Definition Streptococcus pyogenes MGAS315 chromosome, complete genome.
Accession NC_004070
Length 1,900,521

Click here to switch to the map view.

The map label for this gene is dfp [H]

Identifier: 21910398

GI number: 21910398

Start: 918556

End: 919101

Strand: Direct

Name: dfp [H]

Synonym: SpyM3_0862

Alternate gene names: 21910398

Gene position: 918556-919101 (Clockwise)

Preceding gene: 21910397

Following gene: 21910399

Centisome position: 48.33

GC content: 35.9

Gene sequence:

>546_bases
ATGACTAAACATATTACCTTAGCTGTTTCTGGTAGTATATCTGCCTATAAAGCAGCAGATCTTACGAGTCAATTAACTAA
AATTGGCTATGATGTTCACATCATAATGACTCAGGCTGCTACACAATTTATTACACCATTAACCCTGCAAGTGTTATCAA
AAAATGCTATTCATTTAGATGTTATGGATGAGCATGACCCAAAAGTTATCAACCATATCGAATTAGCAAAACGCACAGAT
TTATTTATTGTTGCACCTGCCTCTGCTAATACTATTGCTCATCTAGCATATGGATTCGCTGATAATATTGTAACAAGTGT
TGCTCTTGCCCTACCAGCTACCACACCAAAATTAATAGCCCCAGCCATGAATACCAAAATGTATCAAAACCCTATTACCC
AAGAAAATATTAAACGCTTATCGACAATAGGGTTTACAGAAATTCCTCCAAAATCTAGCTTATTAGCCTGTGGAGATAAA
GGACCTGGTGCTTTGGCTGATATTGATGTTATCTTAGCTACTATTGATACGATTTGGAAACTTTAA

Upstream 100 bases:

>100_bases
ACAGGTATGCACAAGGCTCTTTTGATATCCAATAACGAAGTTGCATCTGCAGATACCAAAGAGGCAATTGCTGACTTATT
ATATGAAAGGATGGCCAAAC

Downstream 100 bases:

>100_bases
CAGTCGTTTTTCTGATCACCTTTTTAGAATTAAGTATTATATTTTTTGGAGAGTAAAATGAATCACCGTAAATCAGCAGA
TATTTCTCGTATTGCTATCT

Product: phosphopantothenoylcysteine decarboxylase

Products: NA

Alternate protein names: PPCDC [H]

Number of amino acids: Translated: 181; Mature: 180

Protein sequence:

>181_residues
MTKHITLAVSGSISAYKAADLTSQLTKIGYDVHIIMTQAATQFITPLTLQVLSKNAIHLDVMDEHDPKVINHIELAKRTD
LFIVAPASANTIAHLAYGFADNIVTSVALALPATTPKLIAPAMNTKMYQNPITQENIKRLSTIGFTEIPPKSSLLACGDK
GPGALADIDVILATIDTIWKL

Sequences:

>Translated_181_residues
MTKHITLAVSGSISAYKAADLTSQLTKIGYDVHIIMTQAATQFITPLTLQVLSKNAIHLDVMDEHDPKVINHIELAKRTD
LFIVAPASANTIAHLAYGFADNIVTSVALALPATTPKLIAPAMNTKMYQNPITQENIKRLSTIGFTEIPPKSSLLACGDK
GPGALADIDVILATIDTIWKL
>Mature_180_residues
TKHITLAVSGSISAYKAADLTSQLTKIGYDVHIIMTQAATQFITPLTLQVLSKNAIHLDVMDEHDPKVINHIELAKRTDL
FIVAPASANTIAHLAYGFADNIVTSVALALPATTPKLIAPAMNTKMYQNPITQENIKRLSTIGFTEIPPKSSLLACGDKG
PGALADIDVILATIDTIWKL

Specific function: Catalyzes the decarboxylation of 4'- phosphopantothenoylcysteine to 4'-phosphopantetheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=177, Percent_Identity=35.5932203389831, Blast_Score=119, Evalue=1e-27,
Organism=Escherichia coli, GI87082301, Length=165, Percent_Identity=43.6363636363636, Blast_Score=134, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17560194, Length=182, Percent_Identity=37.9120879120879, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6322762, Length=196, Percent_Identity=32.6530612244898, Blast_Score=91, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24657262, Length=184, Percent_Identity=36.4130434782609, Blast_Score=118, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011847
- InterPro:   IPR003382 [H]

Pfam domain/function: PF02441 Flavoprotein [H]

EC number: =4.1.1.36 [H]

Molecular weight: Translated: 19444; Mature: 19313

Theoretical pI: Translated: 7.16; Mature: 7.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKHITLAVSGSISAYKAADLTSQLTKIGYDVHIIMTQAATQFITPLTLQVLSKNAIHLD
CCCEEEEEEECCCCHHHHHHHHHHHHHCCCEEEEEEEHHHHHHHHHHHHHHHCCCCEEEE
VMDEHDPKVINHIELAKRTDLFIVAPASANTIAHLAYGFADNIVTSVALALPATTPKLIA
EECCCCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
PAMNTKMYQNPITQENIKRLSTIGFTEIPPKSSLLACGDKGPGALADIDVILATIDTIWK
HHHCCHHHCCCCCHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHC
L
C
>Mature Secondary Structure 
TKHITLAVSGSISAYKAADLTSQLTKIGYDVHIIMTQAATQFITPLTLQVLSKNAIHLD
CCEEEEEEECCCCHHHHHHHHHHHHHCCCEEEEEEEHHHHHHHHHHHHHHHCCCCEEEE
VMDEHDPKVINHIELAKRTDLFIVAPASANTIAHLAYGFADNIVTSVALALPATTPKLIA
EECCCCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
PAMNTKMYQNPITQENIKRLSTIGFTEIPPKSSLLACGDKGPGALADIDVILATIDTIWK
HHHCCHHHCCCCCHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHC
L
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12397186; 8763945 [H]