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The map label for this gene is ispH [H]

Identifier: 21242010

GI number: 21242010

Start: 1434423

End: 1435373

Strand: Direct

Name: ispH [H]

Synonym: XAC1256

Alternate gene names: 21242010

Gene position: 1434423-1435373 (Clockwise)

Preceding gene: 21242009

Following gene: 21242011

Centisome position: 27.72

GC content: 66.35

Gene sequence:

>951_bases
ATGGATGTCCTGCTCGCCAATCCCCGTGGTTTTTGTGCCGGTGTCGACCGTGCGATCGAGATCGTCAAGCGTGCGATCGA
AACGCTGGGCGCGCCGATCTATGTGCGGCACGAGGTCGTGCACAACCGCTTCGTGGTCGACGACCTCAAGCAGCGCGGCG
CGATCTTCGTCGAAGAACTCGACGAGGTGCCCGACGATGCCACGGTGATCTTCAGTGCGCACGGCGTCTCGCAGGCGGTG
CGTCAGGAAGCCGAACGGCGTGGACTGAAGGTGTTCGACGCCACCTGCCCACTGGTGACCAAGGTGCATTTCGAGGTGGC
GCGGCACTGCCGGGCAGGGCGCGACGTGGTGCTGATCGGCCATGCCGGGCACCCGGAAGTGGAAGGCACGATGGGGCAGT
GGAGCCGCGAGCGCGGGGCGGGCACGATCTATCTGGTCGAAGACATCGAGCAGGTCGCCACGCTGGATGTCCGCCAACCC
GATAACCTTGCCTATACCACCCAGACCACCCTGTCGGTGGACGACACCATGGGCATCATCGAGGCCTTGCGTGCGCGCTA
CCCGGCGATGCAGGGCCCGCGCCACGACGACATCTGCTACGCCACCCAGAACCGCCAGGACGCGGTGCGCGATCTGGCGC
GCCAGTGCGATCTGGTGCTGGTGGTCGGTTCGCCCAACAGCTCCAATTCCAACCGGTTGAGCGAGCTGGCCCGGCGCGAC
GGGGTGGAGTCCTACCTGATCGACAATGCCAGCGAGATCGACCCGGCCTGGATCGTCGGCAAGCAGCATATCGGCCTGAC
CGCCGGCGCCTCCGCGCCGCAGGTGCTGGTCGATGGCGTGCTGGAGCGCTTGCGCGAACTGGGCGCGGCCGGCGTCTCCG
AGTTGGAAGGCGAGCCGGAATCGATGGTCTTCGCGCTGCCCAAGGAGCTGCGCTTGCGTCTGGTCAGCTAA

Upstream 100 bases:

>100_bases
CAAGCAGCAGCCGGGAACCGGGAATCTGCGCTGAAGCCTGCCTGCAGGCGCGTGCCGCCCGGTCCGACCCCTCGTCCCTC
ATTCCCGTAGAATGCCCGCC

Downstream 100 bases:

>100_bases
GACGACGCCCTCCGGCAAGGCGAGCACGTTCGGCGATTGACCCAGGGGGCGCTGCGCTCCTACAATTCACGGCTCGCCGG
AATAGCTCAGTTGGTAGAGC

Product: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
MDVLLANPRGFCAGVDRAIEIVKRAIETLGAPIYVRHEVVHNRFVVDDLKQRGAIFVEELDEVPDDATVIFSAHGVSQAV
RQEAERRGLKVFDATCPLVTKVHFEVARHCRAGRDVVLIGHAGHPEVEGTMGQWSRERGAGTIYLVEDIEQVATLDVRQP
DNLAYTTQTTLSVDDTMGIIEALRARYPAMQGPRHDDICYATQNRQDAVRDLARQCDLVLVVGSPNSSNSNRLSELARRD
GVESYLIDNASEIDPAWIVGKQHIGLTAGASAPQVLVDGVLERLRELGAAGVSELEGEPESMVFALPKELRLRLVS

Sequences:

>Translated_316_residues
MDVLLANPRGFCAGVDRAIEIVKRAIETLGAPIYVRHEVVHNRFVVDDLKQRGAIFVEELDEVPDDATVIFSAHGVSQAV
RQEAERRGLKVFDATCPLVTKVHFEVARHCRAGRDVVLIGHAGHPEVEGTMGQWSRERGAGTIYLVEDIEQVATLDVRQP
DNLAYTTQTTLSVDDTMGIIEALRARYPAMQGPRHDDICYATQNRQDAVRDLARQCDLVLVVGSPNSSNSNRLSELARRD
GVESYLIDNASEIDPAWIVGKQHIGLTAGASAPQVLVDGVLERLRELGAAGVSELEGEPESMVFALPKELRLRLVS
>Mature_316_residues
MDVLLANPRGFCAGVDRAIEIVKRAIETLGAPIYVRHEVVHNRFVVDDLKQRGAIFVEELDEVPDDATVIFSAHGVSQAV
RQEAERRGLKVFDATCPLVTKVHFEVARHCRAGRDVVLIGHAGHPEVEGTMGQWSRERGAGTIYLVEDIEQVATLDVRQP
DNLAYTTQTTLSVDDTMGIIEALRARYPAMQGPRHDDICYATQNRQDAVRDLARQCDLVLVVGSPNSSNSNRLSELARRD
GVESYLIDNASEIDPAWIVGKQHIGLTAGASAPQVLVDGVLERLRELGAAGVSELEGEPESMVFALPKELRLRLVS

Specific function: Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) [H]

COG id: COG0761

COG function: function code IM; Penicillin tolerance protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ispH family [H]

Homologues:

Organism=Escherichia coli, GI1786212, Length=312, Percent_Identity=62.8205128205128, Blast_Score=399, Evalue=1e-112,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003451 [H]

Pfam domain/function: PF02401 LYTB [H]

EC number: =1.17.1.2 [H]

Molecular weight: Translated: 34691; Mature: 34691

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVLLANPRGFCAGVDRAIEIVKRAIETLGAPIYVRHEVVHNRFVVDDLKQRGAIFVEEL
CCEEECCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHCCCEEHHHH
DEVPDDATVIFSAHGVSQAVRQEAERRGLKVFDATCPLVTKVHFEVARHCRAGRDVVLIG
HCCCCCCEEEEECCCHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHCCCCCEEEEE
HAGHPEVEGTMGQWSRERGAGTIYLVEDIEQVATLDVRQPDNLAYTTQTTLSVDDTMGII
CCCCCCCCCCHHHHHHHCCCEEEEEHHHHHHHHHCCCCCCCCEEEEEEEEEECHHHHHHH
EALRARYPAMQGPRHDDICYATQNRQDAVRDLARQCDLVLVVGSPNSSNSNRLSELARRD
HHHHHHCCCCCCCCCCCCEEECCCHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHC
GVESYLIDNASEIDPAWIVGKQHIGLTAGASAPQVLVDGVLERLRELGAAGVSELEGEPE
CCHHHHHCCCCCCCCCEEECCCCCCEECCCCCHHHHHHHHHHHHHHHCCCCHHHHCCCCC
SMVFALPKELRLRLVS
CEEEECCHHHHHEECC
>Mature Secondary Structure
MDVLLANPRGFCAGVDRAIEIVKRAIETLGAPIYVRHEVVHNRFVVDDLKQRGAIFVEEL
CCEEECCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHCCCEEHHHH
DEVPDDATVIFSAHGVSQAVRQEAERRGLKVFDATCPLVTKVHFEVARHCRAGRDVVLIG
HCCCCCCEEEEECCCHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHCCCCCEEEEE
HAGHPEVEGTMGQWSRERGAGTIYLVEDIEQVATLDVRQPDNLAYTTQTTLSVDDTMGII
CCCCCCCCCCHHHHHHHCCCEEEEEHHHHHHHHHCCCCCCCCEEEEEEEEEECHHHHHHH
EALRARYPAMQGPRHDDICYATQNRQDAVRDLARQCDLVLVVGSPNSSNSNRLSELARRD
HHHHHHCCCCCCCCCCCCEEECCCHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHC
GVESYLIDNASEIDPAWIVGKQHIGLTAGASAPQVLVDGVLERLRELGAAGVSELEGEPE
CCHHHHHCCCCCCCCCEEECCCCCCEECCCCCHHHHHHHHHHHHHHHCCCCHHHHCCCCC
SMVFALPKELRLRLVS
CEEEECCHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA