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The map label for this gene is lpxD

Identifier: 21242164

GI number: 21242164

Start: 1625113

End: 1626126

Strand: Reverse

Name: lpxD

Synonym: XAC1411

Alternate gene names: 21242164

Gene position: 1626126-1625113 (Counterclockwise)

Preceding gene: 21242166

Following gene: 21242163

Centisome position: 31.42

GC content: 66.17

Gene sequence:

>1014_bases
ATGCGATTGACCGCCAGTGCGATTGCCGAACAATTCGGGTTGACCGTCGTCGGTGACGGCACCACCGAAGTCAGCGGCGT
CGCCACCCTGGCCCATGCAGGTGCAGGCCAGCTGAGCTTCCTGTCCAACCCACGCTATCGTCCGCAACTGGCCGACACCC
AGGCCGCTGTCGTGGTGCTGCGTGCCGACGATGCCGAGGCCGCCAAAGGCACCGCGCTGGTCGCCAAGGACCCGTATACC
GCGTTCGCCAAGATCGCCGCGCTGTTCGATCTGGCACCGGTGCGCGAACCGGGCATCCATGCCTCTGCGGTGATCGACCC
GACCGCCCAGGTCTCGGCCACCGCGCATGTCGGTCCGTTCGTCAGCATCGGCGCGCGTAGTCGCGTGGGCGATGGCTGCG
TGATCGGTACCGGCAGCATCATTGGCGAGGACTGCGTGGTGGACGCCGGCAGCGAGCTGCTTGCCCGCGTCACCCTGGTC
ACCCGCGTGCGGCTGGGCAAGCGCGTGCGCATCCACCCTGGTGCGGTGATCGGCGCCGATGGCTTCGGCCTGGCCATGGA
TGCCGGGCACTGGATCAAGGTGCCGCAGCTCGGCGGTGTGGTCATCGGCGACGACTGCGAAATCGGCGCCAACACCTGCA
TCGACCGCGGCGCGCTGGAAGACACCGTGCTTGAAGAAGACGTGCGCGTGGACAACCTGGTGCAGATCGCGCACAACTGC
CGGATCGGCGCGCACAGTGCGATTGCCGGCTGCACCGGCATTGCCGGTAGCGCCAAGATCGGCCGTTACTGCCTGCTGGG
TGGGCATGTCGGCGTGGTCGGCCACCTGGAGATCTGCGACAAGGTGGTGATCACCGGCAAGTCTGTCGTGCGTAATTCCA
TCCATGAGCCGGGCGAGTATTCGTCCGGCACCCCTCTCACCGACAATCGCACGTGGCGCAAAAACGCCGCGCGCTTCAAG
CAGCTTGATGTGCTCGCTAGGCGCATCCTGGCTGTGGGCAAGGAGAAAGAATGA

Upstream 100 bases:

>100_bases
TGCGGCCCGGCAAGCAATACGCTCGATTGTTTAGCCAACTCTTGACGACGTTTTCGAGCTGTTAAACCAGCCACTTATCG
TTTACGCGAGGTTTACCCTG

Downstream 100 bases:

>100_bases
GCCACCACGTTTACGAACTGCCGATCGACGTCAGTCAGATCCAGACGCTGCTCCCGCACCGTTACCCGTTTCTGCTGGTC
GACCGCATCCTCGAACTCGA

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MRLTASAIAEQFGLTVVGDGTTEVSGVATLAHAGAGQLSFLSNPRYRPQLADTQAAVVVLRADDAEAAKGTALVAKDPYT
AFAKIAALFDLAPVREPGIHASAVIDPTAQVSATAHVGPFVSIGARSRVGDGCVIGTGSIIGEDCVVDAGSELLARVTLV
TRVRLGKRVRIHPGAVIGADGFGLAMDAGHWIKVPQLGGVVIGDDCEIGANTCIDRGALEDTVLEEDVRVDNLVQIAHNC
RIGAHSAIAGCTGIAGSAKIGRYCLLGGHVGVVGHLEICDKVVITGKSVVRNSIHEPGEYSSGTPLTDNRTWRKNAARFK
QLDVLARRILAVGKEKE

Sequences:

