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The map label for this gene is yngG [H]

Identifier: 23098798

GI number: 23098798

Start: 1386574

End: 1387476

Strand: Direct

Name: yngG [H]

Synonym: OB1343

Alternate gene names: 23098798

Gene position: 1386574-1387476 (Clockwise)

Preceding gene: 23098797

Following gene: 23098799

Centisome position: 38.19

GC content: 36.77

Gene sequence:

>903_bases
ATGCGTTCATTACCATCTTATGTCCAATTAAAAGAAGTAGGTCCAAGAGACGGACTTCAAAATGAAAAGTCGTGGATAAC
AACAGAAGATAAAGTAAATTGGATTAATATGTTGTCTACTTCAGGGATAAAAGAGATCGAATATTCATCGTTTGTTAATC
CAAAAATGATTCCAGCTTTATCGGATGCAAGGGAAGTAGGTAAGCGAATTATTAGAAACCCAGATGTTAAATATTCTGCT
TTAGTCCCTAATATAAAAGGTTTAGAGTATGCACTAGAAGCTGGCATTGACGGTGCTTCTGTATTTATGTCCGCTAGTGA
GACTCATAATCAGAAGAATATTAATAAATCGATACAAGATACGTATCCGGTCTTAGATAAAGTTATTGTGGAGGCTAAAC
AAGCAGGGAAGCATGTAACGGGGTATATTTCTACTGTATTTGATTGTCCGTATGAAGGAAAAATATCGCCGGAGAAAGTG
CTGGATGTATGTGATAAATTAATTGAGAGTGGAGTAGATGATTTATCGTTAGGTGATACGATTGGCACGGCGGTTCCGAC
GCAAGTCGAGCAATTATTAGAACTCTTGTTACAACATTATCCAAAAGAAAAATTGATCTTGCACTTTCATGATACAAGAG
GGATGGCAATTGCAAATATTATGACTGCTATGCATTATGGGATTTATCGCTTTGATAGTACGATTGGTGGGTTAGGGGGC
TGTCCATATGCTCCAGGAGCCGCGGGAAATGTAGCCACAAATGATGTTTTATATTTATTAGAGGGACTTGGCATTAATAC
AGGAATTGACGAAAAGAAATTACAAGAAGCTGGTGTTTTTATTCAAAACAAATTGAATAAAACGTTGCCGAGTCGATCAT
TAGCTTATTTAAAGAACGCATAA

Upstream 100 bases:

>100_bases
ATGTGATTTACCTTATTATGATGAAATAAATTCGAACCATAAAATTACTTAAGTATAACCTATTGTAAGCGGATTCAAAA
AATGAAGTGGGGGAGAACCA

Downstream 100 bases:

>100_bases
ATAATGCTATTTAAAGATGAATGAGCGAATTATAACTAGAATAACCCCAAACTATAGTACACAATGTAACTACATTTGTA
TTACAGTTTGGGGTTTTATT

Product: hydroxymethylglutaryl-CoA lyase

Products: NA

Alternate protein names: HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase [H]

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MRSLPSYVQLKEVGPRDGLQNEKSWITTEDKVNWINMLSTSGIKEIEYSSFVNPKMIPALSDAREVGKRIIRNPDVKYSA
LVPNIKGLEYALEAGIDGASVFMSASETHNQKNINKSIQDTYPVLDKVIVEAKQAGKHVTGYISTVFDCPYEGKISPEKV
LDVCDKLIESGVDDLSLGDTIGTAVPTQVEQLLELLLQHYPKEKLILHFHDTRGMAIANIMTAMHYGIYRFDSTIGGLGG
CPYAPGAAGNVATNDVLYLLEGLGINTGIDEKKLQEAGVFIQNKLNKTLPSRSLAYLKNA

Sequences:

>Translated_300_residues
MRSLPSYVQLKEVGPRDGLQNEKSWITTEDKVNWINMLSTSGIKEIEYSSFVNPKMIPALSDAREVGKRIIRNPDVKYSA
LVPNIKGLEYALEAGIDGASVFMSASETHNQKNINKSIQDTYPVLDKVIVEAKQAGKHVTGYISTVFDCPYEGKISPEKV
LDVCDKLIESGVDDLSLGDTIGTAVPTQVEQLLELLLQHYPKEKLILHFHDTRGMAIANIMTAMHYGIYRFDSTIGGLGG
CPYAPGAAGNVATNDVLYLLEGLGINTGIDEKKLQEAGVFIQNKLNKTLPSRSLAYLKNA
>Mature_300_residues
MRSLPSYVQLKEVGPRDGLQNEKSWITTEDKVNWINMLSTSGIKEIEYSSFVNPKMIPALSDAREVGKRIIRNPDVKYSA
LVPNIKGLEYALEAGIDGASVFMSASETHNQKNINKSIQDTYPVLDKVIVEAKQAGKHVTGYISTVFDCPYEGKISPEKV
LDVCDKLIESGVDDLSLGDTIGTAVPTQVEQLLELLLQHYPKEKLILHFHDTRGMAIANIMTAMHYGIYRFDSTIGGLGG
CPYAPGAAGNVATNDVLYLLEGLGINTGIDEKKLQEAGVFIQNKLNKTLPSRSLAYLKNA

Specific function: Involved in the catabolism of branched amino acids such as leucine (Probable) [H]

COG id: COG0119

COG function: function code E; Isopropylmalate/homocitrate/citramalate synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA lyase family [H]

Homologues:

Organism=Homo sapiens, GI62198232, Length=292, Percent_Identity=46.5753424657534, Blast_Score=280, Evalue=8e-76,
Organism=Homo sapiens, GI109150427, Length=292, Percent_Identity=45.5479452054795, Blast_Score=275, Evalue=3e-74,
Organism=Homo sapiens, GI109150422, Length=292, Percent_Identity=45.5479452054795, Blast_Score=275, Evalue=4e-74,
Organism=Homo sapiens, GI260654708, Length=292, Percent_Identity=33.2191780821918, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17510563, Length=269, Percent_Identity=45.3531598513011, Blast_Score=239, Evalue=1e-63,
Organism=Drosophila melanogaster, GI24582381, Length=290, Percent_Identity=42.4137931034483, Blast_Score=251, Evalue=5e-67,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000891 [H]

Pfam domain/function: PF00682 HMGL-like [H]

EC number: =4.1.3.4 [H]

Molecular weight: Translated: 32919; Mature: 32919

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: PS50991 PYR_CT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSLPSYVQLKEVGPRDGLQNEKSWITTEDKVNWINMLSTSGIKEIEYSSFVNPKMIPAL
CCCCCCHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHCCCCCCCCCH
SDAREVGKRIIRNPDVKYSALVPNIKGLEYALEAGIDGASVFMSASETHNQKNINKSIQD
HHHHHHHHHHHCCCCCCCHHHCCCCCHHHHHHHHCCCHHHHEEECHHHHCHHHHHHHHHH
TYPVLDKVIVEAKQAGKHVTGYISTVFDCPYEGKISPEKVLDVCDKLIESGVDDLSLGDT
HHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCH
IGTAVPTQVEQLLELLLQHYPKEKLILHFHDTRGMAIANIMTAMHYGIYRFDSTIGGLGG
HHCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCC
CPYAPGAAGNVATNDVLYLLEGLGINTGIDEKKLQEAGVFIQNKLNKTLPSRSLAYLKNA
CCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHCCC
>Mature Secondary Structure
MRSLPSYVQLKEVGPRDGLQNEKSWITTEDKVNWINMLSTSGIKEIEYSSFVNPKMIPAL
CCCCCCHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHCCCCCCCCCH
SDAREVGKRIIRNPDVKYSALVPNIKGLEYALEAGIDGASVFMSASETHNQKNINKSIQD
HHHHHHHHHHHCCCCCCCHHHCCCCCHHHHHHHHCCCHHHHEEECHHHHCHHHHHHHHHH
TYPVLDKVIVEAKQAGKHVTGYISTVFDCPYEGKISPEKVLDVCDKLIESGVDDLSLGDT
HHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCH
IGTAVPTQVEQLLELLLQHYPKEKLILHFHDTRGMAIANIMTAMHYGIYRFDSTIGGLGG
HHCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCC
CPYAPGAAGNVATNDVLYLLEGLGINTGIDEKKLQEAGVFIQNKLNKTLPSRSLAYLKNA
CCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]