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The map label for this gene is murC

Identifier: 21241550

GI number: 21241550

Start: 925147

End: 926580

Strand: Direct

Name: murC

Synonym: XAC0780

Alternate gene names: 21241550

Gene position: 925147-926580 (Clockwise)

Preceding gene: 21241549

Following gene: 21241551

Centisome position: 17.88

GC content: 67.22

Gene sequence:

>1434_bases
GTGATCCGCCGTCTGCAAGACAGTGGCGATCTGGTGCGGGCGTTCCCGCGCGTGCATTTCGTCGGCATCGGCGGTACCGG
CATGAGCGGCATTGCCGAGGTGATGTTGACGCTGGGCTATGAAGTGTCCGGCTCGGACAACGCCGACAACGCGGCCACGC
GCCGGCTGGCCAAGCTGGGTGCGCGCGTGATGCGCGGCCATTCGGCGGCCAACGTGCTGGGCACCGATTGCGTGGTGGTG
TCCAGCGCCATCCGCGAAGACAATCCCGAGCTGATGGAAGCGCGCAGCCAGCGCATTCCGATCATGCCGCGCGCGGCGAT
GCTGGCCGAGCTGATGCGTTTCCGTCGCGGCATTGCGGTGGCCGGCACGCATGGCAAGACCACCACCACCAGCCTGGCGG
CTGCGGTGCTGAGCGAAGGCGGGTTGGACCCGACGTTCGTGATCGGCGGGCAGCTGCTGGCTGCAGGCGCCAACGCCAAG
CTCGGTGGCGGCCAATGGTTGGTCGCCGAAGCGGACGAGAGCGATGGCAGCTTCCTGCGCCTGAATCCATTGATGGCGGT
CATCACCAACATCGATGCGGATCACCTGGAAAACTACGGCAACGATTTCGCCCGCGTGCAGGCCGCATTCGCCGAATTCC
TGCAGCGCCTGCCGTTCTACGGCCTGGCGTTGCTGTGCATCGACGACCCGGAAGTGGCTGCACTGGCCGGCAAGACGCCG
CGCCACGTGATGAGCTACGGCATGAGCGAAAACGCCGACGTGCGCGCCGAAGATGTGGTGCAGGACGGCCCGTGCATGCG
TTTTACGCTGCGCCTGCCCGAAGGCACCACCACCCCGGTGACGCTTGCACTGCCGGGCCGCCACAACGTGCTCAATGCGC
TGGCGGCTGCCGCAATCGGCTGGCAGCTCGGCGTGGCGCCGGACACCATTGCGCGCGCGCTGGAAAACTTTGCCGGCATC
GGCCGTCGGTTCAACGATCTGGGCGAAGTCACCACCAGCACCGGTGCGCGCGTGCGCGTGGTCGACGATTACGGCCATCA
CCCGCGCGAACTCGAAGCCGTGTTCGCTGCAGCACGTGGCGGCTGGCCGGACAAGCGTCTGGTCGTCGCCTTCCAGCCGC
ACCGCTATAGCCGCACCCGCGATCAGTTCGACGCCTTTGCCGCGGTGCTCAGCACGGTCGACGCGTTGGTGCTGAGCGAG
GTCTACCCCGCCGGCGAAGCGCCGATTCCGGGCGCCGACTCGCGCGCACTGGCGCGCGCCATCCGTGCGCGCGGCCGCAG
CGAACCGGTGGTGGTCGGCCAGATCGCCGGTCTTGCCGAAGTGTTGCCGGACGTCCTGCAGGACGGCGATCTGCTGTTGA
TGATGGGCGCCGGCGATATCGGTTATGTGGCCCAGCACATCATCAACAACGGGTTTGTCGGAGAACCGGCATGA

Upstream 100 bases:

>100_bases
CAGACAAGCGCACCGACCAAGTTTCCGTCGCCGCTGGCGCTCAGCTCCACACCATTCCCGATTCCCGATTCCCGATTCGC
ACCTCCACTGGAGGTGCCCG

Downstream 100 bases:

