| Definition | Xanthomonas axonopodis pv. citri str. 306 chromosome, complete genome. |
|---|---|
| Accession | NC_003919 |
| Length | 5,175,554 |
Click here to switch to the map view.
The map label for this gene is metH [H]
Identifier: 21242310
GI number: 21242310
Start: 1800285
End: 1803038
Strand: Reverse
Name: metH [H]
Synonym: XAC1559
Alternate gene names: 21242310
Gene position: 1803038-1800285 (Counterclockwise)
Preceding gene: 21242311
Following gene: 21242299
Centisome position: 34.84
GC content: 61.91
Gene sequence:
>2754_bases ATGAGCACTCCCCGCTACACCCGCTTGTCCGGCCTTGAGCCGCTGGTCATTACGCCGGACCTGTTGTTCGTCAACGTCGG CGAGCGCACCAACGTCACCGGCAGTGCGCAGTTCCGCAAGCTGATCAAGGAGGAGCGCTACGAGGAAGCGGTGGAGGTCG CGCGTCAGCAGGTGGACAGCGGTGCGCAGATCCTCGACGTCAACATGGATGAAGGCCTGATCGATTCGGAGAAGGCAATG ACGCGCTTTCTCAACCTGATCATGTCCGAGCCGGATATCGCGCGCATTCCGGTGATGGTGGATTCGTCCAAGTGGAGTGT CATCGAAGCGGGATTGAAGTGCCTGCAAGGCAAGAGCGTAGTGAATTCCATCTCGCTCAAGGAAGGCGAAGCGGTGTTCA TCGAACACGCCCGCAAGGTGTTGCGCTACGGCGCCGCCGCGGTGGTGATGGCCTTCGACGAAGCGGGCCAGGCCGACACC TGCGCACGCAAGGTCGAGATCTGCACGCGCGCCTACACGCTGCTGACCGAGCAGGTGGGCTTTCCGCCGGAAGACATCAT CTTCGACCCGAACATCTTTGCCGTGGCCACCGGCATCGAAGAGCACGACAACTACGCGGTGGACTTCATCGAAGCTACCC GCATCATCAAGGACACGCTGCCGCACTGCCATGTGTCCGGCGGCGTTTCCAATGTCTCGTTCTCGTTCCGCGGCAACGAA ACCGTACGCCAGGCAATCCACTCGGTGTTCCTGTTCCATGCGATCAAGGCCGGTATGGACATGGGCATCGTCAACGCCGG CGGCATGCCGATCTACGACGAACTGGACCCGGAACTGCGCGAACGCGTGGAGGACGTGATCCTCAACCGACGCCGTGACG GCACCGAACGTCTGCTGGAAATCGCCGAGCGCTACAAGGGCACCAAGGGCGCGGCAAAAGTCGAAGACCTGGCCTGGCGC GACAAGCCGGTACGCGCGCGCTTGGCGCATGCGCTGGTGCATGGCATCGACGCATTCGTGGAAACCGATACCGAAGAAGC GCGCCAGCATTCCACACGCCCTCTGGACGTGATCGAAGGCCCGCTGATGGACGGCATGAACGTGGTGGGCGATTTGTTCG GCGCCGGCAAGATGTTTTTGCCGCAGGTGGTCAAGTCCGCGCGCGTGATGAAAAAAGCGGTGGCGTATCTGCTGCCCTTC ATCGAAGCGGAAAAACTGCGCACCGGCGATGTCGGCAAGTCCAACGGCAAGATCATCATGGCCACCGTCAAGGGCGACGT GCACGACATCGGCAAGAACATCGTCGGCGTGGTGTTGGCCTGCAACAACTTCGACGTGGTGGATCTGGGCGTGATGGTCT CGGCGCAGGTGATCCTGGATCGCGCACGCGAAGAAAACGCGGATCTGATCGGGCTGTCCGGCCTCATCACGCCATCTCTG GAAGAAATGTCGCATGTGGCGCGCGAGATGCAGCGGCAGGGCTTTGACATTCCGTTGTTGATCGGCGGCGCAACGACCTC GCGCGCGCACACCGCGCTGAAGATCGACCCGCACTACACCGCGCCCACCGTGTGGGTGAAGGACGCCTCGCGTGCCGTGG GCGTGGCGCAGTCGCTGATCTCGCGCGACCTGCGCCAGGCCTTCGTCGCCGCCAACGATGCCGATTACGCGGAAATCCGC GCACGCCACCGTAATCGCGGCGATGCCAAGCGCTTGGTGTCGCTCGAAAAAGCGCGTGCGCAACGCTTCGACGGCGATTG GGGCACTTACACGCCACCGGCCCCACGCCAGCCAGGCATCCACGTCTTCGATGACTACCCGTTGCAGGAGCTGATCGAAC TCATCGACTGGACGCCGTTCTTTCAGGCATGGGAACTGGCCGGCAAGTTTCCCGCGATTCTCAGCGACGAAATCGTCGGC ACCCAGGCCAGCGAGCTGTATCGCGACGCACGCCGCATGCTCAAGCGCATCGTCGAAGAGAAGTGGCTGACGGCCAAGGC CGTGTTCGGGCTGTGGCCGGCAAATAGCGTTGGGGATGATGTTGAGGTGATCCTGACGGACCCCCGGGATTCGGAAGTCG AGATTGGAGATTGGCAGAAGCAAAGCCAATCCCGAATTTCCAATCCCCAATCCCGGCAACTCCTGCACTTCTTGCGCCAA CAAGTCGACAAGCCCATCGACCGCCCGGATTTCTGCCTGGCCGATTTCATCGCTCCGAAAAGCAGCGGCACGCAGGACTG GATCGGCGCCTTCGCGGTCACTGCCGGCATCGGTATCGATGCGCATGTGGCCCGGTTCGAAGCCGCGCACGACGACTACA ATTCCATCCTGCTCAAGGCTCTGGCCGACCGTCTGGCAGAGGCACTGGCCGAGCGCCTGCATCAACGCGTGCGCACCGAG TTCTGGGGTTATGTCGAGGACGAAGCGTTGGACAACGAAGCCTTGATCGCCGAGCGCTATCGCGGCATTCGCCCGGCACC CGGTTACCCGGCCTGCCCCGAACACAGCGAAAAACGTACCTTGTTCGATCTGCTCGATGCCGAGCGCAACGCCGACATGT CGCTGACCGAAAGCTTCGCGATGCTGCCCACTGCCGCGGTCTCCGGGTATTACTTCAGCCACCCCAAGAGCCAGTACTTC GTGGTCGGGCGACTGAGCAAGGAACAGGTGGCCGATTATGCAAAGCGCAAGGGCATCACGCTGGCACTGGCCGAGCGTTG GCTGGCATTGAATCTGGATTACGACCCGGAGTAA
Upstream 100 bases:
>100_bases GGATGAGGGCCGCATTGCACCGCGCCCCAGGGCCGGGCCGTGAACACCGACTCACCACGACCGATCGCGCCGTCGGCGTC GCCTTCCAGCAGAGCCTTGC
Downstream 100 bases:
>100_bases GGGCATCTGCAGTCCGCAGATCGCAGGAGCGCACCCGGGCGCGATGAGGCTTTCCTGGTAGAACCTCATCGCGCCCGGGT GCGCTCCTACGCTGCAACGC
Product: 5-methyltetrahydrofolate-homocysteine methyltransferase
Products: NA
Alternate protein names: 5-methyltetrahydrofolate--homocysteine methyltransferase; Methionine synthase, vitamin-B12-dependent; MS [H]
Number of amino acids: Translated: 917; Mature: 916
Protein sequence:
>917_residues MSTPRYTRLSGLEPLVITPDLLFVNVGERTNVTGSAQFRKLIKEERYEEAVEVARQQVDSGAQILDVNMDEGLIDSEKAM TRFLNLIMSEPDIARIPVMVDSSKWSVIEAGLKCLQGKSVVNSISLKEGEAVFIEHARKVLRYGAAAVVMAFDEAGQADT CARKVEICTRAYTLLTEQVGFPPEDIIFDPNIFAVATGIEEHDNYAVDFIEATRIIKDTLPHCHVSGGVSNVSFSFRGNE TVRQAIHSVFLFHAIKAGMDMGIVNAGGMPIYDELDPELRERVEDVILNRRRDGTERLLEIAERYKGTKGAAKVEDLAWR DKPVRARLAHALVHGIDAFVETDTEEARQHSTRPLDVIEGPLMDGMNVVGDLFGAGKMFLPQVVKSARVMKKAVAYLLPF IEAEKLRTGDVGKSNGKIIMATVKGDVHDIGKNIVGVVLACNNFDVVDLGVMVSAQVILDRAREENADLIGLSGLITPSL EEMSHVAREMQRQGFDIPLLIGGATTSRAHTALKIDPHYTAPTVWVKDASRAVGVAQSLISRDLRQAFVAANDADYAEIR ARHRNRGDAKRLVSLEKARAQRFDGDWGTYTPPAPRQPGIHVFDDYPLQELIELIDWTPFFQAWELAGKFPAILSDEIVG TQASELYRDARRMLKRIVEEKWLTAKAVFGLWPANSVGDDVEVILTDPRDSEVEIGDWQKQSQSRISNPQSRQLLHFLRQ QVDKPIDRPDFCLADFIAPKSSGTQDWIGAFAVTAGIGIDAHVARFEAAHDDYNSILLKALADRLAEALAERLHQRVRTE FWGYVEDEALDNEALIAERYRGIRPAPGYPACPEHSEKRTLFDLLDAERNADMSLTESFAMLPTAAVSGYYFSHPKSQYF VVGRLSKEQVADYAKRKGITLALAERWLALNLDYDPE
Sequences:
>Translated_917_residues MSTPRYTRLSGLEPLVITPDLLFVNVGERTNVTGSAQFRKLIKEERYEEAVEVARQQVDSGAQILDVNMDEGLIDSEKAM TRFLNLIMSEPDIARIPVMVDSSKWSVIEAGLKCLQGKSVVNSISLKEGEAVFIEHARKVLRYGAAAVVMAFDEAGQADT CARKVEICTRAYTLLTEQVGFPPEDIIFDPNIFAVATGIEEHDNYAVDFIEATRIIKDTLPHCHVSGGVSNVSFSFRGNE TVRQAIHSVFLFHAIKAGMDMGIVNAGGMPIYDELDPELRERVEDVILNRRRDGTERLLEIAERYKGTKGAAKVEDLAWR DKPVRARLAHALVHGIDAFVETDTEEARQHSTRPLDVIEGPLMDGMNVVGDLFGAGKMFLPQVVKSARVMKKAVAYLLPF IEAEKLRTGDVGKSNGKIIMATVKGDVHDIGKNIVGVVLACNNFDVVDLGVMVSAQVILDRAREENADLIGLSGLITPSL EEMSHVAREMQRQGFDIPLLIGGATTSRAHTALKIDPHYTAPTVWVKDASRAVGVAQSLISRDLRQAFVAANDADYAEIR ARHRNRGDAKRLVSLEKARAQRFDGDWGTYTPPAPRQPGIHVFDDYPLQELIELIDWTPFFQAWELAGKFPAILSDEIVG TQASELYRDARRMLKRIVEEKWLTAKAVFGLWPANSVGDDVEVILTDPRDSEVEIGDWQKQSQSRISNPQSRQLLHFLRQ QVDKPIDRPDFCLADFIAPKSSGTQDWIGAFAVTAGIGIDAHVARFEAAHDDYNSILLKALADRLAEALAERLHQRVRTE FWGYVEDEALDNEALIAERYRGIRPAPGYPACPEHSEKRTLFDLLDAERNADMSLTESFAMLPTAAVSGYYFSHPKSQYF VVGRLSKEQVADYAKRKGITLALAERWLALNLDYDPE >Mature_916_residues STPRYTRLSGLEPLVITPDLLFVNVGERTNVTGSAQFRKLIKEERYEEAVEVARQQVDSGAQILDVNMDEGLIDSEKAMT RFLNLIMSEPDIARIPVMVDSSKWSVIEAGLKCLQGKSVVNSISLKEGEAVFIEHARKVLRYGAAAVVMAFDEAGQADTC ARKVEICTRAYTLLTEQVGFPPEDIIFDPNIFAVATGIEEHDNYAVDFIEATRIIKDTLPHCHVSGGVSNVSFSFRGNET VRQAIHSVFLFHAIKAGMDMGIVNAGGMPIYDELDPELRERVEDVILNRRRDGTERLLEIAERYKGTKGAAKVEDLAWRD KPVRARLAHALVHGIDAFVETDTEEARQHSTRPLDVIEGPLMDGMNVVGDLFGAGKMFLPQVVKSARVMKKAVAYLLPFI EAEKLRTGDVGKSNGKIIMATVKGDVHDIGKNIVGVVLACNNFDVVDLGVMVSAQVILDRAREENADLIGLSGLITPSLE EMSHVAREMQRQGFDIPLLIGGATTSRAHTALKIDPHYTAPTVWVKDASRAVGVAQSLISRDLRQAFVAANDADYAEIRA RHRNRGDAKRLVSLEKARAQRFDGDWGTYTPPAPRQPGIHVFDDYPLQELIELIDWTPFFQAWELAGKFPAILSDEIVGT QASELYRDARRMLKRIVEEKWLTAKAVFGLWPANSVGDDVEVILTDPRDSEVEIGDWQKQSQSRISNPQSRQLLHFLRQQ VDKPIDRPDFCLADFIAPKSSGTQDWIGAFAVTAGIGIDAHVARFEAAHDDYNSILLKALADRLAEALAERLHQRVRTEF WGYVEDEALDNEALIAERYRGIRPAPGYPACPEHSEKRTLFDLLDAERNADMSLTESFAMLPTAAVSGYYFSHPKSQYFV VGRLSKEQVADYAKRKGITLALAERWLALNLDYDPE
Specific function: Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate [H]
COG id: COG1410
COG function: function code E; Methionine synthase I, cobalamin-binding domain
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 pterin-binding domain [H]
Homologues:
Organism=Homo sapiens, GI169790923, Length=927, Percent_Identity=52.7508090614887, Blast_Score=957, Evalue=0.0, Organism=Escherichia coli, GI1790450, Length=914, Percent_Identity=62.144420131291, Blast_Score=1153, Evalue=0.0, Organism=Caenorhabditis elegans, GI17535405, Length=923, Percent_Identity=53.8461538461538, Blast_Score=949, Evalue=0.0,
Paralogues:
None
Copy number: 513 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 1320 Molecules/Cell In: Glucose minimal media [C]
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR006158 - InterPro: IPR011005 - InterPro: IPR003759 - InterPro: IPR011822 - InterPro: IPR000489 - InterPro: IPR003726 - InterPro: IPR004223 [H]
Pfam domain/function: PF02310 B12-binding; PF02607 B12-binding_2; PF02965 Met_synt_B12; PF00809 Pterin_bind; PF02574 S-methyl_trans [H]
EC number: =2.1.1.13 [H]
Molecular weight: Translated: 102052; Mature: 101921
Theoretical pI: Translated: 5.17; Mature: 5.17
Prosite motif: PS50974 ADOMET_ACTIVATION ; PS50972 PTERIN_BINDING
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.8 %Cys (Translated Protein) 2.2 %Met (Translated Protein) 2.9 %Cys+Met (Translated Protein) 0.8 %Cys (Mature Protein) 2.1 %Met (Mature Protein) 2.8 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MSTPRYTRLSGLEPLVITPDLLFVNVGERTNVTGSAQFRKLIKEERYEEAVEVARQQVDS CCCCCCCHHCCCCCEEECCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC GAQILDVNMDEGLIDSEKAMTRFLNLIMSEPDIARIPVMVDSSKWSVIEAGLKCLQGKSV CCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHCCHHH VNSISLKEGEAVFIEHARKVLRYGAAAVVMAFDEAGQADTCARKVEICTRAYTLLTEQVG HHHCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCC FPPEDIIFDPNIFAVATGIEEHDNYAVDFIEATRIIKDTLPHCHVSGGVSNVSFSFRGNE CCCHHEEECCCCEEEEECCHHCCCHHHHHHHHHHHHHHCCCCCEECCCCCEEEEEECCCH TVRQAIHSVFLFHAIKAGMDMGIVNAGGMPIYDELDPELRERVEDVILNRRRDGTERLLE HHHHHHHHHHHHHHHHHCCCCCEECCCCCCCHHCCCHHHHHHHHHHHHHCCCCHHHHHHH IAERYKGTKGAAKVEDLAWRDKPVRARLAHALVHGIDAFVETDTEEARQHSTRPLDVIEG HHHHHCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHCC PLMDGMNVVGDLFGAGKMFLPQVVKSARVMKKAVAYLLPFIEAEKLRTGDVGKSNGKIIM CHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEE ATVKGDVHDIGKNIVGVVLACNNFDVVDLGVMVSAQVILDRAREENADLIGLSGLITPSL EEECCCHHHHHHHHEEEEEEECCCCEEEHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCH EEMSHVAREMQRQGFDIPLLIGGATTSRAHTALKIDPHYTAPTVWVKDASRAVGVAQSLI HHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEECCCCCCCEEEECCHHHHHHHHHHHH SRDLRQAFVAANDADYAEIRARHRNRGDAKRLVSLEKARAQRFDGDWGTYTPPAPRQPGI HHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC HVFDDYPLQELIELIDWTPFFQAWELAGKFPAILSDEIVGTQASELYRDARRMLKRIVEE EEECCCCHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHH KWLTAKAVFGLWPANSVGDDVEVILTDPRDSEVEIGDWQKQSQSRISNPQSRQLLHFLRQ HHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHH QVDKPIDRPDFCLADFIAPKSSGTQDWIGAFAVTAGIGIDAHVARFEAAHDDYNSILLKA HHCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHH LADRLAEALAERLHQRVRTEFWGYVEDEALDNEALIAERYRGIRPAPGYPACPEHSEKRT HHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHH LFDLLDAERNADMSLTESFAMLPTAAVSGYYFSHPKSQYFVVGRLSKEQVADYAKRKGIT HHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEECCCCCCEEEEECCCHHHHHHHHHHCCCE LALAERWLALNLDYDPE EEEECCEEEEECCCCCC >Mature Secondary Structure STPRYTRLSGLEPLVITPDLLFVNVGERTNVTGSAQFRKLIKEERYEEAVEVARQQVDS CCCCCCHHCCCCCEEECCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC GAQILDVNMDEGLIDSEKAMTRFLNLIMSEPDIARIPVMVDSSKWSVIEAGLKCLQGKSV CCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHCCHHH VNSISLKEGEAVFIEHARKVLRYGAAAVVMAFDEAGQADTCARKVEICTRAYTLLTEQVG HHHCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCC FPPEDIIFDPNIFAVATGIEEHDNYAVDFIEATRIIKDTLPHCHVSGGVSNVSFSFRGNE CCCHHEEECCCCEEEEECCHHCCCHHHHHHHHHHHHHHCCCCCEECCCCCEEEEEECCCH TVRQAIHSVFLFHAIKAGMDMGIVNAGGMPIYDELDPELRERVEDVILNRRRDGTERLLE HHHHHHHHHHHHHHHHHCCCCCEECCCCCCCHHCCCHHHHHHHHHHHHHCCCCHHHHHHH IAERYKGTKGAAKVEDLAWRDKPVRARLAHALVHGIDAFVETDTEEARQHSTRPLDVIEG HHHHHCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHCC PLMDGMNVVGDLFGAGKMFLPQVVKSARVMKKAVAYLLPFIEAEKLRTGDVGKSNGKIIM CHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEE ATVKGDVHDIGKNIVGVVLACNNFDVVDLGVMVSAQVILDRAREENADLIGLSGLITPSL EEECCCHHHHHHHHEEEEEEECCCCEEEHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCH EEMSHVAREMQRQGFDIPLLIGGATTSRAHTALKIDPHYTAPTVWVKDASRAVGVAQSLI HHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEECCCCCCCEEEECCHHHHHHHHHHHH SRDLRQAFVAANDADYAEIRARHRNRGDAKRLVSLEKARAQRFDGDWGTYTPPAPRQPGI HHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC HVFDDYPLQELIELIDWTPFFQAWELAGKFPAILSDEIVGTQASELYRDARRMLKRIVEE EEECCCCHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHH KWLTAKAVFGLWPANSVGDDVEVILTDPRDSEVEIGDWQKQSQSRISNPQSRQLLHFLRQ HHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHH QVDKPIDRPDFCLADFIAPKSSGTQDWIGAFAVTAGIGIDAHVARFEAAHDDYNSILLKA HHCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHH LADRLAEALAERLHQRVRTEFWGYVEDEALDNEALIAERYRGIRPAPGYPACPEHSEKRT HHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHH LFDLLDAERNADMSLTESFAMLPTAAVSGYYFSHPKSQYFVVGRLSKEQVADYAKRKGIT HHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEECCCCCCEEEEECCCHHHHHHHHHHCCCE LALAERWLALNLDYDPE EEEECCEEEEECCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 2185137; 2668277; 8369296; 8265357; 9278503; 1593636; 7992050; 8939751 [H]