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The map label for this gene is gdh [H]

Identifier: 21244156

GI number: 21244156

Start: 4039577

End: 4040392

Strand: Reverse

Name: gdh [H]

Synonym: XAC3431

Alternate gene names: 21244156

Gene position: 4040392-4039577 (Counterclockwise)

Preceding gene: 21244157

Following gene: 21244154

Centisome position: 78.07

GC content: 65.93

Gene sequence:

>816_bases
ATGACGTTATCCGGCAAAACCCTGTTCATCACCGGTGCCTCGCGCGGGATTGGCTTGGCGATTGCGCTGCGGGCGGCGTG
CGATGGGGCGAATGTGGCGATTGCGGCCAAGTCGGCGGTGGCCAATCCCAAATTGCCTGGCACCATCCATAGCGCGGCCA
CGGCGGTGACTGCGGCCGGTGGGCAGGCGCTGGCGCTCAAGTGCGACATCCGCGAAGAAGATCAGGTGCGTGCGGCAGTG
GCGGCAACGGTCGATGCGTTCGGCGGGATCGACATTCTGGTCAACAACGCCAGTGCGATCTGGTTGCGCGGCGCGCTCGA
CACACCGATGAAGCGCTTCGATCTGATGCAGCAGGTCAACGCGCGCGGCAGTTTTCTGTGCGCGCAGGCGTGCCTGCCGC
ATCTGCTGCAGGCGGCCAATCCGCACATTCTCACCTTGGCCCCGCCGCCGTCGTTGAACCCCGCTTGGTGGGGCGCGCAC
ACCGGCTACACGCTGGCCAAGATGGGCATGAGTCTGGTCACCCTGGGGCTGGCGGCGGAATTCGGCCCGCAAGGCGTAGC
GATCAATGCATTGTGGCCGCGTACCGTCATTGCCACTGACGCCATCAACATGCTTGCCGGCGTGGACGCCGCGGCCTGCC
GTCGGCCGGAGATCATGGCCGACGCCGCGCATGCGGTGCTGACGCGCGCCGCGGCCGGGTTTTACGGGCAGTTCCTGATC
GATGATGAGGTCTTGGCCCAGGCCGGCGTCACCGATTTGCGCGGCTATGCGATGGATCCATCGCGCGCGCTGTTGCCGGA
TCTGTTTCTGGACTGA

Upstream 100 bases:

>100_bases
GGGAATCGAAGAGCGCACCGTGCGAGCTGTTCGTTCGGCGCCTGCGGAACGGTTGAGGCGCTAAGCTTTTGCCATTCCCG
ATTCCCGATTCCCGATTCCC

Downstream 100 bases:

>100_bases
GAGCGGTTAACCACAAGGCGAACAGTTGTCGTGAGCGTGGACGGCATGCTGGAACCGCAGTGTACGCGTGGCACACGCGC
TACCGAGCAACGGCCGCGTC

Product: short chain dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 271; Mature: 270

Protein sequence:

>271_residues
MTLSGKTLFITGASRGIGLAIALRAACDGANVAIAAKSAVANPKLPGTIHSAATAVTAAGGQALALKCDIREEDQVRAAV
AATVDAFGGIDILVNNASAIWLRGALDTPMKRFDLMQQVNARGSFLCAQACLPHLLQAANPHILTLAPPPSLNPAWWGAH
TGYTLAKMGMSLVTLGLAAEFGPQGVAINALWPRTVIATDAINMLAGVDAAACRRPEIMADAAHAVLTRAAAGFYGQFLI
DDEVLAQAGVTDLRGYAMDPSRALLPDLFLD

Sequences:

>Translated_271_residues
MTLSGKTLFITGASRGIGLAIALRAACDGANVAIAAKSAVANPKLPGTIHSAATAVTAAGGQALALKCDIREEDQVRAAV
AATVDAFGGIDILVNNASAIWLRGALDTPMKRFDLMQQVNARGSFLCAQACLPHLLQAANPHILTLAPPPSLNPAWWGAH
TGYTLAKMGMSLVTLGLAAEFGPQGVAINALWPRTVIATDAINMLAGVDAAACRRPEIMADAAHAVLTRAAAGFYGQFLI
DDEVLAQAGVTDLRGYAMDPSRALLPDLFLD
>Mature_270_residues
TLSGKTLFITGASRGIGLAIALRAACDGANVAIAAKSAVANPKLPGTIHSAATAVTAAGGQALALKCDIREEDQVRAAVA
ATVDAFGGIDILVNNASAIWLRGALDTPMKRFDLMQQVNARGSFLCAQACLPHLLQAANPHILTLAPPPSLNPAWWGAHT
GYTLAKMGMSLVTLGLAAEFGPQGVAINALWPRTVIATDAINMLAGVDAAACRRPEIMADAAHAVLTRAAAGFYGQFLID
DEVLAQAGVTDLRGYAMDPSRALLPDLFLD

Specific function: Unknown

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI40254986, Length=270, Percent_Identity=51.4814814814815, Blast_Score=285, Evalue=2e-77,
Organism=Homo sapiens, GI10190704, Length=237, Percent_Identity=28.2700421940928, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI209862901, Length=207, Percent_Identity=27.536231884058, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI19923983, Length=207, Percent_Identity=27.536231884058, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI19923817, Length=207, Percent_Identity=28.0193236714976, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI32483357, Length=198, Percent_Identity=25.7575757575758, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI87082100, Length=191, Percent_Identity=31.9371727748691, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1789208, Length=198, Percent_Identity=31.3131313131313, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1787905, Length=264, Percent_Identity=27.6515151515151, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI2367175, Length=191, Percent_Identity=27.2251308900524, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71982365, Length=267, Percent_Identity=51.685393258427, Blast_Score=286, Evalue=8e-78,
Organism=Caenorhabditis elegans, GI17558628, Length=269, Percent_Identity=52.0446096654275, Blast_Score=285, Evalue=1e-77,
Organism=Caenorhabditis elegans, GI71994604, Length=186, Percent_Identity=30.6451612903226, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17562910, Length=198, Percent_Identity=27.7777777777778, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562906, Length=204, Percent_Identity=26.4705882352941, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17544670, Length=219, Percent_Identity=26.4840182648402, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17564282, Length=148, Percent_Identity=31.0810810810811, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71994600, Length=251, Percent_Identity=27.0916334661355, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17560220, Length=201, Percent_Identity=30.8457711442786, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17560332, Length=205, Percent_Identity=28.780487804878, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17562908, Length=197, Percent_Identity=26.9035532994924, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17538480, Length=277, Percent_Identity=25.6317689530686, Blast_Score=64, Evalue=1e-10,
Organism=Drosophila melanogaster, GI21357673, Length=272, Percent_Identity=55.8823529411765, Blast_Score=313, Evalue=1e-85,
Organism=Drosophila melanogaster, GI23397609, Length=197, Percent_Identity=34.5177664974619, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI21355319, Length=193, Percent_Identity=29.5336787564767, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI28571526, Length=209, Percent_Identity=31.5789473684211, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI21357041, Length=225, Percent_Identity=26.6666666666667, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24644339, Length=256, Percent_Identity=25.78125, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI18859837, Length=221, Percent_Identity=29.4117647058824, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.47 [H]

Molecular weight: Translated: 28007; Mature: 27875

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLSGKTLFITGASRGIGLAIALRAACDGANVAIAAKSAVANPKLPGTIHSAATAVTAAG
CCCCCCEEEEEECCCCCEEEEEEEECCCCCCEEEEEHHHCCCCCCCCHHHHHHHHHEECC
GQALALKCDIREEDQVRAAVAATVDAFGGIDILVNNASAIWLRGALDTPMKRFDLMQQVN
CCEEEEEECCCCCHHHHHHHHHHHHHCCCEEEEEECCCEEEEECCCCCHHHHHHHHHHHC
ARGSFLCAQACLPHLLQAANPHILTLAPPPSLNPAWWGAHTGYTLAKMGMSLVTLGLAAE
CCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
FGPQGVAINALWPRTVIATDAINMLAGVDAAACRRPEIMADAAHAVLTRAAAGFYGQFLI
CCCCCEEEEEECCCHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHHHCHHEEEEE
DDEVLAQAGVTDLRGYAMDPSRALLPDLFLD
CHHHHHHCCCHHHCCCCCCCCHHHCCHHHCC
>Mature Secondary Structure 
TLSGKTLFITGASRGIGLAIALRAACDGANVAIAAKSAVANPKLPGTIHSAATAVTAAG
CCCCCEEEEEECCCCCEEEEEEEECCCCCCEEEEEHHHCCCCCCCCHHHHHHHHHEECC
GQALALKCDIREEDQVRAAVAATVDAFGGIDILVNNASAIWLRGALDTPMKRFDLMQQVN
CCEEEEEECCCCCHHHHHHHHHHHHHCCCEEEEEECCCEEEEECCCCCHHHHHHHHHHHC
ARGSFLCAQACLPHLLQAANPHILTLAPPPSLNPAWWGAHTGYTLAKMGMSLVTLGLAAE
CCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
FGPQGVAINALWPRTVIATDAINMLAGVDAAACRRPEIMADAAHAVLTRAAAGFYGQFLI
CCCCCEEEEEECCCHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHHHCHHEEEEE
DDEVLAQAGVTDLRGYAMDPSRALLPDLFLD
CHHHHHHCCCHHHCCCCCCCCHHHCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3082854; 8969502; 9384377 [H]