>100_bases
GCGCGTTGGTCGGCAACGCCCGCACCAGCGATCCGGCTGCCTTTGGCCGCGTCGCCGTACTGCTCGGCGGCACCTCGTCC
GAGCGCGAGGTGTCGTTGAA

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 477; Mature: 477

Protein sequence:

>477_residues
MIRRLQDSGDLVRAFPRVHFVGIGGTGMSGIAEVMLTLGYEVSGSDNADNAATRRLAKLGARVMRGHSAANVLGTDCVVV
SSAIREDNPELMEARSQRIPIMPRAAMLAELMRFRRGIAVAGTHGKTTTTSLAAAVLSEGGLDPTFVIGGQLLAAGANAK
LGGGQWLVAEADESDGSFLRLNPLMAVITNIDADHLENYGNDFARVQAAFAEFLQRLPFYGLALLCIDDPEVAALAGKTP
RHVMSYGMSENADVRAEDVVQDGPCMRFTLRLPEGTTTPVTLALPGRHNVLNALAAAAIGWQLGVAPDTIARALENFAGI
GRRFNDLGEVTTSTGARVRVVDDYGHHPRELEAVFAAARGGWPDKRLVVAFQPHRYSRTRDQFDAFAAVLSTVDALVLSE
VYPAGEAPIPGADSRALARAIRARGRSEPVVVGQIAGLAEVLPDVLQDGDLLLMMGAGDIGYVAQHIINNGFVGEPA

Sequences:

>Translated_477_residues
MIRRLQDSGDLVRAFPRVHFVGIGGTGMSGIAEVMLTLGYEVSGSDNADNAATRRLAKLGARVMRGHSAANVLGTDCVVV
SSAIREDNPELMEARSQRIPIMPRAAMLAELMRFRRGIAVAGTHGKTTTTSLAAAVLSEGGLDPTFVIGGQLLAAGANAK
LGGGQWLVAEADESDGSFLRLNPLMAVITNIDADHLENYGNDFARVQAAFAEFLQRLPFYGLALLCIDDPEVAALAGKTP
RHVMSYGMSENADVRAEDVVQDGPCMRFTLRLPEGTTTPVTLALPGRHNVLNALAAAAIGWQLGVAPDTIARALENFAGI
GRRFNDLGEVTTSTGARVRVVDDYGHHPRELEAVFAAARGGWPDKRLVVAFQPHRYSRTRDQFDAFAAVLSTVDALVLSE
VYPAGEAPIPGADSRALARAIRARGRSEPVVVGQIAGLAEVLPDVLQDGDLLLMMGAGDIGYVAQHIINNGFVGEPA
>Mature_477_residues
MIRRLQDSGDLVRAFPRVHFVGIGGTGMSGIAEVMLTLGYEVSGSDNADNAATRRLAKLGARVMRGHSAANVLGTDCVVV
SSAIREDNPELMEARSQRIPIMPRAAMLAELMRFRRGIAVAGTHGKTTTTSLAAAVLSEGGLDPTFVIGGQLLAAGANAK
LGGGQWLVAEADESDGSFLRLNPLMAVITNIDADHLENYGNDFARVQAAFAEFLQRLPFYGLALLCIDDPEVAALAGKTP
RHVMSYGMSENADVRAEDVVQDGPCMRFTLRLPEGTTTPVTLALPGRHNVLNALAAAAIGWQLGVAPDTIARALENFAGI
GRRFNDLGEVTTSTGARVRVVDDYGHHPRELEAVFAAARGGWPDKRLVVAFQPHRYSRTRDQFDAFAAVLSTVDALVLSE
VYPAGEAPIPGADSRALARAIRARGRSEPVVVGQIAGLAEVLPDVLQDGDLLLMMGAGDIGYVAQHIINNGFVGEPA

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=461, Percent_Identity=53.7960954446855, Blast_Score=441, Evalue=1e-125,
Organism=Escherichia coli, GI1790680, Length=468, Percent_Identity=28.6324786324786, Blast_Score=149, Evalue=4e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_XANAC (Q8PPA7)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_641132.1
- ProteinModelPortal:   Q8PPA7
- SMR:   Q8PPA7
- GeneID:   1154851
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC0780
- NMPDR:   fig|190486.1.peg.776
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- ProtClustDB:   PRK00421
- BioCyc:   XAXO190486:XAC0780-MONOMER
- BRENDA:   6.3.2.8
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 50593; Mature: 50593

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRRLQDSGDLVRAFPRVHFVGIGGTGMSGIAEVMLTLGYEVSGSDNADNAATRRLAKLG
CCCCCCCCCHHHHHCCCEEEEEECCCCHHHHHHHHHHHCCEECCCCCCCHHHHHHHHHHH
ARVMRGHSAANVLGTDCVVVSSAIREDNPELMEARSQRIPIMPRAAMLAELMRFRRGIAV
HHHHHCCCHHHHHCCHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCEEE
AGTHGKTTTTSLAAAVLSEGGLDPTFVIGGQLLAAGANAKLGGGQWLVAEADESDGSFLR
ECCCCCCHHHHHHHHHHHCCCCCCEEEECCEEEECCCCCCCCCCEEEEEECCCCCCCEEE
LNPLMAVITNIDADHLENYGNDFARVQAAFAEFLQRLPFYGLALLCIDDPEVAALAGKTP
ECHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHCCCCH
RHVMSYGMSENADVRAEDVVQDGPCMRFTLRLPEGTTTPVTLALPGRHNVLNALAAAAIG
HHHHHCCCCCCCCCCHHHHHCCCCCEEEEEECCCCCCCCEEEEECCCHHHHHHHHHHHHC
WQLGVAPDTIARALENFAGIGRRFNDLGEVTTSTGARVRVVDDYGHHPRELEAVFAAARG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHC
GWPDKRLVVAFQPHRYSRTRDQFDAFAAVLSTVDALVLSEVYPAGEAPIPGADSRALARA
CCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
IRARGRSEPVVVGQIAGLAEVLPDVLQDGDLLLMMGAGDIGYVAQHIINNGFVGEPA
HHHCCCCCCEEEEHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MIRRLQDSGDLVRAFPRVHFVGIGGTGMSGIAEVMLTLGYEVSGSDNADNAATRRLAKLG
CCCCCCCCCHHHHHCCCEEEEEECCCCHHHHHHHHHHHCCEECCCCCCCHHHHHHHHHHH
ARVMRGHSAANVLGTDCVVVSSAIREDNPELMEARSQRIPIMPRAAMLAELMRFRRGIAV
HHHHHCCCHHHHHCCHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCEEE
AGTHGKTTTTSLAAAVLSEGGLDPTFVIGGQLLAAGANAKLGGGQWLVAEADESDGSFLR
ECCCCCCHHHHHHHHHHHCCCCCCEEEECCEEEECCCCCCCCCCEEEEEECCCCCCCEEE
LNPLMAVITNIDADHLENYGNDFARVQAAFAEFLQRLPFYGLALLCIDDPEVAALAGKTP
ECHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHCCCCH
RHVMSYGMSENADVRAEDVVQDGPCMRFTLRLPEGTTTPVTLALPGRHNVLNALAAAAIG
HHHHHCCCCCCCCCCHHHHHCCCCCEEEEEECCCCCCCCEEEEECCCHHHHHHHHHHHHC
WQLGVAPDTIARALENFAGIGRRFNDLGEVTTSTGARVRVVDDYGHHPRELEAVFAAARG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHC
GWPDKRLVVAFQPHRYSRTRDQFDAFAAVLSTVDALVLSEVYPAGEAPIPGADSRALARA
CCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
IRARGRSEPVVVGQIAGLAEVLPDVLQDGDLLLMMGAGDIGYVAQHIINNGFVGEPA
HHHCCCCCCEEEEHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217