Click here to switch to the map view.

The map label for this gene is lpxA

Identifier: 21242162

GI number: 21242162

Start: 1623841

End: 1624632

Strand: Reverse

Name: lpxA

Synonym: XAC1409

Alternate gene names: 21242162

Gene position: 1624632-1623841 (Counterclockwise)

Preceding gene: 21242163

Following gene: 21242161

Centisome position: 31.39

GC content: 65.15

Gene sequence:

>792_bases
ATGCGCGATTCAACACCTTTGATTCATCCGACGGCGGTCATCGATCCATCGGCAACGCTGGCGGACGACGTGCGCGTCGG
CGCCTTCTCGCTGATCGGCGCCGATGTGCAGATCGGGGCGGGCACCGAGGTGGGGCCACATTGCTCGATCCACGGCCCGA
CCCGGATCGGTCGCAACAACCGCTTCATCGGCCATGCCGCGATCGGCGGCGAACCGCAGGACAAGAAGTACGCCGGCGAA
CGGACCGAATTGGTGATCGGCGACGGCAACGTGATCCGCGAATTCGTCACCATCAATCGCGGCACCGGCGGCGGTGGCGG
CATCACCGTGGTCGGCAACGACAACTGGATGCTGGCCTATACGCACGTGGCGCACGACTGCCATGTGGGCAACCACTGCG
TGTTCTCCAACAACACCACGCTGGCCGGCCACGTCACCGTCGGCGACTACGTGATCATCAGCGGTTTTGCCGGCGCACAT
CAGTTCTGCCGTATCGGCGCGCACGCCTTCCTGGGCATGGGCGCGCTGACCAACGGCGACGTCCCGCCGTTCACCATGGT
AGGCAGCGAATCGCTGGGACGTCCGCGCGGCATCAATAGCGAAGGGCTCAAGCGCCGCGGTTTCGACGCCGAACGCATCA
CCGCGATCAAGCGCGCCTACCGCACGCTGTACGTGGCCGGCCTGCCGCTGGCAGATGCCAAGCTGCAGCTGGCCGAACAG
GCCAAGAGCAGCGACGATGTGCGCGGGATGCTCGAGTTCATCGAAGCAGCAGAACGGCCCTTGTTGCGATGA

Upstream 100 bases:

>100_bases
TGCTTCTACGGCGAAGCCAAGGTCGATGGCGAAGTGGTGGCCAGTGCCGAGGTGATGTGCGCCGGCGCCAGGTAATCACC
CGCTTTCGGAGTAAGACACG

Downstream 100 bases:

>100_bases
AGGGAATTGGGAATCGGGAGTCGGGAATCGTGGACGGCCAGCGCAACGGCGCGTCGGTCGGCAGCGTTACGACTGCGCTA
CCGATTCCCGATTCCCCACT

Product: UDP-N-acetylglucosamine acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase

Number of amino acids: Translated: 263; Mature: 263

Protein sequence:

>263_residues
MRDSTPLIHPTAVIDPSATLADDVRVGAFSLIGADVQIGAGTEVGPHCSIHGPTRIGRNNRFIGHAAIGGEPQDKKYAGE
RTELVIGDGNVIREFVTINRGTGGGGGITVVGNDNWMLAYTHVAHDCHVGNHCVFSNNTTLAGHVTVGDYVIISGFAGAH
QFCRIGAHAFLGMGALTNGDVPPFTMVGSESLGRPRGINSEGLKRRGFDAERITAIKRAYRTLYVAGLPLADAKLQLAEQ
AKSSDDVRGMLEFIEAAERPLLR

Sequences:

>Translated_263_residues
MRDSTPLIHPTAVIDPSATLADDVRVGAFSLIGADVQIGAGTEVGPHCSIHGPTRIGRNNRFIGHAAIGGEPQDKKYAGE
RTELVIGDGNVIREFVTINRGTGGGGGITVVGNDNWMLAYTHVAHDCHVGNHCVFSNNTTLAGHVTVGDYVIISGFAGAH
QFCRIGAHAFLGMGALTNGDVPPFTMVGSESLGRPRGINSEGLKRRGFDAERITAIKRAYRTLYVAGLPLADAKLQLAEQ
AKSSDDVRGMLEFIEAAERPLLR
>Mature_263_residues
MRDSTPLIHPTAVIDPSATLADDVRVGAFSLIGADVQIGAGTEVGPHCSIHGPTRIGRNNRFIGHAAIGGEPQDKKYAGE
RTELVIGDGNVIREFVTINRGTGGGGGITVVGNDNWMLAYTHVAHDCHVGNHCVFSNNTTLAGHVTVGDYVIISGFAGAH
QFCRIGAHAFLGMGALTNGDVPPFTMVGSESLGRPRGINSEGLKRRGFDAERITAIKRAYRTLYVAGLPLADAKLQLAEQ
AKSSDDVRGMLEFIEAAERPLLR

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily

Homologues:

Organism=Escherichia coli, GI1786378, Length=263, Percent_Identity=45.2471482889734, Blast_Score=237, Evalue=6e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXA_XANAC (Q8PML7)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_641744.1
- ProteinModelPortal:   Q8PML7
- SMR:   Q8PML7
- GeneID:   1155480
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC1409
- NMPDR:   fig|190486.1.peg.1388
- HOGENOM:   HBG659295
- OMA:   DLKYQGE
- ProtClustDB:   PRK05289
- BioCyc:   XAXO190486:XAC1409-MONOMER
- BRENDA:   2.3.1.129
- GO:   GO:0005737
- HAMAP:   MF_00387
- InterPro:   IPR010137
- InterPro:   IPR011004
- PIRSF:   PIRSF000456
- TIGRFAMs:   TIGR01852

Pfam domain/function: SSF51161 Trimer_LpxA_like

EC number: =2.3.1.129

Molecular weight: Translated: 27865; Mature: 27865

Theoretical pI: Translated: 7.11; Mature: 7.11

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDSTPLIHPTAVIDPSATLADDVRVGAFSLIGADVQIGAGTEVGPHCSIHGPTRIGRNN
CCCCCCCCCCEEEECCCCCHHCCCCCCEEEEECCEEEECCCCCCCCCEEECCCCEECCCC
RFIGHAAIGGEPQDKKYAGERTELVIGDGNVIREFVTINRGTGGGGGITVVGNDNWMLAY
CEEEEEECCCCCCCCCCCCCCEEEEECCCHHEEEEEEEECCCCCCCEEEEEECCCEEEEE
THVAHDCHVGNHCVFSNNTTLAGHVTVGDYVIISGFAGAHQFCRIGAHAFLGMGALTNGD
EEEECCCCCCCEEEECCCCEEEEEEEECCEEEEECCCCHHHHHHHHHHHHHCCCCCCCCC
VPPFTMVGSESLGRPRGINSEGLKRRGFDAERITAIKRAYRTLYVAGLPLADAKLQLAEQ
CCCEEEECCCCCCCCCCCCHHCHHHCCCCHHHHHHHHHHHHEEEEECCCCCHHHHHHHHH
AKSSDDVRGMLEFIEAAERPLLR
CCCCHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MRDSTPLIHPTAVIDPSATLADDVRVGAFSLIGADVQIGAGTEVGPHCSIHGPTRIGRNN
CCCCCCCCCCEEEECCCCCHHCCCCCCEEEEECCEEEECCCCCCCCCEEECCCCEECCCC
RFIGHAAIGGEPQDKKYAGERTELVIGDGNVIREFVTINRGTGGGGGITVVGNDNWMLAY
CEEEEEECCCCCCCCCCCCCCEEEEECCCHHEEEEEEEECCCCCCCEEEEEECCCEEEEE
THVAHDCHVGNHCVFSNNTTLAGHVTVGDYVIISGFAGAHQFCRIGAHAFLGMGALTNGD
EEEECCCCCCCEEEECCCCEEEEEEEECCEEEEECCCCHHHHHHHHHHHHHCCCCCCCCC
VPPFTMVGSESLGRPRGINSEGLKRRGFDAERITAIKRAYRTLYVAGLPLADAKLQLAEQ
CCCEEEECCCCCCCCCCCCHHCHHHCCCCHHHHHHHHHHHHEEEEECCCCCHHHHHHHHH
AKSSDDVRGMLEFIEAAERPLLR
CCCCHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217