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The map label for this gene is lutP [H]

Identifier: 23097823

GI number: 23097823

Start: 392568

End: 394157

Strand: Direct

Name: lutP [H]

Synonym: OB0368

Alternate gene names: 23097823

Gene position: 392568-394157 (Clockwise)

Preceding gene: 23097822

Following gene: 23097824

Centisome position: 10.81

GC content: 38.18

Gene sequence:

>1590_bases
ATGTATTTACTTATAGCACTAAGTGCGATTATTGCACCGTTTATTTTTTTAGTGTTATTACGTTTTCCGGCAACAAAAGG
AATGACGTGGAGTGCGTTAATTGTGATTTTATTCGCAATTACTGTATGGGGGATGGAAGGAGAAGTTATACTATCATCCA
TTTTCCAGGGGACGCATAAAACATTAACTATTTTATGGATTTTATTTGGGGCACTCGTATTGTTAAATACACTACGTAAT
ACGGGAGCGGTTGATCGAATTAATCAAGGTTTTCAAAGTATTTCAGCAGACATGAGAGTTCAAGTGATTATTGTTGCTTT
TTTGTTCGGAGCTTTAATTGAAGGGGCAGCAGGATTTGGTACTCCTGCGATGGTTACTGGACCTTTATTAGTGGCTTTAG
GCTTTCGACCATTGGCAGCAGCTACAATTGCCGTGGTAGCTGATAGTGCTTCCGTTGCTTTTGGAGCTGTAGGTACACCG
ATTGCCGTTGGATTAAGTAATGTTCCTATTGCAAATGCTACGTTCTATGATGAAATCGGTATCATGGTAACGACACTCGA
TCTTTTTGCAGGAACATTTATTCCATTTGTATTGGTTATCTTACTCACCATATTTTTTGGGAAAAACAAAAGTATCAAAC
AAGCTTTACCTATGCTTCCATGGTCATTATTGATTGGTCTTTCCTATACAGGGTCTGCTTTATTTTATGCAGTTGTATTT
GGGCAAGAATTTGTTGCTATTTTAGCTTCGTTAACAGCATTAGTCATCGCTACACTTACAGCAAAAAAAGGTTGGCTTTT
ACCAAAAGATACGTGGAGAGAGGCTGTTAGAGAAGGATTTGTCGTCAAGGAAAAGAAATCAGAGATGGGTATTATAGCAG
CTTGGGCACCGTATGTAGTTGTCGTTGTTTTATTACTTATGACAAGAATAATACCTTGGCTAACCGAATTTACACAATCA
GCTATTGATTTATCTTGGACGAATATACTAGGTGTGGAAGGCGTTTCTTCAACGTGGGAGTTTCTGTACTCACCAGGTAC
GATATTGGCAGTGGCAGCGGTTCTATCCGTGTTTTTACATAAAAAATCGTTCCATACTTTCGTAAACGCATCAAAAGAGT
CATTATCAACGATGAAGACAACATCCATTTCATTAATTGCTACCCTAGCCATGGTGCATGTATTTACGAATTCAGGAATT
AATCTCAATGAATTAGCAAGTATGCCACAATACATTGCAGAATCCTTAGCAAATTCATTAGGTTTTATTTGGTTAATTGT
CGCACCATTTTTAGGAGAATTAGGTTCATTCATTACAGGAAGTGCCACAGTGTCTACACTTACATTTTCTCCGATTCAAT
ATAGTGTGGCGAATCAAATAGGATTAGATGTAAATGCAGTGCTTGCAGCTCAGGTTATCGGAGCGGGAGCTGGGAATATG
ATTTGTGTGCATAATGTTGTTGCGGCAAGTGCTGTAGTAGGGTTGAGTGGTAAAGAAGGAGATATTATTCGAAAGACCTT
ACTTCCTGCCATTCTCTATGGTTTAATTGTTGGAATCGTTGGATTTATTATTGCTCATTTCTTTTTGTAG

Upstream 100 bases:

>100_bases
TCTTATAAATATCAGAGTAAACTATAAATAAGGTCATCAGATGACCTTATTTATTTTGACATCTATGAAATCGCTTCATT
GGGGAGAAAGAGGGGTTTTG

Downstream 100 bases:

>100_bases
ATTATCGTAGTCCTTGCCATCAGCTTTTCAAACTGGTTCGTTTCCATTAAAATGGTCTCAAGTGATGAGGAGTTGAAATG
AATGGAGTACAAACGTATTA

Product: L-lactate permease

Products: lactate [Cytoplasm]; Proton [Cytoplasm]; glycolate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 529; Mature: 529

Protein sequence:

>529_residues
MYLLIALSAIIAPFIFLVLLRFPATKGMTWSALIVILFAITVWGMEGEVILSSIFQGTHKTLTILWILFGALVLLNTLRN
TGAVDRINQGFQSISADMRVQVIIVAFLFGALIEGAAGFGTPAMVTGPLLVALGFRPLAAATIAVVADSASVAFGAVGTP
IAVGLSNVPIANATFYDEIGIMVTTLDLFAGTFIPFVLVILLTIFFGKNKSIKQALPMLPWSLLIGLSYTGSALFYAVVF
GQEFVAILASLTALVIATLTAKKGWLLPKDTWREAVREGFVVKEKKSEMGIIAAWAPYVVVVVLLLMTRIIPWLTEFTQS
AIDLSWTNILGVEGVSSTWEFLYSPGTILAVAAVLSVFLHKKSFHTFVNASKESLSTMKTTSISLIATLAMVHVFTNSGI
NLNELASMPQYIAESLANSLGFIWLIVAPFLGELGSFITGSATVSTLTFSPIQYSVANQIGLDVNAVLAAQVIGAGAGNM
ICVHNVVAASAVVGLSGKEGDIIRKTLLPAILYGLIVGIVGFIIAHFFL

Sequences:

>Translated_529_residues
MYLLIALSAIIAPFIFLVLLRFPATKGMTWSALIVILFAITVWGMEGEVILSSIFQGTHKTLTILWILFGALVLLNTLRN
TGAVDRINQGFQSISADMRVQVIIVAFLFGALIEGAAGFGTPAMVTGPLLVALGFRPLAAATIAVVADSASVAFGAVGTP
IAVGLSNVPIANATFYDEIGIMVTTLDLFAGTFIPFVLVILLTIFFGKNKSIKQALPMLPWSLLIGLSYTGSALFYAVVF
GQEFVAILASLTALVIATLTAKKGWLLPKDTWREAVREGFVVKEKKSEMGIIAAWAPYVVVVVLLLMTRIIPWLTEFTQS
AIDLSWTNILGVEGVSSTWEFLYSPGTILAVAAVLSVFLHKKSFHTFVNASKESLSTMKTTSISLIATLAMVHVFTNSGI
NLNELASMPQYIAESLANSLGFIWLIVAPFLGELGSFITGSATVSTLTFSPIQYSVANQIGLDVNAVLAAQVIGAGAGNM
ICVHNVVAASAVVGLSGKEGDIIRKTLLPAILYGLIVGIVGFIIAHFFL
>Mature_529_residues
MYLLIALSAIIAPFIFLVLLRFPATKGMTWSALIVILFAITVWGMEGEVILSSIFQGTHKTLTILWILFGALVLLNTLRN
TGAVDRINQGFQSISADMRVQVIIVAFLFGALIEGAAGFGTPAMVTGPLLVALGFRPLAAATIAVVADSASVAFGAVGTP
IAVGLSNVPIANATFYDEIGIMVTTLDLFAGTFIPFVLVILLTIFFGKNKSIKQALPMLPWSLLIGLSYTGSALFYAVVF
GQEFVAILASLTALVIATLTAKKGWLLPKDTWREAVREGFVVKEKKSEMGIIAAWAPYVVVVVLLLMTRIIPWLTEFTQS
AIDLSWTNILGVEGVSSTWEFLYSPGTILAVAAVLSVFLHKKSFHTFVNASKESLSTMKTTSISLIATLAMVHVFTNSGI
NLNELASMPQYIAESLANSLGFIWLIVAPFLGELGSFITGSATVSTLTFSPIQYSVANQIGLDVNAVLAAQVIGAGAGNM
ICVHNVVAASAVVGLSGKEGDIIRKTLLPAILYGLIVGIVGFIIAHFFL

