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The map label for this gene is gmk

Identifier: 21244120

GI number: 21244120

Start: 4002672

End: 4003283

Strand: Reverse

Name: gmk

Synonym: XAC3395

Alternate gene names: 21244120

Gene position: 4003283-4002672 (Counterclockwise)

Preceding gene: 161485708

Following gene: 21244119

Centisome position: 77.35

GC content: 66.34

Gene sequence:

>612_bases
ATGCGCGGCACTCTCTATATCGTTGCGGCCCCCTCGGGCGCCGGCAAGAGCAGCATCGTCAACGCCACCCTGGCACGCGA
CCCGAAGATCGCCCTGTCGATCTCGTTCACCTCGCGCGCGCCGCGGCCGGGCGAACGCCATGCCGAGCACTACCATTTCG
TCTCCGCCGACGAGTTCCAGGGCATGATCGAAGCGGGCGATTTCTTCGAATACGCGCTGGTGCATGGCGACTGGAAGGGC
ACTGCGCGGCAGTCGGTGGAGCCGCAGCTGGCCGCCGGCCACGACGTCTTGCTGGAAATCGACTGGCAGGGCGCACGCCA
GGTGCGCCAGAAGGTGCCCGATGCGGTCAGCGTCTTCATCCTGCCGCCCTCGCGCCAGGCGCTGGACGAGCGCATGCGCA
AGCGCGGGCAGGACAGCGAGGTCGTCATGGCGCAACGCCTGGCCGCCGCCCGCGAAGAGATGCTGCATTTCGAAGAGTTC
GATTACGTGATCATCAACGAGACCTTCGATACGGCGGTTTCGGAGATGTGCGCGATCTTCACCGCCAGCCGGCTGCGTCG
GCAGGCGCAACAGCAGCGGCACGCCGGATTGATCCGGGCGCTGCTGGATTAA

Upstream 100 bases:

>100_bases
CGGGAATGGGGAATCGTCAAAGCGGGTACGATGCATCCCCTCGGCCTGCTTGCTTGGCGCGGTGCCACATTCCCTATTCC
CGACTCTCTATTCCCTAAAA

Downstream 100 bases:

>100_bases
GCGCCGCTGGCAAGGCTGCGCTGATCACCGACGGGCGCAGCCGCCGCGCGAGGCGACATCTATGCGCTTGCACTGCGTTC
AGAACGCGCCCGCCGCACAG

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase

Number of amino acids: Translated: 203; Mature: 203

Protein sequence:

>203_residues
MRGTLYIVAAPSGAGKSSIVNATLARDPKIALSISFTSRAPRPGERHAEHYHFVSADEFQGMIEAGDFFEYALVHGDWKG
TARQSVEPQLAAGHDVLLEIDWQGARQVRQKVPDAVSVFILPPSRQALDERMRKRGQDSEVVMAQRLAAAREEMLHFEEF
DYVIINETFDTAVSEMCAIFTASRLRRQAQQQRHAGLIRALLD

Sequences:

>Translated_203_residues
MRGTLYIVAAPSGAGKSSIVNATLARDPKIALSISFTSRAPRPGERHAEHYHFVSADEFQGMIEAGDFFEYALVHGDWKG
TARQSVEPQLAAGHDVLLEIDWQGARQVRQKVPDAVSVFILPPSRQALDERMRKRGQDSEVVMAQRLAAAREEMLHFEEF
DYVIINETFDTAVSEMCAIFTASRLRRQAQQQRHAGLIRALLD
>Mature_203_residues
MRGTLYIVAAPSGAGKSSIVNATLARDPKIALSISFTSRAPRPGERHAEHYHFVSADEFQGMIEAGDFFEYALVHGDWKG
TARQSVEPQLAAGHDVLLEIDWQGARQVRQKVPDAVSVFILPPSRQALDERMRKRGQDSEVVMAQRLAAAREEMLHFEEF
DYVIINETFDTAVSEMCAIFTASRLRRQAQQQRHAGLIRALLD

Specific function: Essential for recycling GMP and indirectly, cGMP

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain

Homologues:

Organism=Homo sapiens, GI226874831, Length=174, Percent_Identity=36.2068965517241, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI226874833, Length=174, Percent_Identity=36.2068965517241, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI4504221, Length=174, Percent_Identity=36.2068965517241, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI262118259, Length=180, Percent_Identity=29.4444444444444, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI4505237, Length=180, Percent_Identity=29.4444444444444, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI262118255, Length=180, Percent_Identity=28.8888888888889, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI262118263, Length=180, Percent_Identity=29.4444444444444, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI21361598, Length=196, Percent_Identity=26.0204081632653, Blast_Score=70, Evalue=9e-13,
Organism=Homo sapiens, GI38570142, Length=180, Percent_Identity=25.5555555555556, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI1790080, Length=203, Percent_Identity=55.1724137931034, Blast_Score=231, Evalue=4e-62,
Organism=Caenorhabditis elegans, GI193203132, Length=179, Percent_Identity=34.0782122905028, Blast_Score=123, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI17508835, Length=179, Percent_Identity=34.0782122905028, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6320662, Length=175, Percent_Identity=36.5714285714286, Blast_Score=120, Evalue=2e-28,
Organism=Drosophila melanogaster, GI21356141, Length=189, Percent_Identity=33.8624338624339, Blast_Score=109, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KGUA_XANAC (Q8PH65)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_643702.1
- ProteinModelPortal:   Q8PH65
- SMR:   Q8PH65
- GeneID:   1157466
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC3395
- NMPDR:   fig|190486.1.peg.3346
- HOGENOM:   HBG671982
- OMA:   EWAEFAG
- ProtClustDB:   PRK00300
- BioCyc:   XAXO190486:XAC3395-MONOMER
- BRENDA:   2.7.4.8
- GO:   GO:0005737
- HAMAP:   MF_00328
- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665
- SMART:   SM00072
- TIGRFAMs:   TIGR03263

Pfam domain/function: PF00625 Guanylate_kin

EC number: =2.7.4.8

Molecular weight: Translated: 22736; Mature: 22736

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: PS00856 GUANYLATE_KINASE_1; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGTLYIVAAPSGAGKSSIVNATLARDPKIALSISFTSRAPRPGERHAEHYHFVSADEFQ
CCCEEEEEECCCCCCCHHHEEHHHCCCCCEEEEEEECCCCCCCCCCCHHHEEECCHHHHH
GMIEAGDFFEYALVHGDWKGTARQSVEPQLAAGHDVLLEIDWQGARQVRQKVPDAVSVFI
HHHHCCCCEEEEEEECCCCCCHHCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCEEEEEE
LPPSRQALDERMRKRGQDSEVVMAQRLAAAREEMLHFEEFDYVIINETFDTAVSEMCAIF
ECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEECHHHHHHHHHHHHH
TASRLRRQAQQQRHAGLIRALLD
HHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRGTLYIVAAPSGAGKSSIVNATLARDPKIALSISFTSRAPRPGERHAEHYHFVSADEFQ
CCCEEEEEECCCCCCCHHHEEHHHCCCCCEEEEEEECCCCCCCCCCCHHHEEECCHHHHH
GMIEAGDFFEYALVHGDWKGTARQSVEPQLAAGHDVLLEIDWQGARQVRQKVPDAVSVFI
HHHHCCCCEEEEEEECCCCCCHHCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCEEEEEE
LPPSRQALDERMRKRGQDSEVVMAQRLAAAREEMLHFEEFDYVIINETFDTAVSEMCAIF
ECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEECHHHHHHHHHHHHH
TASRLRRQAQQQRHAGLIRALLD
HHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217