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The map label for this gene is tktA [H]

Identifier: 21244097

GI number: 21244097

Start: 3973019

End: 3975019

Strand: Reverse

Name: tktA [H]

Synonym: XAC3372

Alternate gene names: 21244097

Gene position: 3975019-3973019 (Counterclockwise)

Preceding gene: 21244098

Following gene: 21244095

Centisome position: 76.8

GC content: 64.97

Gene sequence:

>2001_bases
ATGACCCAGCCCACCCGCCGCCAGCTGGCCAACGCCATCCGTTTTCTTGCCGCAGATGCGGTCGAAGCCGCCAAGTCCGG
TCATCCCGGCATGCCGATGGGCATGGCCGATATCGCCGAAGTGCTGTGGAACGACTTCTACCGGCACAACCCGAACAATC
CGCAGTGGTTCAACCGCGACCGTTTCGTGCTGTCCAACGGGCATGGATCGATGTTGCAGTACGCCCTGCTGCACCTGTCC
GGCTACGACCTGCCGATCGAACAGCTCAAGCAGTTCCGCCAGCTGCACAGCAAGACCGCCGGTCACCCCGAGCGCAGCGA
AACTCCCGGCGTTGAGACCACCACCGGCCCCCTCGGGCAGGGCTTTGCCAATGCGGTGGGCTTTGCACTGGCCGAGAAGT
TGCTGGCGCAGCGCTACAACCGCCCGGAGCTGGAAATCGTCGATCACCGCACCTGGGTGTTCATGGGCGACGGCTGCCTG
ATGGAAGGCATTTCGCACGAAGCGGCGTCGCTGGCCGGTACCTGGGGCCTGGGCAAGCTGGTGGCGTTCTGGGACAACAA
CCAGATTTCCATCGACGGCAATACGGCCGGCTGGTTCAGCGACGACACCCCGGCGCGTTTCGAGGCCTATGGCTGGCACG
TGATCCGCGATGTGGACGGGCATGACGCCGACAAGATCAAGGCCGCCATCGAGACAGCGCTGGAAAACACCGACAAGCCC
ACGCTGATCTGCTGCCGTACCAAGATCGGTTTCGGTGCGCCGACCAAGGCCGGCAAGGAGTCCTCGCATGGCGCTCCGTT
GGGCAAGGACGAGCTGGAAGGCGCGCGCAAGGCGTTGGAGTGGCCGTACGGCCCGTTCGAAATTCCCGAAGAGATCTACG
CCGGCTGGCGTGCCGGCGGCACCGGTACCTTGCGTCAGGCCGAATGGGAACAGCTGTTCGACAAGTACGCCAAGCAGTAC
GGCGCGCAGGCCGACGAGCTGACCCGTCGTTCGCATGGCGAACTGCCGGCCGACTTCATCGCCAAGGCCGATGCCTACAT
CGCCAAGGCGCAGGAAGAGGGCCAGACCATTGCCTCGCGCAAGGCCTCGCAGCTGGCGATCGAAGCGTTCGCGCCGCTGT
TGCCGGAATTGATCGGTGGCTCGGCCGACCTGGCGCACTCCAACCTGACCTTGTGGAAGGCCAGCAAGTCGGTCGCCACC
GACGACCCGGACGCCAACTACGTGTATTACGGCGTGCGCGAGTTCGGCATGACCGCCATTGCCAACGGTCTGGCGCTGCA
TGGCGGGTTCATTCCGTTCGACGCCACCTTCCTGGTGTTCAGCGACTACGCACGCAACGGCGTGCGCATGAGCGCGTTGA
ACCCGGCGCATGCGATTCATGTGTACACGCATGACTCGATCGGCCTGGGCGAAGACGGCCCGACCCATCAGCCGGTGGAA
CACCTGGCCTCGCTGCGCTACATCCCCAACAACGATGTGTGGCGCCCGGGCGATGCGGTGGAATCGGCAGTGAGCTGGAA
GGCGGCCATTACCCGCAAGGACGGCCCAAGCTGCCTGATCTTCAGCCGCCAGAACCTGCAGCATCAGCCGCGCAGCGCCG
AGCAGCTCAAGCTGATCGAGCGCGGTGGCTACGTGCTGGCCGACGCCGAAGGCGGTACGCCGGACGTGATCCTGATCGCC
ACCGGTTCGGAAGTCGGTCTGGCAGTGGAAGCCAAAAAGACGCTGGATGCGGCCGGCCTCAAGACGCGCGTGGTGTCGAT
GCCGTCGACCGATGTGTTCGATCGCCAGGACGCGGCGTACCGTGAGTCGGTGCTGCCGAACGCCGTGCGCAAGCGCGTGG
CGGTGGAAGCGGGGGTGACCGGCTTCTGGCGCAAGTACGTGGGCCTGGATGGCGATGTCGTCGGCATGGACACCTTCGGT
GCCTCGGCGCCGGCCGACCAGTTGTATGCGTACTTCAAGATCACCGCAGAGCACGTGGTGGCCGCAGCCAAGGCGCTGTA
A

Upstream 100 bases:

>100_bases
GCTGCATCCGACTCTCCATTCCCGATTCCCCTAACGCGCTGTGTGGGAGAATAGGGGTCTCCGCTTCCAGCGGTGTTCCC
CTCCGCTTCCATAGACGCCC

Downstream 100 bases:

>100_bases
CGCCTTGCGTGGTGCTTGAAAGAAAAAGCCGGCGAAAGCCGGCTTTTTTGTTGGATTTCGTGAGCGATGCGCGGTCCGTC
ATCGTTCAACGGACGCCTTG

Product: transketolase

Products: NA

Alternate protein names: TK 1 [H]

Number of amino acids: Translated: 666; Mature: 665

Protein sequence:

>666_residues
MTQPTRRQLANAIRFLAADAVEAAKSGHPGMPMGMADIAEVLWNDFYRHNPNNPQWFNRDRFVLSNGHGSMLQYALLHLS
GYDLPIEQLKQFRQLHSKTAGHPERSETPGVETTTGPLGQGFANAVGFALAEKLLAQRYNRPELEIVDHRTWVFMGDGCL
MEGISHEAASLAGTWGLGKLVAFWDNNQISIDGNTAGWFSDDTPARFEAYGWHVIRDVDGHDADKIKAAIETALENTDKP
TLICCRTKIGFGAPTKAGKESSHGAPLGKDELEGARKALEWPYGPFEIPEEIYAGWRAGGTGTLRQAEWEQLFDKYAKQY
GAQADELTRRSHGELPADFIAKADAYIAKAQEEGQTIASRKASQLAIEAFAPLLPELIGGSADLAHSNLTLWKASKSVAT
DDPDANYVYYGVREFGMTAIANGLALHGGFIPFDATFLVFSDYARNGVRMSALNPAHAIHVYTHDSIGLGEDGPTHQPVE
HLASLRYIPNNDVWRPGDAVESAVSWKAAITRKDGPSCLIFSRQNLQHQPRSAEQLKLIERGGYVLADAEGGTPDVILIA
TGSEVGLAVEAKKTLDAAGLKTRVVSMPSTDVFDRQDAAYRESVLPNAVRKRVAVEAGVTGFWRKYVGLDGDVVGMDTFG
ASAPADQLYAYFKITAEHVVAAAKAL

Sequences:

>Translated_666_residues
MTQPTRRQLANAIRFLAADAVEAAKSGHPGMPMGMADIAEVLWNDFYRHNPNNPQWFNRDRFVLSNGHGSMLQYALLHLS
GYDLPIEQLKQFRQLHSKTAGHPERSETPGVETTTGPLGQGFANAVGFALAEKLLAQRYNRPELEIVDHRTWVFMGDGCL
MEGISHEAASLAGTWGLGKLVAFWDNNQISIDGNTAGWFSDDTPARFEAYGWHVIRDVDGHDADKIKAAIETALENTDKP
TLICCRTKIGFGAPTKAGKESSHGAPLGKDELEGARKALEWPYGPFEIPEEIYAGWRAGGTGTLRQAEWEQLFDKYAKQY
GAQADELTRRSHGELPADFIAKADAYIAKAQEEGQTIASRKASQLAIEAFAPLLPELIGGSADLAHSNLTLWKASKSVAT
DDPDANYVYYGVREFGMTAIANGLALHGGFIPFDATFLVFSDYARNGVRMSALNPAHAIHVYTHDSIGLGEDGPTHQPVE
HLASLRYIPNNDVWRPGDAVESAVSWKAAITRKDGPSCLIFSRQNLQHQPRSAEQLKLIERGGYVLADAEGGTPDVILIA
TGSEVGLAVEAKKTLDAAGLKTRVVSMPSTDVFDRQDAAYRESVLPNAVRKRVAVEAGVTGFWRKYVGLDGDVVGMDTFG
ASAPADQLYAYFKITAEHVVAAAKAL
>Mature_665_residues
TQPTRRQLANAIRFLAADAVEAAKSGHPGMPMGMADIAEVLWNDFYRHNPNNPQWFNRDRFVLSNGHGSMLQYALLHLSG
YDLPIEQLKQFRQLHSKTAGHPERSETPGVETTTGPLGQGFANAVGFALAEKLLAQRYNRPELEIVDHRTWVFMGDGCLM
EGISHEAASLAGTWGLGKLVAFWDNNQISIDGNTAGWFSDDTPARFEAYGWHVIRDVDGHDADKIKAAIETALENTDKPT
LICCRTKIGFGAPTKAGKESSHGAPLGKDELEGARKALEWPYGPFEIPEEIYAGWRAGGTGTLRQAEWEQLFDKYAKQYG
AQADELTRRSHGELPADFIAKADAYIAKAQEEGQTIASRKASQLAIEAFAPLLPELIGGSADLAHSNLTLWKASKSVATD
DPDANYVYYGVREFGMTAIANGLALHGGFIPFDATFLVFSDYARNGVRMSALNPAHAIHVYTHDSIGLGEDGPTHQPVEH
LASLRYIPNNDVWRPGDAVESAVSWKAAITRKDGPSCLIFSRQNLQHQPRSAEQLKLIERGGYVLADAEGGTPDVILIAT
GSEVGLAVEAKKTLDAAGLKTRVVSMPSTDVFDRQDAAYRESVLPNAVRKRVAVEAGVTGFWRKYVGLDGDVVGMDTFGA
SAPADQLYAYFKITAEHVVAAAKAL

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=598, Percent_Identity=27.257525083612, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI4507521, Length=598, Percent_Identity=27.257525083612, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI133778974, Length=586, Percent_Identity=26.4505119453925, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI225637459, Length=275, Percent_Identity=25.0909090909091, Blast_Score=74, Evalue=4e-13,
Organism=Escherichia coli, GI48994911, Length=662, Percent_Identity=65.7099697885196, Blast_Score=895, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=659, Percent_Identity=62.3672230652504, Blast_Score=850, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=673, Percent_Identity=26.4487369985141, Blast_Score=171, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6325331, Length=676, Percent_Identity=47.189349112426, Blast_Score=558, Evalue=1e-159,
Organism=Saccharomyces cerevisiae, GI6319593, Length=668, Percent_Identity=43.7125748502994, Blast_Score=520, Evalue=1e-148,
Organism=Drosophila melanogaster, GI45551847, Length=680, Percent_Identity=26.0294117647059, Blast_Score=159, Evalue=6e-39,
Organism=Drosophila melanogaster, GI45550715, Length=680, Percent_Identity=26.0294117647059, Blast_Score=159, Evalue=6e-39,
Organism=Drosophila melanogaster, GI24666278, Length=507, Percent_Identity=26.8244575936884, Blast_Score=146, Evalue=4e-35,
Organism=Drosophila melanogaster, GI24645119, Length=646, Percent_Identity=25.5417956656347, Blast_Score=137, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 72519; Mature: 72388

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQPTRRQLANAIRFLAADAVEAAKSGHPGMPMGMADIAEVLWNDFYRHNPNNPQWFNRD
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCC
RFVLSNGHGSMLQYALLHLSGYDLPIEQLKQFRQLHSKTAGHPERSETPGVETTTGPLGQ
EEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
GFANAVGFALAEKLLAQRYNRPELEIVDHRTWVFMGDGCLMEGISHEAASLAGTWGLGKL
HHHHHHHHHHHHHHHHHHCCCCCEEEEECEEEEEECCCHHHHCCCHHHHHHHCCCCCCEE
VAFWDNNQISIDGNTAGWFSDDTPARFEAYGWHVIRDVDGHDADKIKAAIETALENTDKP
EEEECCCEEEECCCCCCCCCCCCCCCEECCCEEEEEECCCCCHHHHHHHHHHHHHCCCCC
TLICCRTKIGFGAPTKAGKESSHGAPLGKDELEGARKALEWPYGPFEIPEEIYAGWRAGG
EEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCC
TGTLRQAEWEQLFDKYAKQYGAQADELTRRSHGELPADFIAKADAYIAKAQEEGQTIASR
CCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
KASQLAIEAFAPLLPELIGGSADLAHSNLTLWKASKSVATDDPDANYVYYGVREFGMTAI
HHHHHHHHHHHHHHHHHHCCCCHHCCCCEEEEECCCCCCCCCCCCCEEEEEHHHHHHHHH
ANGLALHGGFIPFDATFLVFSDYARNGVRMSALNPAHAIHVYTHDSIGLGEDGPTHQPVE
HCCCEECCCCCCCCHHEEEEEHHHCCCEEEEECCCCEEEEEEECCCCCCCCCCCCCHHHH
HLASLRYIPNNDVWRPGDAVESAVSWKAAITRKDGPSCLIFSRQNLQHQPRSAEQLKLIE
HHHHEEECCCCCCCCCCHHHHHHHHHHHEEECCCCCCEEEEECCCCCCCCCCHHHHHHHH
RGGYVLADAEGGTPDVILIATGSEVGLAVEAKKTLDAAGLKTRVVSMPSTDVFDRQDAAY
CCCEEEEECCCCCCCEEEEECCCCCCEEEEHHHHHHHCCCEEEEEECCCCCCCCCCHHHH
RESVLPNAVRKRVAVEAGVTGFWRKYVGLDGDVVGMDTFGASAPADQLYAYFKITAEHVV
HHHHCHHHHHHHHHHHHCCHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHEEEHHHHHH
AAAKAL
HHHHCC
>Mature Secondary Structure 
TQPTRRQLANAIRFLAADAVEAAKSGHPGMPMGMADIAEVLWNDFYRHNPNNPQWFNRD
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCC
RFVLSNGHGSMLQYALLHLSGYDLPIEQLKQFRQLHSKTAGHPERSETPGVETTTGPLGQ
EEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
GFANAVGFALAEKLLAQRYNRPELEIVDHRTWVFMGDGCLMEGISHEAASLAGTWGLGKL
HHHHHHHHHHHHHHHHHHCCCCCEEEEECEEEEEECCCHHHHCCCHHHHHHHCCCCCCEE
VAFWDNNQISIDGNTAGWFSDDTPARFEAYGWHVIRDVDGHDADKIKAAIETALENTDKP
EEEECCCEEEECCCCCCCCCCCCCCCEECCCEEEEEECCCCCHHHHHHHHHHHHHCCCCC
TLICCRTKIGFGAPTKAGKESSHGAPLGKDELEGARKALEWPYGPFEIPEEIYAGWRAGG
EEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCC
TGTLRQAEWEQLFDKYAKQYGAQADELTRRSHGELPADFIAKADAYIAKAQEEGQTIASR
CCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
KASQLAIEAFAPLLPELIGGSADLAHSNLTLWKASKSVATDDPDANYVYYGVREFGMTAI
HHHHHHHHHHHHHHHHHHCCCCHHCCCCEEEEECCCCCCCCCCCCCEEEEEHHHHHHHHH
ANGLALHGGFIPFDATFLVFSDYARNGVRMSALNPAHAIHVYTHDSIGLGEDGPTHQPVE
HCCCEECCCCCCCCHHEEEEEHHHCCCEEEEECCCCEEEEEEECCCCCCCCCCCCCHHHH
HLASLRYIPNNDVWRPGDAVESAVSWKAAITRKDGPSCLIFSRQNLQHQPRSAEQLKLIE
HHHHEEECCCCCCCCCCHHHHHHHHHHHEEECCCCCCEEEEECCCCCCCCCCHHHHHHHH
RGGYVLADAEGGTPDVILIATGSEVGLAVEAKKTLDAAGLKTRVVSMPSTDVFDRQDAAY
CCCEEEEECCCCCCCEEEEECCCCCCEEEEHHHHHHHCCCEEEEEECCCCCCCCCCHHHH
RESVLPNAVRKRVAVEAGVTGFWRKYVGLDGDVVGMDTFGASAPADQLYAYFKITAEHVV
HHHHCHHHHHHHHHHHHCCHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHEEEHHHHHH
AAAKAL
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8241274; 9278503; 2153656 [H]