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The map label for this gene is gor [H]

Identifier: 22127723

GI number: 22127723

Start: 4289749

End: 4291131

Strand: Reverse

Name: gor [H]

Synonym: y3852

Alternate gene names: 22127723

Gene position: 4291131-4289749 (Counterclockwise)

Preceding gene: 22127724

Following gene: 22127722

Centisome position: 93.27

GC content: 51.84

Gene sequence:

>1383_bases
ATGACCGGGTATCTCATGGAAACGACCCTGATGACCAAACATTACGATTATCTGGCAATTGGCGGTGGCAGTGGCGGGAT
CGCATCGATCAACCGGGCAGCCATGTACGGTAAAAAATGCGCATTGATCGAAGCTAAACAGCTCGGTGGCACCTGTGTTA
ACGTCGGTTGTGTGCCAAAGAAAGTGATGTGGCATGCAGCGCAGATTGCGGAAGCCATTCATTTGTACGGCCCGGATTAC
GGCTTCGACACCACAGTGAACCACTTCGATTGGAAAAAGCTGATTGCTAACCGTACTGCTTACATCGATCGTATCCATCA
GTCCTATGAGCGCGGTTTAGGCAATAATAAAGTGGATGTTATCCAAGGCTTCGCCCGCTTTGTGGATGCCCACACCGTGG
AAGTTAACGGTGAGACGATCACCGCAGATCACATTCTGATCGCTACCGGTGGCCGCCCAAGCCATCCCGATATCCCTGGT
GCTGAATACGGTATCGACTCCGATGGTTTCTTCGAATTAGATGAGATGCCAAAACGTGTCGCTGTCGTGGGCGCAGGTTA
TATCGCGGTAGAAATTGCTGGCGTACTCAACGGGTTAGGTACCGAGACACACTTGTTTGTCCGCAAACATGCACCGTTGC
GTACCTTTGATCCGCTAATTGTTGAAACCCTGTTGGAAGTGATGAACACCGAAGGGCCGAAACTGCATACCGAATCGGTA
CCGAAAGCGGTTATCAAAAACGCCGATGGCAGCCTGACGCTGCAATTAGAAAATGGTACTGAAGTCACTGTTGACCACCT
GATCTGGGCGATTGGCCGTGAACCCGCAACCGACAACCTGAACCTGTCTGTCACCGGTGTTAAGACCAATGACAAAGGCT
ATATCGAGGTTGATAAGTTCCAGAACACCAACGTCAAAGGCATCTACGCCGTCGGTGATAACACTGGCGTAGTTGAACTG
ACCCCGGTTGCCGTTGCGGCGGGCCGCCGTTTGTCCGAACGTCTGTTCAATAACAAGCCGGATGAGCATTTGGATTACAG
CAATATCCCAACCGTGGTATTCAGCCATCCGCCAATCGGTACTATCGGCCTGACCGAGCCACAAGCCAGAGAGAAATTTG
GCGACGATCAGGTGAAAGTGTACACATCCTCGTTCACCGCGATGTACAGTGCTGTCACTCAACACCGCCAGCCATGCCGG
ATGAAATTAGTCTGCGTGGGTGCCGAAGAGAAGATTGTCGGTATTCACGGCATCGGTTTCGGAATGGACGAGATCCTGCA
AGGGTTCGCAGTCGCCATGAAGATGGGCGCGACCAAGAAAGATTTCGACAACACTGTCGCTATCCACCCTACCGCCGCAG
AAGAGTTCGTTACCATGAGATGA

Upstream 100 bases:

>100_bases
TCATTGATGTACAAAAGGCGCTCAGACGCTACACTGTTAGGCAATTTTAAACGACTCTACCCTCAATAATGCGCGTTACG
CGAAAGCGGCAACGTGCAGT

Downstream 100 bases:

>100_bases
TTTCGTTACTATGGCCCGAACAGGCAGAGACTCCTGCACGGGCCATGTTTCTGAAATACACTAAGCCAGGTTGAAAATGA
GCTAACCTGGCTTTTATCTT

Product: glutathione reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 460; Mature: 459

Protein sequence:

>460_residues
MTGYLMETTLMTKHYDYLAIGGGSGGIASINRAAMYGKKCALIEAKQLGGTCVNVGCVPKKVMWHAAQIAEAIHLYGPDY
GFDTTVNHFDWKKLIANRTAYIDRIHQSYERGLGNNKVDVIQGFARFVDAHTVEVNGETITADHILIATGGRPSHPDIPG
AEYGIDSDGFFELDEMPKRVAVVGAGYIAVEIAGVLNGLGTETHLFVRKHAPLRTFDPLIVETLLEVMNTEGPKLHTESV
PKAVIKNADGSLTLQLENGTEVTVDHLIWAIGREPATDNLNLSVTGVKTNDKGYIEVDKFQNTNVKGIYAVGDNTGVVEL
TPVAVAAGRRLSERLFNNKPDEHLDYSNIPTVVFSHPPIGTIGLTEPQAREKFGDDQVKVYTSSFTAMYSAVTQHRQPCR
MKLVCVGAEEKIVGIHGIGFGMDEILQGFAVAMKMGATKKDFDNTVAIHPTAAEEFVTMR

Sequences:

>Translated_460_residues
MTGYLMETTLMTKHYDYLAIGGGSGGIASINRAAMYGKKCALIEAKQLGGTCVNVGCVPKKVMWHAAQIAEAIHLYGPDY
GFDTTVNHFDWKKLIANRTAYIDRIHQSYERGLGNNKVDVIQGFARFVDAHTVEVNGETITADHILIATGGRPSHPDIPG
AEYGIDSDGFFELDEMPKRVAVVGAGYIAVEIAGVLNGLGTETHLFVRKHAPLRTFDPLIVETLLEVMNTEGPKLHTESV
PKAVIKNADGSLTLQLENGTEVTVDHLIWAIGREPATDNLNLSVTGVKTNDKGYIEVDKFQNTNVKGIYAVGDNTGVVEL
TPVAVAAGRRLSERLFNNKPDEHLDYSNIPTVVFSHPPIGTIGLTEPQAREKFGDDQVKVYTSSFTAMYSAVTQHRQPCR
MKLVCVGAEEKIVGIHGIGFGMDEILQGFAVAMKMGATKKDFDNTVAIHPTAAEEFVTMR
>Mature_459_residues
TGYLMETTLMTKHYDYLAIGGGSGGIASINRAAMYGKKCALIEAKQLGGTCVNVGCVPKKVMWHAAQIAEAIHLYGPDYG
FDTTVNHFDWKKLIANRTAYIDRIHQSYERGLGNNKVDVIQGFARFVDAHTVEVNGETITADHILIATGGRPSHPDIPGA
EYGIDSDGFFELDEMPKRVAVVGAGYIAVEIAGVLNGLGTETHLFVRKHAPLRTFDPLIVETLLEVMNTEGPKLHTESVP
KAVIKNADGSLTLQLENGTEVTVDHLIWAIGREPATDNLNLSVTGVKTNDKGYIEVDKFQNTNVKGIYAVGDNTGVVELT
PVAVAAGRRLSERLFNNKPDEHLDYSNIPTVVFSHPPIGTIGLTEPQAREKFGDDQVKVYTSSFTAMYSAVTQHRQPCRM
KLVCVGAEEKIVGIHGIGFGMDEILQGFAVAMKMGATKKDFDNTVAIHPTAAEEFVTMR

Specific function: Maintains high levels of reduced glutathione in the cytosol [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=462, Percent_Identity=53.8961038961039, Blast_Score=468, Evalue=1e-132,
Organism=Homo sapiens, GI22035672, Length=475, Percent_Identity=39.5789473684211, Blast_Score=276, Evalue=4e-74,
Organism=Homo sapiens, GI148277065, Length=456, Percent_Identity=37.0614035087719, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI33519430, Length=456, Percent_Identity=37.0614035087719, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI33519428, Length=456, Percent_Identity=37.0614035087719, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI33519426, Length=456, Percent_Identity=37.0614035087719, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI148277071, Length=456, Percent_Identity=37.0614035087719, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI291045266, Length=457, Percent_Identity=34.1356673960613, Blast_Score=229, Evalue=4e-60,
Organism=Homo sapiens, GI291045268, Length=457, Percent_Identity=31.5098468271335, Blast_Score=192, Evalue=7e-49,
Organism=Homo sapiens, GI91199540, Length=458, Percent_Identity=27.7292576419214, Blast_Score=158, Evalue=1e-38,
Organism=Escherichia coli, GI1789915, Length=450, Percent_Identity=85.3333333333333, Blast_Score=791, Evalue=0.0,
Organism=Escherichia coli, GI1786307, Length=464, Percent_Identity=29.0948275862069, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI87082354, Length=463, Percent_Identity=30.0215982721382, Blast_Score=154, Evalue=9e-39,
Organism=Escherichia coli, GI87081717, Length=456, Percent_Identity=26.5350877192982, Blast_Score=141, Evalue=8e-35,
Organism=Caenorhabditis elegans, GI71983419, Length=450, Percent_Identity=56.6666666666667, Blast_Score=458, Evalue=1e-129,
Organism=Caenorhabditis elegans, GI71983429, Length=450, Percent_Identity=56.6666666666667, Blast_Score=458, Evalue=1e-129,
Organism=Caenorhabditis elegans, GI17557007, Length=475, Percent_Identity=35.5789473684211, Blast_Score=276, Evalue=2e-74,
Organism=Caenorhabditis elegans, GI71982272, Length=492, Percent_Identity=34.1463414634146, Blast_Score=232, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI32565766, Length=462, Percent_Identity=27.9220779220779, Blast_Score=160, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17559934, Length=186, Percent_Identity=30.1075268817204, Blast_Score=73, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6325166, Length=465, Percent_Identity=50.752688172043, Blast_Score=430, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6321091, Length=477, Percent_Identity=26.8343815513627, Blast_Score=134, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6325240, Length=469, Percent_Identity=24.0938166311301, Blast_Score=107, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24640551, Length=480, Percent_Identity=39.7916666666667, Blast_Score=293, Evalue=2e-79,
Organism=Drosophila melanogaster, GI24640549, Length=471, Percent_Identity=40.1273885350318, Blast_Score=293, Evalue=2e-79,
Organism=Drosophila melanogaster, GI24640553, Length=471, Percent_Identity=40.1273885350318, Blast_Score=292, Evalue=3e-79,
Organism=Drosophila melanogaster, GI17737741, Length=473, Percent_Identity=38.2663847780127, Blast_Score=286, Evalue=2e-77,
Organism=Drosophila melanogaster, GI21358499, Length=462, Percent_Identity=29.4372294372294, Blast_Score=166, Evalue=2e-41,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006322
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 50062; Mature: 49930

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGYLMETTLMTKHYDYLAIGGGSGGIASINRAAMYGKKCALIEAKQLGGTCVNVGCVPK
CCCEEEEEEEHEECCCEEEEECCCCCCHHHHHHHHCCCEEEEEEHHHCCCEEEEECCCCH
KVMWHAAQIAEAIHLYGPDYGFDTTVNHFDWKKLIANRTAYIDRIHQSYERGLGNNKVDV
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
IQGFARFVDAHTVEVNGETITADHILIATGGRPSHPDIPGAEYGIDSDGFFELDEMPKRV
HHHHHHHHCCEEEEECCCEEEECEEEEEECCCCCCCCCCCCCCCCCCCCCEEHHHCCCEE
AVVGAGYIAVEIAGVLNGLGTETHLFVRKHAPLRTFDPLIVETLLEVMNTEGPKLHTESV
EEEECCHHEEEHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCEECHHHH
PKAVIKNADGSLTLQLENGTEVTVDHLIWAIGREPATDNLNLSVTGVKTNDKGYIEVDKF
HHHHHCCCCCEEEEEECCCCEEEHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCEEEECC
QNTNVKGIYAVGDNTGVVELTPVAVAAGRRLSERLFNNKPDEHLDYSNIPTVVFSHPPIG
CCCCCCEEEEECCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCC
TIGLTEPQAREKFGDDQVKVYTSSFTAMYSAVTQHRQPCRMKLVCVGAEEKIVGIHGIGF
CCCCCCCHHHHHCCCCEEEEEEHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEEECCC
GMDEILQGFAVAMKMGATKKDFDNTVAIHPTAAEEFVTMR
CHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCHHHHEECC
>Mature Secondary Structure 
TGYLMETTLMTKHYDYLAIGGGSGGIASINRAAMYGKKCALIEAKQLGGTCVNVGCVPK
CCEEEEEEEHEECCCEEEEECCCCCCHHHHHHHHCCCEEEEEEHHHCCCEEEEECCCCH
KVMWHAAQIAEAIHLYGPDYGFDTTVNHFDWKKLIANRTAYIDRIHQSYERGLGNNKVDV
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
IQGFARFVDAHTVEVNGETITADHILIATGGRPSHPDIPGAEYGIDSDGFFELDEMPKRV
HHHHHHHHCCEEEEECCCEEEECEEEEEECCCCCCCCCCCCCCCCCCCCCEEHHHCCCEE
AVVGAGYIAVEIAGVLNGLGTETHLFVRKHAPLRTFDPLIVETLLEVMNTEGPKLHTESV
EEEECCHHEEEHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCEECHHHH
PKAVIKNADGSLTLQLENGTEVTVDHLIWAIGREPATDNLNLSVTGVKTNDKGYIEVDKF
HHHHHCCCCCEEEEEECCCCEEEHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCEEEECC
QNTNVKGIYAVGDNTGVVELTPVAVAAGRRLSERLFNNKPDEHLDYSNIPTVVFSHPPIG
CCCCCCEEEEECCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCC
TIGLTEPQAREKFGDDQVKVYTSSFTAMYSAVTQHRQPCRMKLVCVGAEEKIVGIHGIGF
CCCCCCCHHHHHCCCCEEEEEEHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEEECCC
GMDEILQGFAVAMKMGATKKDFDNTVAIHPTAAEEFVTMR
CHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3521741; 8041620; 9278503; 2006135; 8061609 [H]