Specific function: Is the principal permease for the uptake of L-lactate in B.subtilis [H]

COG id: COG1620

COG function: function code C; L-lactate permease

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lactate permease family [H]

Homologues:

Organism=Escherichia coli, GI1789347, Length=560, Percent_Identity=29.4642857142857, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI1790031, Length=547, Percent_Identity=28.7020109689214, Blast_Score=147, Evalue=1e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003804 [H]

Pfam domain/function: PF02652 Lactate_perm [H]

EC number: NA

Molecular weight: Translated: 56289; Mature: 56289

Theoretical pI: Translated: 7.75; Mature: 7.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYLLIALSAIIAPFIFLVLLRFPATKGMTWSALIVILFAITVWGMEGEVILSSIFQGTHK
CHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCHHH
TLTILWILFGALVLLNTLRNTGAVDRINQGFQSISADMRVQVIIVAFLFGALIEGAAGFG
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCC
TPAMVTGPLLVALGFRPLAAATIAVVADSASVAFGAVGTPIAVGLSNVPIANATFYDEIG
CCHHHHHHHHHHHCCCHHHHHHHHHEECCCHHHHCCCCCHHHHCCCCCCCCCCCHHHHHH
IMVTTLDLFAGTFIPFVLVILLTIFFGKNKSIKQALPMLPWSLLIGLSYTGSALFYAVVF
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCHHHHHHCCCCCHHHHHHHHH
GQEFVAILASLTALVIATLTAKKGWLLPKDTWREAVREGFVVKEKKSEMGIIAAWAPYVV
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCEEEECCCCCCEEEHHHHHHH
VVVLLLMTRIIPWLTEFTQSAIDLSWTNILGVEGVSSTWEFLYSPGTILAVAAVLSVFLH
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHH
KKSFHTFVNASKESLSTMKTTSISLIATLAMVHVFTNSGINLNELASMPQYIAESLANSL
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
GFIWLIVAPFLGELGSFITGSATVSTLTFSPIQYSVANQIGLDVNAVLAAQVIGAGAGNM
HHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHCCCCHHHHHHHHHHCCCCCCE
ICVHNVVAASAVVGLSGKEGDIIRKTLLPAILYGLIVGIVGFIIAHFFL
EHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MYLLIALSAIIAPFIFLVLLRFPATKGMTWSALIVILFAITVWGMEGEVILSSIFQGTHK
CHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCHHH
TLTILWILFGALVLLNTLRNTGAVDRINQGFQSISADMRVQVIIVAFLFGALIEGAAGFG
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCC
TPAMVTGPLLVALGFRPLAAATIAVVADSASVAFGAVGTPIAVGLSNVPIANATFYDEIG
CCHHHHHHHHHHHCCCHHHHHHHHHEECCCHHHHCCCCCHHHHCCCCCCCCCCCHHHHHH
IMVTTLDLFAGTFIPFVLVILLTIFFGKNKSIKQALPMLPWSLLIGLSYTGSALFYAVVF
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCHHHHHHCCCCCHHHHHHHHH
GQEFVAILASLTALVIATLTAKKGWLLPKDTWREAVREGFVVKEKKSEMGIIAAWAPYVV
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCEEEECCCCCCEEEHHHHHHH
VVVLLLMTRIIPWLTEFTQSAIDLSWTNILGVEGVSSTWEFLYSPGTILAVAAVLSVFLH
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHH
KKSFHTFVNASKESLSTMKTTSISLIATLAMVHVFTNSGINLNELASMPQYIAESLANSL
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
GFIWLIVAPFLGELGSFITGSATVSTLTFSPIQYSVANQIGLDVNAVLAAQVIGAGAGNM
HHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHCCCCHHHHHHHHHHCCCCCCE
ICVHNVVAASAVVGLSGKEGDIIRKTLLPAILYGLIVGIVGFIIAHFFL
EHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: lactate [Periplasm]; Proton [Periplasm]; glycolate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + lactate [Periplasm] = Proton [Cytoplasm] + lactate [Cytoplasm] Proton [Periplasm] + glycolate [Periplasm] = Proton [Cytoplasm] + glycolate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 8969506 [H]