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The map label for this gene is purK [H]

Identifier: 23098195

GI number: 23098195

Start: 787525

End: 788658

Strand: Direct

Name: purK [H]

Synonym: OB0740

Alternate gene names: 23098195

Gene position: 787525-788658 (Clockwise)

Preceding gene: 23098194

Following gene: 23098196

Centisome position: 21.69

GC content: 36.95

Gene sequence:

>1134_bases
TTGCAGACTACTAATACTATCTTACCTTCACAAACAATTGGAATTATTGGTGGTGGACAATTAGGAAGAATGATGGCAAT
CGCTGCACGGTATATGGGATATAAGATTGTTGTTTTAGACCCGACTCCAGATTGCCCTACTGCACATGTGGCAGACCAAC
AAATTGTTGCTGCTTATGATGATTTACATGCAATTGATCAGTTAATAGATGGTTGTGACGTGATTACATATGAATTTGAA
AATGTGGATTTACAAGCTGCTGCAATCATTCATCAGTCTGGTAAGTTACCGCAAGGAACACGTGCTCTAGAAGTAACTCA
AAACCGTGAAAAAGAAAAACAAGTCGTATCTGATTTACGATTGCCAGTCCCAGACTATTATATTGTTACAAGTACAGAAG
AATGTGAACATGCGCTTGATTCCATTGCTTTTCCAGCAGTGATCAAAACGTGTCGTGGTGGTTATGATGGTAAAGGACAA
TTAAAAATTCATAACGAATCTGAAAAAGAACAAGCGATCCAATTTTTTAAGCTACATGGATATTGCATTATTGAGCAATG
GATTACATTTGATAAAGAAGTATCGGTAGTGTTTACAAGGTCTATAAATGGGGATATTGAGTTCTTTCCTTTAGCAGAGA
ACGAACATCGTGATCACATTCTATACAAAACAACTGTTCCAGCTAATGTAGACCAATCTATTCATGACTCTGCCTGTCAG
ATAGCTAAAAAAATTGCGGATTATATGGATATTGTCGGTACTTTTGCTATTGAAATGTTTGTAAAAGGAAAAGAAGTCTA
TGTCAATGAAATGGCTCCTCGTCCTCACAATTCAGGGCATTATACAATCGAAGGCTGCAATATTTCGCAATTCGCCCAGC
ATATCCGAGCAATTTGCGGTTTGCCATTAATCGAAGTGGAGTTACATGGTCCAACGGCTATGATTAATGTTTTAGGAAAT
GATATAAAATATGCAAAAACGTTTCTTTCCAGATCGAATGTTGGCTTTCTTCATTTGTATGGAAAAGAAGAGCCGAAAGA
AAAACGAAAAATGGGACATATTACATTCACTGCGAAGACAACAGAAGAACTAGAGAAACAAGTGAATTACTTCAAGGAGG
AAATACATTCATGA

Upstream 100 bases:

>100_bases
GCGGCACAGATTATTAGCACTTTTGATGAAGGTGCAGAGAAATCTCTAGAGAAATATCGGGAAGAAATGCGAGAATCTGT
AAAAGAAATGAGGGAAAATC

Downstream 100 bases:

>100_bases
TTGAACGTTATACAAGAGAAGAAATGGGTAGTATTTGGACGGAAGAGAATAAATTCAAAGCGTGGTTAGAGGTTGAAATA
CTAGCTTGCGAAGCATGGAG

Product: phosphoribosylaminoimidazole carboxylase II

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 377; Mature: 377

Protein sequence:

>377_residues
MQTTNTILPSQTIGIIGGGQLGRMMAIAARYMGYKIVVLDPTPDCPTAHVADQQIVAAYDDLHAIDQLIDGCDVITYEFE
NVDLQAAAIIHQSGKLPQGTRALEVTQNREKEKQVVSDLRLPVPDYYIVTSTEECEHALDSIAFPAVIKTCRGGYDGKGQ
LKIHNESEKEQAIQFFKLHGYCIIEQWITFDKEVSVVFTRSINGDIEFFPLAENEHRDHILYKTTVPANVDQSIHDSACQ
IAKKIADYMDIVGTFAIEMFVKGKEVYVNEMAPRPHNSGHYTIEGCNISQFAQHIRAICGLPLIEVELHGPTAMINVLGN
DIKYAKTFLSRSNVGFLHLYGKEEPKEKRKMGHITFTAKTTEELEKQVNYFKEEIHS

Sequences:

