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The map label for this gene is nuoCD

Identifier: 21672439

GI number: 21672439

Start: 166375

End: 168168

Strand: Direct

Name: nuoCD

Synonym: BUsg149

Alternate gene names: 21672439

Gene position: 166375-168168 (Clockwise)

Preceding gene: 21672438

Following gene: 21672440

Centisome position: 25.94

GC content: 30.77

Gene sequence:

>1794_bases
ATGATAGATGAAAATAAAAAAAAAAATACTAATTTAAATAAAAATGAGTATGAAGAAAAATCAATTCTTAAAGATTTATT
TCATTTTTTTGGTAAAGATTTTTGTGTTGTACAGGATACTTGTATAGATTTTCCAGTAATCTGGATTAATAAATCTTTAT
TGTTGAAAGTCGGTAAATTTTTATCTAGTTCACCTAAGCCTTATAATATGCTTTTTGATTTGCATGGTGTAGACGAACGT
TTTCGATTAAATCGATTAAATTTACCTGAAGCGGATTTTTCAATTTTTTATCATCTAATATCTATTGAACGGAATAGTGA
TATTCTGATTAAAGTTCCTTTATTGAAAGACGATTTAAATGTATCAACTTTTATTAGTTTATTTCCCAATGCGAATTGGT
ATGAACGTGAAACATGGGAAATGTTTGGTATTATTTTTGATCAACATCCTAATTTAACTCATATTATTATGCCGAATGAA
TGGAAGGGATTTCCTTTGAGGAAAGATTATCCAGCTAGGGCAACTGAGCATGAGTCTTTTTTTTTAGATGAACAAAAAGA
AGATTTAGAAATGGAAAATCTAAGGTTTAAACCTGAGTTGTGGGGGATGAAAAGAAAAAATGATAATGTAGATTTTATGT
TCTTAAACTTAGGACCTAATCATCCTTCTGCTCATGGTGCTTTTAGAATTGTTTTACAATTAGATGGTGAAAACATTGTA
GATTGTGTTCCTGATATTGGTTATCACCATCGTGGTGCAGAAAAAATGGCAGAAAGACAATCATGGCATAGTTATATTCC
ATATACTGATCGTATTGAGTATCTAGGTGGTTGTGTTAATGAAATGCCTTATGTTTTAGCAGTAGAAAAATTAGCTAATA
TTTCTGTTCCAGAAAAAGTAGAAGTAATCCGAGTCATGTTATCTGAATTATTTAGAATAAATAGTCATCTTTTGTATATT
TCTACCTTTATTCAAGATGTGGGATGTATGACACCTGTTTTTCTTGCTTTTACTGATCGTCAAAAAATATACGATTTGAT
TGAAGCAATTACTGGAGCTCGTATGCATCCTGCTTGGTTTCGGATTGGTGGAGTAGCTCACGATCTTCCTAAAGGATGGA
ATGTTTTATTAAAAGAATTTCTTGAATGGATGCCAAAAAGATTAAAATATTATGTACAATTAGCTTTAGAAAATCCAATC
TTAATAAGGCGTTCTAAAGGCATCGCTCAATACAATCAAAAAGAAGCATTACAATGGGGTGTAACAGGATCAGGTTTACG
CTCTACAGGATTAGATTTAGATGTAAGAAAGTGGCGTCCTTATTCTGGATATCAGAATTATACTTTTGAAATTCCTATAG
GTCAAGGTATCAGTGATTGCTATTCGAGAGTTATAATTAAAGTAGAAGAAATATATCAAAGTTTAAGTATTTTAAAACAA
TGCTTAAAAAATATGCCAGAGGGTCCTTTTAAATCTGACCATCCATTAACTACTCCTCCTCCTAAAGAACGCGTTCTAAA
AGATATAGATACAATGATTACTCATTTTTTACAAGTTTCTTGGGGTCCTGTTATTCCAGCTAATGAAAGTTTTCAAATGA
TTGAAGCAACTAAAGGTATTAATAGTTATTATTTAATAAGTGATGGTGGTACAATGAGTTATCGAACAAGAATACGAACA
CCTAGTTTCCCTCATTTACAGCAAATACCTTCAGTTATTCGTGGAAGTTTAATATCAGATTTAATTGTATATTTAGGCAG
TATAGATTTTGTCATGTCAGATGTGGACAGATAA

Upstream 100 bases:

>100_bases
TTTAAAAAGAATATAAATTTTTCATACTACTAGATCGTATTTTTTGTAAATATATTATTAATATTAAAAATTTTTAGGTT
AATGAAAAAATGAGAAATCT

Downstream 100 bases:

>100_bases
TTATGGATAAAAAAAAAAAAATAAAAGAAATCTCTACAACATTTACTTTAACTACTTTTGAAATTAATGAAATAGAAAAG
CAAAAAAAATATTATGAAAA

Product: bifunctional NADH:ubiquinone oxidoreductase subunit C/D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit C/D; NDH-1 subunit C/D

Number of amino acids: Translated: 597; Mature: 597

Protein sequence:

>597_residues
MIDENKKKNTNLNKNEYEEKSILKDLFHFFGKDFCVVQDTCIDFPVIWINKSLLLKVGKFLSSSPKPYNMLFDLHGVDER
FRLNRLNLPEADFSIFYHLISIERNSDILIKVPLLKDDLNVSTFISLFPNANWYERETWEMFGIIFDQHPNLTHIIMPNE
WKGFPLRKDYPARATEHESFFLDEQKEDLEMENLRFKPELWGMKRKNDNVDFMFLNLGPNHPSAHGAFRIVLQLDGENIV
DCVPDIGYHHRGAEKMAERQSWHSYIPYTDRIEYLGGCVNEMPYVLAVEKLANISVPEKVEVIRVMLSELFRINSHLLYI
STFIQDVGCMTPVFLAFTDRQKIYDLIEAITGARMHPAWFRIGGVAHDLPKGWNVLLKEFLEWMPKRLKYYVQLALENPI
LIRRSKGIAQYNQKEALQWGVTGSGLRSTGLDLDVRKWRPYSGYQNYTFEIPIGQGISDCYSRVIIKVEEIYQSLSILKQ
CLKNMPEGPFKSDHPLTTPPPKERVLKDIDTMITHFLQVSWGPVIPANESFQMIEATKGINSYYLISDGGTMSYRTRIRT
PSFPHLQQIPSVIRGSLISDLIVYLGSIDFVMSDVDR

Sequences:

>Translated_597_residues
MIDENKKKNTNLNKNEYEEKSILKDLFHFFGKDFCVVQDTCIDFPVIWINKSLLLKVGKFLSSSPKPYNMLFDLHGVDER
FRLNRLNLPEADFSIFYHLISIERNSDILIKVPLLKDDLNVSTFISLFPNANWYERETWEMFGIIFDQHPNLTHIIMPNE
WKGFPLRKDYPARATEHESFFLDEQKEDLEMENLRFKPELWGMKRKNDNVDFMFLNLGPNHPSAHGAFRIVLQLDGENIV
DCVPDIGYHHRGAEKMAERQSWHSYIPYTDRIEYLGGCVNEMPYVLAVEKLANISVPEKVEVIRVMLSELFRINSHLLYI
STFIQDVGCMTPVFLAFTDRQKIYDLIEAITGARMHPAWFRIGGVAHDLPKGWNVLLKEFLEWMPKRLKYYVQLALENPI
LIRRSKGIAQYNQKEALQWGVTGSGLRSTGLDLDVRKWRPYSGYQNYTFEIPIGQGISDCYSRVIIKVEEIYQSLSILKQ
CLKNMPEGPFKSDHPLTTPPPKERVLKDIDTMITHFLQVSWGPVIPANESFQMIEATKGINSYYLISDGGTMSYRTRIRT
PSFPHLQQIPSVIRGSLISDLIVYLGSIDFVMSDVDR
>Mature_597_residues
MIDENKKKNTNLNKNEYEEKSILKDLFHFFGKDFCVVQDTCIDFPVIWINKSLLLKVGKFLSSSPKPYNMLFDLHGVDER
FRLNRLNLPEADFSIFYHLISIERNSDILIKVPLLKDDLNVSTFISLFPNANWYERETWEMFGIIFDQHPNLTHIIMPNE
WKGFPLRKDYPARATEHESFFLDEQKEDLEMENLRFKPELWGMKRKNDNVDFMFLNLGPNHPSAHGAFRIVLQLDGENIV
DCVPDIGYHHRGAEKMAERQSWHSYIPYTDRIEYLGGCVNEMPYVLAVEKLANISVPEKVEVIRVMLSELFRINSHLLYI
STFIQDVGCMTPVFLAFTDRQKIYDLIEAITGARMHPAWFRIGGVAHDLPKGWNVLLKEFLEWMPKRLKYYVQLALENPI
LIRRSKGIAQYNQKEALQWGVTGSGLRSTGLDLDVRKWRPYSGYQNYTFEIPIGQGISDCYSRVIIKVEEIYQSLSILKQ
CLKNMPEGPFKSDHPLTTPPPKERVLKDIDTMITHFLQVSWGPVIPANESFQMIEATKGINSYYLISDGGTMSYRTRIRT
PSFPHLQQIPSVIRGSLISDLIVYLGSIDFVMSDVDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the complex I 49 kDa subunit family

Homologues:

Organism=Homo sapiens, GI4758786, Length=408, Percent_Identity=37.7450980392157, Blast_Score=295, Evalue=9e-80,
Organism=Homo sapiens, GI260898743, Length=402, Percent_Identity=37.3134328358209, Blast_Score=285, Evalue=8e-77,
Organism=Homo sapiens, GI4758788, Length=137, Percent_Identity=36.4963503649635, Blast_Score=82, Evalue=2e-15,
Organism=Escherichia coli, GI145693162, Length=576, Percent_Identity=76.2152777777778, Blast_Score=940, Evalue=0.0,
Organism=Escherichia coli, GI1789076, Length=537, Percent_Identity=26.6294227188082, Blast_Score=175, Evalue=7e-45,
Organism=Escherichia coli, GI1788832, Length=513, Percent_Identity=25.1461988304094, Blast_Score=144, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17555284, Length=397, Percent_Identity=40.0503778337531, Blast_Score=318, Evalue=5e-87,
Organism=Caenorhabditis elegans, GI17568379, Length=397, Percent_Identity=39.5465994962217, Blast_Score=315, Evalue=5e-86,
Organism=Drosophila melanogaster, GI24638644, Length=389, Percent_Identity=38.560411311054, Blast_Score=308, Evalue=6e-84,
Organism=Drosophila melanogaster, GI221459469, Length=384, Percent_Identity=36.9791666666667, Blast_Score=302, Evalue=3e-82,
Organism=Drosophila melanogaster, GI24656494, Length=137, Percent_Identity=33.5766423357664, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOCD_BUCAP (Q8K9Y5)

Other databases:

- EMBL:   AE013218
- RefSeq:   NP_660506.1
- ProteinModelPortal:   Q8K9Y5
- SMR:   Q8K9Y5
- EnsemblBacteria:   EBBUCT00000000479
- GeneID:   1005966
- GenomeReviews:   AE013218_GR
- KEGG:   bas:BUsg149
- GeneTree:   EBGT00050000007742
- HOGENOM:   HBG459705
- OMA:   PHLQQIP
- ProtClustDB:   PRK11742
- BioCyc:   BAPH198804:BUSG149-MONOMER
- GO:   GO:0006810
- HAMAP:   MF_01359
- InterPro:   IPR010219
- InterPro:   IPR010218
- InterPro:   IPR023062
- InterPro:   IPR001135
- InterPro:   IPR001268
- InterPro:   IPR014029
- InterPro:   IPR022885
- ProDom:   PD001581
- TIGRFAMs:   TIGR01961
- TIGRFAMs:   TIGR01962

Pfam domain/function: PF00329 Complex1_30kDa; PF00346 Complex1_49kDa

EC number: =1.6.99.5

Molecular weight: Translated: 69344; Mature: 69344

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: PS00542 COMPLEX1_30K; PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDENKKKNTNLNKNEYEEKSILKDLFHFFGKDFCVVQDTCIDFPVIWINKSLLLKVGKF
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEHHHCCCEEEEECHHHHHHHHHH
LSSSPKPYNMLFDLHGVDERFRLNRLNLPEADFSIFYHLISIERNSDILIKVPLLKDDLN
HCCCCCCEEEEEEECCCCHHHHCCCCCCCCHHHHHHHHHEEEECCCCEEEEEECCCCCCC
VSTFISLFPNANWYERETWEMFGIIFDQHPNLTHIIMPNEWKGFPLRKDYPARATEHESF
HHHHHEECCCCCCCCCHHHHEEEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCE
FLDEQKEDLEMENLRFKPELWGMKRKNDNVDFMFLNLGPNHPSAHGAFRIVLQLDGENIV
ECCCCHHCCCHHHCCCCHHHCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEEEECCCCHH
DCVPDIGYHHRGAEKMAERQSWHSYIPYTDRIEYLGGCVNEMPYVLAVEKLANISVPEKV
HHCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHH
EVIRVMLSELFRINSHLLYISTFIQDVGCMTPVFLAFTDRQKIYDLIEAITGARMHPAWF
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHHHCCCCCCHHH
RIGGVAHDLPKGWNVLLKEFLEWMPKRLKYYVQLALENPILIRRSKGIAQYNQKEALQWG
EECCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHEECCCEEEEECCCCHHCCHHHHHCCC
VTGSGLRSTGLDLDVRKWRPYSGYQNYTFEIPIGQGISDCYSRVIIKVEEIYQSLSILKQ
CCCCCCCCCCCCCCHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
CLKNMPEGPFKSDHPLTTPPPKERVLKDIDTMITHFLQVSWGPVIPANESFQMIEATKGI
HHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCC
NSYYLISDGGTMSYRTRIRTPSFPHLQQIPSVIRGSLISDLIVYLGSIDFVMSDVDR
CEEEEEECCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCC
>Mature Secondary Structure
MIDENKKKNTNLNKNEYEEKSILKDLFHFFGKDFCVVQDTCIDFPVIWINKSLLLKVGKF
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEHHHCCCEEEEECHHHHHHHHHH
LSSSPKPYNMLFDLHGVDERFRLNRLNLPEADFSIFYHLISIERNSDILIKVPLLKDDLN
HCCCCCCEEEEEEECCCCHHHHCCCCCCCCHHHHHHHHHEEEECCCCEEEEEECCCCCCC
VSTFISLFPNANWYERETWEMFGIIFDQHPNLTHIIMPNEWKGFPLRKDYPARATEHESF
HHHHHEECCCCCCCCCHHHHEEEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCE
FLDEQKEDLEMENLRFKPELWGMKRKNDNVDFMFLNLGPNHPSAHGAFRIVLQLDGENIV
ECCCCHHCCCHHHCCCCHHHCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEEEECCCCHH
DCVPDIGYHHRGAEKMAERQSWHSYIPYTDRIEYLGGCVNEMPYVLAVEKLANISVPEKV
HHCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHH
EVIRVMLSELFRINSHLLYISTFIQDVGCMTPVFLAFTDRQKIYDLIEAITGARMHPAWF
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHHHCCCCCCHHH
RIGGVAHDLPKGWNVLLKEFLEWMPKRLKYYVQLALENPILIRRSKGIAQYNQKEALQWG
EECCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHEECCCEEEEECCCCHHCCHHHHHCCC
VTGSGLRSTGLDLDVRKWRPYSGYQNYTFEIPIGQGISDCYSRVIIKVEEIYQSLSILKQ
CCCCCCCCCCCCCCHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
CLKNMPEGPFKSDHPLTTPPPKERVLKDIDTMITHFLQVSWGPVIPANESFQMIEATKGI
HHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCC
NSYYLISDGGTMSYRTRIRTPSFPHLQQIPSVIRGSLISDLIVYLGSIDFVMSDVDR
CEEEEEECCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12089438