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The map label for this gene is mtlD [H]

Identifier: 21244949

GI number: 21244949

Start: 4997270

End: 4998742

Strand: Direct

Name: mtlD [H]

Synonym: XAC4232

Alternate gene names: 21244949

Gene position: 4997270-4998742 (Clockwise)

Preceding gene: 21244948

Following gene: 21244952

Centisome position: 96.56

GC content: 66.26

Gene sequence:

>1473_bases
ATGCACGCACCACGTCTTTCGCTCGACACCCTCGGCACATTGCCGCCGGTGGTTGCAAGGCCCAGCTATGACCTGGCAAG
CACCACCATCGGCATCGTGCATCTCGGCGCAGGCGCCTTCCACCGTGCTCACCAGGCCGTCTATATCGACGACCTGCTTG
CCGAAGACCCCAGCTGGGCCATCAGCGCCGTCTCGCTGCATCGCCCGCAGGTGCGCGATGCCTTACGTCCGCAAGAGGGC
CTGTACACCCTCGCCCTGCTCGACGAACACCCGCAACTGCGCGTCATCGGGGCCATCGGCGAGGTGCTCTGCGCCGCAGA
CGAACACGCTGCCGTGCTCGCGCGCCTTGCCGACCCGGCAGTACGCCTGGTCACGCTGACCATCACCGAGAAAGGCTATT
GCCTGGCCGGCGACACGCTCGACCTCTCGCATCCGGACATCGCGCACGATATCGCCCATCCCGCAACTCCACAGAGCGCC
ATCGGCTACCTCGTGGCCGGGCTGCGGCAGCGCATGCACAACGGCACCGCGCCGTTCACTGCGCTGAGCTGCGACAACCT
CACCGACAACGGCACGCTGCTGCAGCGCGCGGTTGTGCGGCTCGCAGCGCAGGTCGACCCGGCGCTTGCGGAATGGATCG
CGCAGCACGCCGCCTTCCCGCGCTCGATGGTCGACAGCATCACGCCCGCCACCGATGATGCGCTGCGCGCGCGCATCCAC
GATCAGCTTGGCGTGCACGATGCCTGGCCGATCCAGCGCGAGCGCTACAGCCAGTGGGTGATCGAAGACCGTTTCTGCAA
TGGTCGCCCTGCATTCGAGCGCGCAGGCGTCACCCTGAGCGAAGACATCGCCGGCTACGCGCGCGCCAAACTGCGTCTGC
TCAACGCGCCGCACTCGGCGCTGGCGTATCTCGGCAGCCTGCTGAACCTGGACACCGTGGCCGACGCCATGCGTCACCGC
GAACTTGCCGCGTACGTGCAAACATTGATGCGCGCGGAGATTGCACCCACCTTGCAGACCATGGACGGCTTTGATGCGCA
AGGCTACAGCGACGCCATCCTTGCCCGTTTTCGCAATCCCGCCATCCGCCACCTGCTCGCCCAGATCGCCTGGGACGGCT
CGCTGAAAATTCCGGTGCGACTGCTCGGCACGATCGGCGATGCACTCGCTACCGGCCAACCGATCCGGCACCTATGCCTG
GCCGTTGCCGCGTGGCTGCACTTCGTCCGCAGGCAGGCGCACAACGGCGTTCCGCTGACCGACCCGATGAACGATGCCCT
CGGTGCGCATGGTCGCAATGCGACGGGCGATGCCGGTCATGATGTTGCCGCCTTCCTGACACTGGAGGCGGTGTTCGGAT
CGTTGTCCGCAGACGCGCGTTTTTGTGCGTCCTTGCAGGCGGCTTATGCAGCGCTTGGCACGGCCACCCCGACTGACGTG
ACACACGCCCTTGGGTCGATGGGTGAGGTGTAA

Upstream 100 bases:

>100_bases
CTGCGATTGCTTCAAAACCCCCTCTCCTCCCGGGAGAGGGTTTGGGGTAAGGGTTCGGCGTAGCCCCTCCTCCAAACACC
CCTACCTCGCAGGCGACACG

Downstream 100 bases:

>100_bases
GACGGTGCACAGCGCCATGCATTGCGCGGGCGGGCGCCATCAGGTCGGTGAGCAGCGCAGTCGCCTTGCTCATGCAATGC
ATCACCCTGACGCGATCACC

Product: mannitol dehydrogenase

Products: NA

Alternate protein names: Fructuronate reductase [H]

Number of amino acids: Translated: 490; Mature: 490

Protein sequence:

>490_residues
MHAPRLSLDTLGTLPPVVARPSYDLASTTIGIVHLGAGAFHRAHQAVYIDDLLAEDPSWAISAVSLHRPQVRDALRPQEG
LYTLALLDEHPQLRVIGAIGEVLCAADEHAAVLARLADPAVRLVTLTITEKGYCLAGDTLDLSHPDIAHDIAHPATPQSA
IGYLVAGLRQRMHNGTAPFTALSCDNLTDNGTLLQRAVVRLAAQVDPALAEWIAQHAAFPRSMVDSITPATDDALRARIH
DQLGVHDAWPIQRERYSQWVIEDRFCNGRPAFERAGVTLSEDIAGYARAKLRLLNAPHSALAYLGSLLNLDTVADAMRHR
ELAAYVQTLMRAEIAPTLQTMDGFDAQGYSDAILARFRNPAIRHLLAQIAWDGSLKIPVRLLGTIGDALATGQPIRHLCL
AVAAWLHFVRRQAHNGVPLTDPMNDALGAHGRNATGDAGHDVAAFLTLEAVFGSLSADARFCASLQAAYAALGTATPTDV
THALGSMGEV

Sequences:

>Translated_490_residues
MHAPRLSLDTLGTLPPVVARPSYDLASTTIGIVHLGAGAFHRAHQAVYIDDLLAEDPSWAISAVSLHRPQVRDALRPQEG
LYTLALLDEHPQLRVIGAIGEVLCAADEHAAVLARLADPAVRLVTLTITEKGYCLAGDTLDLSHPDIAHDIAHPATPQSA
IGYLVAGLRQRMHNGTAPFTALSCDNLTDNGTLLQRAVVRLAAQVDPALAEWIAQHAAFPRSMVDSITPATDDALRARIH
DQLGVHDAWPIQRERYSQWVIEDRFCNGRPAFERAGVTLSEDIAGYARAKLRLLNAPHSALAYLGSLLNLDTVADAMRHR
ELAAYVQTLMRAEIAPTLQTMDGFDAQGYSDAILARFRNPAIRHLLAQIAWDGSLKIPVRLLGTIGDALATGQPIRHLCL
AVAAWLHFVRRQAHNGVPLTDPMNDALGAHGRNATGDAGHDVAAFLTLEAVFGSLSADARFCASLQAAYAALGTATPTDV
THALGSMGEV
>Mature_490_residues
MHAPRLSLDTLGTLPPVVARPSYDLASTTIGIVHLGAGAFHRAHQAVYIDDLLAEDPSWAISAVSLHRPQVRDALRPQEG
LYTLALLDEHPQLRVIGAIGEVLCAADEHAAVLARLADPAVRLVTLTITEKGYCLAGDTLDLSHPDIAHDIAHPATPQSA
IGYLVAGLRQRMHNGTAPFTALSCDNLTDNGTLLQRAVVRLAAQVDPALAEWIAQHAAFPRSMVDSITPATDDALRARIH
DQLGVHDAWPIQRERYSQWVIEDRFCNGRPAFERAGVTLSEDIAGYARAKLRLLNAPHSALAYLGSLLNLDTVADAMRHR
ELAAYVQTLMRAEIAPTLQTMDGFDAQGYSDAILARFRNPAIRHLLAQIAWDGSLKIPVRLLGTIGDALATGQPIRHLCL
AVAAWLHFVRRQAHNGVPLTDPMNDALGAHGRNATGDAGHDVAAFLTLEAVFGSLSADARFCASLQAAYAALGTATPTDV
THALGSMGEV

Specific function: Hexuronate conversion to KDG. [C]

COG id: COG0246

COG function: function code G; Mannitol-1-phosphate/altronate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannitol dehydrogenase family. UxuB subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790779, Length=466, Percent_Identity=41.2017167381974, Blast_Score=320, Evalue=2e-88,
Organism=Escherichia coli, GI1788497, Length=469, Percent_Identity=41.36460554371, Blast_Score=317, Evalue=1e-87,
Organism=Escherichia coli, GI1787823, Length=464, Percent_Identity=39.2241379310345, Blast_Score=283, Evalue=2e-77,
Organism=Escherichia coli, GI48994885, Length=414, Percent_Identity=27.7777777777778, Blast_Score=111, Evalue=8e-26,
Organism=Escherichia coli, GI1790028, Length=386, Percent_Identity=24.6113989637306, Blast_Score=89, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6324401, Length=475, Percent_Identity=34.9473684210526, Blast_Score=281, Evalue=2e-76,
Organism=Saccharomyces cerevisiae, GI6320765, Length=475, Percent_Identity=34.9473684210526, Blast_Score=281, Evalue=2e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR000669
- InterPro:   IPR013118
- InterPro:   IPR023027
- InterPro:   IPR013131
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01232 Mannitol_dh; PF08125 Mannitol_dh_C [H]

EC number: =1.1.1.57 [H]

Molecular weight: Translated: 52583; Mature: 52583

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHAPRLSLDTLGTLPPVVARPSYDLASTTIGIVHLGAGAFHRAHQAVYIDDLLAEDPSWA
CCCCCCCHHHHCCCCCCCCCCCCCHHHHHEEHEEECCHHHHHHHHHHHHHHHHCCCCCCE
ISAVSLHRPQVRDALRPQEGLYTLALLDEHPQLRVIGAIGEVLCAADEHAAVLARLADPA
EEHHHHCCHHHHHHCCCCCCCEEEEEECCCCCEEEHHHHHHHHHCCCHHHHHHHHHCCCC
VRLVTLTITEKGYCLAGDTLDLSHPDIAHDIAHPATPQSAIGYLVAGLRQRMHNGTAPFT
EEEEEEEEECCCEEEECCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCEE
ALSCDNLTDNGTLLQRAVVRLAAQVDPALAEWIAQHAAFPRSMVDSITPATDDALRARIH
EEECCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHH
DQLGVHDAWPIQRERYSQWVIEDRFCNGRPAFERAGVTLSEDIAGYARAKLRLLNAPHSA
HHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHCCCHHH
LAYLGSLLNLDTVADAMRHRELAAYVQTLMRAEIAPTLQTMDGFDAQGYSDAILARFRNP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCH
AIRHLLAQIAWDGSLKIPVRLLGTIGDALATGQPIRHLCLAVAAWLHFVRRQAHNGVPLT
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
DPMNDALGAHGRNATGDAGHDVAAFLTLEAVFGSLSADARFCASLQAAYAALGTATPTDV
CCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHH
THALGSMGEV
HHHHHCCCCC
>Mature Secondary Structure
MHAPRLSLDTLGTLPPVVARPSYDLASTTIGIVHLGAGAFHRAHQAVYIDDLLAEDPSWA
CCCCCCCHHHHCCCCCCCCCCCCCHHHHHEEHEEECCHHHHHHHHHHHHHHHHCCCCCCE
ISAVSLHRPQVRDALRPQEGLYTLALLDEHPQLRVIGAIGEVLCAADEHAAVLARLADPA
EEHHHHCCHHHHHHCCCCCCCEEEEEECCCCCEEEHHHHHHHHHCCCHHHHHHHHHCCCC
VRLVTLTITEKGYCLAGDTLDLSHPDIAHDIAHPATPQSAIGYLVAGLRQRMHNGTAPFT
EEEEEEEEECCCEEEECCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCEE
ALSCDNLTDNGTLLQRAVVRLAAQVDPALAEWIAQHAAFPRSMVDSITPATDDALRARIH
EEECCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHH
DQLGVHDAWPIQRERYSQWVIEDRFCNGRPAFERAGVTLSEDIAGYARAKLRLLNAPHSA
HHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHCCCHHH
LAYLGSLLNLDTVADAMRHRELAAYVQTLMRAEIAPTLQTMDGFDAQGYSDAILARFRNP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCH
AIRHLLAQIAWDGSLKIPVRLLGTIGDALATGQPIRHLCLAVAAWLHFVRRQAHNGVPLT
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
DPMNDALGAHGRNATGDAGHDVAAFLTLEAVFGSLSADARFCASLQAAYAALGTATPTDV
CCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHH
THALGSMGEV
HHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7610040; 9278503 [H]