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The map label for this gene is guaD [H]

Identifier: 23097839

GI number: 23097839

Start: 407939

End: 408418

Strand: Direct

Name: guaD [H]

Synonym: OB0384

Alternate gene names: 23097839

Gene position: 407939-408418 (Clockwise)

Preceding gene: 23097838

Following gene: 23097840

Centisome position: 11.24

GC content: 37.5

Gene sequence:

>480_bases
ATGCAAACAAATCCAAATCATCAGCTATTCATGTCAAAGGCTATTGAATTAGCAGTTAGTAATATCTCTCAAGGTGGGGG
GCCTTTTGGAGCTGTGATTATAAAAGATAATAAAATAATTGCAGAAGGAACAAACCAAGTAACCAATTACAATGACCCAA
CTGCACATGCTGAAGTTCAAGCAATTCGCCAAGCTTGCGAGAAGCTTTCGACTTTTGAGTTGAAAGGCTGTACCCTTTAT
ACGAGTTGTGAACCATGTCCAATGTGTTTAGGTGCAATCTATTGGGCAAGAGTTGATGCGGTATATTATGGAGCGAATCG
AAAAGATGCCGCAAAGATTAATTTTGATGACGATTTAATCTATCAAGAAATTGACCTTCATCCTAGTTCCCGTAAACTAC
CTTTTATCACAATTCCTACAAACGATTCCTTACTTCCCTTTGAAACATGGGAAAAATATACAAATAAGACGCATTACTAG

Upstream 100 bases:

>100_bases
TTATTGATTTTATTTATTCATGGTCGTATACGATCTTTCCAAGTAAAGAGGAGAAATAAATCTGATAATTTGGTAAACTA
ATATGAAGGGGGAAGATAGC

Downstream 100 bases:

>100_bases
ATGTCAAATATGAATTGACATCTTCTTTTTTTGGCGTATAATAATTAGTAATTATAAAATTACAAATTACTTCAAAAAAT
TGAGGTGAAGTTATGCCCAA

Product: hypothetical protein

Products: NA

Alternate protein names: GDEase; Guanase; Guanine aminase; Guanine aminohydrolase; GAH [H]

Number of amino acids: Translated: 159; Mature: 159

Protein sequence:

>159_residues
MQTNPNHQLFMSKAIELAVSNISQGGGPFGAVIIKDNKIIAEGTNQVTNYNDPTAHAEVQAIRQACEKLSTFELKGCTLY
TSCEPCPMCLGAIYWARVDAVYYGANRKDAAKINFDDDLIYQEIDLHPSSRKLPFITIPTNDSLLPFETWEKYTNKTHY

Sequences:

>Translated_159_residues
MQTNPNHQLFMSKAIELAVSNISQGGGPFGAVIIKDNKIIAEGTNQVTNYNDPTAHAEVQAIRQACEKLSTFELKGCTLY
TSCEPCPMCLGAIYWARVDAVYYGANRKDAAKINFDDDLIYQEIDLHPSSRKLPFITIPTNDSLLPFETWEKYTNKTHY
>Mature_159_residues
MQTNPNHQLFMSKAIELAVSNISQGGGPFGAVIIKDNKIIAEGTNQVTNYNDPTAHAEVQAIRQACEKLSTFELKGCTLY
TSCEPCPMCLGAIYWARVDAVYYGANRKDAAKINFDDDLIYQEIDLHPSSRKLPFITIPTNDSLLPFETWEKYTNKTHY

Specific function: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia [H]

COG id: COG0590

COG function: function code FJ; Cytosine/adenosine deaminases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Escherichia coli, GI145693172, Length=101, Percent_Identity=38.6138613861386, Blast_Score=86, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17554608, Length=151, Percent_Identity=49.6688741721854, Blast_Score=153, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17555996, Length=157, Percent_Identity=43.9490445859873, Blast_Score=141, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17541138, Length=103, Percent_Identity=37.8640776699029, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: =3.5.4.3 [H]

Molecular weight: Translated: 17839; Mature: 17839

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTNPNHQLFMSKAIELAVSNISQGGGPFGAVIIKDNKIIAEGTNQVTNYNDPTAHAEVQ
CCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCEEEECCCCCCCCCCCCCHHHHHH
AIRQACEKLSTFELKGCTLYTSCEPCPMCLGAIYWARVDAVYYGANRKDAAKINFDDDLI
HHHHHHHHHCCEEECCEEEEECCCCHHHHHHHHHHHHHEEEEECCCCCCCEEECCCCCEE
YQEIDLHPSSRKLPFITIPTNDSLLPFETWEKYTNKTHY
EEEECCCCCCCCCCEEEECCCCCCCCHHHHHHHCCCCCC
>Mature Secondary Structure
MQTNPNHQLFMSKAIELAVSNISQGGGPFGAVIIKDNKIIAEGTNQVTNYNDPTAHAEVQ
CCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCEEEECCCCCCCCCCCCCHHHHHH
AIRQACEKLSTFELKGCTLYTSCEPCPMCLGAIYWARVDAVYYGANRKDAAKINFDDDLI
HHHHHHHHHCCEEECCEEEEECCCCHHHHHHHHHHHHHEEEEECCCCCCCEEECCCCCEE
YQEIDLHPSSRKLPFITIPTNDSLLPFETWEKYTNKTHY
EEEECCCCCCCCCCEEEECCCCCCCCHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 11101664 [H]