Click here to switch to the map view.

The map label for this gene is purE [H]

Identifier: 23098194

GI number: 23098194

Start: 787047

End: 787538

Strand: Direct

Name: purE [H]

Synonym: OB0739

Alternate gene names: 23098194

Gene position: 787047-787538 (Clockwise)

Preceding gene: 23098193

Following gene: 23098195

Centisome position: 21.68

GC content: 42.28

Gene sequence:

>492_bases
ATGGCTCAAGTAGGGGTTATTATGGGAAGTATTTCCGACTGGGAAACGATGCAGTATACTTGTAATGTGCTTGATGAATT
ACAGATCTCTTATGAGAAAGAAGTGATATCCGCACATCGTACTCCGGATGACATGTTTGCTTACTCGAAACAAGCTCGTA
GTAAAGGGCTAAAGGTTATTATTGCTGGGGCAGGGGGAGCAGCACACTTACCAGGAATGGTAGCTTCACAAACAACGTTA
CCCGTTATAGGTGTACCAGTTGAAAGTAAATCATTACAAGGCTTAGATTCCCTGTTATCTATTGTGCAAATGCCTGGTGG
AGTACCAACCGCTACAGTTGCAATTGGGAAAGCCGGAGCCAAAAATGCTGGTATTCTTGCGGCACAGATTATTAGCACTT
TTGATGAAGGTGCAGAGAAATCTCTAGAGAAATATCGGGAAGAAATGCGAGAATCTGTAAAAGAAATGAGGGAAAATCTT
GCAGACTACTAA

Upstream 100 bases:

>100_bases
ATGTTCGTAAATTACAAGTCTATTCATCTTCTCTCTATTCATAATAGATGGAAGATAATAGACTTTTTCGTTTGTAAAAA
GATATAGAAAGAGGGATTGG

Downstream 100 bases:

>100_bases
TACTATCTTACCTTCACAAACAATTGGAATTATTGGTGGTGGACAATTAGGAAGAATGATGGCAATCGCTGCACGGTATA
TGGGATATAAGATTGTTGTT

Product: phosphoribosylaminoimidazole carboxylase I

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 163; Mature: 162

Protein sequence:

>163_residues
MAQVGVIMGSISDWETMQYTCNVLDELQISYEKEVISAHRTPDDMFAYSKQARSKGLKVIIAGAGGAAHLPGMVASQTTL
PVIGVPVESKSLQGLDSLLSIVQMPGGVPTATVAIGKAGAKNAGILAAQIISTFDEGAEKSLEKYREEMRESVKEMRENL
ADY

Sequences:

>Translated_163_residues
MAQVGVIMGSISDWETMQYTCNVLDELQISYEKEVISAHRTPDDMFAYSKQARSKGLKVIIAGAGGAAHLPGMVASQTTL
PVIGVPVESKSLQGLDSLLSIVQMPGGVPTATVAIGKAGAKNAGILAAQIISTFDEGAEKSLEKYREEMRESVKEMRENL
ADY
>Mature_162_residues
AQVGVIMGSISDWETMQYTCNVLDELQISYEKEVISAHRTPDDMFAYSKQARSKGLKVIIAGAGGAAHLPGMVASQTTLP
VIGVPVESKSLQGLDSLLSIVQMPGGVPTATVAIGKAGAKNAGILAAQIISTFDEGAEKSLEKYREEMRESVKEMRENLA
DY

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=154, Percent_Identity=53.2467532467532, Blast_Score=147, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6324702, Length=150, Percent_Identity=51.3333333333333, Blast_Score=152, Evalue=3e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 17406; Mature: 17275

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQVGVIMGSISDWETMQYTCNVLDELQISYEKEVISAHRTPDDMFAYSKQARSKGLKVI
CCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEE
IAGAGGAAHLPGMVASQTTLPVIGVPVESKSLQGLDSLLSIVQMPGGVPTATVAIGKAGA
EECCCCHHHCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHCCCCCCCHHEEECCCCC
KNAGILAAQIISTFDEGAEKSLEKYREEMRESVKEMRENLADY
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AQVGVIMGSISDWETMQYTCNVLDELQISYEKEVISAHRTPDDMFAYSKQARSKGLKVI
CCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEE
IAGAGGAAHLPGMVASQTTLPVIGVPVESKSLQGLDSLLSIVQMPGGVPTATVAIGKAGA
EECCCCHHHCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHCCCCCCCHHEEECCCCC
KNAGILAAQIISTFDEGAEKSLEKYREEMRESVKEMRENLADY
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3036807; 9384377 [H]