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The map label for this gene is gltP [H]

Identifier: 21244098

GI number: 21244098

Start: 3975238

End: 3976566

Strand: Reverse

Name: gltP [H]

Synonym: XAC3373

Alternate gene names: 21244098

Gene position: 3976566-3975238 (Counterclockwise)

Preceding gene: 21244099

Following gene: 21244097

Centisome position: 76.83

GC content: 64.11

Gene sequence:

>1329_bases
ATGGCGTTTGTTAAGCTCCGGTCTTTGTGTCCACCAAGGCCTGACCAGATGACAGCATCCCCAGCCACGCGCCGCCCGGT
CCTGCCCCTGCATTGGAAGATGGGCATTGGCTTTGCCGTTGGCCTGTTGTTGGGTCTGGCTGTCTACTACCTGGCCGGCA
GCGACGCCGAGTGGGTGCGTCTGGCGACCAAGTACGTCACCACGCCGTTTTCGCAGGTCTTCCTCAATCTGATCTTCATG
CTGATCGTGCCGCTGCTGTTCTCGGCGCTGGTCATGGGCATTTCCGAAATGGGCGACATCCGCGCGCTGGGGCGGGTGGG
GTGGCGCACCCTGGGCTATACCGTGGTGCTGTCCGGTGTGGCGGTGTTGCTGGGGTTGGTGCTGGTCAACGTGCTCAAGC
CCGGCGCGGGCGTGGACCCGCAACTGGCCAATCAGCTGATCCAGGAAAACGCCGAGCGCACCCGCGAGATCATTTCCAGC
TCCGGCACGCAGCCGCAGGGCTTGGACATGCTGCTGTCGATCGTGCCCAGCAACGTGATCGCCGCGGCGTCGAGCAACGG
CGCGATTCTGTCGCTGATGTTTTTTGCGGTGATGTTCGGCGTGGGCATGGTGCTGACCGAAGACGAAAAGGTCGCCACGT
TGCGGCGCGGCATCGAGGGGGTCTTCGAGATTTCGATGACCTTGATCGGGCTGGTGATCCGTCTGGCGCCGTATGCGGTG
GCGTGTTTCATGTTCAACCTGGCCGCGCTGTTCGGCTTCGATCTGCTGATCCGTCTGGGCGCCTATGTGGGCGTGGTGGT
GCTGGCGCTGGGCCTGCACATGGTGGTCAGTTACGGCATTGCGGTGAAATTCGCCGGACGCTCGCCGCTGAGCTTTTTCC
GCCAGACCCAGGAAGCGACGGTGATGGCGTTCTCGACCGCCTCCAGCAACGCGACCCTGCCAACGGCGCTACGCGTGGCC
GACGAGATGGGCCTGCCGCCGCGCGTGTCGCGTTTCGTGCTGACCGTGGGCGCCACCGCCAACCAGAACGGCACCGCACT
CTTCGAAGGCGTCACGGTGATCTTTCTGGCGCAGTTCTTCAACGTGGACCTGAGCCTGGGCCAGCAGTTCATGGTGATGC
TGGTCTGCATCCTGGGCGGGATCGGCACGGCCGGCGTGCCGTCCGGCTCGCTGCCGGTGGTGGCGCTGATCTGCGCGATG
GTCGGGGTCAACCCGGTGGGTATCGGCATGATCCTGGGCGTCAACCACTTCCTGGACATGTGCCGCACGGCGCTGAACGT
GACCGGGGATTTGGCTCTGACGACCTTGGTGGCCAAGGGCGAGGAATAG

Upstream 100 bases:

>100_bases
CCAGGCGGATTGTCAGTTCCAACGCCTGCATCACCCAACATCGAAAGACCCCTACCCGCAGGCAGATGCCTAGGCGACTC
CCGGGTAGGTGGCCGCATCC

Downstream 100 bases:

>100_bases
GGACTAGTGAATAGGGAATGGGTGAAGCGGGCTGGTGCGAGCCTGGGGTGTGACGGTGAGCTTCACGTCTGGCGACGGTG
ATTAGGCGCTCGGGTGATTG

Product: proton glutamate symport protein

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 442; Mature: 441

Protein sequence:

>442_residues
MAFVKLRSLCPPRPDQMTASPATRRPVLPLHWKMGIGFAVGLLLGLAVYYLAGSDAEWVRLATKYVTTPFSQVFLNLIFM
LIVPLLFSALVMGISEMGDIRALGRVGWRTLGYTVVLSGVAVLLGLVLVNVLKPGAGVDPQLANQLIQENAERTREIISS
SGTQPQGLDMLLSIVPSNVIAAASSNGAILSLMFFAVMFGVGMVLTEDEKVATLRRGIEGVFEISMTLIGLVIRLAPYAV
ACFMFNLAALFGFDLLIRLGAYVGVVVLALGLHMVVSYGIAVKFAGRSPLSFFRQTQEATVMAFSTASSNATLPTALRVA
DEMGLPPRVSRFVLTVGATANQNGTALFEGVTVIFLAQFFNVDLSLGQQFMVMLVCILGGIGTAGVPSGSLPVVALICAM
VGVNPVGIGMILGVNHFLDMCRTALNVTGDLALTTLVAKGEE

Sequences:

>Translated_442_residues
MAFVKLRSLCPPRPDQMTASPATRRPVLPLHWKMGIGFAVGLLLGLAVYYLAGSDAEWVRLATKYVTTPFSQVFLNLIFM
LIVPLLFSALVMGISEMGDIRALGRVGWRTLGYTVVLSGVAVLLGLVLVNVLKPGAGVDPQLANQLIQENAERTREIISS
SGTQPQGLDMLLSIVPSNVIAAASSNGAILSLMFFAVMFGVGMVLTEDEKVATLRRGIEGVFEISMTLIGLVIRLAPYAV
ACFMFNLAALFGFDLLIRLGAYVGVVVLALGLHMVVSYGIAVKFAGRSPLSFFRQTQEATVMAFSTASSNATLPTALRVA
DEMGLPPRVSRFVLTVGATANQNGTALFEGVTVIFLAQFFNVDLSLGQQFMVMLVCILGGIGTAGVPSGSLPVVALICAM
VGVNPVGIGMILGVNHFLDMCRTALNVTGDLALTTLVAKGEE
>Mature_441_residues
AFVKLRSLCPPRPDQMTASPATRRPVLPLHWKMGIGFAVGLLLGLAVYYLAGSDAEWVRLATKYVTTPFSQVFLNLIFML
IVPLLFSALVMGISEMGDIRALGRVGWRTLGYTVVLSGVAVLLGLVLVNVLKPGAGVDPQLANQLIQENAERTREIISSS
GTQPQGLDMLLSIVPSNVIAAASSNGAILSLMFFAVMFGVGMVLTEDEKVATLRRGIEGVFEISMTLIGLVIRLAPYAVA
CFMFNLAALFGFDLLIRLGAYVGVVVLALGLHMVVSYGIAVKFAGRSPLSFFRQTQEATVMAFSTASSNATLPTALRVAD
EMGLPPRVSRFVLTVGATANQNGTALFEGVTVIFLAQFFNVDLSLGQQFMVMLVCILGGIGTAGVPSGSLPVVALICAMV
GVNPVGIGMILGVNHFLDMCRTALNVTGDLALTTLVAKGEE

Specific function: This carrier protein is part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI4827012, Length=437, Percent_Identity=29.5194508009153, Blast_Score=142, Evalue=6e-34,
Organism=Homo sapiens, GI40254478, Length=417, Percent_Identity=29.4964028776978, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI21314632, Length=409, Percent_Identity=28.1173594132029, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI66773030, Length=397, Percent_Identity=26.1964735516373, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI169790839, Length=427, Percent_Identity=26.9320843091335, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI194239697, Length=423, Percent_Identity=25.0591016548463, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI5032093, Length=383, Percent_Identity=29.242819843342, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI301601644, Length=156, Percent_Identity=35.8974358974359, Blast_Score=102, Evalue=9e-22,
Organism=Homo sapiens, GI223468564, Length=251, Percent_Identity=30.6772908366534, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI223468566, Length=251, Percent_Identity=30.6772908366534, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI262359914, Length=361, Percent_Identity=26.3157894736842, Blast_Score=86, Evalue=5e-17,
Organism=Escherichia coli, GI1790514, Length=418, Percent_Identity=34.4497607655502, Blast_Score=218, Evalue=9e-58,
Organism=Escherichia coli, GI1789947, Length=376, Percent_Identity=30.0531914893617, Blast_Score=149, Evalue=4e-37,
Organism=Escherichia coli, GI1788024, Length=434, Percent_Identity=26.2672811059908, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1789473, Length=226, Percent_Identity=26.5486725663717, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17537407, Length=402, Percent_Identity=29.3532338308458, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI71996953, Length=452, Percent_Identity=28.7610619469027, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI193206505, Length=399, Percent_Identity=31.077694235589, Blast_Score=144, Evalue=8e-35,
Organism=Caenorhabditis elegans, GI71983099, Length=414, Percent_Identity=28.5024154589372, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI71983106, Length=414, Percent_Identity=28.5024154589372, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17541374, Length=405, Percent_Identity=28.641975308642, Blast_Score=126, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI193206654, Length=441, Percent_Identity=26.3038548752834, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24583025, Length=442, Percent_Identity=29.6380090497738, Blast_Score=153, Evalue=3e-37,
Organism=Drosophila melanogaster, GI17137668, Length=442, Percent_Identity=29.6380090497738, Blast_Score=153, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24583023, Length=442, Percent_Identity=29.6380090497738, Blast_Score=153, Evalue=3e-37,
Organism=Drosophila melanogaster, GI281360481, Length=426, Percent_Identity=23.4741784037559, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI281360483, Length=417, Percent_Identity=23.7410071942446, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17137666, Length=417, Percent_Identity=23.7410071942446, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 46837; Mature: 46706

Theoretical pI: Translated: 8.20; Mature: 8.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFVKLRSLCPPRPDQMTASPATRRPVLPLHWKMGIGFAVGLLLGLAVYYLAGSDAEWVR
CCCEEHHHCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
LATKYVTTPFSQVFLNLIFMLIVPLLFSALVMGISEMGDIRALGRVGWRTLGYTVVLSGV
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVLLGLVLVNVLKPGAGVDPQLANQLIQENAERTREIISSSGTQPQGLDMLLSIVPSNVI
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHE
AAASSNGAILSLMFFAVMFGVGMVLTEDEKVATLRRGIEGVFEISMTLIGLVIRLAPYAV
EECCCCCHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ACFMFNLAALFGFDLLIRLGAYVGVVVLALGLHMVVSYGIAVKFAGRSPLSFFRQTQEAT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHEEECCCCHHHHHHHHHHHH
VMAFSTASSNATLPTALRVADEMGLPPRVSRFVLTVGATANQNGTALFEGVTVIFLAQFF
EEEEEECCCCCCCHHHHHHHHHCCCCHHHHHHEEEECCCCCCCCCHHHHHHHHHHHHHHH
NVDLSLGQQFMVMLVCILGGIGTAGVPSGSLPVVALICAMVGVNPVGIGMILGVNHFLDM
HCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
CRTALNVTGDLALTTLVAKGEE
HHHHHCCCCHHHHHHHHHCCCC
>Mature Secondary Structure 
AFVKLRSLCPPRPDQMTASPATRRPVLPLHWKMGIGFAVGLLLGLAVYYLAGSDAEWVR
CCEEHHHCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
LATKYVTTPFSQVFLNLIFMLIVPLLFSALVMGISEMGDIRALGRVGWRTLGYTVVLSGV
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVLLGLVLVNVLKPGAGVDPQLANQLIQENAERTREIISSSGTQPQGLDMLLSIVPSNVI
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHE
AAASSNGAILSLMFFAVMFGVGMVLTEDEKVATLRRGIEGVFEISMTLIGLVIRLAPYAV
EECCCCCHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ACFMFNLAALFGFDLLIRLGAYVGVVVLALGLHMVVSYGIAVKFAGRSPLSFFRQTQEAT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHEEECCCCHHHHHHHHHHHH
VMAFSTASSNATLPTALRVADEMGLPPRVSRFVLTVGATANQNGTALFEGVTVIFLAQFF
EEEEEECCCCCCCHHHHHHHHHCCCCHHHHHHEEEECCCCCCCCCHHHHHHHHHHHHHHH
NVDLSLGQQFMVMLVCILGGIGTAGVPSGSLPVVALICAMVGVNPVGIGMILGVNHFLDM
HCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
CRTALNVTGDLALTTLVAKGEE
HHHHHCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1971622; 1551855; 8265357; 9278503 [H]