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The map label for this gene is panF [H]

Identifier: 30263500

GI number: 30263500

Start: 3316282

End: 3317721

Strand: Reverse

Name: panF [H]

Synonym: BA_3607

Alternate gene names: 30263500

Gene position: 3317721-3316282 (Counterclockwise)

Preceding gene: 30263501

Following gene: 30263499

Centisome position: 63.47

GC content: 36.74

Gene sequence:

>1440_bases
ATGAATTGGTATGTAATCATTCCAATGATAATTTCGTTTATCGTTGTATTTTTAATTGGTGTATATGCTTCAAGACGTGT
ACAAGCAACCGCACCTAATAAATTTTTACAAGAATATTTTTTAGGTGGGCGTGAGCTTGGTGGTTTATTATTAGCGATGA
CAATGATTGCTACATACGGTAGTGCTAGTAGCTTTATTGGTGGTCCTGGTATTGCTTACAATATGGGGCTTGGATGGGTA
TTGTTGTCTGCGATTCAAGTTGTAACAGGATATATCGTTTTAACGGTTATCGGTAAAAAGTTTGCAATTATCGCTAGGAA
GATGGAAGCTATTACTCTTATTGATTATTTAAAGGGAAGATACAATAATAAAGCAGTTGTTATACTTTCTGCGGTATGTA
TTATTATCTTTTTATTTTCAGCAACAGTAGCTCAGTGGGTCGGCGGTGGTCGATTAATTGAGTCACTAACGGGTCTCTCT
TATACAACAGCATTATTTTTATTTACTTTTTCTGTACTTGTGTACGTATTAATTGGTGGATTTCGTGCAGTTGCTTTATC
AGATACGTTATTAGGTATCATTATGTTAGTTGGAACGACAATCATTTTAATTGCTACTGTCATTGCCGGTGGTGGAATTG
AAAAGATTATGCAGGAACTTGTTCAAATCAATCCGAATTTAATTACACCATTTGGAGCGGATGGTAGTTTAACCAAATCA
TATGTGACATCATTTTGGATTTTAATTGGAATTGGCGTTGTCGGTTTACCGCAAATTAGTGTGCGCGCCATGTCTTATAA
AAATTCAAAAGCGATGCATCAAGCGTTAATAATTGGGACGATTGTTGTCGGTACAATTATGATTGGTATGCATTTAACGG
GTGTATTTGCACGAGTCGTACTTCCGGGTATAGCGGTACCAGACAAAGTAATGCCGCTACTCGCAATGGAAGTGTTACCT
CCTTGGTTAGCTGGAGTTTTCTTAGCTGCACCGATGGCGGCAATTATGTCTACAGTAAACTCGCTATTATTACTTGTAAG
TTCATCAATCATTAAAGATATATACGTAAATTACATAAATAAAGATGCGGCAGACAGTACGATTAGAAAAGGAAGTTTAT
GGATTACTGCTATCGTAGGATTGCTCGTTTATGCAGCAGCAATTAAACCACCAGATTTTTTAATATGGTTAAATTTATTT
TCTTTCGGTGGATTAGAAGCAGCATTCATTTGGCCGATTGTATTAGGGTTATATTGGAGGAAAGGAAATGCAACAGGAGC
GCTTGCCTCCATTTTAGTTGGAGTAAGCTCATATATGTGCATTCATCTTTTCTATCCAAATCCGTTCGGTATACATACAG
TTGTCTTCCCGATTTGTTTTGCGTTTATCGCTTATATCTTAGGAAGCATGGTTGCTGTGAAGAAAAACAGTATAGGTTAG

Upstream 100 bases:

>100_bases
CGTTGGATTTATCGTTATGGTTATTTTACTTAGTTTAGTTGTTCGTTTTATATTTCAAGATATTTCACTCGATGAGGAAG
AAAAAAGTGAGGAATAATAG

Downstream 100 bases:

>100_bases
ATGAAAAACGTAGTCCTTACAGGACTGCGTTTTTTCGTATAAATTTGTTCTTTTTATTCTGTAATCCTGTGAATATTCAT
AAATTAATAACAATTGAGGG

Product: sodium/panthothenate symporter

Products: Na (I) [Cytoplasm]; pantothenate [Cytoplasm] [C]

Alternate protein names: Pantothenate permease [H]

Number of amino acids: Translated: 479; Mature: 479

Protein sequence:

>479_residues
MNWYVIIPMIISFIVVFLIGVYASRRVQATAPNKFLQEYFLGGRELGGLLLAMTMIATYGSASSFIGGPGIAYNMGLGWV
LLSAIQVVTGYIVLTVIGKKFAIIARKMEAITLIDYLKGRYNNKAVVILSAVCIIIFLFSATVAQWVGGGRLIESLTGLS
YTTALFLFTFSVLVYVLIGGFRAVALSDTLLGIIMLVGTTIILIATVIAGGGIEKIMQELVQINPNLITPFGADGSLTKS
YVTSFWILIGIGVVGLPQISVRAMSYKNSKAMHQALIIGTIVVGTIMIGMHLTGVFARVVLPGIAVPDKVMPLLAMEVLP
PWLAGVFLAAPMAAIMSTVNSLLLLVSSSIIKDIYVNYINKDAADSTIRKGSLWITAIVGLLVYAAAIKPPDFLIWLNLF
SFGGLEAAFIWPIVLGLYWRKGNATGALASILVGVSSYMCIHLFYPNPFGIHTVVFPICFAFIAYILGSMVAVKKNSIG

Sequences:

>Translated_479_residues
MNWYVIIPMIISFIVVFLIGVYASRRVQATAPNKFLQEYFLGGRELGGLLLAMTMIATYGSASSFIGGPGIAYNMGLGWV
LLSAIQVVTGYIVLTVIGKKFAIIARKMEAITLIDYLKGRYNNKAVVILSAVCIIIFLFSATVAQWVGGGRLIESLTGLS
YTTALFLFTFSVLVYVLIGGFRAVALSDTLLGIIMLVGTTIILIATVIAGGGIEKIMQELVQINPNLITPFGADGSLTKS
YVTSFWILIGIGVVGLPQISVRAMSYKNSKAMHQALIIGTIVVGTIMIGMHLTGVFARVVLPGIAVPDKVMPLLAMEVLP
PWLAGVFLAAPMAAIMSTVNSLLLLVSSSIIKDIYVNYINKDAADSTIRKGSLWITAIVGLLVYAAAIKPPDFLIWLNLF
SFGGLEAAFIWPIVLGLYWRKGNATGALASILVGVSSYMCIHLFYPNPFGIHTVVFPICFAFIAYILGSMVAVKKNSIG
>Mature_479_residues
MNWYVIIPMIISFIVVFLIGVYASRRVQATAPNKFLQEYFLGGRELGGLLLAMTMIATYGSASSFIGGPGIAYNMGLGWV
LLSAIQVVTGYIVLTVIGKKFAIIARKMEAITLIDYLKGRYNNKAVVILSAVCIIIFLFSATVAQWVGGGRLIESLTGLS
YTTALFLFTFSVLVYVLIGGFRAVALSDTLLGIIMLVGTTIILIATVIAGGGIEKIMQELVQINPNLITPFGADGSLTKS
YVTSFWILIGIGVVGLPQISVRAMSYKNSKAMHQALIIGTIVVGTIMIGMHLTGVFARVVLPGIAVPDKVMPLLAMEVLP
PWLAGVFLAAPMAAIMSTVNSLLLLVSSSIIKDIYVNYINKDAADSTIRKGSLWITAIVGLLVYAAAIKPPDFLIWLNLF
SFGGLEAAFIWPIVLGLYWRKGNATGALASILVGVSSYMCIHLFYPNPFGIHTVVFPICFAFIAYILGSMVAVKKNSIG

Specific function: Catalyzes the sodium-dependent uptake of extracellular pantothenate [H]

COG id: COG4145

COG function: function code H; Na+/panthothenate symporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=447, Percent_Identity=28.4116331096197, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI157671931, Length=382, Percent_Identity=21.7277486910995, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI14140236, Length=403, Percent_Identity=23.0769230769231, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI4507035, Length=342, Percent_Identity=23.6842105263158, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI167466278, Length=357, Percent_Identity=22.1288515406162, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI4507031, Length=473, Percent_Identity=23.0443974630021, Blast_Score=65, Evalue=1e-10,
Organism=Escherichia coli, GI87082237, Length=470, Percent_Identity=47.8723404255319, Blast_Score=431, Evalue=1e-122,
Organism=Escherichia coli, GI1787251, Length=448, Percent_Identity=28.5714285714286, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1790503, Length=452, Percent_Identity=24.3362831858407, Blast_Score=85, Evalue=9e-18,
Organism=Escherichia coli, GI1790113, Length=474, Percent_Identity=24.2616033755274, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI115533094, Length=470, Percent_Identity=21.2765957446809, Blast_Score=65, Evalue=9e-11,
Organism=Drosophila melanogaster, GI28573698, Length=388, Percent_Identity=23.1958762886598, Blast_Score=72, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011849
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 51449; Mature: 51449

Theoretical pI: Translated: 9.88; Mature: 9.88

Prosite motif: PS00456 NA_SOLUT_SYMP_1 ; PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNWYVIIPMIISFIVVFLIGVYASRRVQATAPNKFLQEYFLGGRELGGLLLAMTMIATYG
CCEEEEHHHHHHHHHHHHHHHHHCCCEECCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCC
SASSFIGGPGIAYNMGLGWVLLSAIQVVTGYIVLTVIGKKFAIIARKMEAITLIDYLKGR
CCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
YNNKAVVILSAVCIIIFLFSATVAQWVGGGRLIESLTGLSYTTALFLFTFSVLVYVLIGG
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
FRAVALSDTLLGIIMLVGTTIILIATVIAGGGIEKIMQELVQINPNLITPFGADGSLTKS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEECCCCCCCCHHHH
YVTSFWILIGIGVVGLPQISVRAMSYKNSKAMHQALIIGTIVVGTIMIGMHLTGVFARVV
HHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LPGIAVPDKVMPLLAMEVLPPWLAGVFLAAPMAAIMSTVNSLLLLVSSSIIKDIYVNYIN
HCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
KDAADSTIRKGSLWITAIVGLLVYAAAIKPPDFLIWLNLFSFGGLEAAFIWPIVLGLYWR
CCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHC
KGNATGALASILVGVSSYMCIHLFYPNPFGIHTVVFPICFAFIAYILGSMVAVKKNSIG
CCCCHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNWYVIIPMIISFIVVFLIGVYASRRVQATAPNKFLQEYFLGGRELGGLLLAMTMIATYG
CCEEEEHHHHHHHHHHHHHHHHHCCCEECCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCC
SASSFIGGPGIAYNMGLGWVLLSAIQVVTGYIVLTVIGKKFAIIARKMEAITLIDYLKGR
CCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
YNNKAVVILSAVCIIIFLFSATVAQWVGGGRLIESLTGLSYTTALFLFTFSVLVYVLIGG
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
FRAVALSDTLLGIIMLVGTTIILIATVIAGGGIEKIMQELVQINPNLITPFGADGSLTKS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEECCCCCCCCHHHH
YVTSFWILIGIGVVGLPQISVRAMSYKNSKAMHQALIIGTIVVGTIMIGMHLTGVFARVV
HHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LPGIAVPDKVMPLLAMEVLPPWLAGVFLAAPMAAIMSTVNSLLLLVSSSIIKDIYVNYIN
HCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
KDAADSTIRKGSLWITAIVGLLVYAAAIKPPDFLIWLNLFSFGGLEAAFIWPIVLGLYWR
CCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHC
KGNATGALASILVGVSSYMCIHLFYPNPFGIHTVVFPICFAFIAYILGSMVAVKKNSIG
CCCCHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Periplasm]; pantothenate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + pantothenate [Periplasm] = Na (I) [Cytoplasm] + pantothenate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2193919; 9278503; 8226664 [H]