Click here to switch to the map view.

The map label for this gene is pdhB [H]

Identifier: 23098868

GI number: 23098868

Start: 1456308

End: 1457285

Strand: Direct

Name: pdhB [H]

Synonym: OB1413

Alternate gene names: 23098868

Gene position: 1456308-1457285 (Clockwise)

Preceding gene: 23098867

Following gene: 23098869

Centisome position: 40.11

GC content: 39.98

Gene sequence:

>978_bases
ATGGCACAAATGACAATGATTCAAGCTATCACTGATGCAATGCGCGTAGAATTGAAAAATGATGAAAACGTGCTTGTTTT
TGGTGAAGATGTTGGACAAAATGGCGGAGTATTCCGTGCAACAGAAGGTCTTCAAGATGAATTTGGTGAAGATCGTGTGT
TTGATACACCACTTGCTGAATCTGGAATCGGTGGACTTGCGATCGGTTTAGCATTAGAAGGATTTCGTCCGGTACCTGAG
ATTCAATTCTTCGGCTTCGTATATGAAGTAATGGACTCTATTAGTGGACAAATGGCACGTATGCGTTATCGTTCTGGCGG
TCATTATAATGCACCGATTACAGTTCGTGCACCATTTGGTGGAGGAGTACACACTCCAGAATTACACGCGGATTCTTTAG
AAGGTCTAATGGCTCAACAACCAGGTTTAAAAGTGGTTATTCCTTCAACACCTTACGAAGCAAAAGGTCTATTAATTTCT
GCAATCCGTGATAACGATCCGGTTGTATTCTTAGAGCATATGAAATTATATCGTTCTTTCCGTGGCGAAGTTCCTGAAGA
AGACTACACTGTTGAAATTGGGAAAGCTGATGTAAAACGCGAAGGTTCTGATGTAACATTAGTATCCTATGGAGCAATGG
TACATTCATCCTTGAAAGCTGCTGAAGAATTAGAAAAAGACGGAATTCAAGCAGAAGTAATTGATTTACGTACAGTTTCT
CCAATTGATTACGAAACAATCCTAGCATCTGTTAAGAAAACAAATCGCGTAGTCGTTGTACAAGAAGCACAGCGTCAAGC
AGGAGTTGCTGGTCAAGTTATTTCTGAAATTCAAGAAAGAGCAATTCTAGACCTAGAGGCGCCAATTCTTCGTGTTAGTG
CACCTGATACGGTTTATTCATTCTCTGATGCAGAGGAAACATGGTTGCCTAACCATAATGATATCGTAGAGAAAGTTAAT
GAAGTAATTAATTTCTAA

Upstream 100 bases:

>100_bases
ACAAAAAGTAACTGATTTAATTGCGAATATGTACGAAGAGCTACCAACTCATCTACAGGAGCAAAATGAAATTTATAAAG
AAAAGGAGTCGAAGTAAATC

Downstream 100 bases:

>100_bases
AATAGTTTAGGAGGTTTCATAGCATGGCATTTAATTTTAAGTTACCGGATATCGGTGAAGGTATACATGAAGGTGAAATA
GTAAAATGGTTCGTAAAAGA

Product: pyruvate dehydrogenase E1 beta subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 325; Mature: 324

Protein sequence:

>325_residues
MAQMTMIQAITDAMRVELKNDENVLVFGEDVGQNGGVFRATEGLQDEFGEDRVFDTPLAESGIGGLAIGLALEGFRPVPE
IQFFGFVYEVMDSISGQMARMRYRSGGHYNAPITVRAPFGGGVHTPELHADSLEGLMAQQPGLKVVIPSTPYEAKGLLIS
AIRDNDPVVFLEHMKLYRSFRGEVPEEDYTVEIGKADVKREGSDVTLVSYGAMVHSSLKAAEELEKDGIQAEVIDLRTVS
PIDYETILASVKKTNRVVVVQEAQRQAGVAGQVISEIQERAILDLEAPILRVSAPDTVYSFSDAEETWLPNHNDIVEKVN
EVINF

Sequences:

>Translated_325_residues
MAQMTMIQAITDAMRVELKNDENVLVFGEDVGQNGGVFRATEGLQDEFGEDRVFDTPLAESGIGGLAIGLALEGFRPVPE
IQFFGFVYEVMDSISGQMARMRYRSGGHYNAPITVRAPFGGGVHTPELHADSLEGLMAQQPGLKVVIPSTPYEAKGLLIS
AIRDNDPVVFLEHMKLYRSFRGEVPEEDYTVEIGKADVKREGSDVTLVSYGAMVHSSLKAAEELEKDGIQAEVIDLRTVS
PIDYETILASVKKTNRVVVVQEAQRQAGVAGQVISEIQERAILDLEAPILRVSAPDTVYSFSDAEETWLPNHNDIVEKVN
EVINF
>Mature_324_residues
AQMTMIQAITDAMRVELKNDENVLVFGEDVGQNGGVFRATEGLQDEFGEDRVFDTPLAESGIGGLAIGLALEGFRPVPEI
QFFGFVYEVMDSISGQMARMRYRSGGHYNAPITVRAPFGGGVHTPELHADSLEGLMAQQPGLKVVIPSTPYEAKGLLISA
IRDNDPVVFLEHMKLYRSFRGEVPEEDYTVEIGKADVKREGSDVTLVSYGAMVHSSLKAAEELEKDGIQAEVIDLRTVSP
IDYETILASVKKTNRVVVVQEAQRQAGVAGQVISEIQERAILDLEAPILRVSAPDTVYSFSDAEETWLPNHNDIVEKVNE
VINF

