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The map label for this gene is pgi

Identifier: 21672813

GI number: 21672813

Start: 608571

End: 610238

Strand: Reverse

Name: pgi

Synonym: BUsg553

Alternate gene names: 21672813

Gene position: 610238-608571 (Counterclockwise)

Preceding gene: 21672816

Following gene: 21672812

Centisome position: 95.13

GC content: 24.76

Gene sequence:

>1668_bases
ATGAAAAATATTAATCTTATTGAAACTAAATCTTGGAAAGATTTAAAAAATCATTTTAAGGAAGTTAAAAATATCCATTT
AAAAGATCTTTTTTTATCTGATTTCAATAGATTTAAAAAGTTTTCAATTTTTTTTGAAAATGAAATATTAATTGATTTTT
CAAAAAATCGTATTACTGAAAAAACTTTAATACTTTTATTAAATTTAGCAAAAGAAATGAATGTTAAGTCTGCTATTAAA
TTAATGTTTTCTGGATCTAAAATTAATCAAACTGAAAATAGGTCTGTATTGCATATTGCTTTACGCAATAGAAGTAATTT
TCCAATTTTACTAAATAATTCTGATATTATGTCAGAAGTTAATGATGTACTTAAAAAAATGAAAAATTTTTCGGAATTAG
TTATTGATGGAACATGGAAAGGTTACAGTGGAAAATCTATTTCTGATGTTGTTAATATAGGTATTGGAGGATCAGATTTA
GGACCTTATATGGTTACAGAAGCATTGCGTCCATATAAAAATCATTTAAATATACACTATGTTTCTAACATAGATGGTAC
TCATCTTTCTGAGATTTTAAAAAAGATCAATCCTGAAACAACAATTTTTTTAATAGCTTCTAAAACATTTACTACCGATG
AAACTATAACTAATGCTAATAGTGCAAAATTTTGGTTTTTAAAACATTCAAAAACGAAAGAAACTTTAGATAAACATTTT
TTTGCTTTGTCAGCCAATATAAACAATGCTGTGAATTTTGGAATTAATATAAAAAATATTTTTCAATTTTGGGACTGGGT
AGGAGGTCGTTTTTCATTATGGTCTTCTGCTGGATTATCTATTGTTCTATCTATTGGATTTAATAATTTCGAAAAATTTT
TACAGGGAGCACATGTTATGGATAATCATTTTTATCATACTGAATATGATAAAAATATTCCTATTTTACTAGCTCTGATT
AGTATTTGGTATACTAACTTTTTTAATTCTGAAACAGAAGCTATATTTCCATATGATCAATATATGCATCGTTTTTCTGC
ATATTTTCAACAATCTAATATGGAATCTAATGGAAAATCAATTGACAAAAATGGAAATAAGGTATGTTATCAAACTGGAC
CTATTATTTGGGGTGAACCAGGTACCAATGGTCAGCATGCATTTTTTCAGTTGATTCATCAAGGCACTAAATTAATCCCA
AGTGATTTTATCGTACCAACTGTTTCTCATAATAATTTAAATGATCATCATCTTAAATTAATATCTAATTTTTTAGCTCA
AACTCAAGTACTTGCTTTTGGAAAATCTAAAAATTCTTTTTTAAAAGAATCTACTTCTTTTAAAAAAGAAGAAGATGAAT
TTAATAGAATTTTACCTTTTAAAATATGCGAAGGAAATAAACCAACAAATTCTATTTTATTACGGAAAATAACACCTTAT
ACATTAGGAATGTTAATTGCGTTGTATGAACACAAAATTTTTGTTCAAGGTCATATATTAAATATTTTTAGTTTTGATCA
ATGGGGTGTTGAAATAGGAAAGGAAGTAGCACAAAGTATTTATAAAAATATTAATGAAAAAACAAAGAATAGTAAATCTT
ATGATTCTTCAACACAAGGGCTTATTGATTTTTATAATTTTTTTAAAAATAAACAAAATTATCTTTAA

Upstream 100 bases:

>100_bases
TATTTTTTTAGTTAAAAATTAATGAATATAGTATAATAAAAACTCAATAAAAAATAAATGTTTTTAATATATTAATAAAA
ATTAAACACAGGTAAATCAG

Downstream 100 bases:

>100_bases
TTTCAATTAATTAAAATTTTTTCTATTTTTTAAAAATACGATATCAGTCTTTTAATGATATTTTATAAAGTATTTTAAAA
AATTTTTAACTTAAATAAGC

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI

Number of amino acids: Translated: 555; Mature: 555

Protein sequence:

>555_residues
MKNINLIETKSWKDLKNHFKEVKNIHLKDLFLSDFNRFKKFSIFFENEILIDFSKNRITEKTLILLLNLAKEMNVKSAIK
LMFSGSKINQTENRSVLHIALRNRSNFPILLNNSDIMSEVNDVLKKMKNFSELVIDGTWKGYSGKSISDVVNIGIGGSDL
GPYMVTEALRPYKNHLNIHYVSNIDGTHLSEILKKINPETTIFLIASKTFTTDETITNANSAKFWFLKHSKTKETLDKHF
FALSANINNAVNFGINIKNIFQFWDWVGGRFSLWSSAGLSIVLSIGFNNFEKFLQGAHVMDNHFYHTEYDKNIPILLALI
SIWYTNFFNSETEAIFPYDQYMHRFSAYFQQSNMESNGKSIDKNGNKVCYQTGPIIWGEPGTNGQHAFFQLIHQGTKLIP
SDFIVPTVSHNNLNDHHLKLISNFLAQTQVLAFGKSKNSFLKESTSFKKEEDEFNRILPFKICEGNKPTNSILLRKITPY
TLGMLIALYEHKIFVQGHILNIFSFDQWGVEIGKEVAQSIYKNINEKTKNSKSYDSSTQGLIDFYNFFKNKQNYL

Sequences:

>Translated_555_residues
MKNINLIETKSWKDLKNHFKEVKNIHLKDLFLSDFNRFKKFSIFFENEILIDFSKNRITEKTLILLLNLAKEMNVKSAIK
LMFSGSKINQTENRSVLHIALRNRSNFPILLNNSDIMSEVNDVLKKMKNFSELVIDGTWKGYSGKSISDVVNIGIGGSDL
GPYMVTEALRPYKNHLNIHYVSNIDGTHLSEILKKINPETTIFLIASKTFTTDETITNANSAKFWFLKHSKTKETLDKHF
FALSANINNAVNFGINIKNIFQFWDWVGGRFSLWSSAGLSIVLSIGFNNFEKFLQGAHVMDNHFYHTEYDKNIPILLALI
SIWYTNFFNSETEAIFPYDQYMHRFSAYFQQSNMESNGKSIDKNGNKVCYQTGPIIWGEPGTNGQHAFFQLIHQGTKLIP
SDFIVPTVSHNNLNDHHLKLISNFLAQTQVLAFGKSKNSFLKESTSFKKEEDEFNRILPFKICEGNKPTNSILLRKITPY
TLGMLIALYEHKIFVQGHILNIFSFDQWGVEIGKEVAQSIYKNINEKTKNSKSYDSSTQGLIDFYNFFKNKQNYL
>Mature_555_residues
MKNINLIETKSWKDLKNHFKEVKNIHLKDLFLSDFNRFKKFSIFFENEILIDFSKNRITEKTLILLLNLAKEMNVKSAIK
LMFSGSKINQTENRSVLHIALRNRSNFPILLNNSDIMSEVNDVLKKMKNFSELVIDGTWKGYSGKSISDVVNIGIGGSDL
GPYMVTEALRPYKNHLNIHYVSNIDGTHLSEILKKINPETTIFLIASKTFTTDETITNANSAKFWFLKHSKTKETLDKHF
FALSANINNAVNFGINIKNIFQFWDWVGGRFSLWSSAGLSIVLSIGFNNFEKFLQGAHVMDNHFYHTEYDKNIPILLALI
SIWYTNFFNSETEAIFPYDQYMHRFSAYFQQSNMESNGKSIDKNGNKVCYQTGPIIWGEPGTNGQHAFFQLIHQGTKLIP
SDFIVPTVSHNNLNDHHLKLISNFLAQTQVLAFGKSKNSFLKESTSFKKEEDEFNRILPFKICEGNKPTNSILLRKITPY
TLGMLIALYEHKIFVQGHILNIFSFDQWGVEIGKEVAQSIYKNINEKTKNSKSYDSSTQGLIDFYNFFKNKQNYL

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family

Homologues:

Organism=Homo sapiens, GI18201905, Length=546, Percent_Identity=54.5787545787546, Blast_Score=629, Evalue=1e-180,
Organism=Homo sapiens, GI296080693, Length=546, Percent_Identity=50.9157509157509, Blast_Score=572, Evalue=1e-163,
Organism=Escherichia coli, GI1790457, Length=550, Percent_Identity=64.3636363636364, Blast_Score=769, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71996708, Length=549, Percent_Identity=54.6448087431694, Blast_Score=620, Evalue=1e-178,
Organism=Caenorhabditis elegans, GI71996703, Length=547, Percent_Identity=54.6617915904936, Blast_Score=619, Evalue=1e-178,
Organism=Saccharomyces cerevisiae, GI6319673, Length=544, Percent_Identity=51.4705882352941, Blast_Score=553, Evalue=1e-158,
Organism=Drosophila melanogaster, GI24651916, Length=528, Percent_Identity=58.1439393939394, Blast_Score=643, Evalue=0.0,
Organism=Drosophila melanogaster, GI24651914, Length=528, Percent_Identity=58.1439393939394, Blast_Score=643, Evalue=0.0,
Organism=Drosophila melanogaster, GI17737445, Length=528, Percent_Identity=58.1439393939394, Blast_Score=643, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G6PI_BUCAP (Q8K910)

Other databases:

- EMBL:   AE013218
- RefSeq:   NP_660880.1
- ProteinModelPortal:   Q8K910
- SMR:   Q8K910
- EnsemblBacteria:   EBBUCT00000000524
- GeneID:   1005724
- GenomeReviews:   AE013218_GR
- KEGG:   bas:BUsg553
- GeneTree:   EBGT00050000008090
- HOGENOM:   HBG352954
- OMA:   INAQHAF
- ProtClustDB:   PRK00179
- BioCyc:   BAPH198804:BUSG553-MONOMER
- GO:   GO:0005737
- GO:   GO:0006094
- GO:   GO:0006096
- HAMAP:   MF_00473
- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189
- Gene3D:   G3DSA:1.10.1390.10
- PANTHER:   PTHR11469
- PRINTS:   PR00662

Pfam domain/function: PF00342 PGI

EC number: =5.3.1.9

Molecular weight: Translated: 63958; Mature: 63958

Theoretical pI: Translated: 9.67; Mature: 9.67

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1; PS00174 P_GLUCOSE_ISOMERASE_2; PS51463 P_GLUCOSE_ISOMERASE_3

Important sites: ACT_SITE 355-355 ACT_SITE 386-386 ACT_SITE 514-514

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNINLIETKSWKDLKNHFKEVKNIHLKDLFLSDFNRFKKFSIFFENEILIDFSKNRITE
CCCCCEEECCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHEEEEEEECEEEEEECCCCCHH
KTLILLLNLAKEMNVKSAIKLMFSGSKINQTENRSVLHIALRNRSNFPILLNNSDIMSEV
HHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCCEEECCHHHHHHH
NDVLKKMKNFSELVIDGTWKGYSGKSISDVVNIGIGGSDLGPYMVTEALRPYKNHLNIHY
HHHHHHHHCHHHEEEECCCCCCCCCCHHHHHEECCCCCCCCHHHHHHHHHHHHHCCEEEE
VSNIDGTHLSEILKKINPETTIFLIASKTFTTDETITNANSAKFWFLKHSKTKETLDKHF
ECCCCCHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHE
FALSANINNAVNFGINIKNIFQFWDWVGGRFSLWSSAGLSIVLSIGFNNFEKFLQGAHVM
EEEECCCCCEEEECCCHHHHHHHHHCCCCCEEEECCCCCEEEEEECCHHHHHHHCCCHHH
DNHFYHTEYDKNIPILLALISIWYTNFFNSETEAIFPYDQYMHRFSAYFQQSNMESNGKS
CCCEEECCCCCCCHHHHHHHHHHHHHHCCCCCCEECCHHHHHHHHHHHHHHCCCCCCCCC
IDKNGNKVCYQTGPIIWGEPGTNGQHAFFQLIHQGTKLIPSDFIVPTVSHNNLNDHHLKL
CCCCCCEEEEECCCEEECCCCCCCHHHHHHHHHHCCCCCCCCCEEEEECCCCCCHHHHHH
ISNFLAQTQVLAFGKSKNSFLKESTSFKKEEDEFNRILPFKICEGNKPTNSILLRKITPY
HHHHHHHHHHEEECCCCCHHHHHHCCCCCCHHHHCCCCCEEEECCCCCCCCEEEEECCHH
TLGMLIALYEHKIFVQGHILNIFSFDQWGVEIGKEVAQSIYKNINEKTKNSKSYDSSTQG
HHHHHHHHHHCEEEEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
LIDFYNFFKNKQNYL
HHHHHHHHCCCCCCC
>Mature Secondary Structure
MKNINLIETKSWKDLKNHFKEVKNIHLKDLFLSDFNRFKKFSIFFENEILIDFSKNRITE
CCCCCEEECCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHEEEEEEECEEEEEECCCCCHH
KTLILLLNLAKEMNVKSAIKLMFSGSKINQTENRSVLHIALRNRSNFPILLNNSDIMSEV
HHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCCEEECCHHHHHHH
NDVLKKMKNFSELVIDGTWKGYSGKSISDVVNIGIGGSDLGPYMVTEALRPYKNHLNIHY
HHHHHHHHCHHHEEEECCCCCCCCCCHHHHHEECCCCCCCCHHHHHHHHHHHHHCCEEEE
VSNIDGTHLSEILKKINPETTIFLIASKTFTTDETITNANSAKFWFLKHSKTKETLDKHF
ECCCCCHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHE
FALSANINNAVNFGINIKNIFQFWDWVGGRFSLWSSAGLSIVLSIGFNNFEKFLQGAHVM
EEEECCCCCEEEECCCHHHHHHHHHCCCCCEEEECCCCCEEEEEECCHHHHHHHCCCHHH
DNHFYHTEYDKNIPILLALISIWYTNFFNSETEAIFPYDQYMHRFSAYFQQSNMESNGKS
CCCEEECCCCCCCHHHHHHHHHHHHHHCCCCCCEECCHHHHHHHHHHHHHHCCCCCCCCC
IDKNGNKVCYQTGPIIWGEPGTNGQHAFFQLIHQGTKLIPSDFIVPTVSHNNLNDHHLKL
CCCCCCEEEEECCCEEECCCCCCCHHHHHHHHHHCCCCCCCCCEEEEECCCCCCHHHHHH
ISNFLAQTQVLAFGKSKNSFLKESTSFKKEEDEFNRILPFKICEGNKPTNSILLRKITPY
HHHHHHHHHHEEECCCCCHHHHHHCCCCCCHHHHCCCCCEEEECCCCCCCCEEEEECCHH
TLGMLIALYEHKIFVQGHILNIFSFDQWGVEIGKEVAQSIYKNINEKTKNSKSYDSSTQG
HHHHHHHHHHCEEEEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
LIDFYNFFKNKQNYL
HHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12089438