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The map label for this gene is cyoB [H]

Identifier: 21242012

GI number: 21242012

Start: 1436821

End: 1438821

Strand: Direct

Name: cyoB [H]

Synonym: XAC1259

Alternate gene names: 21242012

Gene position: 1436821-1438821 (Clockwise)

Preceding gene: 21242011

Following gene: 21242013

Centisome position: 27.76

GC content: 61.27

Gene sequence:

>2001_bases
ATGCTAGGCAAACTCACCATCGAGGCAGTTCCGTACCACGAGCCGATCATCATGGTCGCGCTGGGTGGTGCCGGCCTGCT
CGGCCTGCTCATCGCGGGCGCCATCACCAAGTACAAGCTGTGGGGCTATCTCTGGAAAGAGTGGTTCACCTCGGTGGATC
ACAAGCGCATCGGCGTGATGTACATCATCGTGGCGCTGGTCATGCTGCTGCGCGGCTTTGCCGACGCGGCGATGATGCGC
ACCCAGCAGGCGCTGGCCGGCGGCGGTGGCGAGGGCGTGCTGCCCCCGCATCACTACGACCAGATCTTTACCGCGCACGG
CGTGATCATGATCTTCTTCATGGCCATGCCGTTCATGACCGGCCTGTTGAACCTGATCGTGCCGCTGCAGATCGGTGCGC
GCGACGTGGCGTTCCCGTTCCTGAACTCGCTGAGCTTCTGGCTGTTCGTGGCCGGTGCGGCGCTGATCAACATCTCGCTG
GGCGTGGGTGAATTCGCGCAGACCGGTTGGCTGGCGTATCCGCCGTTGTCGGGGCTGGAATACAGTCCGGGGGTCGGTGT
CGATTACTACATCTGGGCATTGCAGGTGTCCGGCTTAGGCACATTGCTGACCGGCATCAACTTCTTCGTGACGATCATGC
GCATGCGCGCGCCGGGCATGACCCTGATGCGCATGCCGATCTTCACCTGGACTGCGCTGATCACCAACATCCTGATCATC
GCCGCGTTCCCGATCCTGACCGTGGCGTTGGCGCTGCTGGGTGCCGACCGTTACCTGGGCACGCACTTCTTCACCAATGA
CGGTGGCGGCAACGCCATGATGTACGTCAACCTGATCTGGATCTGGGGTCACCCAGAGGTCTACATCCTGATCCTGCCGG
CATTCGGCATCTTCTCCGAGTTGATCGCGACCTACAGCCGCAAGCGCCTGTTCGGCTACACCTCGATGGTGTACGCCACC
TCCTGCATCGGCGTGCTGTCGTTCGTGGTGTGGTTGCACCACTTCTTCACCATGGGCTCGGGTGCCAACGTCAATGCCTT
CTTCGGCATCACGACGATGATCATCTCGATCCCGACTGGCGTGAAGATCTTCAACTGGCTATTCACCATGTTCCGCGGTC
GCGTGCACATGACCTCGCCGGTGCTGTGGACGATCGGCTTCATCATCACCTTCACCATCGGCGGCATGACCGGCGTGATG
CTGGCGATTCCGGCGGTGGACTTCGTGCTGCACAACAGCCTGTTTCTGATCGCGCACTTCCATAACGTGATCATCGGCGG
CGTGGTGTTCGGTTACCTGGCGGGCCTGACCTACTGGTTCCCGAAGGCGTTCGGCTTCAAGCTCAACGAAAAGATCGGCA
AGGCCTCGTTCTGGTGCTGGATCATCGGCTTCTTCGTGGCCTTCATGCCGCTGTACGTGCTCGGCTTCATGGGCATGACC
CGTCGCATGAACACCTACAACCACCCCGAATGGGCGCCGTGGCTGTACGTTGCCGCCGTGGGTGCTGCGATCATCGGCAT
GGGCATCTTCTTGAACCTGGTGCAGATCGGTTACAGCGTGTGGAAGCGCAAGGAGCACATGGACTACACGGGCGACCCGT
GGGATGGCCGTACGCTGGAATGGGCAACTTCCTCGCCGCCGCCGTTCTACAACTTCGCCGTGCTGCCGCACATCGACGAC
CGCGATCAGTTCTGGGCCGACAAGCAGAACGGCAAGGGCTGGGTGCGTCCGTCCAAGTACGAAGCGATCCACATGCCGCG
TAACACCGGCGCCGGCGTCTACATCGGTGCCTTCAGCGTGCTGCTGGGCTTCGGTCTGATCTGGCACATCTGGTGGCTGG
CCATCATTGGCCTGGTGGGCATGATCGGCAGCTTCATCGCACGCACCTTCGATGACGACATCGATTACTGGGTGCCGGCC
GACGAAGTGGAGCGCATCGAAAACGCACGTTTCGCCCTGCTCGAACAGCAACAAGCGGCGCAGGCCGCGAAGGTGGTATG
A

Upstream 100 bases:

>100_bases
TCGACAAATACATGAATGGTCCGGGCCACAGTAAAGGCCACGGCGACCATCAGGCATCGGCTACGGAGCCGGTCGCCATG
TGCACTTCTGGAGACAAGTG

Downstream 100 bases:

>100_bases
CCATGGCTTCCTCGACCACGCTTGACCACGCCGCCCACGTGGGCGGCCACGATCACGACCACGAGCATCACGACGGCGGT
GGCAACACCGTCTTCGGGTT

Product: cytochrome O ubiquinol oxidase subunit I

Products: NA

Alternate protein names: Cytochrome o subunit 1; Cytochrome o ubiquinol oxidase subunit 1; Oxidase BO(3) subunit 1; Ubiquinol oxidase chain A; Ubiquinol oxidase polypeptide I [H]

Number of amino acids: Translated: 666; Mature: 666

Protein sequence:

>666_residues
MLGKLTIEAVPYHEPIIMVALGGAGLLGLLIAGAITKYKLWGYLWKEWFTSVDHKRIGVMYIIVALVMLLRGFADAAMMR
TQQALAGGGGEGVLPPHHYDQIFTAHGVIMIFFMAMPFMTGLLNLIVPLQIGARDVAFPFLNSLSFWLFVAGAALINISL
GVGEFAQTGWLAYPPLSGLEYSPGVGVDYYIWALQVSGLGTLLTGINFFVTIMRMRAPGMTLMRMPIFTWTALITNILII
AAFPILTVALALLGADRYLGTHFFTNDGGGNAMMYVNLIWIWGHPEVYILILPAFGIFSELIATYSRKRLFGYTSMVYAT
SCIGVLSFVVWLHHFFTMGSGANVNAFFGITTMIISIPTGVKIFNWLFTMFRGRVHMTSPVLWTIGFIITFTIGGMTGVM
LAIPAVDFVLHNSLFLIAHFHNVIIGGVVFGYLAGLTYWFPKAFGFKLNEKIGKASFWCWIIGFFVAFMPLYVLGFMGMT
RRMNTYNHPEWAPWLYVAAVGAAIIGMGIFLNLVQIGYSVWKRKEHMDYTGDPWDGRTLEWATSSPPPFYNFAVLPHIDD
RDQFWADKQNGKGWVRPSKYEAIHMPRNTGAGVYIGAFSVLLGFGLIWHIWWLAIIGLVGMIGSFIARTFDDDIDYWVPA
DEVERIENARFALLEQQQAAQAAKVV

Sequences:

