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The map label for this gene is moaA [H]

Identifier: 21241853

GI number: 21241853

Start: 1249813

End: 1250817

Strand: Direct

Name: moaA [H]

Synonym: XAC1097

Alternate gene names: 21241853

Gene position: 1249813-1250817 (Clockwise)

Preceding gene: 21241852

Following gene: 21241854

Centisome position: 24.15

GC content: 67.16

Gene sequence:

>1005_bases
GTGACGGCGCCGATGCAGGACCGCTACGGCCGCCCGCTGCGCGATCTGCGCCTGTCGGTGATCGAAGCCTGCAATTTCCG
CTGCGGGTACTGCATGCCGGCCGATCGCGTGCCCGACGATTACGGCTTCGATTCACAGCAGCGGTTGAGTTTCGATCAGC
TGGAAACCCTGGTGCGTGCCTTCGTCTCGGTCGGGGTGACCAAGGTGCGCCTGACCGGCGGAGAGCCGCTGCTGCGTCGC
GACCTGCCGAGCCTGATCGCACGGCTGACCGCGATCGAGGGCATCGAAGATCTGGCACTGACCACCAACGGCACCTTGCT
CGCCCGCCAGGCCGTCGCGCTGCGGCAGGCCGGGCTGCGCCGCATCACCGTCAGCATGGATGCGCTGGAACCGGCGTTGT
TCAGGCGCATGAGCGGCGATCGCGGCGAGATTGCGCAGGTGCTGACCGGCATCGCCGCCGCCGAGCAGGCCGGTTTTCAG
CGGCTGAAGATCAATTGCGTGGTGCAGCGTGGCGTCAACGAAGATCAGGTGCTGCCGCTGGTGGAGCACTTCCGCGGCAC
TGGGCACGTGCTGCGCTTCATCGAATTCATGGATGTGGGCAGCTGCAATGGCTGGACCCCGGATGCGGTGGTGACCTCTG
CGCAACTGCACGAACGCATCCACGCGCGCTGGCCGCTGGTGGCGCTGGACGCCAATTACACCGGGGAAGTGGCCCAGCGC
CACGCCTTCGCGGATGGCGCCGGCGAGGTGGGCTTCGTCAGTTCGGTCAGCGTCCCGTTCTGCGGCGATTGCCAGCGTGC
GCGCGTTTCGGCAGACGGGCATCTGTATACCTGCCTGTTCGCCAGCCAGGGGCATGACCTCAAGCCGGCACTGGCCAATG
GCGAGCCTGCGCTGGCGACGCATCTGCGGCAGCGCTGGAGTGTGCGTGGCGACCGCTACAGCGAAGTGCGCGCCTCGGTG
CCACGGCGCGGCAAGCCGGTCGAGATGTTCTTGATCGGCGGATAA

Upstream 100 bases:

>100_bases
CACGTGGCCACCGCGTTGCCGTGCCCGGTCAATACCTCGCGTTGGCGAACCCGACCGCCGCGACGGTACCCTGATGGGCG
CCTTGCTGCAGCCGGATCTC

Downstream 100 bases:

>100_bases
GCGAGGACACGCTGCCGGTGCAGTTGCGCACGCTGGAACAGCGCCTGCGCGATCCGTCGCTGCGTGCCGGTGTACAGGTG
TTGGAAGCGCTGCTGGATCC

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 334; Mature: 333

Protein sequence:

>334_residues
MTAPMQDRYGRPLRDLRLSVIEACNFRCGYCMPADRVPDDYGFDSQQRLSFDQLETLVRAFVSVGVTKVRLTGGEPLLRR
DLPSLIARLTAIEGIEDLALTTNGTLLARQAVALRQAGLRRITVSMDALEPALFRRMSGDRGEIAQVLTGIAAAEQAGFQ
RLKINCVVQRGVNEDQVLPLVEHFRGTGHVLRFIEFMDVGSCNGWTPDAVVTSAQLHERIHARWPLVALDANYTGEVAQR
HAFADGAGEVGFVSSVSVPFCGDCQRARVSADGHLYTCLFASQGHDLKPALANGEPALATHLRQRWSVRGDRYSEVRASV
PRRGKPVEMFLIGG

Sequences:

>Translated_334_residues
MTAPMQDRYGRPLRDLRLSVIEACNFRCGYCMPADRVPDDYGFDSQQRLSFDQLETLVRAFVSVGVTKVRLTGGEPLLRR
DLPSLIARLTAIEGIEDLALTTNGTLLARQAVALRQAGLRRITVSMDALEPALFRRMSGDRGEIAQVLTGIAAAEQAGFQ
RLKINCVVQRGVNEDQVLPLVEHFRGTGHVLRFIEFMDVGSCNGWTPDAVVTSAQLHERIHARWPLVALDANYTGEVAQR
HAFADGAGEVGFVSSVSVPFCGDCQRARVSADGHLYTCLFASQGHDLKPALANGEPALATHLRQRWSVRGDRYSEVRASV
PRRGKPVEMFLIGG
>Mature_333_residues
TAPMQDRYGRPLRDLRLSVIEACNFRCGYCMPADRVPDDYGFDSQQRLSFDQLETLVRAFVSVGVTKVRLTGGEPLLRRD
LPSLIARLTAIEGIEDLALTTNGTLLARQAVALRQAGLRRITVSMDALEPALFRRMSGDRGEIAQVLTGIAAAEQAGFQR
LKINCVVQRGVNEDQVLPLVEHFRGTGHVLRFIEFMDVGSCNGWTPDAVVTSAQLHERIHARWPLVALDANYTGEVAQRH
AFADGAGEVGFVSSVSVPFCGDCQRARVSADGHLYTCLFASQGHDLKPALANGEPALATHLRQRWSVRGDRYSEVRASVP
RRGKPVEMFLIGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI22027536, Length=303, Percent_Identity=36.3036303630363, Blast_Score=199, Evalue=3e-51,
Organism=Homo sapiens, GI116734668, Length=303, Percent_Identity=36.3036303630363, Blast_Score=199, Evalue=4e-51,
Organism=Escherichia coli, GI1786999, Length=293, Percent_Identity=36.1774744027304, Blast_Score=179, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17561210, Length=336, Percent_Identity=31.8452380952381, Blast_Score=165, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI32566329, Length=334, Percent_Identity=31.7365269461078, Blast_Score=160, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI32566331, Length=293, Percent_Identity=33.4470989761092, Blast_Score=158, Evalue=3e-39,
Organism=Drosophila melanogaster, GI28574488, Length=290, Percent_Identity=36.551724137931, Blast_Score=194, Evalue=6e-50,
Organism=Drosophila melanogaster, GI28574490, Length=290, Percent_Identity=36.551724137931, Blast_Score=194, Evalue=1e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 36715; Mature: 36584

Theoretical pI: Translated: 8.02; Mature: 8.02

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAPMQDRYGRPLRDLRLSVIEACNFRCGYCMPADRVPDDYGFDSQQRLSFDQLETLVRA
CCCCCCHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHCCHHHHHHHHHH
FVSVGVTKVRLTGGEPLLRRDLPSLIARLTAIEGIEDLALTTNGTLLARQAVALRQAGLR
HHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCHHHHEEECCCHHHHHHHHHHHHCCCE
RITVSMDALEPALFRRMSGDRGEIAQVLTGIAAAEQAGFQRLKINCVVQRGVNEDQVLPL
EEEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCHHHHHHH
VEHFRGTGHVLRFIEFMDVGSCNGWTPDAVVTSAQLHERIHARWPLVALDANYTGEVAQR
HHHCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHH
HAFADGAGEVGFVSSVSVPFCGDCQRARVSADGHLYTCLFASQGHDLKPALANGEPALAT
HHCCCCCCCCCEEEECCCCCCCCCCHHEECCCCCEEEEEEECCCCCCCCCCCCCCHHHHH
HLRQRWSVRGDRYSEVRASVPRRGKPVEMFLIGG
HHHHHHCCCCCHHHHHHHCCCCCCCCEEEEEECC
>Mature Secondary Structure 
TAPMQDRYGRPLRDLRLSVIEACNFRCGYCMPADRVPDDYGFDSQQRLSFDQLETLVRA
CCCCCHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHCCHHHHHHHHHH
FVSVGVTKVRLTGGEPLLRRDLPSLIARLTAIEGIEDLALTTNGTLLARQAVALRQAGLR
HHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCHHHHEEECCCHHHHHHHHHHHHCCCE
RITVSMDALEPALFRRMSGDRGEIAQVLTGIAAAEQAGFQRLKINCVVQRGVNEDQVLPL
EEEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCHHHHHHH
VEHFRGTGHVLRFIEFMDVGSCNGWTPDAVVTSAQLHERIHARWPLVALDANYTGEVAQR
HHHCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHH
HAFADGAGEVGFVSSVSVPFCGDCQRARVSADGHLYTCLFASQGHDLKPALANGEPALAT
HHCCCCCCCCCEEEECCCCCCCCCCHHEECCCCCEEEEEEECCCCCCCCCCCCCCHHHHH
HLRQRWSVRGDRYSEVRASVPRRGKPVEMFLIGG
HHHHHHCCCCCHHHHHHHCCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA