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The map label for this gene is kynU

Identifier: 21242351

GI number: 21242351

Start: 1849041

End: 1850312

Strand: Reverse

Name: kynU

Synonym: XAC1601

Alternate gene names: 21242351

Gene position: 1850312-1849041 (Counterclockwise)

Preceding gene: 21242352

Following gene: 21242350

Centisome position: 35.75

GC content: 68.32

Gene sequence:

>1272_bases
ATGACCGACCCGCTGTCCCGCGCCCATGCTGCTGCACTGGATGCCGCCGACCCGCTGCGCAACCTGCGCGATGCCTTCGT
GTTCCCGCAGCACGGCGATGACGATCAGACCTATTTCGTCGGCAATTCGCTCGGCCTGCAGCCGCGCGCGGCCCGCGCGA
TGGTGGACGAGGTGCTCGACCAGTGGGGTGCGCTGGCGGTGGAAGGCCACTTCACCGGCCCGACCCAATGGCTGACGTAC
CACCAGTTGGTGGGCGACGCGCTGGCGCGCGTGGTCGGTGCGCAACCCGGCGAAGTGGTGGCCATGAACACCCTCAGCGT
CAATCTGCATCTGATGATGGCGAGCTTCTATCGTCCCACTGCCGAGCGCGGCGCGATCCTGATCGAAGCTGGCGCATTTC
CGTCCGACCGCCATGCGGTGGAATCGCAGCTGCGCCTGCACGGGCTGGACCCGGCCACGCATCTGATCGAAGTGGAAGCC
GACGAACCCAACGGCACCGTGTCGATGTCGGCCATCGCCGAGGCCATTGCGCAGCATGGTCCGCACCTGGCGTTGGTGCT
GTGGCCGGGCATCCAGTACCGCACCGGGCAGGCCTTCGACCTAGCCGAAATCGTGCGGCTGGCGCGCGCGCAGGGCGCGG
CGGTGGGTTTAGATCTGGCGCATGCGGTGGGCAATCTCCCGCTGACCCTGCACGACGACGGCGTGGATTTCGCGGTGTGG
TGCCACTACAAATATCTCAACGCCGGTCCCGGCGCGGTGGGCGGTTGCTTCGTGCACGCGCGGCATGCGACGAGCGACCT
GCCGCGCATGGCCGGCTGGTGGGGACATGAGCAGCAGACCCGCTTCCGCATGGACCCGCAGTTCGTGCCCTCGCCCGGTG
CCGAAGGCTGGCAGCTGAGCAATCCACCGGTGCTGGCGCTGGCACCGCTGCGCGCCTCGCTGGCGTTGTTCGACCAGGCC
GGCATGGCTGCATTGCGCGCCAAGTCCGAACAGCTCACCGGGCATCTGGAGCAGATGATCCACGCGCGGGTGCCGCAGGT
GCTGCAGATCGTCACGCCGGTAGAACCAGCGCGACGCGGTTGCCAGCTCTCGCTGCGGGTGGCCGGCGGACGCGCACGGG
GCCGCGCGCTGTTCGAGCACCTCCACGCAGCCGGCGTGCTTGGCGACTGGCGCGAACCGGACGTGATCCGTATTGCGCCC
GTGCCGCTGTACAACCGCTTCAGCGATCTGCATACCTTCGTGGAGCAGGTGGAAGCCTGGGCGGCTGCTTGA

Upstream 100 bases:

>100_bases
CCCTGCCCGACCGGCCTCGGCCGGCGCGCCGGCCGTGCATGACGGCGTGCACGATGCCGGCAGGTAAACTGCCGCCCTGA
TCCGTGTTGCGAGCCCGACG

Downstream 100 bases:

>100_bases
GCGCGGCAGTCTGACTGCAGTGCCTCCAGCGCACCTGTATGGCACGCGGAATCGCCGCGCGCCCACGTACACTCCCAGCC
CGCCCGGCGTTGCTGCCAGT

Product: kynureninase

Products: NA

Alternate protein names: L-kynurenine hydrolase

Number of amino acids: Translated: 423; Mature: 422

Protein sequence:

>423_residues
MTDPLSRAHAAALDAADPLRNLRDAFVFPQHGDDDQTYFVGNSLGLQPRAARAMVDEVLDQWGALAVEGHFTGPTQWLTY
HQLVGDALARVVGAQPGEVVAMNTLSVNLHLMMASFYRPTAERGAILIEAGAFPSDRHAVESQLRLHGLDPATHLIEVEA
DEPNGTVSMSAIAEAIAQHGPHLALVLWPGIQYRTGQAFDLAEIVRLARAQGAAVGLDLAHAVGNLPLTLHDDGVDFAVW
CHYKYLNAGPGAVGGCFVHARHATSDLPRMAGWWGHEQQTRFRMDPQFVPSPGAEGWQLSNPPVLALAPLRASLALFDQA
GMAALRAKSEQLTGHLEQMIHARVPQVLQIVTPVEPARRGCQLSLRVAGGRARGRALFEHLHAAGVLGDWREPDVIRIAP
VPLYNRFSDLHTFVEQVEAWAAA

Sequences:

>Translated_423_residues
MTDPLSRAHAAALDAADPLRNLRDAFVFPQHGDDDQTYFVGNSLGLQPRAARAMVDEVLDQWGALAVEGHFTGPTQWLTY
HQLVGDALARVVGAQPGEVVAMNTLSVNLHLMMASFYRPTAERGAILIEAGAFPSDRHAVESQLRLHGLDPATHLIEVEA
DEPNGTVSMSAIAEAIAQHGPHLALVLWPGIQYRTGQAFDLAEIVRLARAQGAAVGLDLAHAVGNLPLTLHDDGVDFAVW
CHYKYLNAGPGAVGGCFVHARHATSDLPRMAGWWGHEQQTRFRMDPQFVPSPGAEGWQLSNPPVLALAPLRASLALFDQA
GMAALRAKSEQLTGHLEQMIHARVPQVLQIVTPVEPARRGCQLSLRVAGGRARGRALFEHLHAAGVLGDWREPDVIRIAP
VPLYNRFSDLHTFVEQVEAWAAA
>Mature_422_residues
TDPLSRAHAAALDAADPLRNLRDAFVFPQHGDDDQTYFVGNSLGLQPRAARAMVDEVLDQWGALAVEGHFTGPTQWLTYH
QLVGDALARVVGAQPGEVVAMNTLSVNLHLMMASFYRPTAERGAILIEAGAFPSDRHAVESQLRLHGLDPATHLIEVEAD
EPNGTVSMSAIAEAIAQHGPHLALVLWPGIQYRTGQAFDLAEIVRLARAQGAAVGLDLAHAVGNLPLTLHDDGVDFAVWC
HYKYLNAGPGAVGGCFVHARHATSDLPRMAGWWGHEQQTRFRMDPQFVPSPGAEGWQLSNPPVLALAPLRASLALFDQAG
MAALRAKSEQLTGHLEQMIHARVPQVLQIVTPVEPARRGCQLSLRVAGGRARGRALFEHLHAAGVLGDWREPDVIRIAPV
PLYNRFSDLHTFVEQVEAWAAA

Specific function: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively

COG id: COG3844

COG function: function code E; Kynureninase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kynureninase family

Homologues:

Organism=Homo sapiens, GI4504937, Length=431, Percent_Identity=42.6914153132251, Blast_Score=360, Evalue=1e-99,
Organism=Homo sapiens, GI74101437, Length=284, Percent_Identity=41.5492957746479, Blast_Score=234, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI17550466, Length=435, Percent_Identity=39.0804597701149, Blast_Score=324, Evalue=5e-89,
Organism=Saccharomyces cerevisiae, GI6323261, Length=441, Percent_Identity=41.4965986394558, Blast_Score=324, Evalue=2e-89,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KYNU_XANAC (Q8PM33)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_641933.1
- ProteinModelPortal:   Q8PM33
- SMR:   Q8PM33
- GeneID:   1155672
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC1601
- NMPDR:   fig|190486.1.peg.1577
- HOGENOM:   HBG523016
- OMA:   MTDDIAL
- ProtClustDB:   CLSK903751
- BioCyc:   XAXO190486:XAC1601-MONOMER
- GO:   GO:0005737
- InterPro:   IPR000192
- InterPro:   IPR010111
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR14084
- TIGRFAMs:   TIGR01814

Pfam domain/function: PF00266 Aminotran_5; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =3.7.1.3

Molecular weight: Translated: 45846; Mature: 45714

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: NA

Important sites: BINDING 105-105 BINDING 106-106 BINDING 218-218 BINDING 221-221 BINDING 243-243 BINDING 273-273 BINDING 301-301

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDPLSRAHAAALDAADPLRNLRDAFVFPQHGDDDQTYFVGNSLGLQPRAARAMVDEVLD
CCCCHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHH
QWGALAVEGHFTGPTQWLTYHQLVGDALARVVGAQPGEVVAMNTLSVNLHLMMASFYRPT
HCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEEEEEEHHHHCCC
AERGAILIEAGAFPSDRHAVESQLRLHGLDPATHLIEVEADEPNGTVSMSAIAEAIAQHG
CCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCEEHHHHHHHHHHCC
PHLALVLWPGIQYRTGQAFDLAEIVRLARAQGAAVGLDLAHAVGNLPLTLHDDGVDFAVW
CEEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCEECHHHHHHHCCCCEEEECCCCCEEEE
CHYKYLNAGPGAVGGCFVHARHATSDLPRMAGWWGHEQQTRFRMDPQFVPSPGAEGWQLS
EEEEEECCCCCCCCHHEEEEHHCCCCCHHHHCCCCCCCCCEECCCCCCCCCCCCCCCCCC
NPPVLALAPLRASLALFDQAGMAALRAKSEQLTGHLEQMIHARVPQVLQIVTPVEPARRG
CCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCC
CQLSLRVAGGRARGRALFEHLHAAGVLGDWREPDVIRIAPVPLYNRFSDLHTFVEQVEAW
CEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHH
AAA
HCC
>Mature Secondary Structure 
TDPLSRAHAAALDAADPLRNLRDAFVFPQHGDDDQTYFVGNSLGLQPRAARAMVDEVLD
CCCHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHH
QWGALAVEGHFTGPTQWLTYHQLVGDALARVVGAQPGEVVAMNTLSVNLHLMMASFYRPT
HCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEEEEEEHHHHCCC
AERGAILIEAGAFPSDRHAVESQLRLHGLDPATHLIEVEADEPNGTVSMSAIAEAIAQHG
CCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCEEHHHHHHHHHHCC
PHLALVLWPGIQYRTGQAFDLAEIVRLARAQGAAVGLDLAHAVGNLPLTLHDDGVDFAVW
CEEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCEECHHHHHHHCCCCEEEECCCCCEEEE
CHYKYLNAGPGAVGGCFVHARHATSDLPRMAGWWGHEQQTRFRMDPQFVPSPGAEGWQLS
EEEEEECCCCCCCCHHEEEEHHCCCCCHHHHCCCCCCCCCEECCCCCCCCCCCCCCCCCC
NPPVLALAPLRASLALFDQAGMAALRAKSEQLTGHLEQMIHARVPQVLQIVTPVEPARRG
CCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCC
CQLSLRVAGGRARGRALFEHLHAAGVLGDWREPDVIRIAPVPLYNRFSDLHTFVEQVEAW
CEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHH
AAA
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217