>Translated_666_residues
MLGKLTIEAVPYHEPIIMVALGGAGLLGLLIAGAITKYKLWGYLWKEWFTSVDHKRIGVMYIIVALVMLLRGFADAAMMR
TQQALAGGGGEGVLPPHHYDQIFTAHGVIMIFFMAMPFMTGLLNLIVPLQIGARDVAFPFLNSLSFWLFVAGAALINISL
GVGEFAQTGWLAYPPLSGLEYSPGVGVDYYIWALQVSGLGTLLTGINFFVTIMRMRAPGMTLMRMPIFTWTALITNILII
AAFPILTVALALLGADRYLGTHFFTNDGGGNAMMYVNLIWIWGHPEVYILILPAFGIFSELIATYSRKRLFGYTSMVYAT
SCIGVLSFVVWLHHFFTMGSGANVNAFFGITTMIISIPTGVKIFNWLFTMFRGRVHMTSPVLWTIGFIITFTIGGMTGVM
LAIPAVDFVLHNSLFLIAHFHNVIIGGVVFGYLAGLTYWFPKAFGFKLNEKIGKASFWCWIIGFFVAFMPLYVLGFMGMT
RRMNTYNHPEWAPWLYVAAVGAAIIGMGIFLNLVQIGYSVWKRKEHMDYTGDPWDGRTLEWATSSPPPFYNFAVLPHIDD
RDQFWADKQNGKGWVRPSKYEAIHMPRNTGAGVYIGAFSVLLGFGLIWHIWWLAIIGLVGMIGSFIARTFDDDIDYWVPA
DEVERIENARFALLEQQQAAQAAKVV
>Mature_666_residues
MLGKLTIEAVPYHEPIIMVALGGAGLLGLLIAGAITKYKLWGYLWKEWFTSVDHKRIGVMYIIVALVMLLRGFADAAMMR
TQQALAGGGGEGVLPPHHYDQIFTAHGVIMIFFMAMPFMTGLLNLIVPLQIGARDVAFPFLNSLSFWLFVAGAALINISL
GVGEFAQTGWLAYPPLSGLEYSPGVGVDYYIWALQVSGLGTLLTGINFFVTIMRMRAPGMTLMRMPIFTWTALITNILII
AAFPILTVALALLGADRYLGTHFFTNDGGGNAMMYVNLIWIWGHPEVYILILPAFGIFSELIATYSRKRLFGYTSMVYAT
SCIGVLSFVVWLHHFFTMGSGANVNAFFGITTMIISIPTGVKIFNWLFTMFRGRVHMTSPVLWTIGFIITFTIGGMTGVM
LAIPAVDFVLHNSLFLIAHFHNVIIGGVVFGYLAGLTYWFPKAFGFKLNEKIGKASFWCWIIGFFVAFMPLYVLGFMGMT
RRMNTYNHPEWAPWLYVAAVGAAIIGMGIFLNLVQIGYSVWKRKEHMDYTGDPWDGRTLEWATSSPPPFYNFAVLPHIDD
RDQFWADKQNGKGWVRPSKYEAIHMPRNTGAGVYIGAFSVLLGFGLIWHIWWLAIIGLVGMIGSFIARTFDDDIDYWVPA
DEVERIENARFALLEQQQAAQAAKVV

Specific function: Cytochrome o terminal oxidase complex is the component of the aerobic respiratory chain that predominates when cells are grown at high aeration. This ubiquinol oxidase shows proton pump activity across the membrane in addition to the electron transfer [H]

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=509, Percent_Identity=40.0785854616896, Blast_Score=346, Evalue=3e-95,
Organism=Escherichia coli, GI1786634, Length=651, Percent_Identity=70.9677419354839, Blast_Score=980, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6226519, Length=532, Percent_Identity=37.781954887218, Blast_Score=352, Evalue=1e-97,
Organism=Saccharomyces cerevisiae, GI6226524, Length=331, Percent_Identity=41.9939577039275, Blast_Score=249, Evalue=1e-66,
Organism=Saccharomyces cerevisiae, GI6226523, Length=248, Percent_Identity=34.2741935483871, Blast_Score=134, Evalue=6e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014207 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: 1.10.3.-