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557353, Length=325, Percent_Identity=42.7692307692308, Blast_Score=268, Evalue=7e-72,
Organism=Homo sapiens, GI34101272, Length=325, Percent_Identity=42.7692307692308, Blast_Score=268, Evalue=7e-72,
Organism=Homo sapiens, GI156564403, Length=327, Percent_Identity=37.3088685015291, Blast_Score=228, Evalue=6e-60,
Organism=Homo sapiens, GI291084858, Length=327, Percent_Identity=35.474006116208, Blast_Score=208, Evalue=6e-54,
Organism=Caenorhabditis elegans, GI17506935, Length=326, Percent_Identity=40.1840490797546, Blast_Score=238, Evalue=3e-63,
Organism=Caenorhabditis elegans, GI17538422, Length=328, Percent_Identity=39.3292682926829, Blast_Score=233, Evalue=1e-61,
Organism=Saccharomyces cerevisiae, GI6319698, Length=328, Percent_Identity=39.0243902439024, Blast_Score=226, Evalue=4e-60,
Organism=Drosophila melanogaster, GI160714828, Length=325, Percent_Identity=42.1538461538462, Blast_Score=262, Evalue=2e-70,
Organism=Drosophila melanogaster, GI160714832, Length=325, Percent_Identity=42.1538461538462, Blast_Score=262, Evalue=2e-70,
Organism=Drosophila melanogaster, GI21358145, Length=326, Percent_Identity=39.5705521472393, Blast_Score=237, Evalue=7e-63,
Organism=Drosophila melanogaster, GI24650940, Length=326, Percent_Identity=39.5705521472393, Blast_Score=237, Evalue=7e-63,
Organism=Drosophila melanogaster, GI24650943, Length=90, Percent_Identity=38.8888888888889, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24650945, Length=90, Percent_Identity=38.8888888888889, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI160714826, Length=66, Percent_Identity=50, Blast_Score=72, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 35673; Mature: 35542

Theoretical pI: Translated: 4.31; Mature: 4.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQMTMIQAITDAMRVELKNDENVLVFGEDVGQNGGVFRATEGLQDEFGEDRVFDTPLAE
CCHHHHHHHHHHHHEEEECCCCEEEEEECCCCCCCCEEEECCCHHHHCCCCCEECCCCHH
SGIGGLAIGLALEGFRPVPEIQFFGFVYEVMDSISGQMARMRYRSGGHYNAPITVRAPFG
CCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCC
GGVHTPELHADSLEGLMAQQPGLKVVIPSTPYEAKGLLISAIRDNDPVVFLEHMKLYRSF
CCCCCCCCCHHHHHHHHHCCCCCEEEECCCCCCCCCEEEEEEECCCCEEEHHHHHHHHHH
RGEVPEEDYTVEIGKADVKREGSDVTLVSYGAMVHSSLKAAEELEKDGIQAEVIDLRTVS
CCCCCCCCEEEEECCCHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCEEEEEEEEECC
PIDYETILASVKKTNRVVVVQEAQRQAGVAGQVISEIQERAILDLEAPILRVSAPDTVYS
CCCHHHHHHHHHHCCCEEEEECHHHHCCHHHHHHHHHHHHHHEECCCCEEEECCCCCEEE
FSDAEETWLPNHNDIVEKVNEVINF
CCCCCHHCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
AQMTMIQAITDAMRVELKNDENVLVFGEDVGQNGGVFRATEGLQDEFGEDRVFDTPLAE
CHHHHHHHHHHHHEEEECCCCEEEEEECCCCCCCCEEEECCCHHHHCCCCCEECCCCHH
SGIGGLAIGLALEGFRPVPEIQFFGFVYEVMDSISGQMARMRYRSGGHYNAPITVRAPFG
CCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCC
GGVHTPELHADSLEGLMAQQPGLKVVIPSTPYEAKGLLISAIRDNDPVVFLEHMKLYRSF
CCCCCCCCCHHHHHHHHHCCCCCEEEECCCCCCCCCEEEEEEECCCCEEEHHHHHHHHHH
RGEVPEEDYTVEIGKADVKREGSDVTLVSYGAMVHSSLKAAEELEKDGIQAEVIDLRTVS
CCCCCCCCEEEEECCCHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCEEEEEEEEECC
PIDYETILASVKKTNRVVVVQEAQRQAGVAGQVISEIQERAILDLEAPILRVSAPDTVYS
CCCHHHHHHHHHHCCCEEEEECHHHHCCHHHHHHHHHHHHHHEECCCCEEEECCCCCEEE
FSDAEETWLPNHNDIVEKVNEVINF
CCCCCHHCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2200674; 2253629 [H]