Click here to switch to the map view.

The map label for this gene is exuR [H]

Identifier: 161484750

GI number: 161484750

Start: 4000044

End: 4000838

Strand: Direct

Name: exuR [H]

Synonym: y3602

Alternate gene names: 161484750

Gene position: 4000044-4000838 (Clockwise)

Preceding gene: 22127475

Following gene: 22127477

Centisome position: 86.94

GC content: 44.15

Gene sequence:

>795_bases
ATGGAATTCACAGAAACCAGACGGTTGTACCAGCAGTTAGCTGCAGAGTTAAAACGGCGTATCGAAGCAGGCGTTTATCC
TGTTGGTGATAAATTGCCAGCAGAACGCTACATTTCCGAAGAAATGAACGTCAGCCGAACCGTAGTTCGTGAAGCGATTA
TTATGCTGGAAGTGGAAGGTTATGTAGAAGTACGCAAAGGCTCCGGCATCCATGTGATGTCTAATCAGCAAAAGCATTTA
GTCACCAATCAGGGGATTGAATTTGATACCGCTGGCCCCTTTGAGCTATTACAGGCACGCCAACTGATTGAAAGTAATAT
TGCTGAATTTGCCGCCACACAGGTAACGCGGCAAGATATTGTTCAATTAATTGAAATTCAAAAACATGCGCGTCAGGAAG
ATCGCTTCCGTGACTCTCAATGGGATCTTAAATTCCACGTACAAGTCGCTCTCGCCACCCAAAATACAGCGATGGCAACC
ATTGTCGAAAAAATGTGGAGCCAGCGTACCCATAATCCTTACTGGATTAAACTGCATGAGCACATTGATGATGTCTCGAT
TGAAAGCTGGTGCGAAGATCACGACAAGATCCTTGAAGCGTTAATACGCAAAGATCCTCACGCCAGTAAACTCGCCATGT
GGCAACATCTGGAAAATACCAAACAGATGCTATTCCGTGCCACTACCGATGATTTTGAATTCAATGTTGATCGCTACCTG
TTTACAGAAAACCCAGTTGTGCATCTTGATAACCTGATGAACAACAGCAAAGTCCCTATCAGCAGCAAAAATTAA

Upstream 100 bases:

>100_bases
GGTATAACAAATCCTATTGTGTCTCCTTCGAGATGCCATACCTTCCAGACAAAATGAGCCGCAAAATTTGCCGCCTCGAT
TGATCGCAAGAGCCTTAATC

Downstream 100 bases:

>100_bases
TCCTCATTTAATGATGGGTAATCAGGGAGGAGAAACCGGCATTATTCTTTCTCTTCCCTGTGTAATTACTCCGCTTTAGG
TCAGTAAATGTCGAGTTCTG

Product: DNA-binding transcriptional repressor ExuR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 264; Mature: 264

Protein sequence:

>264_residues
MEFTETRRLYQQLAAELKRRIEAGVYPVGDKLPAERYISEEMNVSRTVVREAIIMLEVEGYVEVRKGSGIHVMSNQQKHL
VTNQGIEFDTAGPFELLQARQLIESNIAEFAATQVTRQDIVQLIEIQKHARQEDRFRDSQWDLKFHVQVALATQNTAMAT
IVEKMWSQRTHNPYWIKLHEHIDDVSIESWCEDHDKILEALIRKDPHASKLAMWQHLENTKQMLFRATTDDFEFNVDRYL
FTENPVVHLDNLMNNSKVPISSKN

Sequences:

>Translated_264_residues
MEFTETRRLYQQLAAELKRRIEAGVYPVGDKLPAERYISEEMNVSRTVVREAIIMLEVEGYVEVRKGSGIHVMSNQQKHL
VTNQGIEFDTAGPFELLQARQLIESNIAEFAATQVTRQDIVQLIEIQKHARQEDRFRDSQWDLKFHVQVALATQNTAMAT
IVEKMWSQRTHNPYWIKLHEHIDDVSIESWCEDHDKILEALIRKDPHASKLAMWQHLENTKQMLFRATTDDFEFNVDRYL
FTENPVVHLDNLMNNSKVPISSKN
>Mature_264_residues
MEFTETRRLYQQLAAELKRRIEAGVYPVGDKLPAERYISEEMNVSRTVVREAIIMLEVEGYVEVRKGSGIHVMSNQQKHL
VTNQGIEFDTAGPFELLQARQLIESNIAEFAATQVTRQDIVQLIEIQKHARQEDRFRDSQWDLKFHVQVALATQNTAMAT
IVEKMWSQRTHNPYWIKLHEHIDDVSIESWCEDHDKILEALIRKDPHASKLAMWQHLENTKQMLFRATTDDFEFNVDRYL
FTENPVVHLDNLMNNSKVPISSKN

Specific function: Repressor for the exu regulon that encode genes involved in hexuronate utilization. It regulates the exuT, uxaCA and uxuRAB operons. Binds D-tagaturonate and D-fructuronate as inducers [H]

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082208, Length=258, Percent_Identity=75.1937984496124, Blast_Score=410, Evalue=1e-116,
Organism=Escherichia coli, GI1790780, Length=255, Percent_Identity=45.8823529411765, Blast_Score=211, Evalue=4e-56,
Organism=Escherichia coli, GI1790032, Length=219, Percent_Identity=26.027397260274, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1789353, Length=253, Percent_Identity=23.3201581027668, Blast_Score=65, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07729 FCD; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 30860; Mature: 30860

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFTETRRLYQQLAAELKRRIEAGVYPVGDKLPAERYISEEMNVSRTVVREAIIMLEVEG
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEECC
YVEVRKGSGIHVMSNQQKHLVTNQGIEFDTAGPFELLQARQLIESNIAEFAATQVTRQDI
EEEEECCCCEEEECCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VQLIEIQKHARQEDRFRDSQWDLKFHVQVALATQNTAMATIVEKMWSQRTHNPYWIKLHE
HHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEECCHHHHHHHHHHHHHCCCCCEEEEEEC
HIDDVSIESWCEDHDKILEALIRKDPHASKLAMWQHLENTKQMLFRATTDDFEFNVDRYL
CCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEECCCEEE
FTENPVVHLDNLMNNSKVPISSKN
ECCCCEEEHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MEFTETRRLYQQLAAELKRRIEAGVYPVGDKLPAERYISEEMNVSRTVVREAIIMLEVEG
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEECC
YVEVRKGSGIHVMSNQQKHLVTNQGIEFDTAGPFELLQARQLIESNIAEFAATQVTRQDI
EEEEECCCCEEEECCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VQLIEIQKHARQEDRFRDSQWDLKFHVQVALATQNTAMATIVEKMWSQRTHNPYWIKLHE
HHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEECCHHHHHHHHHHHHHCCCCCEEEEEEC
HIDDVSIESWCEDHDKILEALIRKDPHASKLAMWQHLENTKQMLFRATTDDFEFNVDRYL
CCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEECCCEEE
FTENPVVHLDNLMNNSKVPISSKN
ECCCCEEEHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA