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The map label for this gene is lspA [H]

Identifier: 22127573

GI number: 22127573

Start: 4110543

End: 4111052

Strand: Reverse

Name: lspA [H]

Synonym: y3699

Alternate gene names: 22127573

Gene position: 4111052-4110543 (Counterclockwise)

Preceding gene: 22127574

Following gene: 22127572

Centisome position: 89.36

GC content: 45.49

Gene sequence:

>510_bases
ATGAATAAACCTATTTGCTCGACCGGATTGCGCTGGTTATGGCTGGCAGTTGTCGTTGTCATCTTGGATATCAGCAGCAA
ACAGTGGGTCATGGCCCACTTTGCTCTGTATGAATCGGTGCCACTGATTCCTTTTTTCAACCTAACCTATGCGCAGAATT
TTGGCGCAGCATTTAGCTTCTTGGCGGATAAAAGTGGTTGGCAGCGTTGGTTCTTTGCCGGTATTGCGATAGGCATCTCC
GTCGTACTGATGGTGATGATGTATCGCTCAACAGCAAAGCAACGCCTGATAAATTGTGCTTATGCATTAATTATCGGTGG
TGCACTCGGGAATTTATATGACCGTTTAGTGCATGGCGCAGTCAACGATTTTCTCGATTTTTACATCAATAACTGGCATT
TCCCGACGTTCAATTTGGCCGATGTGGCGATATGCATTGGCGCTGCGTTGGTTATTTTTGAAGGCTTCTTAAGTCCGGTA
GAAAAAAACGCGGTGAATAACGATGAGTGA

Upstream 100 bases:

>100_bases
ATTACACGCAAGATGTCGGTTTGGTAGCAGAGCACGCTGAACTGTGTGGGCGCTGTGTCACTAACGTTGCTGGTGATGGT
GAGGAGCGTAAGTTCGCCTG

Downstream 100 bases:

>100_bases
TATGTCCGAATTTGTGCAAGATACCGAATCGGTACAAAATACTGGAACGGTAAAAACGACTACAGCGGTGCAAAATAATG
GCGCTGTTTTAGTGCATTTC

Product: lipoprotein signal peptidase

Products: NA

Alternate protein names: Prolipoprotein signal peptidase; Signal peptidase II; SPase II [H]

Number of amino acids: Translated: 169; Mature: 169

Protein sequence:

>169_residues
MNKPICSTGLRWLWLAVVVVILDISSKQWVMAHFALYESVPLIPFFNLTYAQNFGAAFSFLADKSGWQRWFFAGIAIGIS
VVLMVMMYRSTAKQRLINCAYALIIGGALGNLYDRLVHGAVNDFLDFYINNWHFPTFNLADVAICIGAALVIFEGFLSPV
EKNAVNNDE

Sequences:

>Translated_169_residues
MNKPICSTGLRWLWLAVVVVILDISSKQWVMAHFALYESVPLIPFFNLTYAQNFGAAFSFLADKSGWQRWFFAGIAIGIS
VVLMVMMYRSTAKQRLINCAYALIIGGALGNLYDRLVHGAVNDFLDFYINNWHFPTFNLADVAICIGAALVIFEGFLSPV
EKNAVNNDE
>Mature_169_residues
MNKPICSTGLRWLWLAVVVVILDISSKQWVMAHFALYESVPLIPFFNLTYAQNFGAAFSFLADKSGWQRWFFAGIAIGIS
VVLMVMMYRSTAKQRLINCAYALIIGGALGNLYDRLVHGAVNDFLDFYINNWHFPTFNLADVAICIGAALVIFEGFLSPV
EKNAVNNDE

Specific function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins [H]

COG id: COG0597

COG function: function code MU; Lipoprotein signal peptidase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A8 family [H]

Homologues:

Organism=Escherichia coli, GI1786210, Length=163, Percent_Identity=68.0981595092024, Blast_Score=232, Evalue=9e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001872 [H]

Pfam domain/function: PF01252 Peptidase_A8 [H]

EC number: =3.4.23.36 [H]

Molecular weight: Translated: 18937; Mature: 18937

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: PS00855 SPASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKPICSTGLRWLWLAVVVVILDISSKQWVMAHFALYESVPLIPFFNLTYAQNFGAAFSF
CCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHH
LADKSGWQRWFFAGIAIGISVVLMVMMYRSTAKQRLINCAYALIIGGALGNLYDRLVHGA
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VNDFLDFYINNWHFPTFNLADVAICIGAALVIFEGFLSPVEKNAVNNDE
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MNKPICSTGLRWLWLAVVVVILDISSKQWVMAHFALYESVPLIPFFNLTYAQNFGAAFSF
CCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHH
LADKSGWQRWFFAGIAIGISVVLMVMMYRSTAKQRLINCAYALIIGGALGNLYDRLVHGA
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VNDFLDFYINNWHFPTFNLADVAICIGAALVIFEGFLSPVEKNAVNNDE
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA