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The map label for this gene is 21244069

Identifier: 21244069

GI number: 21244069

Start: 3939364

End: 3940368

Strand: Reverse

Name: 21244069

Synonym: XAC3344

Alternate gene names: NA

Gene position: 3940368-3939364 (Counterclockwise)

Preceding gene: 21244070

Following gene: 21244064

Centisome position: 76.13

GC content: 63.58

Gene sequence:

>1005_bases
ATGAGCATCGAACAGCTTGCCGAAACCGCCCAGGCGATGGTCGCCCCGGGTAAGGGCATCATCGCCATCGACGAATCGAC
CAGCACGATCGCCAAGCGTTTTGCCAGCGTCGGCATCGAGAACATCGAAGAGAACCGTCGCGCCTATCGCGAACTGTTGC
TGACCACGCCCAAGCTGAGCGACTACATCTCCGGCGCCATCCTGTTCGACGAGACCATCCGTCAGAAGACCAAGGATGGC
GTGCCGTTCGCCGAGTACATGACCGCCCACGGCATCATCCCGGGCATCAAGGTCGACAAGGGCGCGCAGCCGCTGGCCGG
CATGCCGGGCGAGCTGGTGACCGAAGGCCTGGACGGCCTGCGTGCGCGTCTGGAGGAGTACTACACGCTGGGTGCGCGCT
TCGCCAAGTGGCGTGCGGTCATCAATATCGGCGAAGACATTCCGTCCGGCACCTGCATCGAGGCCAACTCGCATGCGCTG
GCGCGTTACGCTGCGCTGTGCCAGGAACAAGGCTTGGTGCCGATGGTCGAGCCGGAAGTGATCATGGACGGCAGCCACGA
CATCGAAACCTGCTACGAAGTGACCGAAGCCACGCTGCGCTCGCTGTTCGGTGCGCTGTATGAGCAGAACGTCGTGCTCG
AGGGCACCATCCTGAAGGCCTCGATGGTGATCTCCGGCAAGAGCTGCGAAGAGCAGGCCAGTATCGAAGAGGTGGCCGAA
TCCACCGTGATGTGCCTGAAGTCCACCGTGCCGGCGATCCTGCCGGGCATCGTGTTCCTGTCCGGCGGCCAGACCGACGA
GCAGTCCACCGCCCACCTCAACGAAATGCACCAGCTCGGCAATCTGCCCTGGCCGCTGAGCTTCTCCTACGGCCGCGCCA
TGCAGCAGGCCGCGCTGAAGCTGTGGGCCAAGGACATGACCGGCAACTTCGCCAAGGCGCAGCAGGTCATCTACGAGCGC
GCGAAGGAAAACGGCCTGGCCGCGCTGGGTAAGTGGAAGGGTTGA

Upstream 100 bases:

>100_bases
ACGCACGCACGTGTAATCGGTTGCAGGCATTCCGTGAAGGAATGTGTACGACTTTCGTCGCTATACTTTCGTTCTCCCCC
GCAGCTGCCACAGGAACTAC

Downstream 100 bases:

>100_bases
TCGATTGATGAGGGCTGCAAGGCCGCCGCATCGATAGAACAAAAACGCCGGCAGCATGCCGGCGTTTTTGTTTGCTGCAT
CCACGGGTTCGATGCCGCGC

Product: fructose-bisphosphate aldolase

Products: NA

Alternate protein names: Fructose-biphosphate aldolase class I; FBP aldolase

Number of amino acids: Translated: 334; Mature: 333

Protein sequence:

>334_residues
MSIEQLAETAQAMVAPGKGIIAIDESTSTIAKRFASVGIENIEENRRAYRELLLTTPKLSDYISGAILFDETIRQKTKDG
VPFAEYMTAHGIIPGIKVDKGAQPLAGMPGELVTEGLDGLRARLEEYYTLGARFAKWRAVINIGEDIPSGTCIEANSHAL
ARYAALCQEQGLVPMVEPEVIMDGSHDIETCYEVTEATLRSLFGALYEQNVVLEGTILKASMVISGKSCEEQASIEEVAE
STVMCLKSTVPAILPGIVFLSGGQTDEQSTAHLNEMHQLGNLPWPLSFSYGRAMQQAALKLWAKDMTGNFAKAQQVIYER
AKENGLAALGKWKG

Sequences:

>Translated_334_residues
MSIEQLAETAQAMVAPGKGIIAIDESTSTIAKRFASVGIENIEENRRAYRELLLTTPKLSDYISGAILFDETIRQKTKDG
VPFAEYMTAHGIIPGIKVDKGAQPLAGMPGELVTEGLDGLRARLEEYYTLGARFAKWRAVINIGEDIPSGTCIEANSHAL
ARYAALCQEQGLVPMVEPEVIMDGSHDIETCYEVTEATLRSLFGALYEQNVVLEGTILKASMVISGKSCEEQASIEEVAE
STVMCLKSTVPAILPGIVFLSGGQTDEQSTAHLNEMHQLGNLPWPLSFSYGRAMQQAALKLWAKDMTGNFAKAQQVIYER
AKENGLAALGKWKG
>Mature_333_residues
SIEQLAETAQAMVAPGKGIIAIDESTSTIAKRFASVGIENIEENRRAYRELLLTTPKLSDYISGAILFDETIRQKTKDGV
PFAEYMTAHGIIPGIKVDKGAQPLAGMPGELVTEGLDGLRARLEEYYTLGARFAKWRAVINIGEDIPSGTCIEANSHALA
RYAALCQEQGLVPMVEPEVIMDGSHDIETCYEVTEATLRSLFGALYEQNVVLEGTILKASMVISGKSCEEQASIEEVAES
TVMCLKSTVPAILPGIVFLSGGQTDEQSTAHLNEMHQLGNLPWPLSFSYGRAMQQAALKLWAKDMTGNFAKAQQVIYERA
KENGLAALGKWKG

Specific function: Unknown

COG id: COG3588

COG function: function code G; Fructose-1,6-bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class I fructose-bisphosphate aldolase family

Homologues:

Organism=Homo sapiens, GI34577112, Length=331, Percent_Identity=49.5468277945619, Blast_Score=325, Evalue=4e-89,
Organism=Homo sapiens, GI34577110, Length=331, Percent_Identity=49.5468277945619, Blast_Score=325, Evalue=4e-89,
Organism=Homo sapiens, GI4557305, Length=331, Percent_Identity=49.5468277945619, Blast_Score=325, Evalue=4e-89,
Organism=Homo sapiens, GI193794814, Length=331, Percent_Identity=49.5468277945619, Blast_Score=325, Evalue=4e-89,
Organism=Homo sapiens, GI4885063, Length=333, Percent_Identity=47.1471471471471, Blast_Score=317, Evalue=9e-87,
Organism=Homo sapiens, GI40354205, Length=332, Percent_Identity=46.6867469879518, Blast_Score=298, Evalue=5e-81,
Organism=Caenorhabditis elegans, GI25150450, Length=335, Percent_Identity=50.1492537313433, Blast_Score=322, Evalue=1e-88,
Organism=Caenorhabditis elegans, GI71983985, Length=332, Percent_Identity=48.7951807228916, Blast_Score=311, Evalue=3e-85,
Organism=Caenorhabditis elegans, GI71983990, Length=235, Percent_Identity=48.0851063829787, Blast_Score=226, Evalue=1e-59,
Organism=Drosophila melanogaster, GI24650282, Length=331, Percent_Identity=50.1510574018127, Blast_Score=326, Evalue=1e-89,
Organism=Drosophila melanogaster, GI24650280, Length=331, Percent_Identity=50.1510574018127, Blast_Score=326, Evalue=1e-89,
Organism=Drosophila melanogaster, GI24650278, Length=331, Percent_Identity=50.1510574018127, Blast_Score=326, Evalue=1e-89,
Organism=Drosophila melanogaster, GI221459619, Length=331, Percent_Identity=49.8489425981873, Blast_Score=325, Evalue=4e-89,
Organism=Drosophila melanogaster, GI24650288, Length=331, Percent_Identity=49.8489425981873, Blast_Score=325, Evalue=4e-89,
Organism=Drosophila melanogaster, GI45553577, Length=331, Percent_Identity=49.2447129909366, Blast_Score=319, Evalue=1e-87,
Organism=Drosophila melanogaster, GI24650304, Length=331, Percent_Identity=41.6918429003021, Blast_Score=290, Evalue=8e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ALF1_XANAC (Q8PHB5)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_643651.1
- ProteinModelPortal:   Q8PHB5
- SMR:   Q8PHB5
- GeneID:   1157415
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC3344
- NMPDR:   fig|190486.1.peg.3295
- HOGENOM:   HBG559178
- OMA:   RFAKWRG
- ProtClustDB:   CLSK863863
- BioCyc:   XAXO190486:XAC3344-MONOMER
- BRENDA:   4.1.2.13
- GO:   GO:0006096
- InterPro:   IPR000741
- InterPro:   IPR013785
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR11627

Pfam domain/function: PF00274 Glycolytic

EC number: =4.1.2.13

Molecular weight: Translated: 36276; Mature: 36145

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: PS00158 ALDOLASE_CLASS_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIEQLAETAQAMVAPGKGIIAIDESTSTIAKRFASVGIENIEENRRAYRELLLTTPKLS
CCHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCHH
DYISGAILFDETIRQKTKDGVPFAEYMTAHGIIPGIKVDKGAQPLAGMPGELVTEGLDGL
HHHCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCEECCCCCCCCCCCHHHHHHHHHHH
RARLEEYYTLGARFAKWRAVINIGEDIPSGTCIEANSHALARYAALCQEQGLVPMVEPEV
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCHHHHHHHHHHHHCCCCCCCCCCE
IMDGSHDIETCYEVTEATLRSLFGALYEQNVVLEGTILKASMVISGKSCEEQASIEEVAE
EECCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEEEEEECCCCCHHHHHHHHHHH
STVMCLKSTVPAILPGIVFLSGGQTDEQSTAHLNEMHQLGNLPWPLSFSYGRAMQQAALK
HHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
LWAKDMTGNFAKAQQVIYERAKENGLAALGKWKG
HHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
SIEQLAETAQAMVAPGKGIIAIDESTSTIAKRFASVGIENIEENRRAYRELLLTTPKLS
CHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCHH
DYISGAILFDETIRQKTKDGVPFAEYMTAHGIIPGIKVDKGAQPLAGMPGELVTEGLDGL
HHHCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCEECCCCCCCCCCCHHHHHHHHHHH
RARLEEYYTLGARFAKWRAVINIGEDIPSGTCIEANSHALARYAALCQEQGLVPMVEPEV
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCHHHHHHHHHHHHCCCCCCCCCCE
IMDGSHDIETCYEVTEATLRSLFGALYEQNVVLEGTILKASMVISGKSCEEQASIEEVAE
EECCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEEEEEECCCCCHHHHHHHHHHH
STVMCLKSTVPAILPGIVFLSGGQTDEQSTAHLNEMHQLGNLPWPLSFSYGRAMQQAALK
HHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
LWAKDMTGNFAKAQQVIYERAKENGLAALGKWKG
HHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217