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The map label for this gene is tkt

Identifier: 21672378

GI number: 21672378

Start: 97083

End: 99080

Strand: Direct

Name: tkt

Synonym: BUsg086

Alternate gene names: 21672378

Gene position: 97083-99080 (Clockwise)

Preceding gene: 21672377

Following gene: 30410814

Centisome position: 15.13

GC content: 31.23

Gene sequence:

>1998_bases
ATGTGTGTAAGAAGAGAATTAGCAAACGCAATTCGTATGTTGAGTATAGATGCTGTTCAAAATGCAAAATCTGGTCATCC
GGGTATGCCTATGGGAATGGCTGATATTGCAGAAGTTTTATGGAGAAAATTTTTTAAACATAGTCCAACGAATCCTAATT
GGAACAATCGTGATCGTTTTATTCTTTCTAACGGACATGGTTCTATGTTGTTATACAGTTTATTGCATCTTACTGGATAT
GATTTATCAATAGACGAACTTAAAAAATTTAGACAGCTTCATTCAAAAACACCAGGACATCCAGAAACAGGTGAAACGCC
AGGTGTTGAAACTACTACTGGTCCCTTAGGGCAAGGTTTAGCTAATGCGGTTGGAATGGCTATTGCAGAAAGAACATTAA
GTGCTTATTTTAATCGACCAGATTACGATATAGTTGATCATTATACTTGGGTTTTTGTAGGAGACGGTTGTTTAATGGAG
GGTATTTCTCATGAAGTCTGTTCTTTGGCTGGAACATTAAAATTAGGGAAATTAATTGTTTTTTACGATAAAAATGGTAT
TTCAATAGATGGTAAAATTTCGAATTGGTTTACAGATGATACAGTTATGCGATTTAAATCGTATAATTGGCATGTTGTAG
ATAAAGTCGATGGTCATGATGCTAATTCTATTAAAAATAGTATTGAAGAAGCAAAATCAGTAAAAGATCAACCTTCAATT
ATTATTTGTAATACGATTATTGGTTTTGGTTCTCCAAACAAGTCAGGTACAGCTGATTCTCATGGTGCTCCTCTTGGAGA
AGAGGAAATTTTTTTAACGCGAAAAAATTTAAATTGGAAGTATTCACCGTTTGAAATACCTAATAAAATTTATGATAAGT
GGAACTTTGTAAAACAAGGTTTAAAATTAGAAGAAAATTGGAATAAACAATTTCATTTATATAAATCTGAATATCCTGCA
CTTGCAGAAGAATATTCAAGAAGAATCAAAAAAAAATTACCTACACAATGGTATAAAAAAACTAAAGATTATATTTTTAA
TTTGCAAAAAAATCCTCAAAATATTGCAACTAGAAAAGCTTCTCAAAATGCTATAGAAGAATTTGCGGCACTACTTCCAG
AATTAATAGGTGGATCTGCAGATTTGTCACCAAGTAATCTAACTATGTGGTCGAAGTCTAGTTCCATAACAGAAAATTTA
TGTGGAAATTATATTCATTATGGTGTTCGTGAATTTGGAATGACAGCGATTGCTAATGGAATCTCTCATCATGGAGGATT
TATTCCATATACTTCGACATTTTTAATGTTTGTTGAGTATGCTCGAAATGCAGTCCGTATGGCAGCTTTGATGAATACTA
AACATATTTTTGTATATACACATGATTCTATTGGATTAGGTGAGGATGGTCCTACACATCAACCAATAGAACAATTAGCA
AATTTAAGAATGACGCCAAATATAGATGTTTGGAGGCCTAGCGATCAAGTAGAAACTGCTGTAGCATGGAAATATGCGAT
TGAAGAAAAAAATGGTCCAACAGCACTGATTTTGTCACGTCAAAATTTATTCCAATTTTCTAGAAATAATGAACAAATAA
AAAATATTTCTTACGGGGCTTACATATTATATGATTCTAAAAAACCTATCGATATCATTTTTATATCAACAGGTTCTGAA
TTACAAATAACTTTAACTTCTGCTAAAAAAATTGCTGCTTTAGGTTATTCTGTGCGTGTTGTATCTATGCCTTCTAATAA
TGTTTTTGATAGACAAAATATTGATTATAAAGAATCAATATTGCCATCTTATATTACTAAAAGAATTGTAATAGAGGCTA
GTATAAAAGACTTCTGGTATAAATATGCAGGGTCAGAAGGATTAATTATTGGCATGGAAACATTTGGAGAATCTGCTTCA
GAAGAGGTTTTATTTAAAAAATTTGGTTTTACTGTAGAAAATATAGTAAATAAATCTAAAATTTTATTGAAACATTAA

Upstream 100 bases:

>100_bases
TTGGAAAAGATCAATTAAGTTTGGAGAAAATTTTTTCTAAACTAATATAAATGTTGAATAAGATATTAATTTTTTTAAGT
ATAAATTTGGAGAAATATTT

Downstream 100 bases:

>100_bases
TTTTAAACTTTTTTATGATATTAATGGGGGCTTTTTTCTTAGCCCCAATTATTTGAATAAATATGAAAGAAGATATACAT
GAGGAAAAAATGGTTTGTTC

Product: transketolase

Products: NA

Alternate protein names: TK

Number of amino acids: Translated: 665; Mature: 665

Protein sequence:

>665_residues
MCVRRELANAIRMLSIDAVQNAKSGHPGMPMGMADIAEVLWRKFFKHSPTNPNWNNRDRFILSNGHGSMLLYSLLHLTGY
DLSIDELKKFRQLHSKTPGHPETGETPGVETTTGPLGQGLANAVGMAIAERTLSAYFNRPDYDIVDHYTWVFVGDGCLME
GISHEVCSLAGTLKLGKLIVFYDKNGISIDGKISNWFTDDTVMRFKSYNWHVVDKVDGHDANSIKNSIEEAKSVKDQPSI
IICNTIIGFGSPNKSGTADSHGAPLGEEEIFLTRKNLNWKYSPFEIPNKIYDKWNFVKQGLKLEENWNKQFHLYKSEYPA
LAEEYSRRIKKKLPTQWYKKTKDYIFNLQKNPQNIATRKASQNAIEEFAALLPELIGGSADLSPSNLTMWSKSSSITENL
CGNYIHYGVREFGMTAIANGISHHGGFIPYTSTFLMFVEYARNAVRMAALMNTKHIFVYTHDSIGLGEDGPTHQPIEQLA
NLRMTPNIDVWRPSDQVETAVAWKYAIEEKNGPTALILSRQNLFQFSRNNEQIKNISYGAYILYDSKKPIDIIFISTGSE
LQITLTSAKKIAALGYSVRVVSMPSNNVFDRQNIDYKESILPSYITKRIVIEASIKDFWYKYAGSEGLIIGMETFGESAS
EEVLFKKFGFTVENIVNKSKILLKH

Sequences:

>Translated_665_residues
MCVRRELANAIRMLSIDAVQNAKSGHPGMPMGMADIAEVLWRKFFKHSPTNPNWNNRDRFILSNGHGSMLLYSLLHLTGY
DLSIDELKKFRQLHSKTPGHPETGETPGVETTTGPLGQGLANAVGMAIAERTLSAYFNRPDYDIVDHYTWVFVGDGCLME
GISHEVCSLAGTLKLGKLIVFYDKNGISIDGKISNWFTDDTVMRFKSYNWHVVDKVDGHDANSIKNSIEEAKSVKDQPSI
IICNTIIGFGSPNKSGTADSHGAPLGEEEIFLTRKNLNWKYSPFEIPNKIYDKWNFVKQGLKLEENWNKQFHLYKSEYPA
LAEEYSRRIKKKLPTQWYKKTKDYIFNLQKNPQNIATRKASQNAIEEFAALLPELIGGSADLSPSNLTMWSKSSSITENL
CGNYIHYGVREFGMTAIANGISHHGGFIPYTSTFLMFVEYARNAVRMAALMNTKHIFVYTHDSIGLGEDGPTHQPIEQLA
NLRMTPNIDVWRPSDQVETAVAWKYAIEEKNGPTALILSRQNLFQFSRNNEQIKNISYGAYILYDSKKPIDIIFISTGSE
LQITLTSAKKIAALGYSVRVVSMPSNNVFDRQNIDYKESILPSYITKRIVIEASIKDFWYKYAGSEGLIIGMETFGESAS
EEVLFKKFGFTVENIVNKSKILLKH
>Mature_665_residues
MCVRRELANAIRMLSIDAVQNAKSGHPGMPMGMADIAEVLWRKFFKHSPTNPNWNNRDRFILSNGHGSMLLYSLLHLTGY
DLSIDELKKFRQLHSKTPGHPETGETPGVETTTGPLGQGLANAVGMAIAERTLSAYFNRPDYDIVDHYTWVFVGDGCLME
GISHEVCSLAGTLKLGKLIVFYDKNGISIDGKISNWFTDDTVMRFKSYNWHVVDKVDGHDANSIKNSIEEAKSVKDQPSI
IICNTIIGFGSPNKSGTADSHGAPLGEEEIFLTRKNLNWKYSPFEIPNKIYDKWNFVKQGLKLEENWNKQFHLYKSEYPA
LAEEYSRRIKKKLPTQWYKKTKDYIFNLQKNPQNIATRKASQNAIEEFAALLPELIGGSADLSPSNLTMWSKSSSITENL
CGNYIHYGVREFGMTAIANGISHHGGFIPYTSTFLMFVEYARNAVRMAALMNTKHIFVYTHDSIGLGEDGPTHQPIEQLA
NLRMTPNIDVWRPSDQVETAVAWKYAIEEKNGPTALILSRQNLFQFSRNNEQIKNISYGAYILYDSKKPIDIIFISTGSE
LQITLTSAKKIAALGYSVRVVSMPSNNVFDRQNIDYKESILPSYITKRIVIEASIKDFWYKYAGSEGLIIGMETFGESAS
EEVLFKKFGFTVENIVNKSKILLKH

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family

Homologues:

Organism=Homo sapiens, GI205277463, Length=636, Percent_Identity=26.7295597484277, Blast_Score=162, Evalue=7e-40,
Organism=Homo sapiens, GI4507521, Length=636, Percent_Identity=26.7295597484277, Blast_Score=162, Evalue=7e-40,
Organism=Homo sapiens, GI133778974, Length=589, Percent_Identity=26.8251273344652, Blast_Score=146, Evalue=6e-35,
Organism=Escherichia coli, GI48994911, Length=663, Percent_Identity=67.1191553544495, Blast_Score=991, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=660, Percent_Identity=66.2121212121212, Blast_Score=961, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=582, Percent_Identity=25.7731958762887, Blast_Score=158, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6325331, Length=667, Percent_Identity=46.9265367316342, Blast_Score=587, Evalue=1e-168,
Organism=Saccharomyces cerevisiae, GI6319593, Length=667, Percent_Identity=46.1769115442279, Blast_Score=566, Evalue=1e-162,
Organism=Drosophila melanogaster, GI45551847, Length=686, Percent_Identity=26.530612244898, Blast_Score=175, Evalue=8e-44,
Organism=Drosophila melanogaster, GI45550715, Length=686, Percent_Identity=26.530612244898, Blast_Score=175, Evalue=8e-44,
Organism=Drosophila melanogaster, GI24666278, Length=679, Percent_Identity=24.0058910162003, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24645119, Length=652, Percent_Identity=25.7668711656442, Blast_Score=149, Evalue=7e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TKT_BUCAP (Q8KA26)

Other databases:

- EMBL:   AE013218
- RefSeq:   NP_660445.1
- ProteinModelPortal:   Q8KA26
- SMR:   Q8KA26
- EnsemblBacteria:   EBBUCT00000000534
- GeneID:   1005903
- GenomeReviews:   AE013218_GR
- KEGG:   bas:BUsg086
- GeneTree:   EBGT00050000007698
- HOGENOM:   HBG565885
- OMA:   MAVWRPC
- ProtClustDB:   PRK12753
- BioCyc:   BAPH198804:BUSG086-MONOMER
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- PANTHER:   PTHR11624:SF1
- SMART:   SM00861
- TIGRFAMs:   TIGR00232

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N; SSF52922 Transketo_C_like

EC number: =2.2.1.1

Molecular weight: Translated: 75054; Mature: 75054

Theoretical pI: Translated: 8.38; Mature: 8.38

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCVRRELANAIRMLSIDAVQNAKSGHPGMPMGMADIAEVLWRKFFKHSPTNPNWNNRDRF
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEE
ILSNGHGSMLLYSLLHLTGYDLSIDELKKFRQLHSKTPGHPETGETPGVETTTGPLGQGL
EEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHH
ANAVGMAIAERTLSAYFNRPDYDIVDHYTWVFVGDGCLMEGISHEVCSLAGTLKLGKLIV
HHHHHHHHHHHHHHHHHCCCCCCHHCCEEEEEECCCHHHHCCHHHHHHHHHHHEECCEEE
FYDKNGISIDGKISNWFTDDTVMRFKSYNWHVVDKVDGHDANSIKNSIEEAKSVKDQPSI
EECCCCCEECCCCCCCCCCCHHHEEECCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCE
IICNTIIGFGSPNKSGTADSHGAPLGEEEIFLTRKNLNWKYSPFEIPNKIYDKWNFVKQG
EEEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCCEEECCCCCCHHHHHHHHHHHHC
LKLEENWNKQFHLYKSEYPALAEEYSRRIKKKLPTQWYKKTKDYIFNLQKNPQNIATRKA
CCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHHEEECCCCCHHHHHHHH
SQNAIEEFAALLPELIGGSADLSPSNLTMWSKSSSITENLCGNYIHYGVREFGMTAIANG
HHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ISHHGGFIPYTSTFLMFVEYARNAVRMAALMNTKHIFVYTHDSIGLGEDGPTHQPIEQLA
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCHHHHHHHH
NLRMTPNIDVWRPSDQVETAVAWKYAIEEKNGPTALILSRQNLFQFSRNNEQIKNISYGA
CCCCCCCCCEECCCCHHHHHHHEEEEEECCCCCEEEEEEHHHHHHHHCCCCHHHEEECCE
YILYDSKKPIDIIFISTGSELQITLTSAKKIAALGYSVRVVSMPSNNVFDRQNIDYKESI
EEEECCCCCEEEEEEECCCEEEEEEECCHHHHHCCEEEEEEECCCCCCCCCCCCCHHHHH
LPSYITKRIVIEASIKDFWYKYAGSEGLIIGMETFGESASEEVLFKKFGFTVENIVNKSK
HHHHHHHHEEEEEHHHHHHHHHCCCCCEEEEHHHHCCCCHHHHHHHHHCCCHHHHCCCCC
ILLKH
EEECC
>Mature Secondary Structure
MCVRRELANAIRMLSIDAVQNAKSGHPGMPMGMADIAEVLWRKFFKHSPTNPNWNNRDRF
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEE
ILSNGHGSMLLYSLLHLTGYDLSIDELKKFRQLHSKTPGHPETGETPGVETTTGPLGQGL
EEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHH
ANAVGMAIAERTLSAYFNRPDYDIVDHYTWVFVGDGCLMEGISHEVCSLAGTLKLGKLIV
HHHHHHHHHHHHHHHHHCCCCCCHHCCEEEEEECCCHHHHCCHHHHHHHHHHHEECCEEE
FYDKNGISIDGKISNWFTDDTVMRFKSYNWHVVDKVDGHDANSIKNSIEEAKSVKDQPSI
EECCCCCEECCCCCCCCCCCHHHEEECCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCE
IICNTIIGFGSPNKSGTADSHGAPLGEEEIFLTRKNLNWKYSPFEIPNKIYDKWNFVKQG
EEEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCCEEECCCCCCHHHHHHHHHHHHC
LKLEENWNKQFHLYKSEYPALAEEYSRRIKKKLPTQWYKKTKDYIFNLQKNPQNIATRKA
CCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHHEEECCCCCHHHHHHHH
SQNAIEEFAALLPELIGGSADLSPSNLTMWSKSSSITENLCGNYIHYGVREFGMTAIANG
HHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ISHHGGFIPYTSTFLMFVEYARNAVRMAALMNTKHIFVYTHDSIGLGEDGPTHQPIEQLA
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCHHHHHHHH
NLRMTPNIDVWRPSDQVETAVAWKYAIEEKNGPTALILSRQNLFQFSRNNEQIKNISYGA
CCCCCCCCCEECCCCHHHHHHHEEEEEECCCCCEEEEEEHHHHHHHHCCCCHHHEEECCE
YILYDSKKPIDIIFISTGSELQITLTSAKKIAALGYSVRVVSMPSNNVFDRQNIDYKESI
EEEECCCCCEEEEEEECCCEEEEEEECCHHHHHCCEEEEEEECCCCCCCCCCCCCHHHHH
LPSYITKRIVIEASIKDFWYKYAGSEGLIIGMETFGESASEEVLFKKFGFTVENIVNKSK
HHHHHHHHEEEEEHHHHHHHHHCCCCCEEEEHHHHCCCCHHHHHHHHHCCCHHHHCCCCC
ILLKH
EEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12089438