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The map label for this gene is kmo

Identifier: 21242350

GI number: 21242350

Start: 1847520

End: 1848887

Strand: Reverse

Name: kmo

Synonym: XAC1600

Alternate gene names: 21242350

Gene position: 1848887-1847520 (Counterclockwise)

Preceding gene: 21242351

Following gene: 21242349

Centisome position: 35.72

GC content: 66.37

Gene sequence:

>1368_bases
TTGAGCCCAGTTTCTCAGCGTTCCCTGACCCTGATCGGCGCCGGTCTGGCCGGTTGTCTGCTGGCCATCCTGCTGTCGCG
TCGCGGCTGGCAGGTCACCGTGTACGAACGGCGTGGCGACCCGCGCATCAAGGGCTACGAGTCCGGCCGCTCGATTAATC
TGGCGCTGGCCGAACGCGGCCGGCATGCGCTGCGCCAGGCCGGCGCCGAAGATGCGGTGATGGCCAAGGCGGTGATGATG
CGTGGGCGCATGGTGCACCCCTTGGTCGGGCAACCGCAGCTGCAACGCTACGGGCGCGACGACAGCGAGGTGATCTGGTC
GATCCATCGCGCCGCGCTGAATGTCGCCCTGCTCGATCTGGCCGAACAGGCCGGCGCGCGCGTGCACTTCTATCGCCGCC
TGCATACCGTGGATTTCGACGCCGGCTATGCGCGCTTCATCGACGACCGCGACGACCAGCCGCACGAGATCCACTTTCAG
AGTTTGATCGGCAGCGATGGCGCCGGCTCGGCCTTGCGCGCGGCGATGCAGCGCAAATCGCCGCTGGGCGAACGCACCGA
ATTCCTCGATCACTCGTACAAGGAACTGGAAATTCCGCCGCAGCCGGGTGGCGGATTCCGGATCGAAGGCAACGCGCTGC
ATATCTGGCCGCGCGGGCGCTACATGTGTATCGCGCTGCCCAACGATGGCGGGACGTTCACCGTCACCCTGTTCCTGCCC
AACGCCGGCGAGCCGAGCTTCGCCACCACGCGTACCGGCGATGAAGCATTCGCCTTGTTCGCACGCGATTTCCCGGACGC
ATTGCCGCTGATTCCGCAACTCAAGGAACATTGGGAAGAGCATCCGCCCGGGCTGCTCGGCACGCTGACCCTGGATCGCT
GGCATCTGGATGGCCGCGCATTGCTGATCGGCGACGCCGCCCATGCGATGGTGCCGTTCCATGGCCAGGGCATGAATTGC
GCATTCGAAGATTGCGTGGCACTGGCAGATCAACTGGACGCGCACGACGACCTGGCAAGCGCGTTCGCGGCCTTCGAGGC
TGCGCGTCGCGACGATGCGGCCGCCATCCAGCAGATGGCGCTGGAGAACTACCTGGAAATGCGCGACCGCGTCGACGACC
CCGACTTCCTGCTGCAGCGCGAGCTCGAACAGCAGTTGCAGGCGCGCTGGCCCACCCGCTTCGTGCCGCACTACACCATG
GTGACGTTCCTGCGCACGCGCTACTCGATTGCGCTGGCGCGCAGCGAGATCCAGCGCGAGATCCTGGTGCAGGCCACGCG
CGGGCACAGCGATCTGTCGCGCATCGACTGGTCCGCCTTGGAAGCGGTTGTGCACGCACGCCTGGAGCCGCTGGACGGCG
CGCACTGA

Upstream 100 bases:

>100_bases
GCCGCGCGCCCACGTACACTCCCAGCCCGCCCGGCGTTGCTGCCAGTCGCTGTCTTCCCCTTTTCGCCGGCGCTGCGTCC
GGCTGCTTCCGGACATTGCA

Downstream 100 bases:

>100_bases
CGTCTGCGGAGGATGCGGAGGACGGCATTGATGCTTGCAGCGGCGACGGTGACGAGCAGGCTTGCGATTGGCGTGCGGAA
AGGATGTCTCTTCGGTGCGG

Product: kynurenine 3-monooxygenase

Products: NA

Alternate protein names: Kynurenine 3-hydroxylase

Number of amino acids: Translated: 455; Mature: 454

Protein sequence:

>455_residues
MSPVSQRSLTLIGAGLAGCLLAILLSRRGWQVTVYERRGDPRIKGYESGRSINLALAERGRHALRQAGAEDAVMAKAVMM
RGRMVHPLVGQPQLQRYGRDDSEVIWSIHRAALNVALLDLAEQAGARVHFYRRLHTVDFDAGYARFIDDRDDQPHEIHFQ
SLIGSDGAGSALRAAMQRKSPLGERTEFLDHSYKELEIPPQPGGGFRIEGNALHIWPRGRYMCIALPNDGGTFTVTLFLP
NAGEPSFATTRTGDEAFALFARDFPDALPLIPQLKEHWEEHPPGLLGTLTLDRWHLDGRALLIGDAAHAMVPFHGQGMNC
AFEDCVALADQLDAHDDLASAFAAFEAARRDDAAAIQQMALENYLEMRDRVDDPDFLLQRELEQQLQARWPTRFVPHYTM
VTFLRTRYSIALARSEIQREILVQATRGHSDLSRIDWSALEAVVHARLEPLDGAH

Sequences:

>Translated_455_residues
MSPVSQRSLTLIGAGLAGCLLAILLSRRGWQVTVYERRGDPRIKGYESGRSINLALAERGRHALRQAGAEDAVMAKAVMM
RGRMVHPLVGQPQLQRYGRDDSEVIWSIHRAALNVALLDLAEQAGARVHFYRRLHTVDFDAGYARFIDDRDDQPHEIHFQ
SLIGSDGAGSALRAAMQRKSPLGERTEFLDHSYKELEIPPQPGGGFRIEGNALHIWPRGRYMCIALPNDGGTFTVTLFLP
NAGEPSFATTRTGDEAFALFARDFPDALPLIPQLKEHWEEHPPGLLGTLTLDRWHLDGRALLIGDAAHAMVPFHGQGMNC
AFEDCVALADQLDAHDDLASAFAAFEAARRDDAAAIQQMALENYLEMRDRVDDPDFLLQRELEQQLQARWPTRFVPHYTM
VTFLRTRYSIALARSEIQREILVQATRGHSDLSRIDWSALEAVVHARLEPLDGAH
>Mature_454_residues
SPVSQRSLTLIGAGLAGCLLAILLSRRGWQVTVYERRGDPRIKGYESGRSINLALAERGRHALRQAGAEDAVMAKAVMMR
GRMVHPLVGQPQLQRYGRDDSEVIWSIHRAALNVALLDLAEQAGARVHFYRRLHTVDFDAGYARFIDDRDDQPHEIHFQS
LIGSDGAGSALRAAMQRKSPLGERTEFLDHSYKELEIPPQPGGGFRIEGNALHIWPRGRYMCIALPNDGGTFTVTLFLPN
AGEPSFATTRTGDEAFALFARDFPDALPLIPQLKEHWEEHPPGLLGTLTLDRWHLDGRALLIGDAAHAMVPFHGQGMNCA
FEDCVALADQLDAHDDLASAFAAFEAARRDDAAAIQQMALENYLEMRDRVDDPDFLLQRELEQQLQARWPTRFVPHYTMV
TFLRTRYSIALARSEIQREILVQATRGHSDLSRIDWSALEAVVHARLEPLDGAH

Specific function: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid

COG id: COG0654

COG function: function code HC; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aromatic-ring hydroxylase family. KMO subfamily

Homologues:

Organism=Homo sapiens, GI187960045, Length=425, Percent_Identity=37.6470588235294, Blast_Score=297, Evalue=1e-80,
Organism=Caenorhabditis elegans, GI17562934, Length=454, Percent_Identity=33.0396475770925, Blast_Score=248, Evalue=3e-66,
Organism=Caenorhabditis elegans, GI212646493, Length=416, Percent_Identity=25.4807692307692, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI193208447, Length=369, Percent_Identity=24.1192411924119, Blast_Score=123, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6319372, Length=433, Percent_Identity=36.2586605080831, Blast_Score=249, Evalue=9e-67,
Organism=Drosophila melanogaster, GI28573964, Length=417, Percent_Identity=36.6906474820144, Blast_Score=243, Evalue=2e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KMO_XANAC (Q8PM34)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_641932.1
- ProteinModelPortal:   Q8PM34
- GeneID:   1155671
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC1600
- NMPDR:   fig|190486.1.peg.1576
- HOGENOM:   HBG430104
- OMA:   HWQKKVI
- ProtClustDB:   CLSK903475
- BioCyc:   XAXO190486:XAC1600-MONOMER
- InterPro:   IPR002938
- InterPro:   IPR003042
- PRINTS:   PR00420

Pfam domain/function: PF01494 FAD_binding_3

EC number: =1.14.13.9

Molecular weight: Translated: 50858; Mature: 50727

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPVSQRSLTLIGAGLAGCLLAILLSRRGWQVTVYERRGDPRIKGYESGRSINLALAERG
CCCCCCCCEEEECCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCEEEEHHHHHH
RHALRQAGAEDAVMAKAVMMRGRMVHPLVGQPQLQRYGRDDSEVIWSIHRAALNVALLDL
HHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
AEQAGARVHFYRRLHTVDFDAGYARFIDDRDDQPHEIHFQSLIGSDGAGSALRAAMQRKS
HHHCCCEEEEEHHHEEEECCCCHHHHCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHCC
PLGERTEFLDHSYKELEIPPQPGGGFRIEGNALHIWPRGRYMCIALPNDGGTFTVTLFLP
CCCHHHHHHCCCHHHCCCCCCCCCCEEEECCEEEEEECCCEEEEEEECCCCEEEEEEEEC
NAGEPSFATTRTGDEAFALFARDFPDALPLIPQLKEHWEEHPPGLLGTLTLDRWHLDGRA
CCCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEEEEEEEEEEECCCE
LLIGDAAHAMVPFHGQGMNCAFEDCVALADQLDAHDDLASAFAAFEAARRDDAAAIQQMA
EEEECCCCEEEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHH
LENYLEMRDRVDDPDFLLQRELEQQLQARWPTRFVPHYTMVTFLRTRYSIALARSEIQRE
HHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ILVQATRGHSDLSRIDWSALEAVVHARLEPLDGAH
HHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SPVSQRSLTLIGAGLAGCLLAILLSRRGWQVTVYERRGDPRIKGYESGRSINLALAERG
CCCCCCCEEEECCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCEEEEHHHHHH
RHALRQAGAEDAVMAKAVMMRGRMVHPLVGQPQLQRYGRDDSEVIWSIHRAALNVALLDL
HHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
AEQAGARVHFYRRLHTVDFDAGYARFIDDRDDQPHEIHFQSLIGSDGAGSALRAAMQRKS
HHHCCCEEEEEHHHEEEECCCCHHHHCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHCC
PLGERTEFLDHSYKELEIPPQPGGGFRIEGNALHIWPRGRYMCIALPNDGGTFTVTLFLP
CCCHHHHHHCCCHHHCCCCCCCCCCEEEECCEEEEEECCCEEEEEEECCCCEEEEEEEEC
NAGEPSFATTRTGDEAFALFARDFPDALPLIPQLKEHWEEHPPGLLGTLTLDRWHLDGRA
CCCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEEEEEEEEEEECCCE
LLIGDAAHAMVPFHGQGMNCAFEDCVALADQLDAHDDLASAFAAFEAARRDDAAAIQQMA
EEEECCCCEEEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHH
LENYLEMRDRVDDPDFLLQRELEQQLQARWPTRFVPHYTMVTFLRTRYSIALARSEIQRE
HHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ILVQATRGHSDLSRIDWSALEAVVHARLEPLDGAH
HHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217