| Definition | Streptococcus pyogenes MGAS315 chromosome, complete genome. |
|---|---|
| Accession | NC_004070 |
| Length | 1,900,521 |
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The map label for this gene is dpfB [H]
Identifier: 21910397
GI number: 21910397
Start: 917871
End: 918563
Strand: Direct
Name: dpfB [H]
Synonym: SpyM3_0861
Alternate gene names: 21910397
Gene position: 917871-918563 (Clockwise)
Preceding gene: 21910386
Following gene: 21910398
Centisome position: 48.3
GC content: 36.8
Gene sequence:
>693_bases ATGACTATGAAATTAATAATAACATCAGGTGGAACAACTGAACCTATAGATGCAGTACGAGGTATCACTAATCACTCAAC TGGGCAACTTGGAAAATTAATCACAGAGCGATTTTTACAATATCATCATGACGTTACCCTAGTCACTACTAAAACAGCCA CTAAACCCCTGCCAAATAAGCGCCTAAGGATTATTGAAGTGGAAACAGTTAACGACTTAATGGCTGCACTCAAAGATCAG GTTCCTCACCATGACATTCTAATTCATAGTATGGCTGTTTCTGACTATACTCCAGTCTACATGACTGATTTGGAACAAGT CTCTCAAGCTGATAACCTTAATTGTTTTCTATGTGAACATAACAGTGAGCCGAAAATCTCATCTGCATCTGATTATCAGG TTCTTTTTTTGAAAAAAACACCCAAAGTTATCTCTTATGTTAAACAGTGGAATCCTAATATTAAACTAGTCGGCTTCAAA CTTCTAGTTAATGTGCCTCAAGAAGAGTTAATTAAAGTAGCCAGAGCAAGTCTAGCTAAAAACCATGCTGATTATATTCT CGCCAATGATTTAGTTGATATCCAAACAGGTATGCACAAGGCTCTTTTGATATCCAATAACGAAGTTGCATCTGCAGATA CCAAAGAGGCAATTGCTGACTTATTATATGAAAGGATGGCCAAACATGACTAA
Upstream 100 bases:
>100_bases AATTACTAGAAATCTATTACTATTCCATATTAATACAAACGCAAGACAATGTCTGGCGTCATTATCTTCCGTTTACTATC AGCTCCTTTTTTGATAAAAT
Downstream 100 bases:
>100_bases ACATATTACCTTAGCTGTTTCTGGTAGTATATCTGCCTATAAAGCAGCAGATCTTACGAGTCAATTAACTAAAATTGGCT ATGATGTTCACATCATAATG
Product: phosphopantothenate--cysteine ligase
Products: NA
Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]
Number of amino acids: Translated: 230; Mature: 229
Protein sequence:
>230_residues MTMKLIITSGGTTEPIDAVRGITNHSTGQLGKLITERFLQYHHDVTLVTTKTATKPLPNKRLRIIEVETVNDLMAALKDQ VPHHDILIHSMAVSDYTPVYMTDLEQVSQADNLNCFLCEHNSEPKISSASDYQVLFLKKTPKVISYVKQWNPNIKLVGFK LLVNVPQEELIKVARASLAKNHADYILANDLVDIQTGMHKALLISNNEVASADTKEAIADLLYERMAKHD
Sequences:
>Translated_230_residues MTMKLIITSGGTTEPIDAVRGITNHSTGQLGKLITERFLQYHHDVTLVTTKTATKPLPNKRLRIIEVETVNDLMAALKDQ VPHHDILIHSMAVSDYTPVYMTDLEQVSQADNLNCFLCEHNSEPKISSASDYQVLFLKKTPKVISYVKQWNPNIKLVGFK LLVNVPQEELIKVARASLAKNHADYILANDLVDIQTGMHKALLISNNEVASADTKEAIADLLYERMAKHD >Mature_229_residues TMKLIITSGGTTEPIDAVRGITNHSTGQLGKLITERFLQYHHDVTLVTTKTATKPLPNKRLRIIEVETVNDLMAALKDQV PHHDILIHSMAVSDYTPVYMTDLEQVSQADNLNCFLCEHNSEPKISSASDYQVLFLKKTPKVISYVKQWNPNIKLVGFKL LVNVPQEELIKVARASLAKNHADYILANDLVDIQTGMHKALLISNNEVASADTKEAIADLLYERMAKHD
Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]
COG id: COG0452
COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]
Homologues:
None
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR005252 - InterPro: IPR007085 - InterPro: IPR003382 [H]
Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]
EC number: =4.1.1.36; =6.3.2.5 [H]
Molecular weight: Translated: 25743; Mature: 25612
Theoretical pI: Translated: 6.86; Mature: 6.86
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.9 %Cys (Translated Protein) 3.0 %Met (Translated Protein) 3.9 %Cys+Met (Translated Protein) 0.9 %Cys (Mature Protein) 2.6 %Met (Mature Protein) 3.5 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MTMKLIITSGGTTEPIDAVRGITNHSTGQLGKLITERFLQYHHDVTLVTTKTATKPLPNK CEEEEEEECCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCC RLRIIEVETVNDLMAALKDQVPHHDILIHSMAVSDYTPVYMTDLEQVSQADNLNCFLCEH CEEEEEECCHHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEEEC NSEPKISSASDYQVLFLKKTPKVISYVKQWNPNIKLVGFKLLVNVPQEELIKVARASLAK CCCCCCCCCCCEEEEEEECCHHHHHHHHHCCCCEEEEEEEEEEECCHHHHHHHHHHHHHH NHADYILANDLVDIQTGMHKALLISNNEVASADTKEAIADLLYERMAKHD CCCCEEEECCHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCC >Mature Secondary Structure TMKLIITSGGTTEPIDAVRGITNHSTGQLGKLITERFLQYHHDVTLVTTKTATKPLPNK EEEEEEECCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCC RLRIIEVETVNDLMAALKDQVPHHDILIHSMAVSDYTPVYMTDLEQVSQADNLNCFLCEH CEEEEEECCHHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEEEC NSEPKISSASDYQVLFLKKTPKVISYVKQWNPNIKLVGFKLLVNVPQEELIKVARASLAK CCCCCCCCCCCEEEEEEECCHHHHHHHHHCCCCEEEEEEEEEEECCHHHHHHHHHHHHHH NHADYILANDLVDIQTGMHKALLISNNEVASADTKEAIADLLYERMAKHD CCCCEEEECCHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 8688087 [H]