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The map label for this gene is hisC [H]

Identifier: 21242376

GI number: 21242376

Start: 1871684

End: 1872808

Strand: Reverse

Name: hisC [H]

Synonym: XAC1626

Alternate gene names: 21242376

Gene position: 1872808-1871684 (Counterclockwise)

Preceding gene: 77748597

Following gene: 21242368

Centisome position: 36.19

GC content: 69.87

Gene sequence:

>1125_bases
GTGTCGTTGCCCGTCTCGCGCCGTTCGTTTCTCAGCCTCGCTACCACCGGCGTGGCGGTTTCCGCACTGGGGCTGGCACC
CGCAGCCCAGGCGGCCCGCAAGCGCGCCGCGGCCCCGGCAACGCCGGGCGTGGCCGCGGCGGCCGGCACGGTCTACCTCA
ACCTCAACGAGCATCCGCTCGGGCCCGCCCCGGCAGCGATTGAAGCTGCCACACGTTCGCTGGCACGCTCGGGCCGCTAC
CTGCTCGAGATGGAGCACGATCTGCGCAACCTGATGACCGGCGAGCTGCAGTTGCCCAACGATCATCTATCGCTGTTCCC
CGGCTCGCGTGACGCGCTGAACCGGGCCGGCAGCCTGTTGACGTCCGCGCGCGCGGGGCTGGTGGTCGCCGACCCCAGCT
TCGACCCGCTGATCGAAAGCGCCACCGCCCGCGGCGTGGCCGTACGCAAGGTGCCGCTGCGTGCCGATGGCGCGCACGAC
GTCAAGGCGATGGCCAAGGCCGACCCGACTGCCGGCATGCTGTATCTGTGCAACCCCGGCAACGCCACTGGCGCCATCAC
CCCACGCGCCGACATCGAATGGTTGCTGGCCAACAAGCCGGCCAGCGCCGTGCTGGTGGTCGACGAGGCGTACATCCACT
ACAGCAACGAGCCCTCGGTGGCCGATCTGGTGCGTCAGCGCCAGGATCTGATCGTGCTGCGCAGCTTCTCCAAGCTCTAC
GGCATGGCTGGCCTGCGCCTGGGTGCCGCCCTGGCCCCGCCCGGCCTGCAGACCAAGCTTGCCGCATTCGGCAGCAACCC
GTCGTCGGTTCCGGCGATGGCCGCCGGCATCGCCAGCCTGCGCGACCCGCTGCTGGTGCAGACCCGCCGCGCCGAGAACG
CCCGCGTGCGCGAGGAGACCATCGCCTGGCTCAAGGGCAAGGGCTACACCTGCCTGCCCTCGCAAGCCAACTGCTTCCTG
CTGGACGTCAAGCGCGATGCAAGCGTGTTCGCCGATTCGATGCAGAAGCAGGGCGTCATCGTCGGCCGCAGCTGGCCGAT
CTGGCCCAAGCGGGTGCGCGTCAGCGTGGGGACCGAGGCGGAAATGCTGCGGTTCCGTGAGGCGTTCGGGAAGGCCAAGC
GCTAA

Upstream 100 bases:

>100_bases
GCACGCGTCCAACCAGTTTTATGGCAATTCCCCGATAGGCAGACAGACACAAACCGGCTAGCGTGGCGCCCTCTTTGCCC
GCCGCCTATGGAGTTCGCCC

Downstream 100 bases:

>100_bases
CCCTTTTCCCCTTGGGACGTTGCCTCCTTTATGGGGGGAGAAAGTGCCCCGTAGGGGCGGATGAGGGTGCGGGCGAAGCC
TGAGGTTGTTCAACTGCACG

Product: aminotransferase

Products: 3-(imidazol-4-yl)-2-oxopropyl phosphate; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 374; Mature: 373

Protein sequence:

>374_residues
MSLPVSRRSFLSLATTGVAVSALGLAPAAQAARKRAAAPATPGVAAAAGTVYLNLNEHPLGPAPAAIEAATRSLARSGRY
LLEMEHDLRNLMTGELQLPNDHLSLFPGSRDALNRAGSLLTSARAGLVVADPSFDPLIESATARGVAVRKVPLRADGAHD
VKAMAKADPTAGMLYLCNPGNATGAITPRADIEWLLANKPASAVLVVDEAYIHYSNEPSVADLVRQRQDLIVLRSFSKLY
GMAGLRLGAALAPPGLQTKLAAFGSNPSSVPAMAAGIASLRDPLLVQTRRAENARVREETIAWLKGKGYTCLPSQANCFL
LDVKRDASVFADSMQKQGVIVGRSWPIWPKRVRVSVGTEAEMLRFREAFGKAKR

Sequences:

>Translated_374_residues
MSLPVSRRSFLSLATTGVAVSALGLAPAAQAARKRAAAPATPGVAAAAGTVYLNLNEHPLGPAPAAIEAATRSLARSGRY
LLEMEHDLRNLMTGELQLPNDHLSLFPGSRDALNRAGSLLTSARAGLVVADPSFDPLIESATARGVAVRKVPLRADGAHD
VKAMAKADPTAGMLYLCNPGNATGAITPRADIEWLLANKPASAVLVVDEAYIHYSNEPSVADLVRQRQDLIVLRSFSKLY
GMAGLRLGAALAPPGLQTKLAAFGSNPSSVPAMAAGIASLRDPLLVQTRRAENARVREETIAWLKGKGYTCLPSQANCFL
LDVKRDASVFADSMQKQGVIVGRSWPIWPKRVRVSVGTEAEMLRFREAFGKAKR
>Mature_373_residues
SLPVSRRSFLSLATTGVAVSALGLAPAAQAARKRAAAPATPGVAAAAGTVYLNLNEHPLGPAPAAIEAATRSLARSGRYL
LEMEHDLRNLMTGELQLPNDHLSLFPGSRDALNRAGSLLTSARAGLVVADPSFDPLIESATARGVAVRKVPLRADGAHDV
KAMAKADPTAGMLYLCNPGNATGAITPRADIEWLLANKPASAVLVVDEAYIHYSNEPSVADLVRQRQDLIVLRSFSKLYG
MAGLRLGAALAPPGLQTKLAAFGSNPSSVPAMAAGIASLRDPLLVQTRRAENARVREETIAWLKGKGYTCLPSQANCFLL
DVKRDASVFADSMQKQGVIVGRSWPIWPKRVRVSVGTEAEMLRFREAFGKAKR

Specific function: May catalyze the transamination reaction in phenylalanine biosynthesis [H]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=253, Percent_Identity=28.0632411067194, Blast_Score=79, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6322075, Length=276, Percent_Identity=28.2608695652174, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001176
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: 2.6.1.9

Molecular weight: Translated: 39658; Mature: 39527

Theoretical pI: Translated: 10.50; Mature: 10.50

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLPVSRRSFLSLATTGVAVSALGLAPAAQAARKRAAAPATPGVAAAAGTVYLNLNEHPL
CCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCEEECCEEEEEECCCCC
GPAPAAIEAATRSLARSGRYLLEMEHDLRNLMTGELQLPNDHLSLFPGSRDALNRAGSLL
CCCCHHHHHHHHHHHHCCCEEEEEHHHHHHHCCCCEECCCCCEEECCCCHHHHHHHHHHH
TSARAGLVVADPSFDPLIESATARGVAVRKVPLRADGAHDVKAMAKADPTAGMLYLCNPG
HHCCCCEEEECCCCCHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHCCCCCCEEEEECCC
NATGAITPRADIEWLLANKPASAVLVVDEAYIHYSNEPSVADLVRQRQDLIVLRSFSKLY
CCCCEECCCCCEEEEEECCCCCEEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
GMAGLRLGAALAPPGLQTKLAAFGSNPSSVPAMAAGIASLRDPLLVQTRRAENARVREET
HHHHHHHCCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCHHHHHH
IAWLKGKGYTCLPSQANCFLLDVKRDASVFADSMQKQGVIVGRSWPIWPKRVRVSVGTEA
HHHCCCCCCEECCCCCCEEEEEECCCHHHHHHHHHHCCEEEECCCCCCCCEEEEEECCHH
EMLRFREAFGKAKR
HHHHHHHHHCCCCC
>Mature Secondary Structure 
SLPVSRRSFLSLATTGVAVSALGLAPAAQAARKRAAAPATPGVAAAAGTVYLNLNEHPL
CCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCEEECCEEEEEECCCCC
GPAPAAIEAATRSLARSGRYLLEMEHDLRNLMTGELQLPNDHLSLFPGSRDALNRAGSLL
CCCCHHHHHHHHHHHHCCCEEEEEHHHHHHHCCCCEECCCCCEEECCCCHHHHHHHHHHH
TSARAGLVVADPSFDPLIESATARGVAVRKVPLRADGAHDVKAMAKADPTAGMLYLCNPG
HHCCCCEEEECCCCCHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHCCCCCCEEEEECCC
NATGAITPRADIEWLLANKPASAVLVVDEAYIHYSNEPSVADLVRQRQDLIVLRSFSKLY
CCCCEECCCCCEEEEEECCCCCEEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
GMAGLRLGAALAPPGLQTKLAAFGSNPSSVPAMAAGIASLRDPLLVQTRRAENARVREET
HHHHHHHCCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCHHHHHH
IAWLKGKGYTCLPSQANCFLLDVKRDASVFADSMQKQGVIVGRSWPIWPKRVRVSVGTEA
HHHCCCCCCEECCCCCCEEEEEECCCHHHHHHHHHHCCEEEECCCCCCCCEEEEEECCHH
EMLRFREAFGKAKR
HHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Pyridoxal Phosphate. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-histidinol phosphate; 2-oxoglutarate

Specific reaction: L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate

General reaction: Amino group transfer [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA