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The map label for this gene is hldE [H]

Identifier: 57238025

GI number: 57238025

Start: 1203161

End: 1204546

Strand: Reverse

Name: hldE [H]

Synonym: CJE1286

Alternate gene names: 57238025

Gene position: 1204546-1203161 (Counterclockwise)

Preceding gene: 57238026

Following gene: 57238024

Centisome position: 67.75

GC content: 33.26

Gene sequence:

>1386_bases
ATGCTTGAGTTTTTAAGCCAGCAAAAACCTAAAATTTTAATTATAGGGGATTTTATGGTGGATAATTACACTTGGTGTGA
TTGTTCGCGTATCAGTCCTGAAGCCCCTGTTTTGGTAGCTAAAACTCTTAAGGAAGATAAAAGATTAGGCGGGGCTGCGA
ATGTTTATGCAAATTTAAAAAGTTTAGGGGCTGATGTTTTTGCGCTTGGTGTTGTGGGTGATGATAAGAGTGGGAAATTT
TTACAAGAAAATTTAAAAGGAGAATTTTTGATCCAAAAAGGACGCAAAACCCCTTTTAAAAATCGCATTATGGCACACAA
TCAGCAGGTTTTAAGACTAGATGAAGAAGACATAAGTGAGATTTTGCTTGAAAATGAGCTTATTGCTTTGTTTGATGAAA
AGATTAAAGATTTTAAAGCTGTGGTTTTAAGCGATTATGCTAAGGGTATTTTAACGCCTAAGGTTTGTAAGGCTGTGATA
AAAAAGGCTAAGGCTTTAAATATCCCTGTTTTAGTTGATCCTAAAGGGAGTGATTTTAGTAAATATAGCGGTGCAACCTT
GCTCACGCCTAATAAAAAAGAAGCTTTAGAAGCTTTGAAATTTGAAAATTTAGAGGGTGAAAATTTAGAAAAAGGGATTA
AAAAATTAAAAGAAGATTTTTCTTTGCGTTATTCTATCATCACTCTTTCAGAAGCGGGGATTGCGCTTTTTAATGAGGGT
TTAAAAATCGCACCTGCTAAAGCCTTAGAAGTTTATGATGTAACAGGAGCGGGCGATAGTGTGATTGCCGTTTTGGCTTT
TTGTTTGGCAAATGAAATTGAAATTTTTAAAGCTTGTGAACTTGCCAATGAAGCTGCAGCCGTTGTAGTAAGTAAAATAG
GTAGTGTGAGTGTGAGTTTTGATGAGATTAGAAGTTTTAAAAGTATGAGTTTTGAGAAAAAGATCAAAAATAAAGAAGAG
CTTTTAACGCTTTTAAAACAAAATGATAAAAAGATTGTTTTTACAAATGGTTGTTTTGATATCGTGCATTTTGGACATAT
AAAATATCTTGAGAAAGCTAAAAGATTGGGCGATGTTTTGATTGTAGGTTTGAACTCAGATGCGAGTGTGAAAAGACTCA
AAGGTGAGAGTCGTCCTGTAAATTCAGAGTTTCAAAGAGCTTGTATGTTGGCAGCTTTTTATTTTGTAGATTTTGTAGTG
ATTTTTGATGAAGACACACCTTTAGAACTTATAAGCTTTTTAAAGCCTGATATTTTGGTTAAAGGAGCTGATTATAAAGA
TAAGCTTGTTGTAGGTTCAAATTTGATTTCAAGAGTTGAATTAATCGATTTTGAAGAAGGATTTAGTACGAGTAAGATTA
TAGAAAAGATTAAGGATAAAAAATGA

Upstream 100 bases:

>100_bases
AAACTAGATCAAACTTGGGATTATCAGCCAAAATTTAGTCTTGAAGAGGGGATTAAAGATTATTTAGATGAGATAAAAAG
ACTTTTTGAAAAGGAAGTAA

Downstream 100 bases:

>100_bases
TAAATTTAGTAGAAAAAGAATGGCAAGAACATCAAAAAATCGTTCAAGAAAGTGAAATTTTAAAAGGACAAATCGCTAAA
ATAGGCGAGCTTTTATGTGA

Product: D,D-heptose 1-phosphate adenosyltransferase/7-phosphate kinase

Products: NA

Alternate protein names: D-beta-D-heptose 7-phosphate kinase; D-beta-D-heptose 7-phosphotransferase; D-beta-D-heptose 1-phosphate adenosyltransferase [H]

Number of amino acids: Translated: 461; Mature: 461

Protein sequence:

>461_residues
MLEFLSQQKPKILIIGDFMVDNYTWCDCSRISPEAPVLVAKTLKEDKRLGGAANVYANLKSLGADVFALGVVGDDKSGKF
LQENLKGEFLIQKGRKTPFKNRIMAHNQQVLRLDEEDISEILLENELIALFDEKIKDFKAVVLSDYAKGILTPKVCKAVI
KKAKALNIPVLVDPKGSDFSKYSGATLLTPNKKEALEALKFENLEGENLEKGIKKLKEDFSLRYSIITLSEAGIALFNEG
LKIAPAKALEVYDVTGAGDSVIAVLAFCLANEIEIFKACELANEAAAVVVSKIGSVSVSFDEIRSFKSMSFEKKIKNKEE
LLTLLKQNDKKIVFTNGCFDIVHFGHIKYLEKAKRLGDVLIVGLNSDASVKRLKGESRPVNSEFQRACMLAAFYFVDFVV
IFDEDTPLELISFLKPDILVKGADYKDKLVVGSNLISRVELIDFEEGFSTSKIIEKIKDKK

Sequences:

>Translated_461_residues
MLEFLSQQKPKILIIGDFMVDNYTWCDCSRISPEAPVLVAKTLKEDKRLGGAANVYANLKSLGADVFALGVVGDDKSGKF
LQENLKGEFLIQKGRKTPFKNRIMAHNQQVLRLDEEDISEILLENELIALFDEKIKDFKAVVLSDYAKGILTPKVCKAVI
KKAKALNIPVLVDPKGSDFSKYSGATLLTPNKKEALEALKFENLEGENLEKGIKKLKEDFSLRYSIITLSEAGIALFNEG
LKIAPAKALEVYDVTGAGDSVIAVLAFCLANEIEIFKACELANEAAAVVVSKIGSVSVSFDEIRSFKSMSFEKKIKNKEE
LLTLLKQNDKKIVFTNGCFDIVHFGHIKYLEKAKRLGDVLIVGLNSDASVKRLKGESRPVNSEFQRACMLAAFYFVDFVV
IFDEDTPLELISFLKPDILVKGADYKDKLVVGSNLISRVELIDFEEGFSTSKIIEKIKDKK
>Mature_461_residues
MLEFLSQQKPKILIIGDFMVDNYTWCDCSRISPEAPVLVAKTLKEDKRLGGAANVYANLKSLGADVFALGVVGDDKSGKF
LQENLKGEFLIQKGRKTPFKNRIMAHNQQVLRLDEEDISEILLENELIALFDEKIKDFKAVVLSDYAKGILTPKVCKAVI
KKAKALNIPVLVDPKGSDFSKYSGATLLTPNKKEALEALKFENLEGENLEKGIKKLKEDFSLRYSIITLSEAGIALFNEG
LKIAPAKALEVYDVTGAGDSVIAVLAFCLANEIEIFKACELANEAAAVVVSKIGSVSVSFDEIRSFKSMSFEKKIKNKEE
LLTLLKQNDKKIVFTNGCFDIVHFGHIKYLEKAKRLGDVLIVGLNSDASVKRLKGESRPVNSEFQRACMLAAFYFVDFVV
IFDEDTPLELISFLKPDILVKGADYKDKLVVGSNLISRVELIDFEEGFSTSKIIEKIKDKK

Specific function: Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose [H]

COG id: COG2870

COG function: function code M; ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the cytidylyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789432, Length=473, Percent_Identity=42.9175475687104, Blast_Score=341, Evalue=5e-95,
Organism=Caenorhabditis elegans, GI193203447, Length=82, Percent_Identity=41.4634146341463, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17509873, Length=82, Percent_Identity=41.4634146341463, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI19921220, Length=137, Percent_Identity=37.2262773722628, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI45550974, Length=137, Percent_Identity=37.2262773722628, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI45550973, Length=137, Percent_Identity=37.2262773722628, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI45550975, Length=137, Percent_Identity=37.2262773722628, Blast_Score=73, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023030
- InterPro:   IPR011611
- InterPro:   IPR004821
- InterPro:   IPR004820
- InterPro:   IPR011913
- InterPro:   IPR011914
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01467 CTP_transf_2; PF00294 PfkB [H]

EC number: 2.7.-.- [C]

Molecular weight: Translated: 51216; Mature: 51216

Theoretical pI: Translated: 7.28; Mature: 7.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEFLSQQKPKILIIGDFMVDNYTWCDCSRISPEAPVLVAKTLKEDKRLGGAANVYANLK
CCCCCCCCCCCEEEEEEEEECCCEECCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHH
SLGADVFALGVVGDDKSGKFLQENLKGEFLIQKGRKTPFKNRIMAHNQQVLRLDEEDISE
HCCCCEEEEEEECCCCCCHHHHHCCCCEEEEECCCCCCHHHHHHHCCCHHEECCHHHHHH
ILLENELIALFDEKIKDFKAVVLSDYAKGILTPKVCKAVIKKAKALNIPVLVDPKGSDFS
HHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEECCCCCCCC
KYSGATLLTPNKKEALEALKFENLEGENLEKGIKKLKEDFSLRYSIITLSEAGIALFNEG
CCCCCEEECCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCEEEEEEEECCCCHHHHCCC
LKIAPAKALEVYDVTGAGDSVIAVLAFCLANEIEIFKACELANEAAAVVVSKIGSVSVSF
CEECCCCEEEEEEECCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCEEEH
DEIRSFKSMSFEKKIKNKEELLTLLKQNDKKIVFTNGCFDIVHFGHIKYLEKAKRLGDVL
HHHHHHHHCCHHHHHCCHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCEE
IVGLNSDASVKRLKGESRPVNSEFQRACMLAAFYFVDFVVIFDEDTPLELISFLKPDILV
EEEECCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHCCCCEEE
KGADYKDKLVVGSNLISRVELIDFEEGFSTSKIIEKIKDKK
ECCCCCCCEEECHHHHHHHHEEECCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MLEFLSQQKPKILIIGDFMVDNYTWCDCSRISPEAPVLVAKTLKEDKRLGGAANVYANLK
CCCCCCCCCCCEEEEEEEEECCCEECCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHH
SLGADVFALGVVGDDKSGKFLQENLKGEFLIQKGRKTPFKNRIMAHNQQVLRLDEEDISE
HCCCCEEEEEEECCCCCCHHHHHCCCCEEEEECCCCCCHHHHHHHCCCHHEECCHHHHHH
ILLENELIALFDEKIKDFKAVVLSDYAKGILTPKVCKAVIKKAKALNIPVLVDPKGSDFS
HHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEECCCCCCCC
KYSGATLLTPNKKEALEALKFENLEGENLEKGIKKLKEDFSLRYSIITLSEAGIALFNEG
CCCCCEEECCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCEEEEEEEECCCCHHHHCCC
LKIAPAKALEVYDVTGAGDSVIAVLAFCLANEIEIFKACELANEAAAVVVSKIGSVSVSF
CEECCCCEEEEEEECCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCEEEH
DEIRSFKSMSFEKKIKNKEELLTLLKQNDKKIVFTNGCFDIVHFGHIKYLEKAKRLGDVL
HHHHHHHHCCHHHHHCCHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCEE
IVGLNSDASVKRLKGESRPVNSEFQRACMLAAFYFVDFVVIFDEDTPLELISFLKPDILV
EEEECCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHCCCCEEE
KGADYKDKLVVGSNLISRVELIDFEEGFSTSKIIEKIKDKK
ECCCCCCCEEECHHHHHHHHEEECCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA