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The map label for this gene is dxr

Identifier: 21242168

GI number: 21242168

Start: 1630346

End: 1631536

Strand: Reverse

Name: dxr

Synonym: XAC1415

Alternate gene names: 21242168

Gene position: 1631536-1630346 (Counterclockwise)

Preceding gene: 21242169

Following gene: 21242167

Centisome position: 31.52

GC content: 69.35

Gene sequence:

>1191_bases
ATGGCTGGCTCCTCTCCCCGTCAGGTCGCCGTGTTCGGCGCCACCGGCTCGATCGGCACATCGGCGCTGGACGTGATCGC
CCGCCACCCCGAGCGGCTGCGTGCCAGCGTGCTGTCGGCCGGCAGCAAGGTCGATGAGCTGCTGGCGCTGTGCGCGACCC
ACCGGCCTGCGCATGCGCTGATTGCCGATGCGACGCTGTACCCGGCGCTGCGCGATGGCCTGCGCGCACGGGGCCTTGCG
ACCCAGGCGCACGCCGGTGCCGAGGCGCTGGACGCACTGGCGAGCAGCGATGCGTGCGACACCGTGGTGGCCGCGATCGT
GGGTGCGGCCGGGCTGCCGTCTACGCTGGCGGCGGCGCGCGCCGGCAAGCGTCTGCTGCTGGCCAACAAGGAATCCCTGG
TCCTGGCCGGCGAGCTGCTGACCCGCACCGCAGCCGCCGCCGGCGCTGAAATCATCCCGATCGACAGCGAACACAGCGCC
ATCTTCCAGTGCCTGCGCTCTTGCGACGCCAGCCGCGGCGTACGCCGGGTCATCCTGACTGCCTCCGGTGGCCCGTTCCG
TGGCCGCGACCGCGCGGCGCTGGCGGCGGTCACGCCCGCGCAAGCAGTGGCGCATCCCAAGTGGTCGATGGGTCCGAAGA
TCTCGGTGGATTCGGCGACCCTGATGAACAAGGGCCTGGAAGTCATCGAGGCGCATCACCTGTTTGGACTGCCGGGCGAG
CAGATCGATGTGCTGGTGCATCCGCAGAGCCTGGTGCATTCCCTGGTGGAATTCGTCGACGGCTCCACCCTTGCCCAGCT
TGGCCTGCCGGACATGCGCACCACCCTGGCGGTCGGCCTGGCGTGGCCGGAGCGGGTCGAATCCGGCGTCGGCGGGTTGG
ATCTGCTCAGCCAGGGCCGGCTGGATTTCGAGGCCCCCGACACCGCCGCATTCCCATGTCTGCGCCTGGCCTGGGACGCG
TTACGGGCCGGCGGCACCGCCCCGGCGATCCTGAACGCGGCCAATGAAGTGGCTGTTTCAGCGTTTCTTCAGGGCCAGGT
GGGTTTCCTAGCGATCCCTGCGTTGGTCGAACACACGCTGACAACGCTCCAGCGGCACAATGCCGATTCCCTCGACACCC
TGCTTTTTGCCGATGCGCAAGCCCGGCAAATCACTGAACGCGCCCTCGCCCACCACGCCCTTCATGCCTGA

Upstream 100 bases:

>100_bases
CGCTGATTCCGGGCCATGGCGGCGTACTGGACCGCATCGATGGCGTGCTCGCTGCCCTGCCGGTGTTCGCACTCGGCAAG
GAAATTCTCGGATTCTAGGC

Downstream 100 bases:

>100_bases
TCGTTCCACGCACGCGAGTTGCACCCATGGGTGATTTCATCGGTTCGGTCTGGTGGATGATCGTCAGCCTGGGCGTGTTG
GTGACCTTTCACGAATTCGG

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase

Number of amino acids: Translated: 396; Mature: 395

Protein sequence:

>396_residues
MAGSSPRQVAVFGATGSIGTSALDVIARHPERLRASVLSAGSKVDELLALCATHRPAHALIADATLYPALRDGLRARGLA
TQAHAGAEALDALASSDACDTVVAAIVGAAGLPSTLAAARAGKRLLLANKESLVLAGELLTRTAAAAGAEIIPIDSEHSA
IFQCLRSCDASRGVRRVILTASGGPFRGRDRAALAAVTPAQAVAHPKWSMGPKISVDSATLMNKGLEVIEAHHLFGLPGE
QIDVLVHPQSLVHSLVEFVDGSTLAQLGLPDMRTTLAVGLAWPERVESGVGGLDLLSQGRLDFEAPDTAAFPCLRLAWDA
LRAGGTAPAILNAANEVAVSAFLQGQVGFLAIPALVEHTLTTLQRHNADSLDTLLFADAQARQITERALAHHALHA

Sequences:

>Translated_396_residues
MAGSSPRQVAVFGATGSIGTSALDVIARHPERLRASVLSAGSKVDELLALCATHRPAHALIADATLYPALRDGLRARGLA
TQAHAGAEALDALASSDACDTVVAAIVGAAGLPSTLAAARAGKRLLLANKESLVLAGELLTRTAAAAGAEIIPIDSEHSA
IFQCLRSCDASRGVRRVILTASGGPFRGRDRAALAAVTPAQAVAHPKWSMGPKISVDSATLMNKGLEVIEAHHLFGLPGE
QIDVLVHPQSLVHSLVEFVDGSTLAQLGLPDMRTTLAVGLAWPERVESGVGGLDLLSQGRLDFEAPDTAAFPCLRLAWDA
LRAGGTAPAILNAANEVAVSAFLQGQVGFLAIPALVEHTLTTLQRHNADSLDTLLFADAQARQITERALAHHALHA
>Mature_395_residues
AGSSPRQVAVFGATGSIGTSALDVIARHPERLRASVLSAGSKVDELLALCATHRPAHALIADATLYPALRDGLRARGLAT
QAHAGAEALDALASSDACDTVVAAIVGAAGLPSTLAAARAGKRLLLANKESLVLAGELLTRTAAAAGAEIIPIDSEHSAI
FQCLRSCDASRGVRRVILTASGGPFRGRDRAALAAVTPAQAVAHPKWSMGPKISVDSATLMNKGLEVIEAHHLFGLPGEQ
IDVLVHPQSLVHSLVEFVDGSTLAQLGLPDMRTTLAVGLAWPERVESGVGGLDLLSQGRLDFEAPDTAAFPCLRLAWDAL
RAGGTAPAILNAANEVAVSAFLQGQVGFLAIPALVEHTLTTLQRHNADSLDTLLFADAQARQITERALAHHALHA

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family

Homologues:

Organism=Escherichia coli, GI1786369, Length=392, Percent_Identity=46.1734693877551, Blast_Score=320, Evalue=7e-89,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXR_XANAC (Q8PML1)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_641750.1
- ProteinModelPortal:   Q8PML1
- SMR:   Q8PML1
- GeneID:   1155486
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC1415
- NMPDR:   fig|190486.1.peg.1394
- HOGENOM:   HBG430762
- OMA:   IHSMVEY
- ProtClustDB:   PRK05447
- BioCyc:   XAXO190486:XAC1415-MONOMER
- BRENDA:   1.1.1.267
- HAMAP:   MF_00183
- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF006205
- TIGRFAMs:   TIGR00243

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom

EC number: =1.1.1.267

Molecular weight: Translated: 40978; Mature: 40847

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: BINDING 130-130 BINDING 157-157 BINDING 182-182 BINDING 205-205 BINDING 227-227

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGSSPRQVAVFGATGSIGTSALDVIARHPERLRASVLSAGSKVDELLALCATHRPAHAL
CCCCCCCEEEEEECCCCCCHHHHHHHHHCHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHH
IADATLYPALRDGLRARGLATQAHAGAEALDALASSDACDTVVAAIVGAAGLPSTLAAAR
HHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHH
AGKRLLLANKESLVLAGELLTRTAAAAGAEIIPIDSEHSAIFQCLRSCDASRGVRRVILT
CCCEEEEECCCCEEEHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHCCCCCCCEEEEEE
ASGGPFRGRDRAALAAVTPAQAVAHPKWSMGPKISVDSATLMNKGLEVIEAHHLFGLPGE
ECCCCCCCCCCHHEEEECCHHHHCCCCCCCCCCCCCCHHHHHHHCHHHHHHHHHCCCCCC
QIDVLVHPQSLVHSLVEFVDGSTLAQLGLPDMRTTLAVGLAWPERVESGVGGLDLLSQGR
CEEEEECCHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHCCCHHHHHCCCCCHHHHHCCC
LDFEAPDTAAFPCLRLAWDALRAGGTAPAILNAANEVAVSAFLQGQVGFLAIPALVEHTL
CCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
TTLQRHNADSLDTLLFADAQARQITERALAHHALHA
HHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AGSSPRQVAVFGATGSIGTSALDVIARHPERLRASVLSAGSKVDELLALCATHRPAHAL
CCCCCCEEEEEECCCCCCHHHHHHHHHCHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHH
IADATLYPALRDGLRARGLATQAHAGAEALDALASSDACDTVVAAIVGAAGLPSTLAAAR
HHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHH
AGKRLLLANKESLVLAGELLTRTAAAAGAEIIPIDSEHSAIFQCLRSCDASRGVRRVILT
CCCEEEEECCCCEEEHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHCCCCCCCEEEEEE
ASGGPFRGRDRAALAAVTPAQAVAHPKWSMGPKISVDSATLMNKGLEVIEAHHLFGLPGE
ECCCCCCCCCCHHEEEECCHHHHCCCCCCCCCCCCCCHHHHHHHCHHHHHHHHHCCCCCC
QIDVLVHPQSLVHSLVEFVDGSTLAQLGLPDMRTTLAVGLAWPERVESGVGGLDLLSQGR
CEEEEECCHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHCCCHHHHHCCCCCHHHHHCCC
LDFEAPDTAAFPCLRLAWDALRAGGTAPAILNAANEVAVSAFLQGQVGFLAIPALVEHTL
CCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
TTLQRHNADSLDTLLFADAQARQITERALAHHALHA
HHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217