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The map label for this gene is argD

Identifier: 21244154

GI number: 21244154

Start: 4037265

End: 4038491

Strand: Reverse

Name: argD

Synonym: XAC3429

Alternate gene names: 21244154

Gene position: 4038491-4037265 (Counterclockwise)

Preceding gene: 21244156

Following gene: 21244152

Centisome position: 78.03

GC content: 68.3

Gene sequence:

>1227_bases
ATGAGCACCGCTGCCGATTCGCCCCTGTCACTCGCGCACTACTACCTGCCGGTGTATCGCCCGCGCCAGGTGGTGCTGGA
GCGCGGCCAGGGCAGCCGCGTGTGGGACGATGCGGGGCGTGAGTATCTGGATCTGTCGTCGGGCATCGCGGTGAGCGGGC
TCGGCCATAACGATCCCGATCTGGTGGCTGCGCTCACCGAGCAGGCCGGCAAGCTGTGGCACACCAGTAACGTGTTTTTC
AGCGCGCCGCCGCTGAAACTGGCCGAAGAATTGGTGAGCGCCTCGCGTTTCGCGCACAAGGTGTTCCTGTGCAATTCCGG
CACCGAGGCCAACGAGGCGGCGATCAAGCTGGTGCGCAAGTGGGCCAGCAGCCAGGGCCGTCCGGCCGACAAGCGCGTCA
TCGTCACCTTCCGCGGCAGTTTCCATGGCCGCACGCTGGCATCGGTCACCGCCACCGCGCAGCCCAAGTACCAGGAAGGC
TACGAGCCGCTGCCGGGTGGATTTCGCTATGTGGATTTCAACGACGTCGCGGCGCTGGAAGCGGCGATGGCCGGCGGCGA
TGTGGCCGCAGTGATGGTCGAGCCGATCCAGGGCGAGGGTGGCGTGATGCCGGCCGCGCCGGGTTTCCTGAGCCGCGTGC
GCGCGCTGTGCGACCAGCACGATGCGTTGCTGGTGCTGGACGAAATCCAATGCGGCATGGGCCGCACCGGCACGCTGTTC
GCGCATTGGCAGGAACAGGTGACGCCGGACATCGTGACCCTGGCCAAGGCCTTGGGCGGCGGTTTCCCGATCGGTGCGAT
GCTGGCCGGGCCCAAGGTGGCGCAGACCATGCAGTTCGGCGCGCACGGCACCACCTTCGGCGGCAACCCGCTGGCCGCGG
CAGTGGCGCGCGTGGCGCTGCGCAAGCTGGCCTCGCCGCAGATCGCCGACAACGTGGTGCGGCAATCTGCGGCATTGCGC
GCAGGTCTGGAGGCGCTCAACGCCGAGTTCGGCCTGTTTGCGCAGATTCGTGGGCGTGGCTTGATGCTGGGCGCGGTGCT
GGCCCCGGAACACGCCGGGCAGGCGGGGGCGATCCTGGATCTGGCGGCCAAGCATGGCCTGCTGCTGCTGCAGGCCGGCC
CGGATGTGTTGCGCTTCGTGCCGGCACTGAATCTGACCGATGCCGAACTGGCCGATGGTCTGGCGCGCTTGCGTCTGGCC
ACTGCCGAGTATGTCGCGCAGCCGTGA

Upstream 100 bases:

>100_bases
TGAGTTGCGGATCGGAGAAGGGGCGCATGCGCGCATTGTGCCGCAGGCCGGCGAATGCGCGAGAATGCCGCTTCTCCCTC
CGCTTCTGCGACCCATCCTC

Downstream 100 bases:

>100_bases
TGTCCGGCGGTGCTTGCGCGCCCTCTGGCCGGCACTATGCTGGCTAGAAGGGGGGGAGATGCGTGGTGTGCGGCATGTAG
CGCGCTGACGCAGTGCCCGG

Product: acetylornithine transaminase protein

Products: NA

Alternate protein names: ACOAT

Number of amino acids: Translated: 408; Mature: 407

Protein sequence:

>408_residues
MSTAADSPLSLAHYYLPVYRPRQVVLERGQGSRVWDDAGREYLDLSSGIAVSGLGHNDPDLVAALTEQAGKLWHTSNVFF
SAPPLKLAEELVSASRFAHKVFLCNSGTEANEAAIKLVRKWASSQGRPADKRVIVTFRGSFHGRTLASVTATAQPKYQEG
YEPLPGGFRYVDFNDVAALEAAMAGGDVAAVMVEPIQGEGGVMPAAPGFLSRVRALCDQHDALLVLDEIQCGMGRTGTLF
AHWQEQVTPDIVTLAKALGGGFPIGAMLAGPKVAQTMQFGAHGTTFGGNPLAAAVARVALRKLASPQIADNVVRQSAALR
AGLEALNAEFGLFAQIRGRGLMLGAVLAPEHAGQAGAILDLAAKHGLLLLQAGPDVLRFVPALNLTDAELADGLARLRLA
TAEYVAQP

Sequences:

>Translated_408_residues
MSTAADSPLSLAHYYLPVYRPRQVVLERGQGSRVWDDAGREYLDLSSGIAVSGLGHNDPDLVAALTEQAGKLWHTSNVFF
SAPPLKLAEELVSASRFAHKVFLCNSGTEANEAAIKLVRKWASSQGRPADKRVIVTFRGSFHGRTLASVTATAQPKYQEG
YEPLPGGFRYVDFNDVAALEAAMAGGDVAAVMVEPIQGEGGVMPAAPGFLSRVRALCDQHDALLVLDEIQCGMGRTGTLF
AHWQEQVTPDIVTLAKALGGGFPIGAMLAGPKVAQTMQFGAHGTTFGGNPLAAAVARVALRKLASPQIADNVVRQSAALR
AGLEALNAEFGLFAQIRGRGLMLGAVLAPEHAGQAGAILDLAAKHGLLLLQAGPDVLRFVPALNLTDAELADGLARLRLA
TAEYVAQP
>Mature_407_residues
STAADSPLSLAHYYLPVYRPRQVVLERGQGSRVWDDAGREYLDLSSGIAVSGLGHNDPDLVAALTEQAGKLWHTSNVFFS
APPLKLAEELVSASRFAHKVFLCNSGTEANEAAIKLVRKWASSQGRPADKRVIVTFRGSFHGRTLASVTATAQPKYQEGY
EPLPGGFRYVDFNDVAALEAAMAGGDVAAVMVEPIQGEGGVMPAAPGFLSRVRALCDQHDALLVLDEIQCGMGRTGTLFA
HWQEQVTPDIVTLAKALGGGFPIGAMLAGPKVAQTMQFGAHGTTFGGNPLAAAVARVALRKLASPQIADNVVRQSAALRA
GLEALNAEFGLFAQIRGRGLMLGAVLAPEHAGQAGAILDLAAKHGLLLLQAGPDVLRFVPALNLTDAELADGLARLRLAT
AEYVAQP

Specific function: Catalyzes The Transmination Of N(2)-Succinylornithine And Alpha-Ketoglutarate Into N(2)-Succinylglutamate Semialdehyde And Glutamate. Can Also Act As A Acetylornithine Aminotransferase. [C]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily

Homologues:

Organism=Homo sapiens, GI4557809, Length=378, Percent_Identity=39.1534391534392, Blast_Score=250, Evalue=2e-66,
Organism=Homo sapiens, GI284507298, Length=292, Percent_Identity=39.3835616438356, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI13994255, Length=453, Percent_Identity=28.2560706401766, Blast_Score=171, Evalue=8e-43,
Organism=Homo sapiens, GI37574042, Length=420, Percent_Identity=26.9047619047619, Blast_Score=135, Evalue=8e-32,
Organism=Homo sapiens, GI226442705, Length=420, Percent_Identity=26.1904761904762, Blast_Score=125, Evalue=8e-29,
Organism=Homo sapiens, GI226442709, Length=387, Percent_Identity=26.6149870801034, Blast_Score=122, Evalue=8e-28,
Organism=Homo sapiens, GI24119277, Length=400, Percent_Identity=27.5, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI188536080, Length=416, Percent_Identity=24.5192307692308, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI38679950, Length=416, Percent_Identity=24.5192307692308, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI38679946, Length=416, Percent_Identity=24.5192307692308, Blast_Score=90, Evalue=5e-18,
Organism=Escherichia coli, GI1788044, Length=398, Percent_Identity=47.2361809045226, Blast_Score=380, Evalue=1e-106,
Organism=Escherichia coli, GI1789759, Length=390, Percent_Identity=47.9487179487179, Blast_Score=373, Evalue=1e-104,
Organism=Escherichia coli, GI145693181, Length=325, Percent_Identity=39.0769230769231, Blast_Score=213, Evalue=2e-56,
Organism=Escherichia coli, GI1789016, Length=397, Percent_Identity=34.2569269521411, Blast_Score=205, Evalue=3e-54,
Organism=Escherichia coli, GI1787560, Length=403, Percent_Identity=30.7692307692308, Blast_Score=161, Evalue=6e-41,
Organism=Escherichia coli, GI1786991, Length=398, Percent_Identity=31.1557788944724, Blast_Score=125, Evalue=4e-30,
Organism=Escherichia coli, GI1786349, Length=340, Percent_Identity=30.5882352941176, Blast_Score=119, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI25144271, Length=374, Percent_Identity=36.3636363636364, Blast_Score=244, Evalue=5e-65,
Organism=Caenorhabditis elegans, GI32564660, Length=425, Percent_Identity=28.9411764705882, Blast_Score=183, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI25144274, Length=263, Percent_Identity=36.5019011406844, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI71992977, Length=431, Percent_Identity=24.8259860788863, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17541228, Length=431, Percent_Identity=28.0742459396752, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI71981843, Length=159, Percent_Identity=33.9622641509434, Blast_Score=94, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6324432, Length=388, Percent_Identity=39.1752577319588, Blast_Score=281, Evalue=9e-77,
Organism=Saccharomyces cerevisiae, GI6323470, Length=398, Percent_Identity=33.4170854271357, Blast_Score=218, Evalue=2e-57,
Organism=Saccharomyces cerevisiae, GI6324386, Length=359, Percent_Identity=27.5766016713092, Blast_Score=101, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6321456, Length=362, Percent_Identity=25.414364640884, Blast_Score=95, Evalue=3e-20,
Organism=Drosophila melanogaster, GI21357415, Length=382, Percent_Identity=38.4816753926702, Blast_Score=253, Evalue=2e-67,
Organism=Drosophila melanogaster, GI28574759, Length=448, Percent_Identity=29.9107142857143, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI161085790, Length=438, Percent_Identity=30.1369863013699, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI21356575, Length=404, Percent_Identity=27.970297029703, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI281366494, Length=435, Percent_Identity=25.0574712643678, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24667139, Length=435, Percent_Identity=25.0574712643678, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24667143, Length=435, Percent_Identity=25.0574712643678, Blast_Score=103, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARGD_XANAC (Q8PH31)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_643736.1
- ProteinModelPortal:   Q8PH31
- SMR:   Q8PH31
- GeneID:   1157500
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC3429
- NMPDR:   fig|190486.1.peg.3380
- HOGENOM:   HBG725944
- OMA:   SKSSAFG
- ProtClustDB:   PRK04612
- BioCyc:   XAXO190486:XAC3429-MONOMER
- BRENDA:   2.6.1.11
- GO:   GO:0005737
- HAMAP:   MF_01107
- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- PANTHER:   PTHR11986:SF19
- TIGRFAMs:   TIGR00707

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.11

Molecular weight: Translated: 42973; Mature: 42841

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: BINDING 141-141 BINDING 144-144 BINDING 284-284 BINDING 285-285

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTAADSPLSLAHYYLPVYRPRQVVLERGQGSRVWDDAGREYLDLSSGIAVSGLGHNDPD
CCCCCCCCHHHHHHHCCCCCCHHHHHCCCCCCCCHHHHCCHHEECCCCCEEECCCCCCHH
LVAALTEQAGKLWHTSNVFFSAPPLKLAEELVSASRFAHKVFLCNSGTEANEAAIKLVRK
HHHHHHHHHCCEEECCCEEEECCCHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHH
WASSQGRPADKRVIVTFRGSFHGRTLASVTATAQPKYQEGYEPLPGGFRYVDFNDVAALE
HHCCCCCCCCCEEEEEEECCCCCCEEEEEEECCCCCHHCCCCCCCCCEEEECCCHHHHHH
AAMAGGDVAAVMVEPIQGEGGVMPAAPGFLSRVRALCDQHDALLVLDEIQCGMGRTGTLF
HHHCCCCEEEEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECHHCCCCCCCEEE
AHWQEQVTPDIVTLAKALGGGFPIGAMLAGPKVAQTMQFGAHGTTFGGNPLAAAVARVAL
EHHHHHCCHHHHHHHHHHCCCCCHHHHHCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
RKLASPQIADNVVRQSAALRAGLEALNAEFGLFAQIRGRGLMLGAVLAPEHAGQAGAILD
HHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCEEEEEEEECCCCCCCCCHHHH
LAAKHGLLLLQAGPDVLRFVPALNLTDAELADGLARLRLATAEYVAQP
HHHHCCEEEEECCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
STAADSPLSLAHYYLPVYRPRQVVLERGQGSRVWDDAGREYLDLSSGIAVSGLGHNDPD
CCCCCCCHHHHHHHCCCCCCHHHHHCCCCCCCCHHHHCCHHEECCCCCEEECCCCCCHH
LVAALTEQAGKLWHTSNVFFSAPPLKLAEELVSASRFAHKVFLCNSGTEANEAAIKLVRK
HHHHHHHHHCCEEECCCEEEECCCHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHH
WASSQGRPADKRVIVTFRGSFHGRTLASVTATAQPKYQEGYEPLPGGFRYVDFNDVAALE
HHCCCCCCCCCEEEEEEECCCCCCEEEEEEECCCCCHHCCCCCCCCCEEEECCCHHHHHH
AAMAGGDVAAVMVEPIQGEGGVMPAAPGFLSRVRALCDQHDALLVLDEIQCGMGRTGTLF
HHHCCCCEEEEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECHHCCCCCCCEEE
AHWQEQVTPDIVTLAKALGGGFPIGAMLAGPKVAQTMQFGAHGTTFGGNPLAAAVARVAL
EHHHHHCCHHHHHHHHHHCCCCCHHHHHCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
RKLASPQIADNVVRQSAALRAGLEALNAEFGLFAQIRGRGLMLGAVLAPEHAGQAGAILD
HHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCEEEEEEEECCCCCCCCCHHHH
LAAKHGLLLLQAGPDVLRFVPALNLTDAELADGLARLRLATAEYVAQP
HHHHCCEEEEECCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217