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The map label for this gene is lspA

Identifier: 21242009

GI number: 21242009

Start: 1433838

End: 1434356

Strand: Direct

Name: lspA

Synonym: XAC1255

Alternate gene names: 21242009

Gene position: 1433838-1434356 (Clockwise)

Preceding gene: 21242008

Following gene: 21242010

Centisome position: 27.7

GC content: 64.55

Gene sequence:

>519_bases
ATGAGTCAACGCCCCAACCCCTCGGCCCTGATCTGGCTGCTGCTCTCTGCGCTGGTGGTCGGCCTGGATCAGTGGAGCAA
GGCCTGGGTGCTGTCCAGCCTGCCCGAGTACACCCCGGTGCCGGTGATCGACGGCTTCTGGAATTGGTACCGCACCTACA
ACACCGGCGCAGCTTTCAGCTTTCTGAGCGATGCCGGCGGCTGGCAGCTGTGGTTCTTCACTGCGTTGGCGGTGGGCATC
AGCGGCCTGCTGGCGTTCTGGCTCTCGCGCACCGCGCGGGGGCAGTGGCGCAGCGCGCTGCCATATGCGCTGGTGATCGG
CGGGGCGATCGGTAACGTGATCGACCGGCTGATGCACGGCCACGTGGTGGATTTCATCCAGTGGTATATCGGCAGCCACA
CTTGGCCGTCCTTCAATATCGCCGACTCGGCGATCGTGGGCGGCGCGATCGGGATTGCCGTGTTCGGCTTGTTCGACAAA
TCCGACAAGCAGCAGCCGGGAACCGGGAATCTGCGCTGA

Upstream 100 bases:

>100_bases
AGCCAGCATCTGTCGTTTTCTGCCGCTGCCGTCACTCGACCTCCCACCCAGGCGTCTTCTCCGGCATCGGAGCAGCGGCC
ACCAACTGCGATCTTTCGAC

Downstream 100 bases:

>100_bases
AGCCTGCCTGCAGGCGCGTGCCGCCCGGTCCGACCCCTCGTCCCTCATTCCCGTAGAATGCCCGCCATGGATGTCCTGCT
CGCCAATCCCCGTGGTTTTT

Product: lipoprotein signal peptidase

Products: NA

Alternate protein names: Prolipoprotein signal peptidase; Signal peptidase II; SPase II

Number of amino acids: Translated: 172; Mature: 171

Protein sequence:

>172_residues
MSQRPNPSALIWLLLSALVVGLDQWSKAWVLSSLPEYTPVPVIDGFWNWYRTYNTGAAFSFLSDAGGWQLWFFTALAVGI
SGLLAFWLSRTARGQWRSALPYALVIGGAIGNVIDRLMHGHVVDFIQWYIGSHTWPSFNIADSAIVGGAIGIAVFGLFDK
SDKQQPGTGNLR

Sequences:

>Translated_172_residues
MSQRPNPSALIWLLLSALVVGLDQWSKAWVLSSLPEYTPVPVIDGFWNWYRTYNTGAAFSFLSDAGGWQLWFFTALAVGI
SGLLAFWLSRTARGQWRSALPYALVIGGAIGNVIDRLMHGHVVDFIQWYIGSHTWPSFNIADSAIVGGAIGIAVFGLFDK
SDKQQPGTGNLR
>Mature_171_residues
SQRPNPSALIWLLLSALVVGLDQWSKAWVLSSLPEYTPVPVIDGFWNWYRTYNTGAAFSFLSDAGGWQLWFFTALAVGIS
GLLAFWLSRTARGQWRSALPYALVIGGAIGNVIDRLMHGHVVDFIQWYIGSHTWPSFNIADSAIVGGAIGIAVFGLFDKS
DKQQPGTGNLR

Specific function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins

COG id: COG0597

COG function: function code MU; Lipoprotein signal peptidase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A8 family

Homologues:

Organism=Escherichia coli, GI1786210, Length=165, Percent_Identity=43.030303030303, Blast_Score=124, Evalue=4e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LSPA_XANAC (Q8PN18)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_641591.1
- MEROPS:   A08.001
- GeneID:   1155326
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC1255
- NMPDR:   fig|190486.1.peg.1235
- HOGENOM:   HBG724422
- OMA:   MATRNNG
- ProtClustDB:   PRK00376
- BioCyc:   XAXO190486:XAC1255-MONOMER
- BRENDA:   3.4.23.36
- GO:   GO:0006508
- HAMAP:   MF_00161
- InterPro:   IPR001872
- PRINTS:   PR00781
- TIGRFAMs:   TIGR00077

Pfam domain/function: PF01252 Peptidase_A8

EC number: =3.4.23.36

Molecular weight: Translated: 18918; Mature: 18787

Theoretical pI: Translated: 8.91; Mature: 8.91

Prosite motif: PS00855 SPASE_II

Important sites: ACT_SITE 115-115 ACT_SITE 142-142

Signals:

None

Transmembrane regions:

HASH(0xdcc3e48)-; HASH(0xe2527e4)-; HASH(0xe1febf4)-; HASH(0xdc38970)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQRPNPSALIWLLLSALVVGLDQWSKAWVLSSLPEYTPVPVIDGFWNWYRTYNTGAAFS
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHH
FLSDAGGWQLWFFTALAVGISGLLAFWLSRTARGQWRSALPYALVIGGAIGNVIDRLMHG
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHHHHHHH
HVVDFIQWYIGSHTWPSFNIADSAIVGGAIGIAVFGLFDKSDKQQPGTGNLR
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCH
>Mature Secondary Structure 
SQRPNPSALIWLLLSALVVGLDQWSKAWVLSSLPEYTPVPVIDGFWNWYRTYNTGAAFS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHH
FLSDAGGWQLWFFTALAVGISGLLAFWLSRTARGQWRSALPYALVIGGAIGNVIDRLMHG
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHHHHHHH
HVVDFIQWYIGSHTWPSFNIADSAIVGGAIGIAVFGLFDKSDKQQPGTGNLR
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12024217