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The map label for this gene is ggt [H]

Identifier: 21244175

GI number: 21244175

Start: 4069823

End: 4071532

Strand: Reverse

Name: ggt [H]

Synonym: XAC3450

Alternate gene names: 21244175

Gene position: 4071532-4069823 (Counterclockwise)

Preceding gene: 21244181

Following gene: 21244174

Centisome position: 78.67

GC content: 65.15

Gene sequence:

>1710_bases
ATGCGTCGCGTACCTGTGTTGTTGGTGTCTGCTCTGGCGCTGCTCGCGCCGCCTCTCGGCGCTGCCGACCGCGTCACCGG
GCAGCCGTTTGCCACCCGCTCGGAAGTCATTGCGCCGCATGCCATGGCCGCGACTTCGCAACCGCTGGCCACCCAGATCG
CGCTGGATGTGATGAAGGACGGCGGCTCGGCGGTGGATGCAGCGATCGCGGCCAATGCGGCGCTGGGCCTGATGGAGCCG
ACCGGCAATGGCGTGGGAGGGGACCTGTTTGCGATCGTCTGGGACCCCAAGACCCACAAGCTCTACGGTTACAACGGCTC
CGGCCGCTCGCCCAAATCGCTGACCCTGGCCGAGTTCCAGCGCCGTGGCTTGAAGGACATTCCGCCGACCGGCCCGTTGC
CGGTATCGGTGCCGGGTGCGGTGGACGGCTGGTTCGCGCTGCACGCGCGCTTCGGGCGCAAGCCGATGGCACAGAACCTG
GCGCCAGCGATCCGCTACGCGCGCGAAGGCCATCCGGTCGCCGAGACCATCGCCTATTACTGGGACCGTTCGGTGCCGCG
CTTGTCGCAATACCCCGGTTTCAAGGAGCAATTCACCATCGACGGCCACGCCCCGCGCAAGGGCGAGCTGTGGAAGAACC
CGAACCTGGCCAACACGCTGCAGCAGATTGCCGACGGCGGTCGCGATGCGTTCTACAAGGGCGACATCGCCCGTACCATC
GGTGCCTACTTCAAGGCCAATGGCGGCTACCTCAGCTATGAGGACCTGGCCAGTCATACGGGCGAGTGGGTCGAACCGGT
GTCCACCAACTACCGTGGCGTTGATGTGTGGGAGCTGCCGCCCAACAGCCAGGGCATCGCCGCGTTGCAGATGCTCAACA
TCCTCGAAGGCTACGACTTCTCCAAGATTCCGTTCGGCTCGGCTGAGCACGTGCACTTGTTCACCGAGGCCAAGAAGCTG
GCGTTCGCCGACCGCGCGCGCTTCTACGCCGACCCGGCGTTTCAGCCGGCACCGCTGGCCAAGTTGATCTCCAAGGACTA
CGCCAACCGGCGGCGCGCGCTGATTTCGATGGACAAGGCACTCAAGGAAGTACAGCCGGGGACACCCAAGCAGCTGGAAG
AAGGCGACACCATCTACATGACCGTGGCCGATGCCGACGGCATGATGGTCTCGCTGATCCAGTCCAACTATCGCGGCATG
GGCAGTGGCATGGCGCCGCCGGGGCTGGGTTTCATCCTGCAGGACCGCGGCGAGATGTTCGTGCTGAAGAAGGATCATCT
TAACGGCTATGCGCCGGGCAAGCGGCCGTTTCAGACCATCATCCCGGCCTTCGTCACCAAGGACGGCAAGCCCTGGCTGA
GCTTCGGCGTGATGGGCGGGGCGATGCAGCCGCAGGGGCATGTGCAGATCGTGATGAACCTGGTGGACTTCCACATGAAC
CTGCAGGAAGCCGGCGACGCGCCGCGCATCCAGCATGAAGGGTCCACCGAACCGACCGGGCAGGCCACCGCGATGAGCGA
TGGCGGCGAGGTCAATCTGGAAACCGGCTTCTCCTACGACACCATCCGCGCGCTGATGCGCAAAGGCCATCGGGTGATCT
TTGCCGACGGCCCGTACGGTGGGTATCAGGCCATCGCCCGCGACCCGGTCAGCGGCGTGTACTACGGTGCTTCGGAAAGC
CGCAAGGACGGCCAGGCGGCCGGATACTGA

Upstream 100 bases:

>100_bases
GCGCGGTATTGAGCGCGCTGGCAAGTGTCGATTGGACGGCAGGGCACAGCCCGCTGGTATGGTTGGCACCTCATTCTCAG
TGTCTTAGGGGCCATCGGTG

Downstream 100 bases:

>100_bases
GCGCGCCGGCGCGCCGGCCCGCGCCTCAATTCCCCGCGCAGCGCGCCGATAATCACCGGATGGAGCAGGAGCCCCTCATG
AATTCGATGCAACAGCCCGA

Product: gamma-glutamyltranspeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 569; Mature: 569

Protein sequence:

>569_residues
MRRVPVLLVSALALLAPPLGAADRVTGQPFATRSEVIAPHAMAATSQPLATQIALDVMKDGGSAVDAAIAANAALGLMEP
TGNGVGGDLFAIVWDPKTHKLYGYNGSGRSPKSLTLAEFQRRGLKDIPPTGPLPVSVPGAVDGWFALHARFGRKPMAQNL
APAIRYAREGHPVAETIAYYWDRSVPRLSQYPGFKEQFTIDGHAPRKGELWKNPNLANTLQQIADGGRDAFYKGDIARTI
GAYFKANGGYLSYEDLASHTGEWVEPVSTNYRGVDVWELPPNSQGIAALQMLNILEGYDFSKIPFGSAEHVHLFTEAKKL
AFADRARFYADPAFQPAPLAKLISKDYANRRRALISMDKALKEVQPGTPKQLEEGDTIYMTVADADGMMVSLIQSNYRGM
GSGMAPPGLGFILQDRGEMFVLKKDHLNGYAPGKRPFQTIIPAFVTKDGKPWLSFGVMGGAMQPQGHVQIVMNLVDFHMN
LQEAGDAPRIQHEGSTEPTGQATAMSDGGEVNLETGFSYDTIRALMRKGHRVIFADGPYGGYQAIARDPVSGVYYGASES
RKDGQAAGY

Sequences:

>Translated_569_residues
MRRVPVLLVSALALLAPPLGAADRVTGQPFATRSEVIAPHAMAATSQPLATQIALDVMKDGGSAVDAAIAANAALGLMEP
TGNGVGGDLFAIVWDPKTHKLYGYNGSGRSPKSLTLAEFQRRGLKDIPPTGPLPVSVPGAVDGWFALHARFGRKPMAQNL
APAIRYAREGHPVAETIAYYWDRSVPRLSQYPGFKEQFTIDGHAPRKGELWKNPNLANTLQQIADGGRDAFYKGDIARTI
GAYFKANGGYLSYEDLASHTGEWVEPVSTNYRGVDVWELPPNSQGIAALQMLNILEGYDFSKIPFGSAEHVHLFTEAKKL
AFADRARFYADPAFQPAPLAKLISKDYANRRRALISMDKALKEVQPGTPKQLEEGDTIYMTVADADGMMVSLIQSNYRGM
GSGMAPPGLGFILQDRGEMFVLKKDHLNGYAPGKRPFQTIIPAFVTKDGKPWLSFGVMGGAMQPQGHVQIVMNLVDFHMN
LQEAGDAPRIQHEGSTEPTGQATAMSDGGEVNLETGFSYDTIRALMRKGHRVIFADGPYGGYQAIARDPVSGVYYGASES
RKDGQAAGY
>Mature_569_residues
MRRVPVLLVSALALLAPPLGAADRVTGQPFATRSEVIAPHAMAATSQPLATQIALDVMKDGGSAVDAAIAANAALGLMEP
TGNGVGGDLFAIVWDPKTHKLYGYNGSGRSPKSLTLAEFQRRGLKDIPPTGPLPVSVPGAVDGWFALHARFGRKPMAQNL
APAIRYAREGHPVAETIAYYWDRSVPRLSQYPGFKEQFTIDGHAPRKGELWKNPNLANTLQQIADGGRDAFYKGDIARTI
GAYFKANGGYLSYEDLASHTGEWVEPVSTNYRGVDVWELPPNSQGIAALQMLNILEGYDFSKIPFGSAEHVHLFTEAKKL
AFADRARFYADPAFQPAPLAKLISKDYANRRRALISMDKALKEVQPGTPKQLEEGDTIYMTVADADGMMVSLIQSNYRGM
GSGMAPPGLGFILQDRGEMFVLKKDHLNGYAPGKRPFQTIIPAFVTKDGKPWLSFGVMGGAMQPQGHVQIVMNLVDFHMN
LQEAGDAPRIQHEGSTEPTGQATAMSDGGEVNLETGFSYDTIRALMRKGHRVIFADGPYGGYQAIARDPVSGVYYGASES
RKDGQAAGY

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=543, Percent_Identity=29.8342541436464, Blast_Score=179, Evalue=5e-45,
Organism=Homo sapiens, GI73915090, Length=543, Percent_Identity=29.8342541436464, Blast_Score=179, Evalue=5e-45,
Organism=Homo sapiens, GI73915096, Length=543, Percent_Identity=29.8342541436464, Blast_Score=179, Evalue=5e-45,
Organism=Homo sapiens, GI73915094, Length=543, Percent_Identity=29.8342541436464, Blast_Score=179, Evalue=5e-45,
Organism=Homo sapiens, GI113429324, Length=549, Percent_Identity=28.0510018214936, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI113429326, Length=554, Percent_Identity=27.9783393501805, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI109148539, Length=506, Percent_Identity=27.0750988142292, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI153266885, Length=560, Percent_Identity=25.1785714285714, Blast_Score=122, Evalue=1e-27,
Organism=Homo sapiens, GI153266901, Length=561, Percent_Identity=25.1336898395722, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI153266907, Length=560, Percent_Identity=24.1071428571429, Blast_Score=110, Evalue=5e-24,
Organism=Escherichia coli, GI1789856, Length=555, Percent_Identity=32.972972972973, Blast_Score=258, Evalue=7e-70,
Organism=Caenorhabditis elegans, GI193208245, Length=499, Percent_Identity=23.2464929859719, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI193208247, Length=499, Percent_Identity=23.2464929859719, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17506189, Length=485, Percent_Identity=24.1237113402062, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI72000294, Length=474, Percent_Identity=24.0506329113924, Blast_Score=111, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI212646519, Length=476, Percent_Identity=24.3697478991597, Blast_Score=111, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17542894, Length=485, Percent_Identity=25.979381443299, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI45551474, Length=550, Percent_Identity=26.1818181818182, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI24642670, Length=550, Percent_Identity=26.1818181818182, Blast_Score=166, Evalue=4e-41,
Organism=Drosophila melanogaster, GI24642666, Length=550, Percent_Identity=26.1818181818182, Blast_Score=166, Evalue=4e-41,
Organism=Drosophila melanogaster, GI161077878, Length=550, Percent_Identity=26.1818181818182, Blast_Score=166, Evalue=4e-41,
Organism=Drosophila melanogaster, GI161077880, Length=550, Percent_Identity=26.1818181818182, Blast_Score=166, Evalue=4e-41,
Organism=Drosophila melanogaster, GI18859893, Length=463, Percent_Identity=26.9978401727862, Blast_Score=129, Evalue=5e-30,
Organism=Drosophila melanogaster, GI161077496, Length=509, Percent_Identity=25.3438113948919, Blast_Score=125, Evalue=1e-28,
Organism=Drosophila melanogaster, GI18859741, Length=482, Percent_Identity=25.5186721991701, Blast_Score=111, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 61546; Mature: 61546

Theoretical pI: Translated: 7.99; Mature: 7.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRVPVLLVSALALLAPPLGAADRVTGQPFATRSEVIAPHAMAATSQPLATQIALDVMKD
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHCCCHHHHHCCCCHHHHHHHHHHHC
GGSAVDAAIAANAALGLMEPTGNGVGGDLFAIVWDPKTHKLYGYNGSGRSPKSLTLAEFQ
CCCHHHHHHHHHHHHEEECCCCCCCCCCEEEEEECCCCCEEEEECCCCCCCCCCHHHHHH
RRGLKDIPPTGPLPVSVPGAVDGWFALHARFGRKPMAQNLAPAIRYAREGHPVAETIAYY
HCCCCCCCCCCCCCEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHH
WDRSVPRLSQYPGFKEQFTIDGHAPRKGELWKNPNLANTLQQIADGGRDAFYKGDIARTI
HCCCCCHHHHCCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEECCHHHHHH
GAYFKANGGYLSYEDLASHTGEWVEPVSTNYRGVDVWELPPNSQGIAALQMLNILEGYDF
HHHHCCCCCEEEHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCC
SKIPFGSAEHVHLFTEAKKLAFADRARFYADPAFQPAPLAKLISKDYANRRRALISMDKA
CCCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LKEVQPGTPKQLEEGDTIYMTVADADGMMVSLIQSNYRGMGSGMAPPGLGFILQDRGEMF
HHHCCCCCCCHHCCCCEEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCEE
VLKKDHLNGYAPGKRPFQTIIPAFVTKDGKPWLSFGVMGGAMQPQGHVQIVMNLVDFHMN
EEEECCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHC
LQEAGDAPRIQHEGSTEPTGQATAMSDGGEVNLETGFSYDTIRALMRKGHRVIFADGPYG
HHHCCCCCCCCCCCCCCCCCCEEEECCCCEEEEECCCCHHHHHHHHHCCCEEEEECCCCC
GYQAIARDPVSGVYYGASESRKDGQAAGY
CHHHHHCCCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MRRVPVLLVSALALLAPPLGAADRVTGQPFATRSEVIAPHAMAATSQPLATQIALDVMKD
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHCCCHHHHHCCCCHHHHHHHHHHHC
GGSAVDAAIAANAALGLMEPTGNGVGGDLFAIVWDPKTHKLYGYNGSGRSPKSLTLAEFQ
CCCHHHHHHHHHHHHEEECCCCCCCCCCEEEEEECCCCCEEEEECCCCCCCCCCHHHHHH
RRGLKDIPPTGPLPVSVPGAVDGWFALHARFGRKPMAQNLAPAIRYAREGHPVAETIAYY
HCCCCCCCCCCCCCEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHH
WDRSVPRLSQYPGFKEQFTIDGHAPRKGELWKNPNLANTLQQIADGGRDAFYKGDIARTI
HCCCCCHHHHCCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEECCHHHHHH
GAYFKANGGYLSYEDLASHTGEWVEPVSTNYRGVDVWELPPNSQGIAALQMLNILEGYDF
HHHHCCCCCEEEHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCC
SKIPFGSAEHVHLFTEAKKLAFADRARFYADPAFQPAPLAKLISKDYANRRRALISMDKA
CCCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LKEVQPGTPKQLEEGDTIYMTVADADGMMVSLIQSNYRGMGSGMAPPGLGFILQDRGEMF
HHHCCCCCCCHHCCCCEEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCEE
VLKKDHLNGYAPGKRPFQTIIPAFVTKDGKPWLSFGVMGGAMQPQGHVQIVMNLVDFHMN
EEEECCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHC
LQEAGDAPRIQHEGSTEPTGQATAMSDGGEVNLETGFSYDTIRALMRKGHRVIFADGPYG
HHHCCCCCCCCCCCCCCCCCCEEEECCCCEEEEECCCCHHHHHHHHHCCCEEEEECCCCC
GYQAIARDPVSGVYYGASESRKDGQAAGY
CHHHHHCCCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]