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The map label for this gene is asnC

Identifier: 21242368

GI number: 21242368

Start: 1863022

End: 1864416

Strand: Reverse

Name: asnC

Synonym: XAC1618

Alternate gene names: 21242368

Gene position: 1864416-1863022 (Counterclockwise)

Preceding gene: 21242376

Following gene: 21242367

Centisome position: 36.02

GC content: 63.3

Gene sequence:

>1395_bases
ATGACGGTGGTCAGCGTTGAACATGCGCTTGCGGGAAAGCTCCCGGAAGGCGGCGAAGTCACGGTACGGGGGTGGGTGCG
CACCTTGCGCGGATCTGCCGGACTGGCCTTCATCAACGTGACCGACGGCTCGTGCTTTGCTCCGATCCAGGTGGTGGCCA
ACGACACGCTGCCCAATTTCGACGAGATCAAGCGCCTGACCAGCGGCTGCTCGCTGATCGCCAAGGGCGTGCTGGTGAAA
TCGCAGGGCAAGGGTCAATCGTTCGAGATCCAGGCCAGTGGCGTGGACGTCGTCGGCTGGGTCGAAGACCCGCTGACCTA
CCCGATCCAGCCCAAGCCGATGACGCCGGAATTCCTGCGCGAAGTGGCGCACCTGCGTCCGCGCACCAACCTGTTCGGTG
CGGTGACCCGCATCCGCAACTGCCTGGCGCAGGCCGTGCACCGCTTCTTCCACCAGAACGGCTTCAACTGGATCAGCACA
CCGATCATCACCACCTCCGATGCCGAAGGCGCCGGGCAGATGTTTCGCGTCTCCACGCTGGACATGGTCAACCTTCCACG
CGATGCCAGCGGCGCAGTGGATTTCAGCCGCGATTTCTTCGGCAAGGAAACCTTTCTGACCGTGTCCGGCCAGCTCAATG
TGGAGGCGTATTGCCTGGCGCTGAGCAAGGTCTACACCTTCGGCCCGACCTTCCGCGCTGAAAACAGCCATACCACGCGT
CATCTGGCCGAGTTCTGGATGATCGAGCCGGAAATCGCCTTCGCCGATCTGGCCGAAGACGCACGCCTGGCCGAGCAGTT
CCTCAAATACCTGTTCCGCGCGGTGCTCGATGAGCGTGGCGACGACCTGGCGTTCCTGGCCGAGCGCGTGGACAAGAACG
CGATCGCCAAGCTCGAAGCGTTCATCAATGCACCGTTCGAGCAGATCGACTACACCGACGCAGTGAAGCTGCTGCAGAAC
TCCGGCAAGAAATTCGATTTCCCGGTGGAATGGGGCCTGGACCTGCAGACCGAGCACGAACGCTGGCTGACCGAAGAACA
CATCGGCCGCCCGGTGGTGGTGACCAACTATCCCGAGCACATCAAGGCGTTCTACATGCGCTTGAACGACGACGGCAAGA
CCGTCGCGGCGATGGACGTGCTGGCGCCGGGCATTGGCGAAATCATCGGGGGCAGCCAGCGCGAAGAGCGCCTGGATGTG
CTCGACGCGCGCATGGCGCAGTTCGGCCTGGATAAGGAGCACTACAGCTGGTACCGCGATTTCCGTCGCTACGGTTCGGT
GCCGCATGCCGGCTTCGGCCTGGGCTTCGAGCGGCTGGTGGTGTACGTGTGCGGGCTGAGCAACATCCGCGACGCGATCC
CCTACCCGCGTGCGCCTGGCAGCGCGGAGTTCTGA

Upstream 100 bases:

>100_bases
ACAAGCACAGCGCTCGGCAAGCTGTTCAGATGCTCGCGCCGGCGCGGCCGCAGCCAGTAAACTCGCAGGCCATTCAAGGT
CGCTACGGCGAGGAACAGTC

Downstream 100 bases:

>100_bases
GGTGAGCTTGCCGGCCGCCGCCCCCCTGCTGCAATCGCTGGCCTTCTGGCTTGCGGCGATCATGACCGGGCTGACGGCGG
TACGTAGCGTGTTGCTGACG

Product: asparaginyl-tRNA synthetase

Products: NA

Alternate protein names: Asparagine--tRNA ligase; AsnRS

Number of amino acids: Translated: 464; Mature: 463

Protein sequence:

>464_residues
MTVVSVEHALAGKLPEGGEVTVRGWVRTLRGSAGLAFINVTDGSCFAPIQVVANDTLPNFDEIKRLTSGCSLIAKGVLVK
SQGKGQSFEIQASGVDVVGWVEDPLTYPIQPKPMTPEFLREVAHLRPRTNLFGAVTRIRNCLAQAVHRFFHQNGFNWIST
PIITTSDAEGAGQMFRVSTLDMVNLPRDASGAVDFSRDFFGKETFLTVSGQLNVEAYCLALSKVYTFGPTFRAENSHTTR
HLAEFWMIEPEIAFADLAEDARLAEQFLKYLFRAVLDERGDDLAFLAERVDKNAIAKLEAFINAPFEQIDYTDAVKLLQN
SGKKFDFPVEWGLDLQTEHERWLTEEHIGRPVVVTNYPEHIKAFYMRLNDDGKTVAAMDVLAPGIGEIIGGSQREERLDV
LDARMAQFGLDKEHYSWYRDFRRYGSVPHAGFGLGFERLVVYVCGLSNIRDAIPYPRAPGSAEF

Sequences:

>Translated_464_residues
MTVVSVEHALAGKLPEGGEVTVRGWVRTLRGSAGLAFINVTDGSCFAPIQVVANDTLPNFDEIKRLTSGCSLIAKGVLVK
SQGKGQSFEIQASGVDVVGWVEDPLTYPIQPKPMTPEFLREVAHLRPRTNLFGAVTRIRNCLAQAVHRFFHQNGFNWIST
PIITTSDAEGAGQMFRVSTLDMVNLPRDASGAVDFSRDFFGKETFLTVSGQLNVEAYCLALSKVYTFGPTFRAENSHTTR
HLAEFWMIEPEIAFADLAEDARLAEQFLKYLFRAVLDERGDDLAFLAERVDKNAIAKLEAFINAPFEQIDYTDAVKLLQN
SGKKFDFPVEWGLDLQTEHERWLTEEHIGRPVVVTNYPEHIKAFYMRLNDDGKTVAAMDVLAPGIGEIIGGSQREERLDV
LDARMAQFGLDKEHYSWYRDFRRYGSVPHAGFGLGFERLVVYVCGLSNIRDAIPYPRAPGSAEF
>Mature_463_residues
TVVSVEHALAGKLPEGGEVTVRGWVRTLRGSAGLAFINVTDGSCFAPIQVVANDTLPNFDEIKRLTSGCSLIAKGVLVKS
QGKGQSFEIQASGVDVVGWVEDPLTYPIQPKPMTPEFLREVAHLRPRTNLFGAVTRIRNCLAQAVHRFFHQNGFNWISTP
IITTSDAEGAGQMFRVSTLDMVNLPRDASGAVDFSRDFFGKETFLTVSGQLNVEAYCLALSKVYTFGPTFRAENSHTTRH
LAEFWMIEPEIAFADLAEDARLAEQFLKYLFRAVLDERGDDLAFLAERVDKNAIAKLEAFINAPFEQIDYTDAVKLLQNS
GKKFDFPVEWGLDLQTEHERWLTEEHIGRPVVVTNYPEHIKAFYMRLNDDGKTVAAMDVLAPGIGEIIGGSQREERLDVL
DARMAQFGLDKEHYSWYRDFRRYGSVPHAGFGLGFERLVVYVCGLSNIRDAIPYPRAPGSAEF

Specific function: Unknown

COG id: COG0017

COG function: function code J; Aspartyl/asparaginyl-tRNA synthetases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI226491502, Length=463, Percent_Identity=42.3326133909287, Blast_Score=369, Evalue=1e-102,
Organism=Homo sapiens, GI4758762, Length=455, Percent_Identity=27.6923076923077, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI45439306, Length=350, Percent_Identity=28.5714285714286, Blast_Score=119, Evalue=5e-27,
Organism=Escherichia coli, GI1787161, Length=466, Percent_Identity=67.5965665236051, Blast_Score=668, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17556372, Length=425, Percent_Identity=32.4705882352941, Blast_Score=206, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI71984122, Length=456, Percent_Identity=30.7017543859649, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI17551876, Length=341, Percent_Identity=29.3255131964809, Blast_Score=110, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6319872, Length=474, Percent_Identity=36.9198312236287, Blast_Score=293, Evalue=5e-80,
Organism=Saccharomyces cerevisiae, GI6321807, Length=461, Percent_Identity=31.6702819956616, Blast_Score=211, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6323011, Length=348, Percent_Identity=28.448275862069, Blast_Score=109, Evalue=9e-25,
Organism=Drosophila melanogaster, GI19922416, Length=452, Percent_Identity=34.9557522123894, Blast_Score=270, Evalue=1e-72,
Organism=Drosophila melanogaster, GI19921528, Length=452, Percent_Identity=29.4247787610619, Blast_Score=178, Evalue=7e-45,
Organism=Drosophila melanogaster, GI17136276, Length=487, Percent_Identity=27.3100616016427, Blast_Score=115, Evalue=5e-26,

Paralogues:

None

Copy number: 80 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): SYN_XANAC (Q8PM16)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_641950.1
- ProteinModelPortal:   Q8PM16
- SMR:   Q8PM16
- GeneID:   1155689
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC1618
- NMPDR:   fig|190486.1.peg.1594
- HOGENOM:   HBG745843
- OMA:   EPEMAFC
- ProtClustDB:   PRK03932
- BioCyc:   XAXO190486:XAC1618-MONOMER
- BRENDA:   6.1.1.22
- GO:   GO:0005737
- HAMAP:   MF_00534
- InterPro:   IPR004364
- InterPro:   IPR018150
- InterPro:   IPR006195
- InterPro:   IPR004522
- InterPro:   IPR002312
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004365
- Gene3D:   G3DSA:2.40.50.140
- PANTHER:   PTHR22594
- PRINTS:   PR01042
- TIGRFAMs:   TIGR00457

Pfam domain/function: PF00152 tRNA-synt_2; PF01336 tRNA_anti; SSF50249 Nucleic_acid_OB

EC number: =6.1.1.22

Molecular weight: Translated: 51811; Mature: 51680

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVVSVEHALAGKLPEGGEVTVRGWVRTLRGSAGLAFINVTDGSCFAPIQVVANDTLPNF
CEEEEECHHHHCCCCCCCCEEHHHHHHHHCCCCCEEEEEECCCCCCCCEEEEECCCCCCH
DEIKRLTSGCSLIAKGVLVKSQGKGQSFEIQASGVDVVGWVEDPLTYPIQPKPMTPEFLR
HHHHHHHHHHHHHHHCCEEECCCCCCEEEEEECCEEEEEECCCCCCCCCCCCCCCHHHHH
EVAHLRPRTNLFGAVTRIRNCLAQAVHRFFHQNGFNWISTPIITTSDAEGAGQMFRVSTL
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCEEEECCCCCCCCEEEEEEE
DMVNLPRDASGAVDFSRDFFGKETFLTVSGQLNVEAYCLALSKVYTFGPTFRAENSHTTR
HHHCCCCCCCCCCCCHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEECCCCCHHH
HLAEFWMIEPEIAFADLAEDARLAEQFLKYLFRAVLDERGDDLAFLAERVDKNAIAKLEA
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCHHHHHHHHH
FINAPFEQIDYTDAVKLLQNSGKKFDFPVEWGLDLQTEHERWLTEEHIGRPVVVTNYPEH
HHCCCHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEECCCHHH
IKAFYMRLNDDGKTVAAMDVLAPGIGEIIGGSQREERLDVLDARMAQFGLDKEHYSWYRD
HHHHHHEECCCCCEEEHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHH
FRRYGSVPHAGFGLGFERLVVYVCGLSNIRDAIPYPRAPGSAEF
HHHHCCCCCCCCCCCHHHHHHHHHCHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
TVVSVEHALAGKLPEGGEVTVRGWVRTLRGSAGLAFINVTDGSCFAPIQVVANDTLPNF
EEEEECHHHHCCCCCCCCEEHHHHHHHHCCCCCEEEEEECCCCCCCCEEEEECCCCCCH
DEIKRLTSGCSLIAKGVLVKSQGKGQSFEIQASGVDVVGWVEDPLTYPIQPKPMTPEFLR
HHHHHHHHHHHHHHHCCEEECCCCCCEEEEEECCEEEEEECCCCCCCCCCCCCCCHHHHH
EVAHLRPRTNLFGAVTRIRNCLAQAVHRFFHQNGFNWISTPIITTSDAEGAGQMFRVSTL
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCEEEECCCCCCCCEEEEEEE
DMVNLPRDASGAVDFSRDFFGKETFLTVSGQLNVEAYCLALSKVYTFGPTFRAENSHTTR
HHHCCCCCCCCCCCCHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEECCCCCHHH
HLAEFWMIEPEIAFADLAEDARLAEQFLKYLFRAVLDERGDDLAFLAERVDKNAIAKLEA
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCHHHHHHHHH
FINAPFEQIDYTDAVKLLQNSGKKFDFPVEWGLDLQTEHERWLTEEHIGRPVVVTNYPEH
HHCCCHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEECCCHHH
IKAFYMRLNDDGKTVAAMDVLAPGIGEIIGGSQREERLDVLDARMAQFGLDKEHYSWYRD
HHHHHHEECCCCCEEEHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHH
FRRYGSVPHAGFGLGFERLVVYVCGLSNIRDAIPYPRAPGSAEF
HHHHCCCCCCCCCCCHHHHHHHHHCHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217