Molecular weight: Translated: 74270; Mature: 74270

Theoretical pI: Translated: 8.50; Mature: 8.50

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLGKLTIEAVPYHEPIIMVALGGAGLLGLLIAGAITKYKLWGYLWKEWFTSVDHKRIGVM
CCCCEEEEECCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
YIIVALVMLLRGFADAAMMRTQQALAGGGGEGVLPPHHYDQIFTAHGVIMIFFMAMPFMT
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
GLLNLIVPLQIGARDVAFPFLNSLSFWLFVAGAALINISLGVGEFAQTGWLAYPPLSGLE
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHCCCEECCCCCCCC
YSPGVGVDYYIWALQVSGLGTLLTGINFFVTIMRMRAPGMTLMRMPIFTWTALITNILII
CCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
AAFPILTVALALLGADRYLGTHFFTNDGGGNAMMYVNLIWIWGHPEVYILILPAFGIFSE
HHHHHHHHHHHHHCCHHHHCCEEEECCCCCCEEEEEEEEEEECCCCEEEEEECHHHHHHH
LIATYSRKRLFGYTSMVYATSCIGVLSFVVWLHHFFTMGSGANVNAFFGITTMIISIPTG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCC
VKIFNWLFTMFRGRVHMTSPVLWTIGFIITFTIGGMTGVMLAIPAVDFVLHNSLFLIAHF
HHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
HNVIIGGVVFGYLAGLTYWFPKAFGFKLNEKIGKASFWCWIIGFFVAFMPLYVLGFMGMT
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RRMNTYNHPEWAPWLYVAAVGAAIIGMGIFLNLVQIGYSVWKRKEHMDYTGDPWDGRTLE
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEE
WATSSPPPFYNFAVLPHIDDRDQFWADKQNGKGWVRPSKYEAIHMPRNTGAGVYIGAFSV
ECCCCCCCCCEEEEECCCCCCHHHCCCCCCCCCCCCCCCCCEEECCCCCCCEEHHHHHHH
LLGFGLIWHIWWLAIIGLVGMIGSFIARTFDDDIDYWVPADEVERIENARFALLEQQQAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
QAAKVV
HHHCCC
>Mature Secondary Structure
MLGKLTIEAVPYHEPIIMVALGGAGLLGLLIAGAITKYKLWGYLWKEWFTSVDHKRIGVM
CCCCEEEEECCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
YIIVALVMLLRGFADAAMMRTQQALAGGGGEGVLPPHHYDQIFTAHGVIMIFFMAMPFMT
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
GLLNLIVPLQIGARDVAFPFLNSLSFWLFVAGAALINISLGVGEFAQTGWLAYPPLSGLE
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHCCCEECCCCCCCC
YSPGVGVDYYIWALQVSGLGTLLTGINFFVTIMRMRAPGMTLMRMPIFTWTALITNILII
CCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
AAFPILTVALALLGADRYLGTHFFTNDGGGNAMMYVNLIWIWGHPEVYILILPAFGIFSE
HHHHHHHHHHHHHCCHHHHCCEEEECCCCCCEEEEEEEEEEECCCCEEEEEECHHHHHHH
LIATYSRKRLFGYTSMVYATSCIGVLSFVVWLHHFFTMGSGANVNAFFGITTMIISIPTG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCC
VKIFNWLFTMFRGRVHMTSPVLWTIGFIITFTIGGMTGVMLAIPAVDFVLHNSLFLIAHF
HHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
HNVIIGGVVFGYLAGLTYWFPKAFGFKLNEKIGKASFWCWIIGFFVAFMPLYVLGFMGMT
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RRMNTYNHPEWAPWLYVAAVGAAIIGMGIFLNLVQIGYSVWKRKEHMDYTGDPWDGRTLE
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEE
WATSSPPPFYNFAVLPHIDDRDQFWADKQNGKGWVRPSKYEAIHMPRNTGAGVYIGAFSV
ECCCCCCCCCEEEEECCCCCCHHHCCCCCCCCCCCCCCCCCEEECCCCCCCEEHHHHHHH
LLGFGLIWHIWWLAIIGLVGMIGSFIARTFDDDIDYWVPADEVERIENARFALLEQQQAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
QAAKVV
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Protoheme IX (Heme B55 and B562); Copper B. [C]

Metal ions: Fe; Cu [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Oxidoreductases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]