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The map label for this gene is nuoM

Identifier: 21672448

GI number: 21672448

Start: 177130

End: 178635

Strand: Direct

Name: nuoM

Synonym: BUsg158

Alternate gene names: 21672448

Gene position: 177130-178635 (Clockwise)

Preceding gene: 21672447

Following gene: 21672449

Centisome position: 27.61

GC content: 24.5

Gene sequence:

>1506_bases
ATGTTGCTTTCTCTATTAGTTATAATTCCATTTCTTAGTGGTATTTTTTCATTTTTTTCTTTTAGATTCCAGAAAAATAT
TCCTCGTTGGATTGCATTGACAGGAATGGGATTAACTTTATTAACTGTTATTAGAATATGGTTTTTTGAAGATTATTATA
CTTATCAAATACAAAGTTACACTCATTTAAGTTATCAATTAATATTGCCTTGGATATCAAGTTTTGGAATTCAATTTCAT
ATTGCTGTTGATGGTTTTTCAATTGTCATGCTTTTTTTAACTTTATTTTTAGGGATAATTGCTATTTTGTGCTCATGGAA
TGAAATTAAAAAAAATGAAGGATTTTTTTATCTGAATATTATGCTTGTTTTAATGGGTACAATTGGTGTTTTTATTGCTT
TTGATTTATTTTTATTTTTCTTTTTTTGGGAAATTATACTTATTCCAATGTATTTTTTAATTTCATTATGGAATCAAAAA
AAAGAAGATAAAAAAAAATGTATAAATATTGCTAATAAGTTTTTTATATATACTCAAATATCAGGTTTAATAATGTTAGC
ATCAATTTTATTATTGGTTTTGAATTATTATATTAACAATAAAATTTTGACTTTTAATTATGATTTGTTACTTATTCAAC
CAGTTGATAAAAGTATAGAATATATTATTATGTTAGGTTTTTTTTTAGCCTTCATTATAAAAATGCCGATTGTTCCCTTT
CATGGATGGTTAGCAGATTTTCATGAAAGATCTCCATATTGTGGTGCTGTTGACATAATTGGTGCTTTATTAAAAACTGC
TCCATATGGTCTTTTACGCTATAATAAAATGCTTTTTCCGAATGCAACAGAACAGTTTGCACCTATAGCGATCTTTTTAG
GTTTTTTGAGTATGTTTTATGGAGCTTGGGTTGCTTTTTCTCAAGTCAATATTAAACGTTTAATCGCTTATTCGTCTATT
TCTCATATGGGATTAATGTTAATTGCTATTTACGGTGGTAATGAAATATCTTTTCAAGGCTTAATCATTCAAATTTTATC
TAATAGTATATCTACTTCTGCTTTGTTTATTTTATCAGGTCAAATTTACAAATATCTCAAAACACAAGATATAAGTGAAA
TGGGAGGATTATGGACGAATATTTATTGGATTCCAGGTTTTTCTTTATTTTTCGCGTTATCTAATTTAGGTATTCCAGGA
ACAGGGAATTTTATTGGTGAATTTTTAATATTATTTGGTATATTTAAAGAACATCCACTTGTGTCTATAATTTCTACAAT
AGGTATTATTTTTTCATCTATTTATTCTTTAAACATGATTCAAAAAATATATTATGGTTTATCTAAGCATGATTTTCCTA
AATTTTTTTTAAATATAAAAGAATTTTGGATATCAATAGTACTGATTTTTGCATTAATTTTTTTAGGTTTAATACCTCAA
AAAATATTAAATATTTCATTTGAATCGATACATTTTATATATAATTTTTCAAAAAGAATTCAGTAA

Upstream 100 bases:

>100_bases
TTCTTTTTTATCATAGAAATGTTTTTTATTAGTTGTTTTTAAATTTTTACATCCTTTTTTTGATTATATTAATATAATAA
ATAATAGGAATATACGTCTA

Downstream 100 bases:

>100_bases
TTCTATTTTAAAGATAAGGTTATGATTAATAATGATAATTAATCTACAAGAATTAATAGCACTTTTACCTTTTTTAATTT
TACTACTAACTGTAGTAATA

Product: NADH dehydrogenase I chain M

Products: NA

Alternate protein names: NADH dehydrogenase I subunit M; NDH-1 subunit M

Number of amino acids: Translated: 501; Mature: 501

Protein sequence:

>501_residues
MLLSLLVIIPFLSGIFSFFSFRFQKNIPRWIALTGMGLTLLTVIRIWFFEDYYTYQIQSYTHLSYQLILPWISSFGIQFH
IAVDGFSIVMLFLTLFLGIIAILCSWNEIKKNEGFFYLNIMLVLMGTIGVFIAFDLFLFFFFWEIILIPMYFLISLWNQK
KEDKKKCINIANKFFIYTQISGLIMLASILLLVLNYYINNKILTFNYDLLLIQPVDKSIEYIIMLGFFLAFIIKMPIVPF
HGWLADFHERSPYCGAVDIIGALLKTAPYGLLRYNKMLFPNATEQFAPIAIFLGFLSMFYGAWVAFSQVNIKRLIAYSSI
SHMGLMLIAIYGGNEISFQGLIIQILSNSISTSALFILSGQIYKYLKTQDISEMGGLWTNIYWIPGFSLFFALSNLGIPG
TGNFIGEFLILFGIFKEHPLVSIISTIGIIFSSIYSLNMIQKIYYGLSKHDFPKFFLNIKEFWISIVLIFALIFLGLIPQ
KILNISFESIHFIYNFSKRIQ

Sequences:

>Translated_501_residues
MLLSLLVIIPFLSGIFSFFSFRFQKNIPRWIALTGMGLTLLTVIRIWFFEDYYTYQIQSYTHLSYQLILPWISSFGIQFH
IAVDGFSIVMLFLTLFLGIIAILCSWNEIKKNEGFFYLNIMLVLMGTIGVFIAFDLFLFFFFWEIILIPMYFLISLWNQK
KEDKKKCINIANKFFIYTQISGLIMLASILLLVLNYYINNKILTFNYDLLLIQPVDKSIEYIIMLGFFLAFIIKMPIVPF
HGWLADFHERSPYCGAVDIIGALLKTAPYGLLRYNKMLFPNATEQFAPIAIFLGFLSMFYGAWVAFSQVNIKRLIAYSSI
SHMGLMLIAIYGGNEISFQGLIIQILSNSISTSALFILSGQIYKYLKTQDISEMGGLWTNIYWIPGFSLFFALSNLGIPG
TGNFIGEFLILFGIFKEHPLVSIISTIGIIFSSIYSLNMIQKIYYGLSKHDFPKFFLNIKEFWISIVLIFALIFLGLIPQ
KILNISFESIHFIYNFSKRIQ
>Mature_501_residues
MLLSLLVIIPFLSGIFSFFSFRFQKNIPRWIALTGMGLTLLTVIRIWFFEDYYTYQIQSYTHLSYQLILPWISSFGIQFH
IAVDGFSIVMLFLTLFLGIIAILCSWNEIKKNEGFFYLNIMLVLMGTIGVFIAFDLFLFFFFWEIILIPMYFLISLWNQK
KEDKKKCINIANKFFIYTQISGLIMLASILLLVLNYYINNKILTFNYDLLLIQPVDKSIEYIIMLGFFLAFIIKMPIVPF
HGWLADFHERSPYCGAVDIIGALLKTAPYGLLRYNKMLFPNATEQFAPIAIFLGFLSMFYGAWVAFSQVNIKRLIAYSSI
SHMGLMLIAIYGGNEISFQGLIIQILSNSISTSALFILSGQIYKYLKTQDISEMGGLWTNIYWIPGFSLFFALSNLGIPG
TGNFIGEFLILFGIFKEHPLVSIISTIGIIFSSIYSLNMIQKIYYGLSKHDFPKFFLNIKEFWISIVLIFALIFLGLIPQ
KILNISFESIHFIYNFSKRIQ

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cyto

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family

Homologues:

Organism=Homo sapiens, GI251831116, Length=340, Percent_Identity=28.2352941176471, Blast_Score=122, Evalue=1e-27,
Organism=Escherichia coli, GI1788613, Length=495, Percent_Identity=50.3030303030303, Blast_Score=524, Evalue=1e-150,
Organism=Escherichia coli, GI1788614, Length=512, Percent_Identity=24.0234375, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1788827, Length=306, Percent_Identity=22.2222222222222, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI145693160, Length=408, Percent_Identity=24.7549019607843, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1788831, Length=198, Percent_Identity=28.7878787878788, Blast_Score=69, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOM_BUCAP (Q8K9X6)

Other databases:

- EMBL:   AE013218
- RefSeq:   NP_660515.1
- EnsemblBacteria:   EBBUCT00000000424
- GeneID:   1005356
- GenomeReviews:   AE013218_GR
- KEGG:   bas:BUsg158
- GeneTree:   EBGT00050000007699
- HOGENOM:   HBG643593
- OMA:   CINIANK
- ProtClustDB:   CLSK315615
- BioCyc:   BAPH198804:BUSG158-MONOMER
- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918
- PRINTS:   PR01437
- TIGRFAMs:   TIGR01972

Pfam domain/function: PF00361 Oxidored_q1

EC number: =1.6.99.5

Molecular weight: Translated: 57885; Mature: 57885

Theoretical pI: Translated: 9.24; Mature: 9.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xb240d4c)-; HASH(0xb2bb820)-; HASH(0xaf0710c)-; HASH(0xc3a99e4)-; HASH(0xbc914b4)-; HASH(0xba0ff08)-; HASH(0xbcfc6f8)-; HASH(0xc1403bc)-; HASH(0x96e81c0)-; HASH(0xb29a0c0)-; HASH(0xbbfcb30)-; HASH(0xbcdb33c)-; HASH(0xae41f78)-; HASH(0xb882b54)-;

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLSLLVIIPFLSGIFSFFSFRFQKNIPRWIALTGMGLTLLTVIRIWFFEDYYTYQIQSY
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHEEEEEECC
THLSYQLILPWISSFGIQFHIAVDGFSIVMLFLTLFLGIIAILCSWNEIKKNEGFFYLNI
HHHHHHHHHHHHHHCCEEEEEEECHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCEEHHHH
MLVLMGTIGVFIAFDLFLFFFFWEIILIPMYFLISLWNQKKEDKKKCINIANKFFIYTQI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEHHHH
SGLIMLASILLLVLNYYINNKILTFNYDLLLIQPVDKSIEYIIMLGFFLAFIIKMPIVPF
HHHHHHHHHHHHHHHHHHCCEEEEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCH
HGWLADFHERSPYCGAVDIIGALLKTAPYGLLRYNKMLFPNATEQFAPIAIFLGFLSMFY
HHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
GAWVAFSQVNIKRLIAYSSISHMGLMLIAIYGGNEISFQGLIIQILSNSISTSALFILSG
HHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCEEEHHHHHHHHHHCCCCHHEEEEEHH
QIYKYLKTQDISEMGGLWTNIYWIPGFSLFFALSNLGIPGTGNFIGEFLILFGIFKEHPL
HHHHHHHHCCHHHHCCHHHEEEECCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHH
VSIISTIGIIFSSIYSLNMIQKIYYGLSKHDFPKFFLNIKEFWISIVLIFALIFLGLIPQ
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KILNISFESIHFIYNFSKRIQ
HHHCCCHHHHHHHEEHHHHCH
>Mature Secondary Structure
MLLSLLVIIPFLSGIFSFFSFRFQKNIPRWIALTGMGLTLLTVIRIWFFEDYYTYQIQSY
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHEEEEEECC
THLSYQLILPWISSFGIQFHIAVDGFSIVMLFLTLFLGIIAILCSWNEIKKNEGFFYLNI
HHHHHHHHHHHHHHCCEEEEEEECHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCEEHHHH
MLVLMGTIGVFIAFDLFLFFFFWEIILIPMYFLISLWNQKKEDKKKCINIANKFFIYTQI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEHHHH
SGLIMLASILLLVLNYYINNKILTFNYDLLLIQPVDKSIEYIIMLGFFLAFIIKMPIVPF
HHHHHHHHHHHHHHHHHHCCEEEEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCH
HGWLADFHERSPYCGAVDIIGALLKTAPYGLLRYNKMLFPNATEQFAPIAIFLGFLSMFY
HHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
GAWVAFSQVNIKRLIAYSSISHMGLMLIAIYGGNEISFQGLIIQILSNSISTSALFILSG
HHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCEEEHHHHHHHHHHCCCCHHEEEEEHH
QIYKYLKTQDISEMGGLWTNIYWIPGFSLFFALSNLGIPGTGNFIGEFLILFGIFKEHPL
HHHHHHHHCCHHHHCCHHHEEEECCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHH
VSIISTIGIIFSSIYSLNMIQKIYYGLSKHDFPKFFLNIKEFWISIVLIFALIFLGLIPQ
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KILNISFESIHFIYNFSKRIQ
HHHCCCHHHHHHHEEHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12089438