Definition | Streptococcus pyogenes MGAS315 chromosome, complete genome. |
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Accession | NC_004070 |
Length | 1,900,521 |
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The map label for this gene is topA [H]
Identifier: 21910356
GI number: 21910356
Start: 872539
End: 874668
Strand: Direct
Name: topA [H]
Synonym: SpyM3_0820
Alternate gene names: 21910356
Gene position: 872539-874668 (Clockwise)
Preceding gene: 21910355
Following gene: 21910357
Centisome position: 45.91
GC content: 38.4
Gene sequence:
>2130_bases TTGGGAACAAAAACTACAACTAAGCCAAAAACGGGTACTAAAAAGTCCACCACTAAAAAGAAATCAACAGCGAAAAAAAA TCTCGTTATTGTTGAATCACCTGCCAAAGCTAAGACTATTGAAAAATATCTTGGACGCAGTTATAAAGTTGTTGCTTCGG TAGGACATATTCGTGACTTAAAAAAATCGTCTATGTCTATTGATTTTGATAATAATTATGAGCCACAATACATTAATATC CGTGGTAAGGGACCCCTTATCAATTCTTTAAAAAAAGAAGCCAAAGCTGCTAAAAAAGTTTACTTGGCAAGTGACCCGGA CCGTGAGGGAGAGGCTATTTCTTGGCATTTGTCACATATTCTAGGACTCGATCCTGAAGATAAAAACCGAGTGGTTTTCA ATGAAATTACCAAAGATGCGGTGAAAAATGCTTTTGTGGAACCTCGTCAAATTGACATGAACTTAGTGGATTCTCAACAA GCCCGTCGCGTCTTGGACCGTATTGTAGGTTACTCCATCTCACCTATTCTTTGGAAAAAGGTCAAAAAAGGCCTTTCAGC AGGACGTGTCCAGTCGGTTGCTTTAAAACTCATCATTGACCGTGAAAATGAAATCAAAGCCTTTGTTCCAAAGGAATACT GGTCTATTGATGGTCTTTTTAAAAAAGGAACTAAAAAGTTTCAAGCGACTTTTTACGGTATTAATGGCAAAAAAACAAAG CTTGATAATAACAACGATGTCAAAGAGGTATTAGCAAAGCTAACAAATGAAGATTTTCTTGTCAGCAAGGTTGACAAGAA AGAGCGACGTCGTAATGCTCCCTTACCTTACACAACATCATCTCTTCAACAAGATGCTGCTAATAAAATCAATTTCAGAA CGCGTAAAACCATGATGGTAGCCCAACAACTGTATGAGGGGATTCATTTAGGAGAAAATGGAACTCAAGGTTTAATTACC TATATGCGTACGGATTCTACTCGTATCAGTCCAGTAGCACAAAACGATGCTGCTCAATTTATTATCAATCGCTTTGGAGC TAATTATTCAAAACATGGTAATCGTGTCAAAAATACCAGTGGTGCCCAAGATGCTCACGAGGCGATTCGTCCATCTAGTG TTAATCATACGCCAGACTCTATTGCCAAATACCTTAACAAGGATCAGTTAAAACTTTATACGCTTATTTGGAATCGTTTT GTGGCTAGCCAAATGACAGCAGCTGTTTTTGATACCGTAAAGGTAAACTTGGAGCAAAATGGCGTGCTTTTTGTTGCCAA TGGTAGCCAAATGAAGTTTGATGGTTACATGGCTGTTTACAATGATTCCGATAAAAACAAAATGTTACCTGAGATGGCAG AAGGAGAAACGGTTAAAAAAATATCGACCTCTCCAGAACAGCACTTTACGCAGCCACCAGCTCGTTATTCTGAAGCAACT CTGATTAAAACGCTAGAAGAAAATGGTGTTGGACGTCCATCAACTTACGCTCCAACCTTAGAAGTTATTCAACGCAGATA CTATGTTAAATTGTCTGCTAAGCGCTTTGAGCCAACTGAGCTTGGGGAAATTGTCAACAAGCTTATTGTCGAATTTTTCC CAGATATTGTTGATGTTGCTTTTACTGCCGAGATGGAAGGTAAGCTAGATCAAGTTGAAATTGGAGAAGAACAATGGCAA CATGTTATCGATCAATTCTATCAACCCTTTGTCAAAGAATTGAATAAGGCTGAGTCTGAAATTGAAAAGATTCAAATCAA AGATGAACCAGCTGGCTTCGACTGTGATGTTTGTGGTCACCCAATGGTCATTAAGTTAGGACGTTTTGGGAAATTTTACG CGTGTAGCAACTTCCCAGAGTGCCGTAATACAAAAGCCATCACTAAAGAAATTGGTGTTACTTGTCCGGTTTGTCATAAA GGACAAGTTATCGAGCGTAAAACCAAAAAAAATAGGATATTTTATGGTTGTGATCAGTATCCAGATTGTGAGTTTATCTC GTGGGATTTACCTATTGGACGTGCTTGCCCTAAGTCAGGTGACTATCTTATTGAGAAAAAAGTTCGTGGTGGCAAACAAG TAATGTGTAGCAATGAGACCTGTGATTACAAGGAAGAAAAAATTAAATGA
Upstream 100 bases:
>100_bases TTAAAGTTTCTTCCTATATAGCATTTTTTATTGACAGTTTCTTAAAAATGGGATATTATGCTATAAGCTTTAAACAAACT GTTATAGGAAGTGTGTCGAA
Downstream 100 bases:
>100_bases GGATTACAAAAGAGGCTACACATAGCCTCTTTTGCTTTTTTCCCCTTTCTGTTATAATAAGTCAGGTAACTACATTAGAA AGATTTGTGGGTCTGTCATC
Product: DNA topoisomerase I
Products: NA
Alternate protein names: DNA topoisomerase I; Omega-protein; Relaxing enzyme; Swivelase; Untwisting enzyme [H]
Number of amino acids: Translated: 709; Mature: 708
Protein sequence:
>709_residues MGTKTTTKPKTGTKKSTTKKKSTAKKNLVIVESPAKAKTIEKYLGRSYKVVASVGHIRDLKKSSMSIDFDNNYEPQYINI RGKGPLINSLKKEAKAAKKVYLASDPDREGEAISWHLSHILGLDPEDKNRVVFNEITKDAVKNAFVEPRQIDMNLVDSQQ ARRVLDRIVGYSISPILWKKVKKGLSAGRVQSVALKLIIDRENEIKAFVPKEYWSIDGLFKKGTKKFQATFYGINGKKTK LDNNNDVKEVLAKLTNEDFLVSKVDKKERRRNAPLPYTTSSLQQDAANKINFRTRKTMMVAQQLYEGIHLGENGTQGLIT YMRTDSTRISPVAQNDAAQFIINRFGANYSKHGNRVKNTSGAQDAHEAIRPSSVNHTPDSIAKYLNKDQLKLYTLIWNRF VASQMTAAVFDTVKVNLEQNGVLFVANGSQMKFDGYMAVYNDSDKNKMLPEMAEGETVKKISTSPEQHFTQPPARYSEAT LIKTLEENGVGRPSTYAPTLEVIQRRYYVKLSAKRFEPTELGEIVNKLIVEFFPDIVDVAFTAEMEGKLDQVEIGEEQWQ HVIDQFYQPFVKELNKAESEIEKIQIKDEPAGFDCDVCGHPMVIKLGRFGKFYACSNFPECRNTKAITKEIGVTCPVCHK GQVIERKTKKNRIFYGCDQYPDCEFISWDLPIGRACPKSGDYLIEKKVRGGKQVMCSNETCDYKEEKIK
Sequences:
>Translated_709_residues MGTKTTTKPKTGTKKSTTKKKSTAKKNLVIVESPAKAKTIEKYLGRSYKVVASVGHIRDLKKSSMSIDFDNNYEPQYINI RGKGPLINSLKKEAKAAKKVYLASDPDREGEAISWHLSHILGLDPEDKNRVVFNEITKDAVKNAFVEPRQIDMNLVDSQQ ARRVLDRIVGYSISPILWKKVKKGLSAGRVQSVALKLIIDRENEIKAFVPKEYWSIDGLFKKGTKKFQATFYGINGKKTK LDNNNDVKEVLAKLTNEDFLVSKVDKKERRRNAPLPYTTSSLQQDAANKINFRTRKTMMVAQQLYEGIHLGENGTQGLIT YMRTDSTRISPVAQNDAAQFIINRFGANYSKHGNRVKNTSGAQDAHEAIRPSSVNHTPDSIAKYLNKDQLKLYTLIWNRF VASQMTAAVFDTVKVNLEQNGVLFVANGSQMKFDGYMAVYNDSDKNKMLPEMAEGETVKKISTSPEQHFTQPPARYSEAT LIKTLEENGVGRPSTYAPTLEVIQRRYYVKLSAKRFEPTELGEIVNKLIVEFFPDIVDVAFTAEMEGKLDQVEIGEEQWQ HVIDQFYQPFVKELNKAESEIEKIQIKDEPAGFDCDVCGHPMVIKLGRFGKFYACSNFPECRNTKAITKEIGVTCPVCHK GQVIERKTKKNRIFYGCDQYPDCEFISWDLPIGRACPKSGDYLIEKKVRGGKQVMCSNETCDYKEEKIK >Mature_708_residues GTKTTTKPKTGTKKSTTKKKSTAKKNLVIVESPAKAKTIEKYLGRSYKVVASVGHIRDLKKSSMSIDFDNNYEPQYINIR GKGPLINSLKKEAKAAKKVYLASDPDREGEAISWHLSHILGLDPEDKNRVVFNEITKDAVKNAFVEPRQIDMNLVDSQQA RRVLDRIVGYSISPILWKKVKKGLSAGRVQSVALKLIIDRENEIKAFVPKEYWSIDGLFKKGTKKFQATFYGINGKKTKL DNNNDVKEVLAKLTNEDFLVSKVDKKERRRNAPLPYTTSSLQQDAANKINFRTRKTMMVAQQLYEGIHLGENGTQGLITY MRTDSTRISPVAQNDAAQFIINRFGANYSKHGNRVKNTSGAQDAHEAIRPSSVNHTPDSIAKYLNKDQLKLYTLIWNRFV ASQMTAAVFDTVKVNLEQNGVLFVANGSQMKFDGYMAVYNDSDKNKMLPEMAEGETVKKISTSPEQHFTQPPARYSEATL IKTLEENGVGRPSTYAPTLEVIQRRYYVKLSAKRFEPTELGEIVNKLIVEFFPDIVDVAFTAEMEGKLDQVEIGEEQWQH VIDQFYQPFVKELNKAESEIEKIQIKDEPAGFDCDVCGHPMVIKLGRFGKFYACSNFPECRNTKAITKEIGVTCPVCHKG QVIERKTKKNRIFYGCDQYPDCEFISWDLPIGRACPKSGDYLIEKKVRGGKQVMCSNETCDYKEEKIK
Specific function: The reaction catalyzed by topoisomerases leads to the conversion of one topological isomer of DNA to another [H]
COG id: COG0550
COG function: function code L; Topoisomerase IA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 Toprim domain [H]
Homologues:
Organism=Homo sapiens, GI10835218, Length=617, Percent_Identity=26.742301458671, Blast_Score=152, Evalue=1e-36, Organism=Homo sapiens, GI4507635, Length=617, Percent_Identity=21.0696920583468, Blast_Score=97, Evalue=7e-20, Organism=Escherichia coli, GI1787529, Length=751, Percent_Identity=38.2157123834887, Blast_Score=485, Evalue=1e-138, Organism=Escherichia coli, GI1788061, Length=624, Percent_Identity=23.0769230769231, Blast_Score=116, Evalue=4e-27, Organism=Escherichia coli, GI48994931, Length=110, Percent_Identity=39.0909090909091, Blast_Score=100, Evalue=3e-22, Organism=Caenorhabditis elegans, GI32563869, Length=559, Percent_Identity=24.5080500894454, Blast_Score=127, Evalue=3e-29, Organism=Caenorhabditis elegans, GI17555378, Length=508, Percent_Identity=24.4094488188976, Blast_Score=113, Evalue=4e-25, Organism=Saccharomyces cerevisiae, GI6323263, Length=510, Percent_Identity=23.5294117647059, Blast_Score=97, Evalue=1e-20, Organism=Drosophila melanogaster, GI24585251, Length=620, Percent_Identity=23.3870967741935, Blast_Score=136, Evalue=7e-32, Organism=Drosophila melanogaster, GI24640096, Length=628, Percent_Identity=21.1783439490446, Blast_Score=93, Evalue=8e-19,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003601 - InterPro: IPR013497 - InterPro: IPR013824 - InterPro: IPR013825 - InterPro: IPR000380 - InterPro: IPR003602 - InterPro: IPR013498 - InterPro: IPR005733 - InterPro: IPR006171 [H]
Pfam domain/function: PF01131 Topoisom_bac; PF01751 Toprim; PF01396 zf-C4_Topoisom [H]
EC number: =5.99.1.2 [H]
Molecular weight: Translated: 80275; Mature: 80144
Theoretical pI: Translated: 9.75; Mature: 9.75
Prosite motif: PS00396 TOPOISOMERASE_I_PROK
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.6 %Cys (Translated Protein) 2.0 %Met (Translated Protein) 3.5 %Cys+Met (Translated Protein) 1.6 %Cys (Mature Protein) 1.8 %Met (Mature Protein) 3.4 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MGTKTTTKPKTGTKKSTTKKKSTAKKNLVIVESPAKAKTIEKYLGRSYKVVASVGHIRDL CCCCCCCCCCCCCCCCHHHHHHHHHCCEEEEECCCHHHHHHHHHCCCEEEEHHHHHHHHH KKSSMSIDFDNNYEPQYINIRGKGPLINSLKKEAKAAKKVYLASDPDREGEAISWHLSHI HHHCCEEECCCCCCCCEEEEECCCCHHHHHHHHHHHHHEEEECCCCCCCCCEEEEEHHHH LGLDPEDKNRVVFNEITKDAVKNAFVEPRQIDMNLVDSQQARRVLDRIVGYSISPILWKK HCCCCCCCCEEHHHHHHHHHHHHHCCCCHHCCCHHHCHHHHHHHHHHHHCCCCCHHHHHH VKKGLSAGRVQSVALKLIIDRENEIKAFVPKEYWSIDGLFKKGTKKFQATFYGINGKKTK HHHCCCCCHHHHEEEEEEECCCCCCEEECCHHHHCHHHHHHHCCCEEEEEEEECCCCEEC LDNNNDVKEVLAKLTNEDFLVSKVDKKERRRNAPLPYTTSSLQQDAANKINFRTRKTMMV CCCCCCHHHHHHHHCCCCCEEEHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHH AQQLYEGIHLGENGTQGLITYMRTDSTRISPVAQNDAAQFIINRFGANYSKHGNRVKNTS HHHHHHCEECCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCHHHCCCCCCCCC GAQDAHEAIRPSSVNHTPDSIAKYLNKDQLKLYTLIWNRFVASQMTAAVFDTVKVNLEQN CCHHHHHHCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECC GVLFVANGSQMKFDGYMAVYNDSDKNKMLPEMAEGETVKKISTSPEQHFTQPPARYSEAT CEEEEECCCEEEECCEEEEEECCCCCCCCCHHHCCCHHHHHCCCCHHHCCCCCCHHHHHH LIKTLEENGVGRPSTYAPTLEVIQRRYYVKLSAKRFEPTELGEIVNKLIVEFFPDIVDVA HHHHHHHCCCCCCCCCCHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH FTAEMEGKLDQVEIGEEQWQHVIDQFYQPFVKELNKAESEIEKIQIKDEPAGFDCDVCGH HEEHHCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCC PMVIKLGRFGKFYACSNFPECRNTKAITKEIGVTCPVCHKGQVIERKTKKNRIFYGCDQY CEEEEECCCCCEEEECCCCCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHCCCEEECCCCC PDCEFISWDLPIGRACPKSGDYLIEKKVRGGKQVMCSNETCDYKEEKIK CCCCEEEECCCCCCCCCCCCCEEEEHHHCCCCEEEECCCCCCCHHHCCC >Mature Secondary Structure GTKTTTKPKTGTKKSTTKKKSTAKKNLVIVESPAKAKTIEKYLGRSYKVVASVGHIRDL CCCCCCCCCCCCCCCHHHHHHHHHCCEEEEECCCHHHHHHHHHCCCEEEEHHHHHHHHH KKSSMSIDFDNNYEPQYINIRGKGPLINSLKKEAKAAKKVYLASDPDREGEAISWHLSHI HHHCCEEECCCCCCCCEEEEECCCCHHHHHHHHHHHHHEEEECCCCCCCCCEEEEEHHHH LGLDPEDKNRVVFNEITKDAVKNAFVEPRQIDMNLVDSQQARRVLDRIVGYSISPILWKK HCCCCCCCCEEHHHHHHHHHHHHHCCCCHHCCCHHHCHHHHHHHHHHHHCCCCCHHHHHH VKKGLSAGRVQSVALKLIIDRENEIKAFVPKEYWSIDGLFKKGTKKFQATFYGINGKKTK HHHCCCCCHHHHEEEEEEECCCCCCEEECCHHHHCHHHHHHHCCCEEEEEEEECCCCEEC LDNNNDVKEVLAKLTNEDFLVSKVDKKERRRNAPLPYTTSSLQQDAANKINFRTRKTMMV CCCCCCHHHHHHHHCCCCCEEEHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHH AQQLYEGIHLGENGTQGLITYMRTDSTRISPVAQNDAAQFIINRFGANYSKHGNRVKNTS HHHHHHCEECCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCHHHCCCCCCCCC GAQDAHEAIRPSSVNHTPDSIAKYLNKDQLKLYTLIWNRFVASQMTAAVFDTVKVNLEQN CCHHHHHHCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECC GVLFVANGSQMKFDGYMAVYNDSDKNKMLPEMAEGETVKKISTSPEQHFTQPPARYSEAT CEEEEECCCEEEECCEEEEEECCCCCCCCCHHHCCCHHHHHCCCCHHHCCCCCCHHHHHH LIKTLEENGVGRPSTYAPTLEVIQRRYYVKLSAKRFEPTELGEIVNKLIVEFFPDIVDVA HHHHHHHCCCCCCCCCCHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH FTAEMEGKLDQVEIGEEQWQHVIDQFYQPFVKELNKAESEIEKIQIKDEPAGFDCDVCGH HEEHHCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCC PMVIKLGRFGKFYACSNFPECRNTKAITKEIGVTCPVCHKGQVIERKTKKNRIFYGCDQY CEEEEECCCCCEEEECCCCCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHCCCEEECCCCC PDCEFISWDLPIGRACPKSGDYLIEKKVRGGKQVMCSNETCDYKEEKIK CCCCEEEECCCCCCCCCCCCCEEEEHHHCCCCEEEECCCCCCCHHHCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 11337471 [H]