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The map label for this gene is uxaC

Identifier: 23097822

GI number: 23097822

Start: 390632

End: 392050

Strand: Direct

Name: uxaC

Synonym: OB0367

Alternate gene names: 23097822

Gene position: 390632-392050 (Clockwise)

Preceding gene: 23097821

Following gene: 23097823

Centisome position: 10.76

GC content: 35.38

Gene sequence:

>1419_bases
GTGAAAAAGTTTATGGATGATAATTTTTTACTGAGCAACGATACTGCAGAAGAGTTATTTCATCATTATGCAAAAGATAT
GCCGATTATAGACTATCATTGTCATTTAAGCCCAAAAGAAATCTATATGAATAAAAGGTATTCTAACATTACTGAGGTTT
GGCTTTATGGAGATCATTACAAGTGGAGAGCGATGCGAGCAGCCGGTGTAGAAGAATCACTTATAACAGGTGATGCAAAT
GATTATGATAAATTTATGGCTTGGGCTGAAACCGTTCCTAAACTAATTGGAAATCCTCTGTATAATTGGACTCACCTTGA
GCTACAAAGATATTTTGGTGTAGATGAAATTTTAAACAAAGAATCAGGACCATCTATTTGGGAAAAGGTAAATAAATGCT
TAGCCCAAGATGATTTTGGGGTTAGAGAATTAATTAATCAGTCTAATGTGCAAGTCGTTTGTACTACGGACGATCCAATT
GATGATTTATCTTTTCATCAAATGTTGGTTGAAGATGATGATTTTTCGGTTAAGGTGCTGCCCGGTTTTCGGCCAGATAA
AGCAATAGAAATAAATCAAGAAGGATTTATTGACTATGTAGATTCGCTTGAAAAAGTCACTTCTCATTCTACAAAGACTT
ATGACGGTTTTTTAAGGGCGCTTAAGTCTAGAGTAGACTATTTTCACCAAAATGGATGCAGCGTCGCTGATCATGCATTA
AATACGATGATGTTTACGGAAACAACCAAAGAAAAAGCCAGAAATTATTATGAAAAAGCCATGAATGGTCAGAAACTTTC
TCCTAAAGAAGAAAGTGATTTTAAAAGCTTCACACTAGTATTTTTAGGGGAACAATATGCAGATAAAGGATGGGTAATGC
AATATCACATAAATGCACTGCGTAATAATAATTCTAGGATGTACAATAATCTTGGGCCAGATACTGGATACGATGCCATG
AATGACGAAGTAATTTCTAAACCTTTAGTCAATCTATTAAATGAGCTTGAAAAAAAGGATAGACTTCCAAAAACGATTTT
ATATTCGCTTAATCCAAACGATAATCCTGTTATTGCCTCTATCATTGGAAGTTTTCAACGTGGTGGAGTTCCTGGAAAGC
TCCAATTTGGAACAGCGTGGTGGTTTAATGATACAAAATCAGGAATGATTAAACAAATGCAGACGTTAGCAGATATTGGT
GTGTTCAGCCAATTTATTGGCATGTTAACCGATTCAAGAAGCTTTTTATCTTATCCTAGACATGAATACTTTAGGCGTTT
AGTTTGTTCGTTGATTGGTGAGTGGGTTCACAACGGTGAAGTTCCTTATGACCTAAAATCTTTAGGGGAAATCGTTCAAG
ATATATCCTACTATAATGCAGCAAGATACTTTGACTTTGGACTCCTCTCGGATGAATGA

Upstream 100 bases:

>100_bases
TACTCTACGCTTAGTGAATATGAAGATGTTTATCGTGATTATCTTATTAAACATATTGGTAGACATGTAGATACATTAGA
TCTATAAAGGAGGCTTTTTC

Downstream 100 bases:

>100_bases
AAAAAAGGGAGAAGCTGGGACATAACAACAAATTCTGATCAAAAGACGACGAATGAAAGCTAGAATAAGCGTAAGAAATA
TACGGAGACTCCTTGAAAAT

Product: glucuronate isomerase

Products: NA

Alternate protein names: Glucuronate isomerase; Uronic isomerase

Number of amino acids: Translated: 472; Mature: 472

Protein sequence:

>472_residues
MKKFMDDNFLLSNDTAEELFHHYAKDMPIIDYHCHLSPKEIYMNKRYSNITEVWLYGDHYKWRAMRAAGVEESLITGDAN
DYDKFMAWAETVPKLIGNPLYNWTHLELQRYFGVDEILNKESGPSIWEKVNKCLAQDDFGVRELINQSNVQVVCTTDDPI
DDLSFHQMLVEDDDFSVKVLPGFRPDKAIEINQEGFIDYVDSLEKVTSHSTKTYDGFLRALKSRVDYFHQNGCSVADHAL
NTMMFTETTKEKARNYYEKAMNGQKLSPKEESDFKSFTLVFLGEQYADKGWVMQYHINALRNNNSRMYNNLGPDTGYDAM
NDEVISKPLVNLLNELEKKDRLPKTILYSLNPNDNPVIASIIGSFQRGGVPGKLQFGTAWWFNDTKSGMIKQMQTLADIG
VFSQFIGMLTDSRSFLSYPRHEYFRRLVCSLIGEWVHNGEVPYDLKSLGEIVQDISYYNAARYFDFGLLSDE

Sequences:

>Translated_472_residues
MKKFMDDNFLLSNDTAEELFHHYAKDMPIIDYHCHLSPKEIYMNKRYSNITEVWLYGDHYKWRAMRAAGVEESLITGDAN
DYDKFMAWAETVPKLIGNPLYNWTHLELQRYFGVDEILNKESGPSIWEKVNKCLAQDDFGVRELINQSNVQVVCTTDDPI
DDLSFHQMLVEDDDFSVKVLPGFRPDKAIEINQEGFIDYVDSLEKVTSHSTKTYDGFLRALKSRVDYFHQNGCSVADHAL
NTMMFTETTKEKARNYYEKAMNGQKLSPKEESDFKSFTLVFLGEQYADKGWVMQYHINALRNNNSRMYNNLGPDTGYDAM
NDEVISKPLVNLLNELEKKDRLPKTILYSLNPNDNPVIASIIGSFQRGGVPGKLQFGTAWWFNDTKSGMIKQMQTLADIG
VFSQFIGMLTDSRSFLSYPRHEYFRRLVCSLIGEWVHNGEVPYDLKSLGEIVQDISYYNAARYFDFGLLSDE
>Mature_472_residues
MKKFMDDNFLLSNDTAEELFHHYAKDMPIIDYHCHLSPKEIYMNKRYSNITEVWLYGDHYKWRAMRAAGVEESLITGDAN
DYDKFMAWAETVPKLIGNPLYNWTHLELQRYFGVDEILNKESGPSIWEKVNKCLAQDDFGVRELINQSNVQVVCTTDDPI
DDLSFHQMLVEDDDFSVKVLPGFRPDKAIEINQEGFIDYVDSLEKVTSHSTKTYDGFLRALKSRVDYFHQNGCSVADHAL
NTMMFTETTKEKARNYYEKAMNGQKLSPKEESDFKSFTLVFLGEQYADKGWVMQYHINALRNNNSRMYNNLGPDTGYDAM
NDEVISKPLVNLLNELEKKDRLPKTILYSLNPNDNPVIASIIGSFQRGGVPGKLQFGTAWWFNDTKSGMIKQMQTLADIG
VFSQFIGMLTDSRSFLSYPRHEYFRRLVCSLIGEWVHNGEVPYDLKSLGEIVQDISYYNAARYFDFGLLSDE

Specific function: Hexuronate conversion to KDG. [C]

COG id: COG1904

COG function: function code G; Glucuronate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uronate isomerase family

Homologues:

Organism=Escherichia coli, GI2367192, Length=469, Percent_Identity=51.1727078891258, Blast_Score=521, Evalue=1e-149,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UXAC_OCEIH (Q8CXN4)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_691288.1
- ProteinModelPortal:   Q8CXN4
- SMR:   Q8CXN4
- GeneID:   1015653
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB0367
- NMPDR:   fig|221109.1.peg.372
- HOGENOM:   HBG297087
- OMA:   AWAKTVP
- ProtClustDB:   PRK02925
- BioCyc:   OIHE221109:OB0367-MONOMER
- BRENDA:   5.3.1.12
- HAMAP:   MF_00675
- InterPro:   IPR003766
- InterPro:   IPR023177
- Gene3D:   G3DSA:1.10.2020.10

Pfam domain/function: PF02614 UxaC

EC number: =5.3.1.12

Molecular weight: Translated: 54549; Mature: 54549

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKFMDDNFLLSNDTAEELFHHYAKDMPIIDYHCHLSPKEIYMNKRYSNITEVWLYGDHY
CCCCCCCCCEECCCHHHHHHHHHHCCCCEEEEEECCCHHHHHHCCCCCCCEEEEEECCCC
KWRAMRAAGVEESLITGDANDYDKFMAWAETVPKLIGNPLYNWTHLELQRYFGVDEILNK
HHHHHHHCCCCHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCHHHHHCC
ESGPSIWEKVNKCLAQDDFGVRELINQSNVQVVCTTDDPIDDLSFHQMLVEDDDFSVKVL
CCCCHHHHHHHHHHHCCCCCHHHHHCCCCCEEEECCCCCCCHHHHHHHHCCCCCCEEEEC
PGFRPDKAIEINQEGFIDYVDSLEKVTSHSTKTYDGFLRALKSRVDYFHQNGCSVADHAL
CCCCCCCEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
NTMMFTETTKEKARNYYEKAMNGQKLSPKEESDFKSFTLVFLGEQYADKGWVMQYHINAL
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECHHHCCCCCEEEEEHHHH
RNNNSRMYNNLGPDTGYDAMNDEVISKPLVNLLNELEKKDRLPKTILYSLNPNDNPVIAS
HCCCCCEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHH
IIGSFQRGGVPGKLQFGTAWWFNDTKSGMIKQMQTLADIGVFSQFIGMLTDSRSFLSYPR
HHHHHHHCCCCCEEEECEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCH
HEYFRRLVCSLIGEWVHNGEVPYDLKSLGEIVQDISYYNAARYFDFGLLSDE
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHEECCCCCCC
>Mature Secondary Structure
MKKFMDDNFLLSNDTAEELFHHYAKDMPIIDYHCHLSPKEIYMNKRYSNITEVWLYGDHY
CCCCCCCCCEECCCHHHHHHHHHHCCCCEEEEEECCCHHHHHHCCCCCCCEEEEEECCCC
KWRAMRAAGVEESLITGDANDYDKFMAWAETVPKLIGNPLYNWTHLELQRYFGVDEILNK
HHHHHHHCCCCHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCHHHHHCC
ESGPSIWEKVNKCLAQDDFGVRELINQSNVQVVCTTDDPIDDLSFHQMLVEDDDFSVKVL
CCCCHHHHHHHHHHHCCCCCHHHHHCCCCCEEEECCCCCCCHHHHHHHHCCCCCCEEEEC
PGFRPDKAIEINQEGFIDYVDSLEKVTSHSTKTYDGFLRALKSRVDYFHQNGCSVADHAL
CCCCCCCEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
NTMMFTETTKEKARNYYEKAMNGQKLSPKEESDFKSFTLVFLGEQYADKGWVMQYHINAL
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECHHHCCCCCEEEEEHHHH
RNNNSRMYNNLGPDTGYDAMNDEVISKPLVNLLNELEKKDRLPKTILYSLNPNDNPVIAS
HCCCCCEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHH
IIGSFQRGGVPGKLQFGTAWWFNDTKSGMIKQMQTLADIGVFSQFIGMLTDSRSFLSYPR
HHHHHHHCCCCCEEEECEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCH
HEYFRRLVCSLIGEWVHNGEVPYDLKSLGEIVQDISYYNAARYFDFGLLSDE
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12235376