>Translated_337_residues
MRLTASAIAEQFGLTVVGDGTTEVSGVATLAHAGAGQLSFLSNPRYRPQLADTQAAVVVLRADDAEAAKGTALVAKDPYT
AFAKIAALFDLAPVREPGIHASAVIDPTAQVSATAHVGPFVSIGARSRVGDGCVIGTGSIIGEDCVVDAGSELLARVTLV
TRVRLGKRVRIHPGAVIGADGFGLAMDAGHWIKVPQLGGVVIGDDCEIGANTCIDRGALEDTVLEEDVRVDNLVQIAHNC
RIGAHSAIAGCTGIAGSAKIGRYCLLGGHVGVVGHLEICDKVVITGKSVVRNSIHEPGEYSSGTPLTDNRTWRKNAARFK
QLDVLARRILAVGKEKE
>Mature_337_residues
MRLTASAIAEQFGLTVVGDGTTEVSGVATLAHAGAGQLSFLSNPRYRPQLADTQAAVVVLRADDAEAAKGTALVAKDPYT
AFAKIAALFDLAPVREPGIHASAVIDPTAQVSATAHVGPFVSIGARSRVGDGCVIGTGSIIGEDCVVDAGSELLARVTLV
TRVRLGKRVRIHPGAVIGADGFGLAMDAGHWIKVPQLGGVVIGDDCEIGANTCIDRGALEDTVLEEDVRVDNLVQIAHNC
RIGAHSAIAGCTGIAGSAKIGRYCLLGGHVGVVGHLEICDKVVITGKSVVRNSIHEPGEYSSGTPLTDNRTWRKNAARFK
QLDVLARRILAVGKEKE

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily

Homologues:

Organism=Escherichia coli, GI1786376, Length=328, Percent_Identity=44.2073170731707, Blast_Score=291, Evalue=6e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXD_XANAC (Q8PML5)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_641746.1
- ProteinModelPortal:   Q8PML5
- GeneID:   1155482
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC1411
- NMPDR:   fig|190486.1.peg.1390
- HOGENOM:   HBG469615
- OMA:   CFVGKNT
- ProtClustDB:   PRK00892
- BioCyc:   XAXO190486:XAC1411-MONOMER
- HAMAP:   MF_00523
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573
- TIGRFAMs:   TIGR01853

Pfam domain/function: PF04613 LpxD; SSF51161 Trimer_LpxA_like

EC number: 2.3.1.-

Molecular weight: Translated: 34960; Mature: 34960

Theoretical pI: Translated: 7.03; Mature: 7.03

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLTASAIAEQFGLTVVGDGTTEVSGVATLAHAGAGQLSFLSNPRYRPQLADTQAAVVVL
CCCCHHHHHHHHCEEEEECCCCCHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCEEEEEE
RADDAEAAKGTALVAKDPYTAFAKIAALFDLAPVREPGIHASAVIDPTAQVSATAHVGPF
ECCCCCCCCCCEEEECCCHHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHEEEEECCCCE
VSIGARSRVGDGCVIGTGSIIGEDCVVDAGSELLARVTLVTRVRLGKRVRIHPGAVIGAD
EEECCCCCCCCCEEEECCCCCCCCCEECCCHHHHHHHHHHHHHHCCCEEEECCCEEECCC
GFGLAMDAGHWIKVPQLGGVVIGDDCEIGANTCIDRGALEDTVLEEDVRVDNLVQIAHNC
CCEEEECCCCEEECCCCCCEEECCCCCCCCHHHHCCCCCHHHHHHHHCCHHHHHHHHHHC
RIGAHSAIAGCTGIAGSAKIGRYCLLGGHVGVVGHLEICDKVVITGKSVVRNSIHEPGEY
CCCCCHHHHHHCCCCCCCCCCCEEEECCCCCEEEHHHHHCEEEECCHHHHHHHCCCCCCC
SSGTPLTDNRTWRKNAARFKQLDVLARRILAVGKEKE
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MRLTASAIAEQFGLTVVGDGTTEVSGVATLAHAGAGQLSFLSNPRYRPQLADTQAAVVVL
CCCCHHHHHHHHCEEEEECCCCCHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCEEEEEE
RADDAEAAKGTALVAKDPYTAFAKIAALFDLAPVREPGIHASAVIDPTAQVSATAHVGPF
ECCCCCCCCCCEEEECCCHHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHEEEEECCCCE
VSIGARSRVGDGCVIGTGSIIGEDCVVDAGSELLARVTLVTRVRLGKRVRIHPGAVIGAD
EEECCCCCCCCCEEEECCCCCCCCCEECCCHHHHHHHHHHHHHHCCCEEEECCCEEECCC
GFGLAMDAGHWIKVPQLGGVVIGDDCEIGANTCIDRGALEDTVLEEDVRVDNLVQIAHNC
CCEEEECCCCEEECCCCCCEEECCCCCCCCHHHHCCCCCHHHHHHHHCCHHHHHHHHHHC
RIGAHSAIAGCTGIAGSAKIGRYCLLGGHVGVVGHLEICDKVVITGKSVVRNSIHEPGEY
CCCCCHHHHHHCCCCCCCCCCCEEEECCCCCEEEHHHHHCEEEECCHHHHHHHCCCCCCC
SSGTPLTDNRTWRKNAARFKQLDVLARRILAVGKEKE
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217