVALGIKKRGNKNVAITYTGDGGTSQGDFYEGINFA
CCCHHHHHHCCCCEEEEHHHHHHCCCEEEEEECCCCCEEEEEECCCCCCCCCHHHCCCCC
GAYKAPAIFVVQNNRFAISVPVEKQTNAKTLAQKAVAAGIEGIQVDGMDVLAVYAATKFA
CCCCCCEEEEEECCEEEEEECCCCCCCHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHH
RERAVNGEGPTLIETLTYRFGPHTLSGDDPTRYRTEDMDNEWEKKDPIVRFRTYLESKKL
HHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHH
WSEEDENNAIEQAKEDIKKAIKQAEEQPKQKVTDLIANMYEELPTHLQEQNEIYKEKESK
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKQVLENIESQFEMFQILDENGKIVNKDDMPDLSDDELKEIMRRMVYTRILDQRSTALNR
CHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
QGRLGFYAPTAGQEASQLGSQFALEKEDFILPGYRDVPQLIWQGLPLYQAFLFSKGHFHG
CCCCEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHCCCCCC
NQYPDELRALSPQIIIGAQYVQTAGVALGIKKRGNKNVAITYTGDGGTSQGDFYEGINFA
CCCHHHHHHCCCCEEEEHHHHHHCCCEEEEEECCCCCEEEEEECCCCCCCCCHHHCCCCC
GAYKAPAIFVVQNNRFAISVPVEKQTNAKTLAQKAVAAGIEGIQVDGMDVLAVYAATKFA
CCCCCCEEEEEECCEEEEEECCCCCCCHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHH
RERAVNGEGPTLIETLTYRFGPHTLSGDDPTRYRTEDMDNEWEKKDPIVRFRTYLESKKL
HHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHH
WSEEDENNAIEQAKEDIKKAIKQAEEQPKQKVTDLIANMYEELPTHLQEQNEIYKEKESK
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2200674 [H]