>Translated_377_residues
MQTTNTILPSQTIGIIGGGQLGRMMAIAARYMGYKIVVLDPTPDCPTAHVADQQIVAAYDDLHAIDQLIDGCDVITYEFE
NVDLQAAAIIHQSGKLPQGTRALEVTQNREKEKQVVSDLRLPVPDYYIVTSTEECEHALDSIAFPAVIKTCRGGYDGKGQ
LKIHNESEKEQAIQFFKLHGYCIIEQWITFDKEVSVVFTRSINGDIEFFPLAENEHRDHILYKTTVPANVDQSIHDSACQ
IAKKIADYMDIVGTFAIEMFVKGKEVYVNEMAPRPHNSGHYTIEGCNISQFAQHIRAICGLPLIEVELHGPTAMINVLGN
DIKYAKTFLSRSNVGFLHLYGKEEPKEKRKMGHITFTAKTTEELEKQVNYFKEEIHS
>Mature_377_residues
MQTTNTILPSQTIGIIGGGQLGRMMAIAARYMGYKIVVLDPTPDCPTAHVADQQIVAAYDDLHAIDQLIDGCDVITYEFE
NVDLQAAAIIHQSGKLPQGTRALEVTQNREKEKQVVSDLRLPVPDYYIVTSTEECEHALDSIAFPAVIKTCRGGYDGKGQ
LKIHNESEKEQAIQFFKLHGYCIIEQWITFDKEVSVVFTRSINGDIEFFPLAENEHRDHILYKTTVPANVDQSIHDSACQ
IAKKIADYMDIVGTFAIEMFVKGKEVYVNEMAPRPHNSGHYTIEGCNISQFAQHIRAICGLPLIEVELHGPTAMINVLGN
DIKYAKTFLSRSNVGFLHLYGKEEPKEKRKMGHITFTAKTTEELEKQVNYFKEEIHS

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=355, Percent_Identity=32.9577464788732, Blast_Score=172, Evalue=4e-44,
Organism=Escherichia coli, GI1788155, Length=371, Percent_Identity=26.6846361185984, Blast_Score=132, Evalue=5e-32,
Organism=Saccharomyces cerevisiae, GI6324702, Length=387, Percent_Identity=31.0077519379845, Blast_Score=185, Evalue=1e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006115
- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02222 ATP-grasp; PF03446 NAD_binding_2 [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 42335; Mature: 42335

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTTNTILPSQTIGIIGGGQLGRMMAIAARYMGYKIVVLDPTPDCPTAHVADQQIVAAYD
CCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHCEEEEEECCCCCCCCCCCCCCHHHHHHH
DLHAIDQLIDGCDVITYEFENVDLQAAAIIHQSGKLPQGTRALEVTQNREKEKQVVSDLR
HHHHHHHHHCCCCEEEEEECCCCEEEEEEEECCCCCCCCCEEEEEHHCHHHHHHHHHHCC
LPVPDYYIVTSTEECEHALDSIAFPAVIKTCRGGYDGKGQLKIHNESEKEQAIQFFKLHG
CCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHCC
YCIIEQWITFDKEVSVVFTRSINGDIEFFPLAENEHRDHILYKTTVPANVDQSIHDSACQ
EEEEEEHHCCCCCEEEEEEEECCCCEEEEECCCCCCCCEEEEEEECCCCCCCHHHHHHHH
IAKKIADYMDIVGTFAIEMFVKGKEVYVNEMAPRPHNSGHYTIEGCNISQFAQHIRAICG
HHHHHHHHHHHHHHHHHHHEECCCEEEEECCCCCCCCCCCEEEECCCHHHHHHHHHHHHC
LPLIEVELHGPTAMINVLGNDIKYAKTFLSRSNVGFLHLYGKEEPKEKRKMGHITFTAKT
CCEEEEEECCCEEEEEHHCCHHHHHHHHHHCCCCEEEEEECCCCCHHHHHCCCEEEEECC
TEELEKQVNYFKEEIHS
HHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQTTNTILPSQTIGIIGGGQLGRMMAIAARYMGYKIVVLDPTPDCPTAHVADQQIVAAYD
CCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHCEEEEEECCCCCCCCCCCCCCHHHHHHH
DLHAIDQLIDGCDVITYEFENVDLQAAAIIHQSGKLPQGTRALEVTQNREKEKQVVSDLR
HHHHHHHHHCCCCEEEEEECCCCEEEEEEEECCCCCCCCCEEEEEHHCHHHHHHHHHHCC
LPVPDYYIVTSTEECEHALDSIAFPAVIKTCRGGYDGKGQLKIHNESEKEQAIQFFKLHG
CCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHCC
YCIIEQWITFDKEVSVVFTRSINGDIEFFPLAENEHRDHILYKTTVPANVDQSIHDSACQ
EEEEEEHHCCCCCEEEEEEEECCCCEEEEECCCCCCCCEEEEEEECCCCCCCHHHHHHHH
IAKKIADYMDIVGTFAIEMFVKGKEVYVNEMAPRPHNSGHYTIEGCNISQFAQHIRAICG
HHHHHHHHHHHHHHHHHHHEECCCEEEEECCCCCCCCCCCEEEECCCHHHHHHHHHHHHC
LPLIEVELHGPTAMINVLGNDIKYAKTFLSRSNVGFLHLYGKEEPKEKRKMGHITFTAKT
CCEEEEEECCCEEEEEHHCCHHHHHHHHHHCCCCEEEEEECCCCCHHHHHCCCEEEEECC
TEELEKQVNYFKEEIHS
HHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3036807; 9384377 [H]