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The map label for this gene is slpA [H]

Identifier: 22127572

GI number: 22127572

Start: 4110017

End: 4110550

Strand: Reverse

Name: slpA [H]

Synonym: y3698

Alternate gene names: 22127572

Gene position: 4110550-4110017 (Counterclockwise)

Preceding gene: 22127573

Following gene: 161484743

Centisome position: 89.35

GC content: 47.19

Gene sequence:

>534_bases
ATGAGTGATATGTCCGAATTTGTGCAAGATACCGAATCGGTACAAAATACTGGAACGGTAAAAACGACTACAGCGGTGCA
AAATAATGGCGCTGTTTTAGTGCATTTCACTCTGAAGCTTGAAGATGGTTCAACGGCCGAGTCAACACGCACTCACGGTA
AACCGGCGCTCTTTCGTTTAGGTGATAACAGCCTTTCTGATGCACTGGAACAGCAATTGTTGGGGCTGACCGTGGGCGAT
AAGCACGCTTTTACGTTACGCCCTGAAGATGCTTTTGGTGTAGAAAATCCAGACCTTATTCAGTATTTCACTCCACGTGA
TTTTGCTGAGACTGGTGTGCCAGATGCCGGCACCATCATGTTATTCAGCTCTCGCGATGGCAGCGAAATGCCGGGTGTCG
TACGGGAAGTCGCAGAAGAGTCTATTACTGTTGATTTTAATCACCCGTTGGCTGGGCACTCTGTCAGTTTTGAACTTGAA
ATACTGGAGATTGACCCCCAACAGGAGGTTGTCTATGCAGATATTGCTGGCTAA

Upstream 100 bases:

>100_bases
CCGACGTTCAATTTGGCCGATGTGGCGATATGCATTGGCGCTGCGTTGGTTATTTTTGAAGGCTTCTTAAGTCCGGTAGA
AAAAAACGCGGTGAATAACG

Downstream 100 bases:

>100_bases
TCCACGTGGCTTTTGTGCTGGCGTTGACCGGGCTATCAGTATTGTTGAACGTGCGATAGAAATGTATGGCGCGCCAATTT
ATGTACGCCATGAGGTGGTA

Product: FKBP-type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 177; Mature: 176

Protein sequence:

>177_residues
MSDMSEFVQDTESVQNTGTVKTTTAVQNNGAVLVHFTLKLEDGSTAESTRTHGKPALFRLGDNSLSDALEQQLLGLTVGD
KHAFTLRPEDAFGVENPDLIQYFTPRDFAETGVPDAGTIMLFSSRDGSEMPGVVREVAEESITVDFNHPLAGHSVSFELE
ILEIDPQQEVVYADIAG

Sequences:

>Translated_177_residues
MSDMSEFVQDTESVQNTGTVKTTTAVQNNGAVLVHFTLKLEDGSTAESTRTHGKPALFRLGDNSLSDALEQQLLGLTVGD
KHAFTLRPEDAFGVENPDLIQYFTPRDFAETGVPDAGTIMLFSSRDGSEMPGVVREVAEESITVDFNHPLAGHSVSFELE
ILEIDPQQEVVYADIAG
>Mature_176_residues
SDMSEFVQDTESVQNTGTVKTTTAVQNNGAVLVHFTLKLEDGSTAESTRTHGKPALFRLGDNSLSDALEQQLLGLTVGDK
HAFTLRPEDAFGVENPDLIQYFTPRDFAETGVPDAGTIMLFSSRDGSEMPGVVREVAEESITVDFNHPLAGHSVSFELEI
LEIDPQQEVVYADIAG

Specific function: PPIases accelerate the folding of proteins. Substrate specificity carried out with 'Suc-Ala-Xaa-Pro-Phe-4-nitroanilide', where Xaa is the amino acid tested, was found to be Phe > Leu >> Ile > Lys = Ala > Trp > His >> Gln [H]

COG id: COG1047

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 2

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Escherichia coli, GI1786211, Length=145, Percent_Identity=68.2758620689655, Blast_Score=209, Evalue=1e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179 [H]

Pfam domain/function: PF00254 FKBP_C [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 19188; Mature: 19057

Theoretical pI: Translated: 4.02; Mature: 4.02

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDMSEFVQDTESVQNTGTVKTTTAVQNNGAVLVHFTLKLEDGSTAESTRTHGKPALFRL
CCHHHHHHHHHHHHHCCCCEEEEEEEECCCEEEEEEEEEECCCCCCCCCCCCCCCEEEEE
GDNSLSDALEQQLLGLTVGDKHAFTLRPEDAFGVENPDLIQYFTPRDFAETGVPDAGTIM
CCCHHHHHHHHHHHCEEECCCEEEEECCCCCCCCCCCCEEEEECCCCHHHCCCCCCCEEE
LFSSRDGSEMPGVVREVAEESITVDFNHPLAGHSVSFELEILEIDPQQEVVYADIAG
EEECCCCCCCCHHHHHHHHCCEEEEECCCCCCCEEEEEEEEEEECCCCEEEEEEECC
>Mature Secondary Structure 
SDMSEFVQDTESVQNTGTVKTTTAVQNNGAVLVHFTLKLEDGSTAESTRTHGKPALFRL
CHHHHHHHHHHHHHCCCCEEEEEEEECCCEEEEEEEEEECCCCCCCCCCCCCCCEEEEE
GDNSLSDALEQQLLGLTVGDKHAFTLRPEDAFGVENPDLIQYFTPRDFAETGVPDAGTIM
CCCHHHHHHHHHHHCEEECCCEEEEECCCCCCCCCCCCEEEEECCCCHHHCCCCCCCEEE
LFSSRDGSEMPGVVREVAEESITVDFNHPLAGHSVSFELEILEIDPQQEVVYADIAG
EEECCCCCCCCHHHHHHHHCCEEEEECCCCCCCEEEEEEEEEEECCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]